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AMR Drug RepurposingSmart Screeningresearch prototype

Beta Carotene

FDA-approved product (capsule, oral), marketed as Solatene.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Beta Carotene
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Beta Carotene. Its therapeutic class is shown instead.

WHO therapeutic group
Vitamin a, plain; Protectives against uv-radiation for systemic use
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

No supported pathogen reaches ≥40% AI-predicted activity for Beta Carotene, so it is not among the repurposing candidates. Its predictions are shown below.

AI-predicted activity

AI prediction · nothing measured
  • MRSA18.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli22.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae10.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis35.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Beta Carotene in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Beta Carotene with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effects of Vitamin A and Carotenoids on Iron Absorption

    NCT01493297 · start 2011-09

    Registered record
    Registry ID
    NCT01493297
    Conditions
    Iron Absorption
    Interventions
    Labeled iron solutions
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-09
    Completion
    2012-07
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIron Absorption
    InterventionLabeled iron solutions
    PhaseNot applicable
    Registry statusCompleted

  • Vitamin A Absorption From Cassava in Women

    NCT01381276 · start 2011-06

    Registered record
    Registry ID
    NCT01381276
    Conditions
    Vitamin A Deficiency
    Interventions
    Beta-Carotene bio-fortified cassava porridge without oil; Beta-Carotene bio-fortified cassava porridge with oil; White cassava porridge with retinyl palmitate reference dose
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-06
    Completion
    2011-10
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin A Deficiency
    InterventionBeta-Carotene bio-fortified cassava porridge without oil; Beta-Carotene bio-fortified cassava porridge with oil; White cassava porridge with retinyl palmitate reference dose
    PhasePhase 2
    Registry statusCompleted

  • Low Dose β-carotene Supplementation Diminishes Oxidative Stress in Type 2 Diabetics and Healthy Individuals

    NCT01477112 · start 2010-01

    Registered record
    Registry ID
    NCT01477112
    Conditions
    Diabetes Mellitus; Oxidative Stress; Iron Metabolism Disorders
    Interventions
    Betacarotene; Controls. No treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-01
    Completion
    2010-12
    Enrolment
    117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus; Oxidative Stress; Iron Metabolism Disorders
    InterventionBetacarotene; Controls. No treatment
    PhaseNot applicable
    Registry statusCompleted

  • Combination Chemotherapy in Treating Young Patients With Newly Diagnosed Acute Promyelocytic Leukemia

    NCT00866918 · start 2009-03-09

    Registered record
    Registry ID
    NCT00866918
    Conditions
    Childhood Acute Promyelocytic Leukemia With PML-RARA; Myeloid Neoplasm
    Interventions
    Arsenic Trioxide; Cytarabine; Diagnostic Laboratory Biomarker Analysis; Idarubicin; Mercaptopurine; Methotrexate; Mitoxantrone Hydrochloride; Tretinoin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-03-09
    Completion
    2022-09-30
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChildhood Acute Promyelocytic Leukemia With PML-RARA; Myeloid Neoplasm
    InterventionArsenic Trioxide; Cytarabine; Diagnostic Laboratory Biomarker Analysis; Idarubicin +4 more
    PhasePhase 3
    Registry statusCompleted

  • Micronutrients to Prevent Noise-induced Hearing Loss

    NCT00808470 · start 2008-10

    Registered record
    Registry ID
    NCT00808470
    Conditions
    Noise-Induced Hearing Loss
    Interventions
    beta-carotene, vitamins C and E, magnesium; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-10
    Completion
    2013-12
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNoise-Induced Hearing Loss
    Interventionbeta-carotene, vitamins C and E, magnesium; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Combined Vitamins and Minerals Decrease Incidence of Upper Respiratory Tract Infections in Older Persons

    NCT01484756 · start 2008-08

    Registered record
    Registry ID
    NCT01484756
    Conditions
    Upper Respiratory Tract Infection
    Interventions
    daily multi micronutrient supplement; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-08
    Completion
    2009-03
    Enrolment
    270

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUpper Respiratory Tract Infection
    Interventiondaily multi micronutrient supplement; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Vitamin A Equivalence of Plant Carotenoids in Children

    NCT00680212 · start 2008-07

    Registered record
    Registry ID
    NCT00680212
    Conditions
    Vitamin A Deficiency
    Interventions
    dietary carotenoids; spinach, rice, and synthetic beta-carotene
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-07
    Completion
    2009-01
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin A Deficiency
    Interventiondietary carotenoids; spinach, rice, and synthetic beta-carotene
    PhasePhase 2
    Registry statusCompleted

