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AMR Drug RepurposingSmart Screeningresearch prototype

Vincristine Sulfate

FDA-approved product (injectable, injection), marketed as Marqibo Kit, Oncovin, Vincasar Pfs and 3 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Vincristine Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Neoplasm

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Vinca alkaloids and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA59.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli47.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis67.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Vincristine Sulfate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Vincristine Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study Comparing the Efficacy and Safety Between H-CHOP and R-CHOP in Untreated CD20-Positive Diffuse Large B-cell Lymphoma Patients

    NCT05040906 · start 2020-10-13

    Registered record
    Registry ID
    NCT05040906
    Conditions
    Recruiting
    Interventions
    H02+CHOP; Rituxan +CHOP
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2020-10-13
    Completion
    2023-12-31
    Enrolment
    416

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecruiting
    InterventionH02+CHOP; Rituxan +CHOP
    PhasePhase 3
    Registry statusUnknown

  • Thalidomide Combined With R-CHOP in Newly Diagnosed，Untreated Double-expressor Diffuse Large B-Cell Lymphoma Patients

    NCT03318835 · start 2017-08-22

    Registered record
    Registry ID
    NCT03318835
    Conditions
    Thalidomide
    Interventions
    Thalidomide combined with R-CHOP; R-CHOP
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2017-08-22
    Completion
    2020-08-22
    Enrolment
    162

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThalidomide
    InterventionThalidomide combined with R-CHOP; R-CHOP
    PhasePhase 3
    Registry statusUnknown

  • Safety and Efficacy of Blinatumomab in Adults With Newly Diagnosed High-risk Diffuse Large B-Cell Lymphoma

    NCT03023878 · start 2017-03-13

    Registered record
    Registry ID
    NCT03023878
    Conditions
    High-risk Diffuse Large B-Cell Lymphoma
    Interventions
    Blinatumomab; Investigator's Choice Chemotherapy; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2017-03-13
    Completion
    2019-10-28
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHigh-risk Diffuse Large B-Cell Lymphoma
    InterventionBlinatumomab; Investigator's Choice Chemotherapy; Dexamethasone
    PhasePhase 2
    Registry statusCompleted

  • Volasertib and Vincristine Sulfate Liposome in Treating Patients With Relapsed or Refractory Acute Lymphoblastic Leukemia

    NCT02861040 · start 2016-08

    Registered record
    Registry ID
    NCT02861040
    Conditions
    Recurrent Adult Acute Lymphoblastic Leukemia; Refractory Adult Acute Lymphoblastic Leukemia
    Interventions
    Laboratory Biomarker Analysis; Pharmacological Study; Vincristine Sulfate Liposome; Volasertib
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Withdrawn
    Start
    2016-08
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRecurrent Adult Acute Lymphoblastic Leukemia; Refractory Adult Acute Lymphoblastic Leukemia
    InterventionLaboratory Biomarker Analysis; Pharmacological Study; Vincristine Sulfate Liposome; Volasertib
    PhasePhase 1
    Registry statusWithdrawn

  • Treatment for Classical Hodgkin Lymphoma in Children and Adolescents

    NCT02797717 · start 2015-11

    Registered record
    Registry ID
    NCT02797717
    Conditions
    Classical Hodgkins Lymphoma in Children and Adolescents.
    Interventions
    Radiotherapy:; Vincristine; Etoposide; Prednisone; Doxorubicin; Dacarbazine; Cyclophosphamide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2015-11
    Completion
    2027-12
    Enrolment
    2,200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionClassical Hodgkins Lymphoma in Children and Adolescents.
    InterventionRadiotherapy:; Vincristine; Etoposide; Prednisone +3 more
    PhaseNot applicable
    Registry statusRecruiting

  • Study of Palifermin (Kepivance) in Persons Undergoing Unrelated Donor Allogeneic Hematopoietic Cell Transplantation

