Beta Carotene
FDA-approved product (capsule, oral), marketed as Solatene.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 0 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLNo approved indication recorded
ChEMBL records no approved indication for Beta Carotene. Its therapeutic class is shown instead.
- WHO therapeutic group
- Vitamin a, plain; Protectives against uv-radiation for systemic use
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
No supported pathogen reaches ≥40% AI-predicted activity for Beta Carotene, so it is not among the repurposing candidates. Its predictions are shown below.
AI-predicted activity
AI prediction · nothing measured- MRSA18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli22.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae10.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis35.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Beta Carotene with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Beta-carotene and Alpha-tocopherol Chemoprevention of Second Primary Malignancies in Head and Neck Cancer Patients
NCT00169845 · start 1994-10
Registered record
- Registry ID
- NCT00169845
- Conditions
- Neoplasms
- Interventions
- Alpha-Tocopherol and Beta-Carotene; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 1994-10
- Completion
- 2018-03
- Enrolment
- 540
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionNeoplasmsInterventionAlpha-Tocopherol and Beta-Carotene; PlaceboPhasePhase 3Registry statusCompletedPrimary Prevention Trial of the Health Effects of Antioxidant Vitamins and Minerals.
NCT00272428 · start 1994-10
Registered record
- Registry ID
- NCT00272428
- Conditions
- Healthy
- Interventions
- ascorbic acid, vitamin E, beta carotene, selenium, zinc
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 1994-10
- Completion
- 2005-09
- Enrolment
- 13,000
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthyInterventionascorbic acid, vitamin E, beta carotene, selenium, zincPhasePhase 3Registry statusCompletedArterial Disease Multifactorial Intervention Trial (ADMIT)
NCT00000539 · start 1992-09
Registered record
- Registry ID
- NCT00000539
- Conditions
- Arterial Occlusive Diseases; Cardiovascular Diseases; Heart Diseases; Vascular Diseases; Diabetes Mellitus
- Interventions
- niacin; pravastatin; beta-carotene; vitamin E; dietary supplements; vitamin C; warfarin
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 1992-09
- Completion
- 1999-03
- Enrolment
- Not recorded
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionArterial Occlusive Diseases; Cardiovascular Diseases; Heart Diseases; Vascular Diseases +1 moreInterventionniacin; pravastatin; beta-carotene; vitamin E +3 morePhasePhase 3Registry statusCompletedAge-Related Eye Disease Study (AREDS)
NCT00000145 · start 1990-09
Registered record
- Registry ID
- NCT00000145
- Conditions
- Macular Degeneration; Cataract; Lens Opacities
- Interventions
- Antioxidants; Zinc; Antioxidants and zinc
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 1990-09
- Completion
- 2006-12
- Enrolment
- 4,757
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionMacular Degeneration; Cataract; Lens OpacitiesInterventionAntioxidants; Zinc; Antioxidants and zincPhasePhase 3Registry statusCompletedCarotene and Retinol Efficacy Trial
NCT00712647 · start 1985-05
Registered record
- Registry ID
- NCT00712647
- Conditions
- Lung Cancer
- Interventions
- Beta Carotene and Retinol; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 1985-05
- Completion
- 2005-06
- Enrolment
- 18,314
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionLung CancerInterventionBeta Carotene and Retinol; PlaceboPhasePhase 4Registry statusCompleted