  • Vitamin/Mineral Supplement for Children and Adults With Autism

    NCT01225198 · start 2008-05

    Registered record
    Registry ID
    NCT01225198
    Conditions
    Autism
    Interventions
    Multi-Vitamin/Mineral Supplement; Liquid Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2008-05
    Completion
    2009-02
    Enrolment
    143

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAutism
    InterventionMulti-Vitamin/Mineral Supplement; Liquid Placebo
    PhasePhase 2
    Registry statusCompleted

  • Glutathione Metabolism in Adolescents With Type 1 Diabetes - Study B

    NCT00858273 · start 2008-03

    Registered record
    Registry ID
    NCT00858273
    Conditions
    Diabetes Mellitus, Type 1
    Interventions
    Antioxidant supplement; Diabetes treatment; Regular Insulin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-03
    Completion
    2011-08
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus, Type 1
    InterventionAntioxidant supplement; Diabetes treatment; Regular Insulin
    PhaseNot applicable
    Registry statusCompleted

  • Human Lycopene and Beta-cryptoxanthin Absorption From Citrus Fruit

    NCT02348164 · start 2007-12

    Registered record
    Registry ID
    NCT02348164
    Conditions
    Bioavailability of Carotenoids
    Interventions
    Pink grapefruit first followed by tangerines two weeks later; Tangerines first followed by pink grapefruit two weeks later
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-12
    Completion
    2009-02
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBioavailability of Carotenoids
    InterventionPink grapefruit first followed by tangerines two weeks later; Tangerines first followed by pink grapefruit two weeks later
    PhaseNot applicable
    Registry statusCompleted

  • A Randomized Controlled Trial Testing The Effect Of A Multi-Nutrient Fortified Juice

    NCT01909063 · start 2005-01

    Registered record
    Registry ID
    NCT01909063
    Conditions
    Vitamin D Deficiency; Hypovitaminosis A; Vitamin E Deficiency
    Interventions
    Vitamin D; Vitamin D, Vitamin E, and Vitamin A; Control, 700 mg Calcium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-01
    Completion
    2008-01
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Hypovitaminosis A; Vitamin E Deficiency
    InterventionVitamin D; Vitamin D, Vitamin E, and Vitamin A; Control, 700 mg Calcium
    PhaseNot applicable
    Registry statusCompleted

  • Vitamins, Breastmilk HIV Shedding, and Child Health

    NCT00197756 · start 2004-09

    Registered record
    Registry ID
    NCT00197756
    Conditions
    Maternal and Child Health Outcomes
    Interventions
    Vitamin A alone; Multivitamins excluding vitamin A; multivitamins including vitamin A; Placebo
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2004-09
    Completion
    2007-08
    Enrolment
    771

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMaternal and Child Health Outcomes
    InterventionVitamin A alone; Multivitamins excluding vitamin A; multivitamins including vitamin A; Placebo
    PhaseNot recorded
    Registry statusCompleted

  • The CARO Study - Bioefficacy of Beta-Carotene in Oil and in a Mixed Diet in Healthy Subjects

    NCT00128752 · start 2003-03

    Registered record
    Registry ID
    NCT00128752
    Conditions
    Healthy
    Interventions
    absorption and conversion of beta-carotene in human gastrointestinal (GI) tract
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2003-03
    Completion
    2003-10
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionabsorption and conversion of beta-carotene in human gastrointestinal (GI) tract
    PhaseNot applicable
    Registry statusCompleted

  • Beta Carotene From Natural Source for Patients With Non-Active Crohn's Disease

    NCT00275418 · start 2002-07

    Registered record
    Registry ID
    NCT00275418
    Conditions
    Crohn's Disease
    Interventions
    beta carotene from Dunaliella algae
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2002-07
    Completion
    Not recorded
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCrohn's Disease
    Interventionbeta carotene from Dunaliella algae
    PhasePhase 3
    Registry statusUnknown

  • Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study

    NCT00342992 · start 1995-03-03

    Registered record
    Registry ID
    NCT00342992
    Conditions
    Stroke; Diabetes Mellitus; Heart Disease; Cancer
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    1995-03-03
    Completion
    2020-09-04
    Enrolment
    29,133

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStroke; Diabetes Mellitus; Heart Disease; Cancer
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted