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AMR Drug RepurposingSmart Screeningresearch prototype

Carvedilol

FDA-approved product (tablet, oral), marketed as Carvedilol, Coreg, Carvedilol Phosphate and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Carvedilol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Congestive heart failure
  • Heart failure
  • Hypertension
  • Myocardial infarction
  • Ventricular Dysfunction, Left

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Alpha and beta blocking agents
FDA pharmacologic class
alpha-Adrenergic Blocker; beta-Adrenergic Blocker FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA25.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli28.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae16.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Carvedilol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Carvedilol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Carvedilol for Prevention of Paroxysmal Atrial Fibrillation

    NCT01608893 · start 2012-05

    Registered record
    Registry ID
    NCT01608893
    Conditions
    Atrial Fibrillation
    Interventions
    Carvedilol; Metoprolol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2012-05
    Completion
    2025-06
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionCarvedilol; Metoprolol
    PhaseNot applicable
    Registry statusUnknown

  • Evaluating Dose-proportionality of Dilatrend Suspended-Release Capsule

    NCT01369472 · start 2011-06

    Registered record
    Registry ID
    NCT01369472
    Conditions
    Chronic Stable Angina
    Interventions
    Dilatrend SR capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-06
    Completion
    2011-10
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Stable Angina
    InterventionDilatrend SR capsule
    PhasePhase 1
    Registry statusCompleted

  • Clinical Trial to Evaluate the Antihypertensive Effect of AGSCT101 in Patient With Hypertension

    NCT01413048 · start 2011-01

    Registered record
    Registry ID
    NCT01413048
    Conditions
    Essential Hypertension
    Interventions
    Carvedilol 25mg; AGSCT101 12.5mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2011-01
    Completion
    2012-09
    Enrolment
    260

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Hypertension
    InterventionCarvedilol 25mg; AGSCT101 12.5mg
    PhasePhase 3
    Registry statusUnknown

  • Comparison of Effect of cARvedilol Compared To bISoprolol on cenTral Pulse Pressure in Hypertension (ARTIST) Study

    NCT01243827 · start 2010-11

    Registered record
    Registry ID
    NCT01243827
    Conditions
    Hypertension
    Interventions
    carvedilol; bisoprolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2010-11
    Completion
    2013-04
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventioncarvedilol; bisoprolol
    PhasePhase 4
    Registry statusUnknown

  • Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab

    NCT01009918 · start 2010-03

    Registered record
    Registry ID
    NCT01009918
    Conditions
    Breast Cancer; Cardiac Toxicity
    Interventions
    Coreg CR®; lisinopril; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-03
    Completion
    2018-11
    Enrolment
    468

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer; Cardiac Toxicity
    InterventionCoreg CR®; lisinopril; placebo
    PhasePhase 2
    Registry statusCompleted

  • Study on B-blockers to Prevent Decompensation of Cirrhosis With HTPortal

    NCT01059396 · start 2010-01-28

    Registered record
    Registry ID
    NCT01059396
    Conditions
    Portal Hypertension Gastropathy; Esophageal Varices; Spontaneous Bacterial Peritonitis; Hepatic Encephalopathy; Ascites
    Interventions
    propranolol; carvedilol; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-01-28
    Completion
    2015-07-15
    Enrolment
    201

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPortal Hypertension Gastropathy; Esophageal Varices; Spontaneous Bacterial Peritonitis; Hepatic Encephalopathy +1 more
    Interventionpropranolol; carvedilol; placebo
    PhasePhase 4
    Registry statusCompleted

  • Heart Rate Reduction in Heart Failure

    NCT01178528 · start 2009-09

    Registered record
    Registry ID
    NCT01178528
    Conditions
    Heart Failure
    Interventions
    ivabradine; "Drug:Carvedilol" and "Drug:Ivabradine"; Carvedilol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-09
    Completion
    2010-10
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure
    Interventionivabradine; "Drug:Carvedilol" and "Drug:Ivabradine"; Carvedilol
    PhasePhase 3
    Registry statusCompleted

  • Catheter Ablation Versus Medical Rate Control for Atrial Fibrillation in Patients With Heart Failure

