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AMR Drug RepurposingSmart Screeningresearch prototype

Tetracycline Hydrochloride

FDA-approved product (suspension, oral), marketed as Achromycin, Achromycin V, Actisite and 12 more.

Registered studies
50+
Lab records
46
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Tetracycline Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Burn
  • Duodenal ulcer
  • Eye infection
  • Fever
  • Infection
  • Ornithosis
  • Skin infection
  • Tularemia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Antiinfectives and antiseptics for local oral treatment; Tetracycline and derivatives; Tetracyclines; Antibiotics; Antiinfectives
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01AA07; WHO ATC D06AA04; WHO ATC S01AA09

Repurposing investigation

Tetracycline Hydrochloride is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA85.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli87.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae90.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis68.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 1 of 1 lab record
  • K. pneumoniae: measured active in 25 of 43 lab records
Open Tetracycline Hydrochloride in ChEMBL Registered studies below
Show the 46 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.6 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tetracycline Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Impact of DFD-29 on Microbial Flora of Healthy, Adult Human Subjects When Administered Over 16 Weeks

    NCT05597462 · start 2022-09-30

    Registered record
    Registry ID
    NCT05597462
    Conditions
    Rosacea
    Interventions
    Minocycline hydrochloride capsules; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2022-09-30
    Completion
    2023-05-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRosacea
    InterventionMinocycline hydrochloride capsules; Placebo
    PhasePhase 1
    Registry statusCompleted

  • A Comparative Bioavailability Study of DFD-29 Capsules 40 mg Versus SOLODYN® Tablets 105 mg, Under Fasting & Fed Conditions in Healthy Adult Human Subjects

    NCT05452785 · start 2022-05-07

    Registered record
    Registry ID
    NCT05452785
    Conditions
    Pharmacokinetics
    Interventions
    DFD-29 (Minocycline) Fasting; DFD-29 (Minocycline) Fed; Solodyn (Minocycline) Fasting
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2022-05-07
    Completion
    2022-05-25
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacokinetics
    InterventionDFD-29 (Minocycline) Fasting; DFD-29 (Minocycline) Fed; Solodyn (Minocycline) Fasting
    PhasePhase 1
    Registry statusCompleted

  • To Evaluate the Efficacy and Safety of Minocycline Hydrochloride Foam in the Treatment of Moderate-to-severe Acne Vulgaris

    NCT04960930 · start 2021-09-17

    Registered record
    Registry ID
    NCT04960930
    Conditions
    Acne Vulgaris
    Interventions
    FMX101
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2021-09-17
    Completion
    2022-10-14
    Enrolment
    372

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionFMX101
    PhasePhase 3
    Registry statusCompleted

  • APT™ T3X on the COVID-19 Contamination Rate

    NCT04716426 · start 2021-01-28

    Registered record
    Registry ID
    NCT04716426
    Conditions
    COVID-19
    Interventions
    Tetracycline hydrochloride 3%; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-01-28
    Completion
    2021-03-25
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID-19
    InterventionTetracycline hydrochloride 3%; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Trial of Combination Therapy to Treat COVID-19 Infection

    NCT04482686 · start 2020-12-09

    Registered record
    Registry ID
    NCT04482686
    Conditions
    COVID; Covid-19; Corona Virus Infection; Coronavirus Infection; Coronavirus-19; SARS-CoV2; SARS-CoV Infection
    Interventions
    Ivermectin; Doxycycline Hcl; Zinc; Vitamin D3; Vitamin C
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2020-12-09
    Completion
    2022-07-15
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID; Covid-19; Corona Virus Infection; Coronavirus Infection +3 more
    InterventionIvermectin; Doxycycline Hcl; Zinc; Vitamin D3 +1 more
    PhasePhase 1
    Registry statusCompleted

  • Evaluate the Efficacy and Safety of Intense Pulsed Light Filters Combined With Oral Medication in the Treatment of Acne

    NCT04433143 · start 2020-05-15

    Registered record
    Registry ID
    NCT04433143
    Conditions
    Acne Vulgaris
    Interventions
    Minocycline hydrochloride capsules were taken orally
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2020-05-15
    Completion
    2021-05-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionMinocycline hydrochloride capsules were taken orally
    PhaseNot applicable
    Registry statusUnknown

  • Scaling and Root Planing (SRP) With and Without Minocycline HCl Microspheres, 1 mg

    NCT03762915 · start 2019-05-20

    Registered record
    Registry ID
    NCT03762915
    Conditions
    SRP; Minocycline HCl Microspheres; Biomarkers
    Interventions
    minocycline HCl microspheres
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-05-20
    Completion
    2022-04-01
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSRP; Minocycline HCl Microspheres; Biomarkers
    Interventionminocycline HCl microspheres
    PhasePhase 4
    Registry statusCompleted

  • Evaluate the PK of Multiple Oral Doses of Tegoprazan, Metronidazole, Tetracycline and Bismuth in Healthy Volunteers

