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AMR Drug RepurposingSmart Screeningresearch prototype

Teniposide

FDA-approved product (injectable, injection), marketed as Vumon.

Registered studies
30
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Teniposide
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Neoplasm

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Podophyllotoxin derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae28.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis38.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

30registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Teniposide in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Teniposide with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Intensified Post Remission Therapy Containing PEG-Asparaginase

    NCT00184041 · start 2004-07

    Registered record
    Registry ID
    NCT00184041
    Conditions
    Acute Lymphoblastic Leukemia
    Interventions
    Daunorubicin, Vincristine, Prednisone, Methotrexate, PEG-Asparaginase, 6-Mercaptopurine, Cytoxan, Cytosine Arabinoside, VM-26 and 6-Thioguanine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-07
    Completion
    2012-12
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphoblastic Leukemia
    InterventionDaunorubicin, Vincristine, Prednisone, Methotrexate, PEG-Asparaginase, 6-Mercaptopurine, Cytoxan, Cytosine Arabinoside, VM-26 and 6-Thioguanine
    PhasePhase 2
    Registry statusCompleted

  • Trial for Treatment of Adult Patients With Standard Risk Acute Lymphoblastic Leukemia With Chemotherapy and Rituximab

    NCT00199004 · start 2004-04

    Registered record
    Registry ID
    NCT00199004
    Conditions
    Adult Acute Lymphocytic Leukemia
    Interventions
    Cyclophosphamide; Dexamethasone / Prednisolone; Vincristine; Daunorubicin; Asparaginase; Methotrexate; Cytarabine; Mercaptopurine; G-CSF; Vindesine; VP16; Adriamycin; Thioguanine; VM26; Rituximab; CNS irradiation; Mediastinal irradiation (if residual TU); Stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-04
    Completion
    2009-03
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Acute Lymphocytic Leukemia
    InterventionCyclophosphamide; Dexamethasone / Prednisolone; Vincristine; Daunorubicin +14 more
    PhasePhase 4
    Registry statusCompleted

  • Therapy for Pediatric Relapsed or Refractory Acute Lymphoblastic Leukemia

    NCT00186875 · start 2003-11

    Registered record
    Registry ID
    NCT00186875
    Conditions
    Acute Lymphoblastic Leukemia; Lymphoma, Lymphoblastic
    Interventions
    Etoposide, cytarabine, vincristine, dexamethasone; methotrexate, teniposide, PEG-asparaginase; mitoxantrone, cyclophosphamide, mercaptopurine, vinblastine; L-asparaginase, erwinia asparaginase; chemotherapy, intrathecal chemotherapy, steroid therapy; Hematopoietic Stem Cell Transplant; Natural Killer (NK) Cell Transplant
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-11
    Completion
    2016-08
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphoblastic Leukemia; Lymphoma, Lymphoblastic
    InterventionEtoposide, cytarabine, vincristine, dexamethasone; methotrexate, teniposide, PEG-asparaginase; mitoxantrone, cyclophosphamide, mercaptopurine, vinblastine; L-asparaginase, erwinia asparaginase +3 more
    PhasePhase 2
    Registry statusCompleted

  • German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (07/2003)

    NCT00198991 · start 2003-04

    Registered record
    Registry ID
    NCT00198991
    Conditions
    Adult Acute Lymphocytic Leukemia
    Interventions
    Cyclophosphamide; Dexamethasone; Vincristine; Daunorubicin; Asparaginase; Methotrexate; Cytarabine; Mercaptopurine; G-CSF; Vindesine; Etoposide; Prednisolone; Adriamycin; Thioguanine; Teniposide; CNS irradiation; Mediastinal Irradiation; Stem cell transplantation (SCT); Idarubicin; Fludarabine; Cladribine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-04
    Completion
    2013-06-30
    Enrolment
    1,883

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Acute Lymphocytic Leukemia
    InterventionCyclophosphamide; Dexamethasone; Vincristine; Daunorubicin +17 more
    PhasePhase 4
    Registry statusCompleted

