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AMR Drug RepurposingSmart Screeningresearch prototype

Trimetrexate Glucuronate

FDA-approved product (injectable, injection), marketed as Neutrexin.

Registered studies
17
Lab records
7
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Trimetrexate Glucuronate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Trimetrexate Glucuronate. Its therapeutic class is shown instead.

WHO therapeutic group
Other agents against amoebiasis and other protozoal diseases
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC P01AX07

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA34.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli88.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae17.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis50.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

17registered studies name this medicine, for any condition. See them below.

Experimental

  • E. coli: measured active in 7 of 7 lab records
Open Trimetrexate Glucuronate in ChEMBL Registered studies below
Show the 7 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Trimetrexate Glucuronate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Methotrexate, Trimetrexate Glucuronate, and Leucovorin in Treating Patients With Refractory or Recurrent Osteosarcoma

    NCT00119301 · start 2005-04

    Registered record
    Registry ID
    NCT00119301
    Conditions
    Sarcoma
    Interventions
    leucovorin calcium; methotrexate; trimetrexate glucuronate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2005-04
    Completion
    Not recorded
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSarcoma
    Interventionleucovorin calcium; methotrexate; trimetrexate glucuronate
    PhasePhase 1
    Registry statusCompleted

  • Combination Chemotherapy and Surgery in Treating Patients With Newly Diagnosed Metastatic Osteosarcoma

    NCT00003776 · start 1998-12

    Registered record
    Registry ID
    NCT00003776
    Conditions
    Sarcoma
    Interventions
    filgrastim; cisplatin; doxorubicin hydrochloride; ifosfamide; leucovorin calcium; methotrexate; trimetrexate glucuronate; surgical procedure
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1998-12
    Completion
    2000-03
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSarcoma
    Interventionfilgrastim; cisplatin; doxorubicin hydrochloride; ifosfamide +4 more
    PhasePhase 2
    Registry statusCompleted

  • Chemotherapy in Treating Patients With Recurrent or Metastatic Colorectal Cancer

    NCT00003446 · start 1997-12

    Registered record
    Registry ID
    NCT00003446
    Conditions
    Colorectal Cancer
    Interventions
    fluorouracil; leucovorin calcium; trimetrexate glucuronate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1997-12
    Completion
    2005-08
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Cancer
    Interventionfluorouracil; leucovorin calcium; trimetrexate glucuronate
    PhasePhase 2
    Registry statusCompleted

  • Combination Chemotherapy in Treating Children With Acute Lymphoblastic Leukemia, Osteosarcoma, or Non-Hodgkin's Lymphoma

    NCT00002738 · start 1996-01

    Registered record
    Registry ID
    NCT00002738
    Conditions
    Leukemia; Lymphoma; Sarcoma
    Interventions
    leucovorin calcium; trimetrexate glucuronate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1996-01
    Completion
    2006-06
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia; Lymphoma; Sarcoma
    Interventionleucovorin calcium; trimetrexate glucuronate
    PhasePhase 2
    Registry statusCompleted

  • Combination Chemotherapy in Treating Patients With Advanced Cancer of the Pancreas

    NCT00002955 · start 1995-08

    Registered record
    Registry ID
    NCT00002955
    Conditions
    Pancreatic Cancer
    Interventions
    fluorouracil; leucovorin calcium; trimetrexate glucuronate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1995-08
    Completion
    2006-06
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPancreatic Cancer
    Interventionfluorouracil; leucovorin calcium; trimetrexate glucuronate
    PhasePhase 2
    Registry statusCompleted

  • An Open, Prospective, Multicenter Study of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia (PCP) and Serious Intolerance to Approved Therapies

    NCT00000714

    Registered record
    Registry ID
    NCT00000714
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2004-07
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Leucovorin calcium
    PhasePhase 3
    Registry statusCompleted

  • A Study of Trimetrexate With Leucovorin Rescue for AIDS Patients Who Are Refractory to Standard Therapies for Pneumocystis Carinii Pneumonia

    NCT00000724

    Registered record
    Registry ID
    NCT00000724
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2004-07
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Leucovorin calcium
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Three Treatments for Pneumocystis Pneumonia in AIDS Patients

    NCT00000730

    Registered record
    Registry ID
    NCT00000730
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Methylprednisolone; Pentamidine isethionate; Sulfamethoxazole-Trimethoprim; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    Not recorded
    Completion
    1989-03
    Enrolment
    240

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Methylprednisolone; Pentamidine isethionate; Sulfamethoxazole-Trimethoprim +1 more
    PhasePhase 3
    Registry statusTerminated

  • A Study of Trimetrexate in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS Not Previously Treated for PCP

    NCT00000998

    Registered record
    Registry ID
    NCT00000998
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1989-04
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Leucovorin calcium
    PhasePhase 1
    Registry statusCompleted

  • Comparison of Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

    NCT00001013

    Registered record
    Registry ID
    NCT00001013
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Pentamidine isethionate; Sulfamethoxazole-Trimethoprim; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1991-09
    Enrolment
    364

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Pentamidine isethionate; Sulfamethoxazole-Trimethoprim; Leucovorin calcium
    PhasePhase 3
    Registry statusCompleted

  • Trimetrexate Plus Leucovorin Calcium Rescue Versus Sulfamethoxazole-Trimethoprim in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS

    NCT00001014

    Registered record
    Registry ID
    NCT00001014
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Sulfamethoxazole-Trimethoprim; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1991-09
    Enrolment
    302

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Sulfamethoxazole-Trimethoprim; Leucovorin calcium
    PhasePhase 3
    Registry statusCompleted

  • A Treatment Protocol for the Use of Trimetrexate With Leucovorin Rescue for AIDS Patients With Pneumocystis Carinii Pneumonia and Serious Intolerance to Approved Therapies

    NCT00001016

    Registered record
    Registry ID
    NCT00001016
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2007-08
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Leucovorin calcium
    PhasePhase 3
    Registry statusCompleted

  • A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate With Leucovorin Protection for Patients With Pneumocystis Carinii Pneumonia.

    NCT00002102

    Registered record
    Registry ID
    NCT00002102
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Leucovorin calcium
    PhaseNot applicable
    Registry statusCompleted

  • A Compassionate Treatment Protocol for the Use of Trimetrexate Glucuronate (Neutrexin) With Leucovorin Protection for European Adult Patients (>= 13 Years Old) With Pneumocystis Carinii Pneumonia

    NCT00002103

    Registered record
    Registry ID
    NCT00002103
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Leucovorin calcium
    PhaseNot applicable
    Registry statusCompleted

  • Randomized Phase I Study of Trimetrexate Glucuronate (TMTX) With Leucovorin (LCV) Protection Plus Dapsone Versus Trimethoprim / Sulfamethoxazole (TMP/SMX) for Treatment of Moderately Severe Episodes of Pneumocystis Carinii Pneumonia

    NCT00002120

    Registered record
    Registry ID
    NCT00002120
    Conditions
    Pneumonia, Pneumocystis Carinii; HIV Infections
    Interventions
    Trimetrexate glucuronate; Trimethoprim; Sulfamethoxazole; Dapsone; Leucovorin calcium
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia, Pneumocystis Carinii; HIV Infections
    InterventionTrimetrexate glucuronate; Trimethoprim; Sulfamethoxazole; Dapsone +1 more
    PhasePhase 1
    Registry statusCompleted