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AMR Drug RepurposingSmart Screeningresearch prototype

Nitrofurantoin

FDA-approved product (tablet, oral), marketed as Furadantin, Furalan, Nitrofurantoin and 3 more.

Registered studies
50+
Lab records
6
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Nitrofurantoin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Cystitis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nitrofuran derivatives
FDA pharmacologic class
Nitrofuran Antibacterial FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01XE01; WHO ATC J01XE51; FDA class Nitrofuran Antibacterial

Repurposing investigation

Nitrofurantoin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA25.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli31.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis92.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 0 of 4 lab records
  • M. tuberculosis: measured active in 1 of 2 lab records
Open Nitrofurantoin in ChEMBL Registered studies below
Show the 6 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nitrofurantoin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Electronic Prescription Data to Improve Primary Care Prescribing

    NCT02512198 · start 2015-07

    Registered record
    Registry ID
    NCT02512198
    Conditions
    Physician's Practice Patterns
    Interventions
    Prescription Data Feedback to GP Practices
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-07
    Completion
    2017-07-01
    Enrolment
    236

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPhysician's Practice Patterns
    InterventionPrescription Data Feedback to GP Practices
    PhaseNot applicable
    Registry statusCompleted

  • Point of Care Susceptibility Testing in Primary Care

    NCT02323087 · start 2015-03

    Registered record
    Registry ID
    NCT02323087
    Conditions
    Urinary Tract Infections
    Interventions
    FLEXICULT™ SSI-Urinary Kit; ID FlexicultTM
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-03
    Completion
    2016-05
    Enrolment
    377

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionFLEXICULT™ SSI-Urinary Kit; ID FlexicultTM
    PhaseNot applicable
    Registry statusCompleted

  • Researchers At UC San Diego Are Learning About the Benefits of Human Milk and How It Influences Infant and Child Health

    NCT05553743 · start 2014-03-27

    Registered record
    Registry ID
    NCT05553743
    Conditions
    Breastfeeding; COVID-19 Infection; COVID-19 Vaccine; Remdesivir; Antibiotics
    Interventions
    COVID-19 Exposure; Antibiotic
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2014-03-27
    Completion
    2040-03
    Enrolment
    5,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreastfeeding; COVID-19 Infection; COVID-19 Vaccine; Remdesivir +1 more
    InterventionCOVID-19 Exposure; Antibiotic
    PhaseNot recorded
    Registry statusRecruiting

  • Study Comparing Nitrofurantoin to Fosfomycin for Acute Urinary Tract Infection in Women

    NCT01966653 · start 2013-10

    Registered record
    Registry ID
    NCT01966653
    Conditions
    Urinary Tract Infections; Cystitis
    Interventions
    nitrofurantoin; fosfomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-10
    Completion
    2017-08
    Enrolment
    600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections; Cystitis
    Interventionnitrofurantoin; fosfomycin
    PhasePhase 4
    Registry statusUnknown

  • Topical Umbilical Cord Care for the Prevention of Colonization and Invasive Infections

    NCT01886001 · start 2012-11

    Registered record
    Registry ID
    NCT01886001
    Conditions
    Colonization
    Interventions
    Povidone-Iodine; Chlorhexidine; Pluronic; Control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-11
    Completion
    2013-07
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColonization
    InterventionPovidone-Iodine; Chlorhexidine; Pluronic; Control
    PhaseNot applicable
    Registry statusCompleted

  • Effects of Antibiotic Prophylaxis on Recurrent UTI in Children

    NCT02357758 · start 2012-09

    Registered record
    Registry ID
    NCT02357758
    Conditions
    Urinary Tract Infection; Recurrent Urinary Tract Infection
    Interventions
    Antibiotic Prophylaxis
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-09
    Completion
    2016-03
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infection; Recurrent Urinary Tract Infection
    InterventionAntibiotic Prophylaxis
    PhasePhase 4
    Registry statusCompleted

  • Rechallenge, Potential Drug Induced Liver Injury (Kaiser)

    NCT01584765 · start 2012-02

    Registered record
    Registry ID
    NCT01584765
    Conditions
    Drug-induced Liver Injury
    Interventions
    Prescription drugs with known hepatotoxicity
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-02
    Completion
    2013-04
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug-induced Liver Injury
    InterventionPrescription drugs with known hepatotoxicity
    PhaseNot recorded
    Registry statusCompleted