    NCT02356159 · start 2015-09-24

    Registered record
    Registry ID
    NCT02356159
    Conditions
    Myelodysplastic Syndromes; Hodgkin's Lymphoma; Non-Hodgkin's Lymphoma; Acute Leukemia; Multiple Myeloma
    Interventions
    Rituximab; Conditioning chemotherapy; TMS; FLAG; EPOCH-F; Hematopoietic stem cell transplant; Palifermin; Acetaminophen; Diphenhydramine; Prednisone; Epinephrine; IV Saline; ECG; ECHO; MUGA; DEXA; CT chest; PET; MRI; BM aspirate; BM biopsy; Lumbar puncture
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2015-09-24
    Completion
    2025-03-25
    Enrolment
    34

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyelodysplastic Syndromes; Hodgkin's Lymphoma; Non-Hodgkin's Lymphoma; Acute Leukemia +1 more
    InterventionRituximab; Conditioning chemotherapy; TMS; FLAG +18 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Combination Chemotherapy With or Without Blinatumomab in Treating Patients With Newly Diagnosed BCR-ABL-Negative B Lineage Acute Lymphoblastic Leukemia

    NCT02003222 · start 2014-05-19

    Registered record
    Registry ID
    NCT02003222
    Conditions
    Acute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
    Interventions
    Allogeneic Hematopoietic Stem Cell Transplantation; Biospecimen Collection; Blinatumomab; Bone Marrow Aspiration; Bone Marrow Biopsy; Cyclophosphamide; Cytarabine; Daunorubicin; Daunorubicin Hydrochloride; Dexamethasone; Etoposide; Leucovorin Calcium; Lumbar Puncture; Mercaptopurine; Methotrexate; Pegaspargase; Prednisone; Rituximab; Vincristine; Vincristine Sulfate; X-Ray Imaging
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Active not recruiting
    Start
    2014-05-19
    Completion
    2027-02-25
    Enrolment
    488

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphoblastic Leukemia; B Acute Lymphoblastic Leukemia, Philadelphia Chromosome Negative
    InterventionAllogeneic Hematopoietic Stem Cell Transplantation; Biospecimen Collection; Blinatumomab; Bone Marrow Aspiration +17 more
    PhasePhase 3
    Registry statusActive not recruiting

  • A Study of the Effect of Vinca Alkaloids on c-Jun N-terminal Kinase (JNK) Phosphorylation in Patients With Chronic Lymphocytic Leukemia (CLL)

    NCT01463852 · start 2012-10

    Registered record
    Registry ID
    NCT01463852
    Conditions
    Chronic Lymphocytic Leukemia (CLL)
    Interventions
    vincristine
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2012-10
    Completion
    2014-12
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Lymphocytic Leukemia (CLL)
    Interventionvincristine
    PhaseEarly phase 1
    Registry statusTerminated

  • Metformin in Children With Relapsed or Refractory Solid Tumors

    NCT01528046 · start 2012-09-24

    Registered record
    Registry ID
    NCT01528046
    Conditions
    Solid Tumors; Primary Brain Tumors
    Interventions
    Vincristine; Irinotecan; Temozolomide; Metformin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-09-24
    Completion
    2020-02-03
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSolid Tumors; Primary Brain Tumors
    InterventionVincristine; Irinotecan; Temozolomide; Metformin
    PhasePhase 1
    Registry statusCompleted

  • Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings Sarcoma

    NCT01313884 · start 2011-05

    Registered record
    Registry ID
    NCT01313884
    Conditions
    Bone Cancer; Ewing's Sarcoma
    Interventions
    Irinotecan; Vincristine; Temozolomide; Doxorubicin; Cytoxan; Pegfilgrastim
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-05
    Completion
    2014-07
    Enrolment
    3

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBone Cancer; Ewing's Sarcoma
    InterventionIrinotecan; Vincristine; Temozolomide; Doxorubicin +2 more
    PhasePhase 2
    Registry statusTerminated