    NCT04066257 · start 2019-01-17

    Registered record
    Registry ID
    NCT04066257
    Conditions
    Healthy
    Interventions
    Tegoprazan; Metronidazole; Tetracycline; Bismuth
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2019-01-17
    Completion
    2019-04-25
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTegoprazan; Metronidazole; Tetracycline; Bismuth
    PhasePhase 1
    Registry statusCompleted

  • Lycopene vs Minocycline Hydrochloride as Adjunctive to Periodontal Treatment

    NCT03964935 · start 2018-12-01

    Registered record
    Registry ID
    NCT03964935
    Conditions
    Periodontal Pocket
    Interventions
    Lycopene; Minocycline HCl 1mg Oral Powder; Distilled water
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2018-12-01
    Completion
    2019-08-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontal Pocket
    InterventionLycopene; Minocycline HCl 1mg Oral Powder; Distilled water
    PhasePhase 2
    Registry statusUnknown

  • Locally Delivered Minocycline in Advanced Periodontitis

    NCT04076098 · start 2018-06-25

    Registered record
    Registry ID
    NCT04076098
    Conditions
    Periodontitis, Adult
    Interventions
    Minocycline Hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-06-25
    Completion
    2021-09-20
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeriodontitis, Adult
    InterventionMinocycline Hydrochloride
    PhasePhase 4
    Registry statusCompleted

  • Evaluating the Role of Neuroinflammation in Low Back Pain

    NCT03106740 · start 2017-10-10

    Registered record
    Registry ID
    NCT03106740
    Conditions
    Low Back Pain; Back Pain With Radiation; Back Pain Without Radiation; Back Pain Lower Back Chronic; Back Ache; Pain, Chronic
    Interventions
    Minocycline Hydrochloride 100mg Capsule; Magnetic Resonance-Positron Emission Tomography Imaging; Placebo Capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-10-10
    Completion
    2024-04-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain; Back Pain With Radiation; Back Pain Without Radiation; Back Pain Lower Back Chronic +2 more
    InterventionMinocycline Hydrochloride 100mg Capsule; Magnetic Resonance-Positron Emission Tomography Imaging; Placebo Capsule
    PhasePhase 2
    Registry statusCompleted

  • A Controlled Study to Assess the Efficacy, Safety and Tolerability of Oral DFD-29 Extended Release Capsules

    NCT03340961 · start 2017-10-01

    Registered record
    Registry ID
    NCT03340961
    Conditions
    Rosacea
    Interventions
    DFD-29 Extended Release Capsules (40 mg); DFD-29 Extended Release Capsules (20 mg); Oraycea® (doxycycline) Capsules; Placebo Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-10-01
    Completion
    2019-03-31
    Enrolment
    205

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRosacea
    InterventionDFD-29 Extended Release Capsules (40 mg); DFD-29 Extended Release Capsules (20 mg); Oraycea® (doxycycline) Capsules; Placebo Capsules
    PhasePhase 2
    Registry statusCompleted

  • Low Dose Bismuth Versus Lactobacillus Reuteri for H. Pylori Eradication

    NCT03925818 · start 2017-08-29

    Registered record
    Registry ID
    NCT03925818
    Conditions
    Helicobacter Pylori Infection
    Interventions
    Bismuth Subcitrate Potassium; Gastrus
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2017-08-29
    Completion
    2018-12-23
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHelicobacter Pylori Infection
    InterventionBismuth Subcitrate Potassium; Gastrus
    PhaseNot applicable
    Registry statusTerminated

  • Evaluate Safety and Pharmacokinetics of Minocin (Minocycline) for Injection in Subjects With Renal Insufficiency

    NCT02808052 · start 2017-05-29

    Registered record
    Registry ID
    NCT02808052
    Conditions
    Renal Insufficiency, Acute; Renal Insufficiency, Chronic; Healthy Subjects
    Interventions
    Minocin (minocycline) for Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2017-05-29
    Completion
    2018-06-04
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Insufficiency, Acute; Renal Insufficiency, Chronic; Healthy Subjects
    InterventionMinocin (minocycline) for Injection
    PhasePhase 1
    Registry statusTerminated

  • Metformin Hydrochloride and Doxycycline in Treating Patients With Head and Neck Squamous Cell Carcinoma

    NCT03076281 · start 2017-04-03

    Registered record
    Registry ID
    NCT03076281
    Conditions
    Larynx; LIP; Oral Cavity; Pharynx
    Interventions
    Metformin Hydrochloride; Doxycycline; Metformin +Doxycycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2017-04-03
    Completion
    2018-12-03
    Enrolment
    7

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLarynx; LIP; Oral Cavity; Pharynx
    InterventionMetformin Hydrochloride; Doxycycline; Metformin +Doxycycline
    PhasePhase 2
    Registry statusTerminated