    NCT00878384 · start 2009-04

    Registered record
    Registry ID
    NCT00878384
    Conditions
    Atrial Fibrillation; Heart Failure
    Interventions
    Medication to control ventricular rate in AF; Catheter Ablation for Persistent Atrial Fibrillation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-04
    Completion
    2012-07
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Heart Failure
    InterventionMedication to control ventricular rate in AF; Catheter Ablation for Persistent Atrial Fibrillation
    PhaseNot applicable
    Registry statusCompleted

  • Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment

    NCT00741585 · start 2008-09-01

    Registered record
    Registry ID
    NCT00741585
    Conditions
    Essential Hypertension; Cardiovascular Disease; Stroke; Chronic Kidney Disease
    Interventions
    Any antihypertensive medication alone or in combination; Any antihypertensive medication alone or in combination; Ambulatory blood pressure monitoring
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-09-01
    Completion
    2018-06-30
    Enrolment
    21,983

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Hypertension; Cardiovascular Disease; Stroke; Chronic Kidney Disease
    InterventionAny antihypertensive medication alone or in combination; Any antihypertensive medication alone or in combination; Ambulatory blood pressure monitoring
    PhasePhase 4
    Registry statusCompleted

  • The Effect of Nebivolol in Hypertensive Patients With Coronary Artery Disease

    NCT00673075 · start 2008-05

    Registered record
    Registry ID
    NCT00673075
    Conditions
    Hypertension; Coronary Artery Disease
    Interventions
    Nebivolol; Carvedilol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-05
    Completion
    Not recorded
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Coronary Artery Disease
    InterventionNebivolol; Carvedilol
    PhasePhase 4
    Registry statusCompleted

  • Effect of Carvedilol Controlled-Release (CR) and Atenolol on Central Blood Pressure

    NCT00669279 · start 2008-04

    Registered record
    Registry ID
    NCT00669279
    Conditions
    Hypertension
    Interventions
    Carvedilol CR; Atenolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-04
    Completion
    2010-07
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionCarvedilol CR; Atenolol
    PhasePhase 4
    Registry statusCompleted

  • Research Study To Test Carvedilol CR + Lisinopril Versus Lisinopril + Placebo In Patients With High Blood Pressure

    NCT00624065 · start 2008-03

    Registered record
    Registry ID
    NCT00624065
    Conditions
    Hypertension
    Interventions
    carvedilol controlled release/lisinopril; lisinopril + placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2008-08
    Enrolment
    348

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventioncarvedilol controlled release/lisinopril; lisinopril + placebo
    PhasePhase 3
    Registry statusCompleted

  • A Study Investigating the Bioequivalence of the Fixed Dose Combination of COREG CR to COREG CR and ZESTRIL.

    NCT00552708 · start 2007-09

    Registered record
    Registry ID
    NCT00552708
    Conditions
    Hypertension
    Interventions
    COREG CR; Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-09
    Completion
    2007-12
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionCOREG CR; Lisinopril
    PhasePhase 1
    Registry statusCompleted

  • Ablation vs Drug Therapy for Atrial Fibrillation - Pilot Trial

    NCT00578617 · start 2006-09

    Registered record
    Registry ID
    NCT00578617
    Conditions
    Atrial Fibrillation; Arrhythmia
    Interventions
    Rate Control; Ablation Therapy; Rate Control; Rate control; Rate control; Rate control; Rate Control; Rate Control; Rate Control; Rhythm Control; Rhythm control; Rhythm control; Rhythm control; Rhythm control; Rhythm control
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-09
    Completion
    2010-06
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation; Arrhythmia
    InterventionRate Control; Ablation Therapy; Rate Control; Rate control +11 more
    PhaseNot applicable
    Registry statusCompleted

  • RATe Control in Atrial Fibrillation

    NCT00313157 · start 2006-04

    Registered record
    Registry ID
    NCT00313157
    Conditions
    Atrial Fibrillation
    Interventions
    Metoprolol; Diltiazem; Verapamil; Carvedilol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-04
    Completion
    2010-09
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionMetoprolol; Diltiazem; Verapamil; Carvedilol
    PhasePhase 3
    Registry statusCompleted