  • Examination of the Efficacy of Preventive Antibiotic Treatment During the Puerperium Among Pregnant Women With Recurrent Urinary Tract Infections

    NCT01507974 · start 2012-01-16

    Registered record
    Registry ID
    NCT01507974
    Conditions
    Pregnancy Complications
    Interventions
    Preventive antibiotic treatment- NITROFURANTOIN; Preventive antibiotic treatment- CEPHALEXIN; PREVENTIVE TREATMENT- AMOXICILLIN; PREVENTIVE TREATMENT- AMOXICILLIN AND CLAVULANATE POTASSIUM; PREVENTIVE TREATMENT- CEFUROXIME; PREVENTIVE TREATMENT SULFAMETHOXAZOLE AND TRIMETHOPRIM
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-01-16
    Completion
    2015-01-01
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPregnancy Complications
    InterventionPreventive antibiotic treatment- NITROFURANTOIN; Preventive antibiotic treatment- CEPHALEXIN; PREVENTIVE TREATMENT- AMOXICILLIN; PREVENTIVE TREATMENT- AMOXICILLIN AND CLAVULANATE POTASSIUM +2 more
    PhaseNot applicable
    Registry statusCompleted

  • A Pilot Comparison of Short-course Nitrofurantoin in Females With Uncomplicated Bacterial Cystitis in the Emergency Department

    NCT01749605 · start 2010-10

    Registered record
    Registry ID
    NCT01749605
    Conditions
    Uncomplicated Bacterial Cystitis
    Interventions
    Nitrofurantoin monohydrate/macrocrystals 100 mg BID x 3 days; ciprofloxacin 250 mg BID x 3 days
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-10
    Completion
    2012-01
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUncomplicated Bacterial Cystitis
    InterventionNitrofurantoin monohydrate/macrocrystals 100 mg BID x 3 days; ciprofloxacin 250 mg BID x 3 days
    PhasePhase 4
    Registry statusCompleted

  • Antibiotic Prophylaxis in Children With Pyelonephritis

    NCT00752375 · start 2009-02

    Registered record
    Registry ID
    NCT00752375
    Conditions
    Pyelonephritis
    Interventions
    Trimethoprim Sulfamethoxazole; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2009-02
    Completion
    2014-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPyelonephritis
    InterventionTrimethoprim Sulfamethoxazole; placebo
    PhasePhase 3
    Registry statusWithdrawn

  • Incidence of Symptomatic and Asymptomatic Bacteriuria After Urodynamic Study in Women

    NCT03106103 · start 2009-02

    Registered record
    Registry ID
    NCT03106103
    Conditions
    Female Stress Incontinence
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-02
    Completion
    2014-12
    Enrolment
    217

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFemale Stress Incontinence
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Efficacy of Oxybutynin in Paediatric Cystitis

    NCT03877289 · start 2008-10

    Registered record
    Registry ID
    NCT03877289
    Conditions
    Cystitis
    Interventions
    Oxybutynin; "Orasweet" Liquid Placebo; Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-10
    Completion
    2014-07
    Enrolment
    81

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystitis
    InterventionOxybutynin; "Orasweet" Liquid Placebo; Antibiotics
    PhasePhase 4
    Registry statusCompleted

  • Nitrofurantoin and Urinary Tract Infections (UTIs)

    NCT00678041 · start 2008-05

    Registered record
    Registry ID
    NCT00678041
    Conditions
    Urinary Tract Infections
    Interventions
    Nitrofurantoin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-05
    Completion
    2009-05
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionNitrofurantoin; Placebo
    PhaseNot applicable
    Registry statusTerminated

  • Does Treatment With Macrobid Reduce Urinary Tract Infections in Patients Receiving a Sub-Urethral Sling for Incontinence

    NCT00734968 · start 2008-05

    Registered record
    Registry ID
    NCT00734968
    Conditions
    Stress Incontinence
    Interventions
    Nitrofurantoin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-05
    Completion
    2010-05
    Enrolment
    161

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStress Incontinence
    InterventionNitrofurantoin; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Efficacy and Safety of Nitrofurantoin in the Treatment of Uncomplicated Urinary Tract Infections in Adults

    NCT01092351 · start 2007-01

    Registered record
    Registry ID
    NCT01092351
    Conditions
    Urinary Tract Infection
    Interventions
    Nitrofurantoin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-01
    Completion
    2008-09
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infection
    InterventionNitrofurantoin
    PhasePhase 4
    Registry statusCompleted