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AMR Drug RepurposingSmart Screeningresearch prototype

Tetracycline Hydrochloride

FDA-approved product (suspension, oral), marketed as Achromycin, Achromycin V, Actisite and 12 more.

Registered studies
50+
Lab records
46
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Tetracycline Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Burn
  • Duodenal ulcer
  • Eye infection
  • Fever
  • Infection
  • Ornithosis
  • Skin infection
  • Tularemia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Tetracycline and derivatives; Tetracyclines; Antibiotics; Antiinfectives
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01AA07; WHO ATC D06AA04; WHO ATC S01AA09

Repurposing investigation

Tetracycline Hydrochloride is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA85.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli87.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae90.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis68.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 1 of 1 lab record
  • K. pneumoniae: measured active in 25 of 43 lab records
Open Tetracycline Hydrochloride in ChEMBL Registered studies below
Show the 46 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tetracycline Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Antimalarial Drugs to Rabies Vaccine for Post-exposure Prophylaxis.

    NCT02564471 · start 2016-11-11

    Registered record
    Registry ID
    NCT02564471
    Conditions
    Rabies
    Interventions
    Chloroquine; Atovaquone and Proguanil; Doxycycline; Rabies Vaccine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-11-11
    Completion
    2019-02
    Enrolment
    103

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRabies
    InterventionChloroquine; Atovaquone and Proguanil; Doxycycline; Rabies Vaccine
    PhasePhase 4
    Registry statusCompleted

  • PeRiodontal Treatment to Eliminate Minority InEquality and Rural Disparities in Stroke

    NCT02541032 · start 2015-12

    Registered record
    Registry ID
    NCT02541032
    Conditions
    Periodontal Disease; Stroke; TIA
    Interventions
    Intensive dental treatment; Standard dental treatment; Arestin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2015-12
    Completion
    2020-06
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Disease; Stroke; TIA
    InterventionIntensive dental treatment; Standard dental treatment; Arestin
    PhasePhase 3
    Registry statusUnknown

  • Minocycline Hydrochloride in Reducing Chemotherapy Induced Depression and Anxiety in Patients With Stage I-III Breast Cancer

    NCT02203552 · start 2015-06-23

    Registered record
    Registry ID
    NCT02203552
    Conditions
    Anxiety Disorder; Depression; Recurrent Breast Cancer; Stage IA Breast Cancer; Stage IB Breast Cancer; Stage II Breast Cancer; Stage IIIA Breast Cancer; Stage IIIB Breast Cancer; Stage IIIC Breast Cancer
    Interventions
    minocycline hydrochloride; placebo; laboratory biomarker analysis; Questionnaire administration
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-06-23
    Completion
    2020-06-15
    Enrolment
    56

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety Disorder; Depression; Recurrent Breast Cancer; Stage IA Breast Cancer +5 more
    Interventionminocycline hydrochloride; placebo; laboratory biomarker analysis; Questionnaire administration
    PhasePhase 2
    Registry statusCompleted

  • Minocycline Hydrochloride in Reducing Chemotherapy-Induced Peripheral Neuropathy and Acute Pain in Patients With Breast Cancer Undergoing Treatment With Paclitaxel

    NCT02297412 · start 2014-11

    Registered record
    Registry ID
    NCT02297412
    Conditions
    Acute Pain; Breast Carcinoma; Peripheral Neuropathy
    Interventions
    Minocycline Hydrochloride; Placebo; Quality-of-Life Assessment; Questionnaire Administration
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2014-11
    Completion
    2016-07-08
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Pain; Breast Carcinoma; Peripheral Neuropathy
    InterventionMinocycline Hydrochloride; Placebo; Quality-of-Life Assessment; Questionnaire Administration
    PhasePhase 2
    Registry statusCompleted

  • Minocycline Bioequivalence Study

    NCT01938508 · start 2013-05

    Registered record
    Registry ID
    NCT01938508
    Conditions
    Skin Diseases
    Interventions
    Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-05
    Completion
    2013-06
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Diseases
    InterventionMinocycline
    PhasePhase 1
    Registry statusCompleted

  • Minocycline in the Treatment of Angelman Syndrome

    NCT01531582 · start 2012-04

    Registered record
    Registry ID
    NCT01531582
    Conditions
    Angelman Syndrome
    Interventions
    minocycline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-04
    Completion
    2015-09
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAngelman Syndrome
    Interventionminocycline
    PhaseNot applicable
    Registry statusCompleted

  • The Impact of Parathyroid Hormone (PTH) on Craniofacial Osseous Regeneration in Bone

