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AMR Drug RepurposingSmart Screeningresearch prototype

Nitrofurantoin

FDA-approved product (tablet, oral), marketed as Furadantin, Furalan, Nitrofurantoin and 3 more.

Registered studies
50+
Lab records
6
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Nitrofurantoin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Cystitis
  • Urinary tract infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Nitrofuran derivatives
FDA pharmacologic class
Nitrofuran Antibacterial FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01XE01; WHO ATC J01XE51; FDA class Nitrofuran Antibacterial

Repurposing investigation

Nitrofurantoin is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA25.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli31.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae8.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis92.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • K. pneumoniae: measured active in 0 of 4 lab records
  • M. tuberculosis: measured active in 1 of 2 lab records
Open Nitrofurantoin in ChEMBL Registered studies below
Show the 6 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.7 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.1 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nitrofurantoin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Gag Therapy for Recurrent Urinary Tract Infection Assessing Comparability to International Nitrofurantoin Gold Standard Study

    NCT05652374 · start 2022-10-20

    Registered record
    Registry ID
    NCT05652374
    Conditions
    Recurrent Urinary Tract Infection
    Interventions
    Ialuril 50ml Prefill; Nitrofurantoin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2022-10-20
    Completion
    2027-10
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Urinary Tract Infection
    InterventionIaluril 50ml Prefill; Nitrofurantoin
    PhasePhase 4
    Registry statusRecruiting

  • Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting

    NCT05702762 · start 2022-10-01

    Registered record
    Registry ID
    NCT05702762
    Conditions
    Urinary Tract Infections
    Interventions
    Gentamicin; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2022-10-01
    Completion
    2024-06-30
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionGentamicin; Standard of Care
    PhasePhase 2
    Registry statusUnknown

  • Use of Prophylactic Antibiotics Prior to OnabotulinumtoxinA

    NCT05519072 · start 2022-08-16

    Registered record
    Registry ID
    NCT05519072
    Conditions
    Antibiotic Prophylaxis
    Interventions
    Nitrofurantoin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2022-08-16
    Completion
    2024-08-16
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntibiotic Prophylaxis
    InterventionNitrofurantoin
    PhasePhase 4
    Registry statusRecruiting

  • Safety, Tolerability, Pharmacokinetic and Microbiological Investigation of GSK3882347 in Female Participants With Urinary Tract Infections

    NCT05138822 · start 2022-05-18

    Registered record
    Registry ID
    NCT05138822
    Conditions
    Uncomplicated Urinary Tract Infections; Urinary Tract Infections
    Interventions
    GSK3882347; Nitrofurantoin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2022-05-18
    Completion
    2024-12-03
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUncomplicated Urinary Tract Infections; Urinary Tract Infections
    InterventionGSK3882347; Nitrofurantoin; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Enhanced Versus Extended Preoperative Antibiotic Prophylaxis Regimens for Retrograde Intrarenal Surgery in High Infectious Risk Patients

    NCT05384197 · start 2022-05-01

    Registered record
    Registry ID
    NCT05384197
    Conditions
    Renal Stone
    Interventions
    Enhanced regimen; Extended regimen
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2022-05-01
    Completion
    2023-07-01
    Enrolment
    280

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Stone
    InterventionEnhanced regimen; Extended regimen
    PhasePhase 3
    Registry statusUnknown

  • Effect of Nitrofurantion Used as an Intracanal Medicament

    NCT05074628 · start 2021-12-01

    Registered record
    Registry ID
    NCT05074628
    Conditions
    Intracanal Medication
    Interventions
    Nitrofurantoin capsules
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2021-12-01
    Completion
    2023-12-01
    Enrolment
    38

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIntracanal Medication
    InterventionNitrofurantoin capsules
    PhaseEarly phase 1
    Registry statusUnknown

  • Clinical Effectiveness and Bacteriological Eradication of 4 Short-course Antibiotics for Uncomplicated UTIs in Women.

    NCT04959331 · start 2021-11-02

    Registered record
    Registry ID
    NCT04959331
    Conditions
    Urinary Tract Infections
    Interventions
    Fosfomycin Trometamol Salt; Nitrofurantoin; Pivmecillinam; Fosfomycin Trometamol Salt
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2021-11-02
    Completion
    2024-12-31
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionFosfomycin Trometamol Salt; Nitrofurantoin; Pivmecillinam; Fosfomycin Trometamol Salt
    PhasePhase 4
    Registry statusCompleted

