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AMR Drug RepurposingSmart Screeningresearch prototype

Nevirapine

FDA-approved product (tablet, oral), marketed as Nevirapine, Viramune, Viramune Xr.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Nevirapine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • HIV infection
  • HIV-1 infection
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Non-nucleoside reverse transcriptase inhibitors
FDA pharmacologic class
Human Immunodeficiency Virus 1 Non-Nucleoside Analog Reverse Transcriptase Inhibitor FDA label ↗
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AG01

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli49.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae29.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis49.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Nevirapine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nevirapine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Case-Control Viramune (Nevirapine) Toxicogenomics Study

    NCT00310843 · start 2006-02

    Registered record
    Registry ID
    NCT00310843
    Conditions
    HIV Infections
    Interventions
    Nevirapine
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-02
    Completion
    Not recorded
    Enrolment
    889

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNevirapine
    PhaseNot recorded
    Registry statusCompleted

  • Pharmacoscintigraphic Investigation Into the Absorption of Nevirapine When Released Into Different Parts of the Gastro-intestinal Tract in Healthy Males

    NCT02191189 · start 2005-05

    Registered record
    Registry ID
    NCT02191189
    Conditions
    Healthy
    Interventions
    Nevirapine suspension, into Enterion™ capsule; Nevirapine suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2005-05
    Completion
    Not recorded
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionNevirapine suspension, into Enterion™ capsule; Nevirapine suspension
    PhasePhase 1
    Registry statusCompleted

  • Three Generic Nevirapine-Based Antiretroviral Treatments in Chinese Patients:Multicentric Observation Cohort

    NCT00618176 · start 2005-01

    Registered record
    Registry ID
    NCT00618176
    Conditions
    HIV Infections
    Interventions
    Zidovudine (AZT)+ Didanosine (ddI)+ Nevirapine (NVP); Stavudine (d4T), Lamivudine (3TC), Nevirapine (NVP); Zidovudine (AZT), Lamivudine (3TC), Nevirapine (NVP)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-01
    Completion
    Not recorded
    Enrolment
    198

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionZidovudine (AZT)+ Didanosine (ddI)+ Nevirapine (NVP); Stavudine (d4T), Lamivudine (3TC), Nevirapine (NVP); Zidovudine (AZT), Lamivudine (3TC), Nevirapine (NVP)
    PhasePhase 4
    Registry statusCompleted

  • One Month Dual Antiretroviral Prophylaxis to Prevent Resistance Mutations in Mothers Exposed to Single Dose Nevirapine

    NCT00142337 · start 2004-12

    Registered record
    Registry ID
    NCT00142337
    Conditions
    HIV Infections
    Interventions
    Zidovudine (ZDV); Didanosine (ddI)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-12
    Completion
    2009-02
    Enrolment
    244

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionZidovudine (ZDV); Didanosine (ddI)
    PhasePhase 2
    Registry statusCompleted

  • Pharmacokinetic Study of Antiretroviral Drugs and Related Drugs During and After Pregnancy

    NCT00042289 · start 2003-06-09

    Registered record
    Registry ID
    NCT00042289
    Conditions
    HIV Infections
    Interventions
    atazanavir/cobicistat; darunavir/ritonavir dosage #1; darunavir/ritonavir dosage #2; darunavir/ritonavir dosage #3; elvitegravir/cobicistat; dolutegravir; tenofovir alafenamide fumarate (TAF); TAF w/cobicistat; TAF w/cobicistat or ritonavir; efavirenz; darunavir/cobicistat; lopinavir/ritonavir dosage #1; atazanavir/ritonavir/tenofovir dosage #1; rifampicin; ethambutol; isoniazid; pyrazinamide; kanamycin; amikacin; capreomycin; moxifloxacin; levoflaxacin; ofloxacin; ethionamide/prothionamide; terizidone/cycloserine; para-aminosalicylic acid (PAS); high dose INH; bedaquiline; clofazamine; delamanid; linezolid; pretomanid; ethinyl estradiol; etonogestrel implant; nevirapine; amprenavir; abacavir; lopinavir/ritonavir dosage #2; indinavir/ritonavir dosage #1; fosamprenavir/ritonavir; lopinavir/ritonavir dosage #3; atazanavir/ritonavir dosage #1; didanosine delayed release (Videx® EC); emtricitabine; tenofovir; nelfinavir dosage #1; tipranavir/ritonavir; lopinavir/ritonavir dosage #4; ralteg
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2003-06-09
    Completion
    2020-09-30
    Enrolment
    1,578

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    Interventionatazanavir/cobicistat; darunavir/ritonavir dosage #1; darunavir/ritonavir dosage #2; darunavir/ritonavir dosage #3 +45 more
    PhaseNot recorded
    Registry statusCompleted

  • Open Label Study of NVP+CBV Treatment in Women Who Have Received sdNVP for the pMTCT of HIV

    NCT00144157 · start 2003-06

    Registered record
    Registry ID
    NCT00144157
    Conditions
    Acquired Immunodeficiency Syndrome
    Interventions
    Nevirapine; Zidovudine; 3TC
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-06
    Completion
    2006-07
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcquired Immunodeficiency Syndrome
    InterventionNevirapine; Zidovudine; 3TC
    PhasePhase 4
    Registry statusCompleted

  • Nevirapine (NVP) Use to Prevent Mother-to-Child Transmission of HIV

    NCT00074399 · start 2001-02

    Registered record
    Registry ID
    NCT00074399
    Conditions
    HIV Infections
    Interventions
    Nevirapine; Nevirapine placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2001-02
    Completion
    2007-04
    Enrolment
    775

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNevirapine; Nevirapine placebo
    PhasePhase 3
    Registry statusCompleted

  • Efficacy of Nevirapine Compared to ZDV + 3TC Administered in Labor and Again at Postdelivery in HIV Positive Women

    NCT02181933 · start 1999-04

    Registered record
    Registry ID
    NCT02181933
    Conditions
    HIV Infections
    Interventions
    Nevirapine; Zidovudine (ZDV); Lamivudine (3TC)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1999-04
    Completion
    Not recorded
    Enrolment
    2,648

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNevirapine; Zidovudine (ZDV); Lamivudine (3TC)
    PhasePhase 3
    Registry statusCompleted

  • Study of Nevirapine and Prednisone to Determine the Safety and Effectiveness in Preventing Nevirapine Associated Rash in Human Immunodeficiency Virus (HIV) Infected Patients

    NCT02184299 · start 1999-04

    Registered record
    Registry ID
    NCT02184299
    Conditions
    HIV Infections
    Interventions
    Nevirapine; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    1999-04
    Completion
    Not recorded
    Enrolment
    138

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNevirapine; Prednisone
    PhasePhase 4
    Registry statusCompleted

  • An Open-Label, Staggered Rising Dose Cohort Study Assessing the Pharmacokinetics, Safety, and Tolerance of BI-RG-587 in Combination With Zidovudine in Patients With HIV Infection (CD4+ Cell Count < 400/mm3)

    NCT00000649

    Registered record
    Registry ID
    NCT00000649
    Conditions
    HIV Infections
    Interventions
    Nevirapine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNevirapine; Zidovudine
    PhasePhase 1
    Registry statusCompleted

  • A Randomized, Double-Blind, Four-Arm Study Comparing Combination Nucleoside, Alternating Nucleoside, and Triple-Drug Therapy for the Treatment of Advanced HIV Disease (CD4 <= 50/mm3)

    NCT00000781

    Registered record
    Registry ID
    NCT00000781
    Conditions
    HIV Infections
    Interventions
    Nevirapine; Zidovudine; Zalcitabine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1996-09
    Enrolment
    1,292

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNevirapine; Zidovudine; Zalcitabine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • A Comparative Study of Combination Antiretroviral Therapy in Children and Adolescents With Advanced HIV Disease

    NCT00000814

    Registered record
    Registry ID
    NCT00000814
    Conditions
    HIV Infections
    Interventions
    Nevirapine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1998-11
    Enrolment
    390

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNevirapine; Zidovudine; Didanosine
    PhasePhase 1
    Registry statusCompleted

  • A Study to Compare Two Different Anti-HIV Drug Regimens

    NCT00000924

    Registered record
    Registry ID
    NCT00000924
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate; Nevirapine; Stavudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2001-06
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate; Nevirapine; Stavudine +1 more
    PhasePhase 2
    Registry statusCompleted

  • A Study of Nevirapine to Prevent HIV Transmission From Mothers to Their Babies

    NCT00000942

    Registered record
    Registry ID
    NCT00000942
    Conditions
    HIV Infections; Pregnancy
    Interventions
    Nevirapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2001-05
    Enrolment
    1,244

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Pregnancy
    InterventionNevirapine
    PhasePhase 3
    Registry statusCompleted

  • A Study of Nevirapine Used Alone or in Combination With AZT in HIV-1-Infected Children

    NCT00001111

    Registered record
    Registry ID
    NCT00001111
    Conditions
    HIV Infections
    Interventions
    Nevirapine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNevirapine; Zidovudine
    PhaseNot applicable
    Registry statusCompleted