  • A Phase 1 Study of Brentuximab Vedotin Given Sequentially and Combined With Multi-Agent Chemotherapy for CD30-Positive Mature T-Cell and NK-Cell Neoplasms

    NCT01309789 · start 2011-02

    Registered record
    Registry ID
    NCT01309789
    Conditions
    Lymphoma, Large-Cell, Anaplastic; Lymphoma, NK-cell; Lymphoma, T-cell
    Interventions
    brentuximab vedotin; cyclophosphamide; brentuximab vedotin; prednisone; cyclophosphamide; doxorubicin; doxorubicin; prednisone; vincristine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-02
    Completion
    2017-02-28
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLymphoma, Large-Cell, Anaplastic; Lymphoma, NK-cell; Lymphoma, T-cell
    Interventionbrentuximab vedotin; cyclophosphamide; brentuximab vedotin; prednisone +5 more
    PhasePhase 1
    Registry statusCompleted

  • Clofarabine or High-Dose Cytarabine and Pegaspargase in Children with ALL

    NCT01228331 · start 2010-10

    Registered record
    Registry ID
    NCT01228331
    Conditions
    Leukemia
    Interventions
    Amsacrine; Clofarabine; Cyclophosphamide; Cytarabine; Daunorubicin hydrochloride; Dexamethasone; Doxorubicin hydrochloride; Etoposide phosphate; Mercaptopurine; Methotrexate; Methylprednisolone; Pegaspargase; Thioguanine; Vincristine sulfate; Whole-brain radiation therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2010-10
    Completion
    2024-11-20
    Enrolment
    745

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia
    InterventionAmsacrine; Clofarabine; Cyclophosphamide; Cytarabine +11 more
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • International Collaborative Treatment Protocol For Children And Adolescents With Acute Lymphoblastic Leukemia

    NCT01117441 · start 2010-06

    Registered record
    Registry ID
    NCT01117441
    Conditions
    Leukemia
    Interventions
    PEG-L-asparaginase; cyclophosphamide; cytarabine; daunorubicin hydrochloride; dexamethasone; doxorubicin hydrochloride; etoposide; ifosfamide; mercaptopurine; methotrexate; prednisone; thioguanine; vincristine sulfate; vindesine; daunoxome; fludarabine; Radiation Therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-06
    Completion
    2021-12-31
    Enrolment
    6,136

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia
    InterventionPEG-L-asparaginase; cyclophosphamide; cytarabine; daunorubicin hydrochloride +13 more
    PhasePhase 3
    Registry statusCompleted

  • Intercontinental Multidisciplinary Registry and Treatment Optimization Study for Choroid Plexus Tumors

    NCT01014767 · start 2009-11

    Registered record
    Registry ID
    NCT01014767
    Conditions
    Brain Cancer; Choroid Plexus Tumors
    Interventions
    Carboplatin; Cisplatin; Cyclophosphamide; Dactinomycin; Doxorubicin; Etoposide; Irinotecan; Leucovorin; Methotrexate; Temozolomide; Vincristine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2009-11
    Completion
    2014-01
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBrain Cancer; Choroid Plexus Tumors
    InterventionCarboplatin; Cisplatin; Cyclophosphamide; Dactinomycin +7 more
    PhasePhase 3
    Registry statusTerminated

  • Pre-reinductive Decitabine and Vorinostat in Relapsed Lymphoblastic Lymphoma or Acute Lymphoblastic Leukemia

    NCT00882206 · start 2009-04

    Registered record
    Registry ID
    NCT00882206
    Conditions
    Leukemia; Lymphoma
    Interventions
    cytarabine; decitabine; doxorubicin hydrochloride; imatinib mesylate; methotrexate; pegaspargase; prednisone; vincristine sulfate; vorinostat
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-04
    Completion
    2013-01
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLeukemia; Lymphoma
    Interventioncytarabine; decitabine; doxorubicin hydrochloride; imatinib mesylate +5 more
    PhasePhase 2
    Registry statusTerminated