  • EXtended Use of FOsfomycin for the Treatment of CYstitis in Primary Care

    NCT05254808 · start 2021-09-06

    Registered record
    Registry ID
    NCT05254808
    Conditions
    Urinary Tract Infections
    Interventions
    Fosfomycin; Nitrofurantoin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2021-09-06
    Completion
    2022-02-14
    Enrolment
    13

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionFosfomycin; Nitrofurantoin
    PhasePhase 3
    Registry statusTerminated

  • Prophylactic Antibiotics for Urinary Tract Infections After Robot-Assisted Radical Cystectomy

    NCT04502095 · start 2020-09-02

    Registered record
    Registry ID
    NCT04502095
    Conditions
    Bladder Carcinoma; Refractory Bladder Carcinoma; Urinary Tract Infection
    Interventions
    Clindamycin; Diary; Ertapenem; Levofloxacin; Nitrofurantoin; Trimethoprim-Sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-09-02
    Completion
    2025-03-13
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBladder Carcinoma; Refractory Bladder Carcinoma; Urinary Tract Infection
    InterventionClindamycin; Diary; Ertapenem; Levofloxacin +2 more
    PhasePhase 4
    Registry statusCompleted

  • Cranberry Tablets Versus Nitrofurantoin Prophylaxis for Urinary Tract Infection Prevention After Urogynecologic Surgery

    NCT03522961 · start 2018-08-15

    Registered record
    Registry ID
    NCT03522961
    Conditions
    Urinary Tract Infections; Pelvic Organ Prolapse; Urinary Incontinence
    Interventions
    Nitrofurantoin Prophylaxis/Placebo; Cranberry capsules
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Active not recruiting
    Start
    2018-08-15
    Completion
    2026-12-31
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections; Pelvic Organ Prolapse; Urinary Incontinence
    InterventionNitrofurantoin Prophylaxis/Placebo; Cranberry capsules
    PhaseNot applicable
    Registry statusActive not recruiting

  • Comparison of Methods for Prevention of Urinary Tract Infection Following Botox Injection

    NCT03508921 · start 2018-07-01

    Registered record
    Registry ID
    NCT03508921
    Conditions
    Overactive Bladder; Urinary Tract Infections
    Interventions
    Periprocedural Antibiotics; Extended Antibiotics; Injection of OnabotulinumtoxinA (BTX-A)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2018-07-01
    Completion
    2022-06-01
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOveractive Bladder; Urinary Tract Infections
    InterventionPeriprocedural Antibiotics; Extended Antibiotics; Injection of OnabotulinumtoxinA (BTX-A)
    PhasePhase 4
    Registry statusTerminated

  • Lactobacillus Reuteri for Treatment of Uncomplicated UTI in Pregnant Women

    NCT03362697 · start 2017-12-15

    Registered record
    Registry ID
    NCT03362697
    Conditions
    Urinary Tract Infection in Pregnancy
    Interventions
    Probiotics; Antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-12-15
    Completion
    2019-06-18
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infection in Pregnancy
    InterventionProbiotics; Antibiotics
    PhaseNot applicable
    Registry statusCompleted

  • Nitrofurantoin Administration for the Prevention of Short-Term Catheter Associated Urinary Tract Infection After Pelvic Surgery

    NCT03287089 · start 2017-09-29

    Registered record
    Registry ID
    NCT03287089
    Conditions
    Catheter-Associated Urinary Tract Infection
    Interventions
    Nitrofurantoin 100 MG; Placebo Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-09-29
    Completion
    2019-06-01
    Enrolment
    164

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCatheter-Associated Urinary Tract Infection
    InterventionNitrofurantoin 100 MG; Placebo Oral Tablet
    PhasePhase 4
    Registry statusCompleted

  • INtravesical Antimicrobial Agents v STANDard Oral Antibiotics for the Treatment of Acute UTI in Women With rUTI

    NCT03299387 · start 2017-06-28

    Registered record
    Registry ID
    NCT03299387
    Conditions
    Urinary Tract Infections
    Interventions
    Nitrofurantoin; Gentamicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2017-06-28
    Completion
    2018-07-05
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionNitrofurantoin; Gentamicin
    PhasePhase 4
    Registry statusWithdrawn

  • The Preventive Infection Role of One Week Antibiotics Before Minimally Invasive Upper Tract Lithotomy

    NCT02789579 · start 2016-09

    Registered record
    Registry ID
    NCT02789579
    Conditions
    Complication of Surgical Procedure
    Interventions
    levofloxacin; Nitrofurantoin; cefuroxime
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Unknown
    Start
    2016-09
    Completion
    2019-12
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionComplication of Surgical Procedure
    Interventionlevofloxacin; Nitrofurantoin; cefuroxime
    PhaseEarly phase 1
    Registry statusUnknown