    NCT01279187 · start 2011-02

    Registered record
    Registry ID
    NCT01279187
    Conditions
    Implant
    Interventions
    Teriparatide; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-02
    Completion
    2015-11
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImplant
    InterventionTeriparatide; Placebo
    PhasePhase 2
    Registry statusTerminated

  • Combination Treatment for Moderate to Severe Acne

    NCT01206348 · start 2010-09

    Registered record
    Registry ID
    NCT01206348
    Conditions
    Acne
    Interventions
    Minocycline, Clindamycin, Tretinoin, Benzoyl Peroxide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-09
    Completion
    2011-07
    Enrolment
    97

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne
    InterventionMinocycline, Clindamycin, Tretinoin, Benzoyl Peroxide
    PhasePhase 4
    Registry statusCompleted

  • The Study of Minocycline for Negative and Cognitive Symptoms in Schizophrenia

    NCT01493622 · start 2010-06

    Registered record
    Registry ID
    NCT01493622
    Conditions
    Schizophrenia
    Interventions
    minocycline; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-06
    Completion
    2011-12
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    Interventionminocycline; placebo
    PhasePhase 4
    Registry statusCompleted

  • A Study to Compare the Efficacy and Safety of a Combination of Ketoconazole and Clindamycin Compared to Tetracycline/Amphotericin B Combination Cream for the Treatment of Bacterial Vaginosis and Vaginal Candidiasis (P08077)

    NCT01293643 · start 2010-05

    Registered record
    Registry ID
    NCT01293643
    Conditions
    Vaginosis, Bacterial; Candidiasis, Vulvovaginal
    Interventions
    100 mg clindamycin /800 mg ketoconazole vaginal ovule; 100 mg tetracycline hydrochloride /50 mg amphotericin B cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-05
    Completion
    2011-01
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVaginosis, Bacterial; Candidiasis, Vulvovaginal
    Intervention100 mg clindamycin /800 mg ketoconazole vaginal ovule; 100 mg tetracycline hydrochloride /50 mg amphotericin B cream
    PhasePhase 3
    Registry statusCompleted

  • Trial of Minocycline to Treat Children With Fragile X Syndrome

    NCT01053156 · start 2010-01

    Registered record
    Registry ID
    NCT01053156
    Conditions
    Fragile X Syndrome
    Interventions
    minocycline hydrochloride; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-01
    Completion
    2011-12
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFragile X Syndrome
    Interventionminocycline hydrochloride; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Systemic and Topical Treatments for Rash Secondary to Erlotinib in Lung Cancer

    NCT00473083 · start 2009-01

    Registered record
    Registry ID
    NCT00473083
    Conditions
    Rash
    Interventions
    Minocycline; Clindamycin 2% in hydrocortisone 1% lotion; Erlotinib; Topical clindamycin 2%, triamcinolone acetonide 0.1% soln
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-01
    Completion
    2013-08
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRash
    InterventionMinocycline; Clindamycin 2% in hydrocortisone 1% lotion; Erlotinib; Topical clindamycin 2%, triamcinolone acetonide 0.1% soln
    PhasePhase 2
    Registry statusCompleted

  • Minocycline in Clinically Isolated Syndromes (CIS)

    NCT00666887 · start 2009-01

    Registered record
    Registry ID
    NCT00666887
    Conditions
    Clinically Isolated Syndromes; Early Single Relapse of Multiple Sclerosis
    Interventions
    Minocycline; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-01
    Completion
    2015-07
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClinically Isolated Syndromes; Early Single Relapse of Multiple Sclerosis
    InterventionMinocycline; Placebo
    PhasePhase 3
    Registry statusCompleted

  • S0307A, Long-Term Bone Quality in Women With Breast Cancer Enrolled on Clinical Trial SWOG-S0307

    NCT00873808 · start 2008-10

    Registered record
    Registry ID
    NCT00873808
    Conditions
    Breast Cancer
    Interventions
    clodronate disodium; demeclocycline hydrochloride; ibandronate sodium; tetracycline hydrochloride; zoledronic acid; laboratory biomarker analysis; adjuvant therapy; computed tomography; dual x-ray absorptiometry
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Withdrawn
    Start
    2008-10
    Completion
    2010-02
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    Interventionclodronate disodium; demeclocycline hydrochloride; ibandronate sodium; tetracycline hydrochloride +5 more
    PhaseNot recorded
    Registry statusWithdrawn

  • Bioequivalence Study of Minocycline HCl 135 mg ER Tablet Sunder Fed Conditions

    NCT02312609 · start 2008-09

    Registered record
    Registry ID
    NCT02312609
    Conditions
    Healthy
    Interventions
    Minocycline hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-09
    Completion
    2008-12
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionMinocycline hydrochloride
    PhaseNot applicable
    Registry statusCompleted