  • Combination Chemotherapy in Treating Young Patients With Acute Lymphoblastic Leukemia

    NCT00343369 · start 2003-01

    Registered record
    Registry ID
    NCT00343369
    Conditions
    Leukemia
    Interventions
    asparaginase; cyclophosphamide; cytarabine; daunorubicin hydrochloride; dexamethasone; doxorubicin hydrochloride; mercaptopurine; methotrexate; pegaspargase; prednisolone; teniposide; thioguanine; vincristine sulfate; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2003-01
    Completion
    Not recorded
    Enrolment
    550

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia
    Interventionasparaginase; cyclophosphamide; cytarabine; daunorubicin hydrochloride +10 more
    PhaseNot applicable
    Registry statusUnknown

  • Treatment of High Risk Adult Acute Lymphoblastic Leukemia

    NCT00853008 · start 2003-01

    Registered record
    Registry ID
    NCT00853008
    Conditions
    Acute Lymphoblastic Leukemia
    Interventions
    Vincristine; Daunorubicin; Prednisone; Mitoxantrone; Cytosine Arabinoside; Dexamethasone; Methotrexate (MTX); Cytarabine; ASP; Mercaptopurine; Teniposide; Hydrocortisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-01
    Completion
    2012-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphoblastic Leukemia
    InterventionVincristine; Daunorubicin; Prednisone; Mitoxantrone +8 more
    PhasePhase 4
    Registry statusCompleted

  • Chemotherapy Plus Rituximab Combination for Adult Lymphoblastic Leukemia (B-ALL) and Burkitt's Non-Hodgkin Lymphoma

    NCT01290120 · start 2002-11

    Registered record
    Registry ID
    NCT01290120
    Conditions
    Burkitt Lymphoma; B-ALL
    Interventions
    Chemotherapy-Rituximab combination
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2002-11
    Completion
    2014-06
    Enrolment
    182

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBurkitt Lymphoma; B-ALL
    InterventionChemotherapy-Rituximab combination
    PhasePhase 2
    Registry statusCompleted

  • Combination Chemotherapy, Bone Marrow or Peripheral Stem Cell Transplantation, and/or Biological Therapy in Treating Patients With Stage III or Stage IV Mantle Cell Lymphoma

    NCT00004231 · start 1999-10

    Registered record
    Registry ID
    NCT00004231
    Conditions
    Lymphoma
    Interventions
    aldesleukin; filgrastim; recombinant interferon alfa; busulfan; cyclophosphamide; cytarabine; doxorubicin hydrochloride; leucovorin calcium; methotrexate; prednisone; teniposide; vincristine sulfate; allogeneic bone marrow transplantation; autologous bone marrow transplantation; peripheral blood stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    1999-10
    Completion
    2006-08
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    Interventionaldesleukin; filgrastim; recombinant interferon alfa; busulfan +11 more
    PhasePhase 2
    Registry statusCompleted

  • German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (06/99)

    NCT00199056 · start 1999-10

    Registered record
    Registry ID
    NCT00199056
    Conditions
    Adult Acute Lymphocytic Leukemia
    Interventions
    Dexamethasone / Prednisolone; Cyclophosphamide; Methotrexate; Vincristine / Vindesine; Daunorubicin; Asparaginase; G-CSF; Cytarabine; 6-Mercaptopurine; VP16; Adriamycin; Thioguanine; VM26; Idarubicin; Fludarabine; Ifosfamide; CNS irradiation; Mediastinal irradiation (if residual tumor); stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    1999-10
    Completion
    2005-12
    Enrolment
    225

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Acute Lymphocytic Leukemia
    InterventionDexamethasone / Prednisolone; Cyclophosphamide; Methotrexate; Vincristine / Vindesine +15 more
    PhasePhase 4
    Registry statusCompleted

  • Ifosfamide, Teniposide, and Paclitaxel in Treating Patients With Relapsed Non-Hodgkin's Lymphoma

    NCT00004916 · start 1999-02

    Registered record
    Registry ID
    NCT00004916
    Conditions
    Lymphoma
    Interventions
    ifosfamide; paclitaxel; teniposide; peripheral blood stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    1999-02
    Completion
    2002-10
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma
    Interventionifosfamide; paclitaxel; teniposide; peripheral blood stem cell transplantation
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • A Study of Children With Refractory or Relapsed ALL

    NCT00187083 · start 1997-02

    Registered record
    Registry ID
    NCT00187083
    Conditions
    Acute Lymphoblastic Leukemia
    Interventions
    Topotecan, dexamethasone, vincristine; E. coli Asparaginase, PEG-L-asparaginase; erwinia asparaginase; fludarabine, methotrexate, mercaptopurine; idarubicin, etoposide, cytarbine, teniposide; chemotherapy, intrathecal chemotherapy, steroid therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1997-02
    Completion
    2003-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphoblastic Leukemia
    InterventionTopotecan, dexamethasone, vincristine; E. coli Asparaginase, PEG-L-asparaginase; erwinia asparaginase; fludarabine, methotrexate, mercaptopurine +2 more
    PhasePhase 3
    Registry statusCompleted

  • Treatment of Elderly Patients (>65 Years) With Acute Lymphoblastic Leukemia

    NCT00199095 · start 1997-02

    Registered record
    Registry ID
    NCT00199095
    Conditions
    Adult Acute Lymphocytic Leukemia
    Interventions
    Adriamycin; Cyclophosphamide; Cytarabine; Dexamethasone; Idarubicin; Ifosfamide; Methotrexate; Mercaptopurine; VM26; Vincristine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    1997-02
    Completion
    2003-06
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Acute Lymphocytic Leukemia
    InterventionAdriamycin; Cyclophosphamide; Cytarabine; Dexamethasone +6 more
    PhasePhase 4
    Registry statusCompleted

  • High-Dose Therapy Treatment in Patients With Follicular Lymphoma

    NCT00696735 · start 1994-06

    Registered record
    Registry ID
    NCT00696735
    Conditions
    Follicular Lymphoma
    Interventions
    chemotherapy; high dose therapy and autologous stem cell transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    1994-06
    Completion
    2006-05
    Enrolment
    172

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFollicular Lymphoma
    Interventionchemotherapy; high dose therapy and autologous stem cell transplantation
    PhasePhase 3
    Registry statusCompleted

  • German Multicenter Trial for Treatment of Newly Diagnosed Acute Lymphoblastic Leukemia in Adults (05/93)

    NCT00199069 · start 1993-04

    Registered record
    Registry ID
    NCT00199069
    Conditions
    Adult Acute Lymphocytic Leukemia
    Interventions
    Asparaginase; Vincristine; Daunorubicin, Adriamycin; Cyclophosphamide; Ifosfamide; Cytarabine; Mitoxantrone; Methotrexate; 6-Mercaptopurine; 6-Thioguanine; VM26; Dexamethasone / Prednisolone; CNS Irradiation; Mediastinal Irradiation; Stem Cell Transplantation
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    1993-04
    Completion
    2001-05
    Enrolment
    720

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdult Acute Lymphocytic Leukemia
    InterventionAsparaginase; Vincristine; Daunorubicin, Adriamycin; Cyclophosphamide +11 more
    PhasePhase 4
    Registry statusCompleted

  • Combination Chemotherapy in Treating Adults With Acute Lymphocytic Leukemia

    NCT00002531 · start 1993-01

    Registered record
    Registry ID
    NCT00002531
    Conditions
    Leukemia
    Interventions
    asparaginase; cyclophosphamide; cytarabine; daunorubicin hydrochloride; dexamethasone; doxorubicin hydrochloride; etoposide; ifosfamide; leucovorin calcium; mercaptopurine; methotrexate; mitoxantrone hydrochloride; prednisolone; teniposide; thioguanine; vincristine sulfate; vindesine; allogeneic bone marrow transplantation; peripheral blood stem cell transplantation; radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    1993-01
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia
    Interventionasparaginase; cyclophosphamide; cytarabine; daunorubicin hydrochloride +16 more
    PhasePhase 2
    Registry statusUnknown