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AMR Drug RepurposingSmart Screeningresearch prototype

Prednisolone

FDA-approved product (tablet, oral), marketed as Cortalone, Delta-Cortef, Fernisolone-P and 4 more.

Registered studies
39
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Prednisolone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Allergic conjunctivitis
  • Allergic rhinitis
  • Ankylosing spondylitis
  • Aplastic anemia
  • Asthma
  • Atopic eczema
  • Chorioretinitis
  • Choroiditis
  • Classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
  • Contact dermatitis
  • Crohn's disease
  • Dermatitis herpetiformis
  • Dermatomyositis
  • Eosinophilic pneumonia
  • Epicondylitis
  • Erythema multiforme
  • and 42 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Corticosteroids for local oral treatment; Corticosteroids acting locally; Corticosteroids; Corticosteroids, weak (group i); Corticosteroids, weak, other combinations
FDA pharmacologic class
Corticosteroid FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli32.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae21.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis33.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

39registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Prednisolone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.2 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Prednisolone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Intramedullary Calcium Sulfate Antibiotic Depot

    NCT05766670 · start 2024-04-08

    Registered record
    Registry ID
    NCT05766670
    Conditions
    Open tíbia Fracture; Osteomyelitis Tibia; Tibial Fractures
    Interventions
    Vancomycin Hydrochloride; Gentamicin; Standard Intramedullary Nail
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2024-04-08
    Completion
    2028-01
    Enrolment
    497

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen tíbia Fracture; Osteomyelitis Tibia; Tibial Fractures
    InterventionVancomycin Hydrochloride; Gentamicin; Standard Intramedullary Nail
    PhasePhase 3
    Registry statusRecruiting

  • The Safety and Efficacy of Addition of Gentamicin on Irrigation Fluid in Prevention of Post-Transurethral Resection of the Prostate Infectious Complications.

    NCT06168708 · start 2023-12-07

    Registered record
    Registry ID
    NCT06168708
    Conditions
    Post-TURP Infectious Complications
    Interventions
    Transurethral resection of the prostate (TURP); Gentamicin; normal saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-12-07
    Completion
    2024-07-07
    Enrolment
    220

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-TURP Infectious Complications
    InterventionTransurethral resection of the prostate (TURP); Gentamicin; normal saline
    PhaseNot applicable
    Registry statusUnknown

  • Irrisept vs Traditional Antibiotic Irrigation for Virgin Penile Prosthesis Placement

    NCT06489431 · start 2023-12-04

    Registered record
    Registry ID
    NCT06489431
    Conditions
    Erectile Dysfunction; Penile Prosthesis; Complications, Infection or Inflammation
    Interventions
    Chlorhexidine; Gentamicin; Rifampin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Active not recruiting
    Start
    2023-12-04
    Completion
    2027-12-31
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionErectile Dysfunction; Penile Prosthesis; Complications, Infection or Inflammation
    InterventionChlorhexidine; Gentamicin; Rifampin
    PhasePhase 3
    Registry statusActive not recruiting

  • Diabetic Foot Osteomyelitis Treatment Using Gentamicin-loaded Calcium Sulfate-hydroxyapatite Biocomposite

    NCT05316298 · start 2022-12-01

    Registered record
    Registry ID
    NCT05316298
    Conditions
    Diabetic Foot Ulcer; Osteomyelitis; Diabetes Mellitus
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2022-12-01
    Completion
    2025-01-01
    Enrolment
    182

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Foot Ulcer; Osteomyelitis; Diabetes Mellitus
    InterventionNot recorded
    PhaseNot recorded
    Registry statusUnknown

  • Ozonated Olive Oil in Treatment of Pemphigus Vulgaris and Bullous Pemphigoid

    NCT05594472 · start 2022-11-01

    Registered record
    Registry ID
    NCT05594472
    Conditions
    Pemphigus Vulgaris; Bullous Pemphigoid
    Interventions
    Ozonated olive oil; Topical garamycin cream
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2022-11-01
    Completion
    2023-06-30
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPemphigus Vulgaris; Bullous Pemphigoid
    InterventionOzonated olive oil; Topical garamycin cream
    PhasePhase 3
    Registry statusUnknown

  • Hydrocolloid Dressing for Catheter Exit Site Care in Peritoneal Dialysis Patients

    NCT05143164 · start 2022-03-11

    Registered record
    Registry ID
    NCT05143164
    Conditions
    Peritoneal Dialysis Catheter Exit Site Infection
    Interventions
    hydrocolloid dressing; Gentamicin Sulfate, Topical
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-03-11
    Completion
    2025-12-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPeritoneal Dialysis Catheter Exit Site Infection
    Interventionhydrocolloid dressing; Gentamicin Sulfate, Topical
    PhaseNot applicable
    Registry statusCompleted

  • Topical Gentamicin Nonsense Suppression Therapy of EB

    NCT04644627 · start 2020-12-01

    Registered record
    Registry ID
    NCT04644627
    Conditions
    Epidermolysis Bullosa
    Interventions
    Gentamicin Sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2020-12-01
    Completion
    2022-05-01
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpidermolysis Bullosa
    InterventionGentamicin Sulfate
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Topical Gentamicin and Vancomycin for Vascular Surgical Site Infection Prophylaxis

    NCT04238923 · start 2020-05-01

    Registered record
    Registry ID
    NCT04238923
    Conditions
    Vascular Diseases; Peripheral Vascular Disease; Surgical Site Infection; Bypass Complication
    Interventions
    Topical vancomycin paste (1g vancomycin powder + 4mL sterile saline) and Collatamp G gentamicin-eluting sponge (Azralez Pharmaceuticals; 2.0mg gentamicin sulphate/cm2 to cover wound)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2020-05-01
    Completion
    2021-07-01
    Enrolment
    356

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVascular Diseases; Peripheral Vascular Disease; Surgical Site Infection; Bypass Complication
    InterventionTopical vancomycin paste (1g vancomycin powder + 4mL sterile saline) and Collatamp G gentamicin-eluting sponge (Azralez Pharmaceuticals; 2.0mg gentamicin sulphate/cm2 to cover wound)
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Gentamicin Intravesical Efficacy for Infection of Urinary Tract

    NCT04246996 · start 2020-01-29

    Registered record
    Registry ID
    NCT04246996
    Conditions
    Postoperative Urinary Tract Infection; Pelvic Organ Prolapse; Stress Urinary Incontinence
    Interventions
    gentamicin sulfate; Catheter clamping only
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2020-01-29
    Completion
    2021-12-05
    Enrolment
    370

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Urinary Tract Infection; Pelvic Organ Prolapse; Stress Urinary Incontinence
    Interventiongentamicin sulfate; Catheter clamping only
    PhasePhase 2
    Registry statusCompleted

  • Optimizing IV Gentamicin in JEB

    NCT04140786 · start 2019-10-31

    Registered record
    Registry ID
    NCT04140786
    Conditions
    Junctional Epidermolysis Bullosa
    Interventions
    Gentamicin Sulfate, Injectable
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Unknown
    Start
    2019-10-31
    Completion
    2023-11-01
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionJunctional Epidermolysis Bullosa
    InterventionGentamicin Sulfate, Injectable
    PhasePhase 1 / Phase 2
    Registry statusUnknown

  • A Study to Compare Different Antibiotics and Different Modes of Fluid Treatment for Children With Severe Pneumonia

    NCT04041791 · start 2019-08-19

    Registered record
    Registry ID
    NCT04041791
    Conditions
    Pneumonia
    Interventions
    Benzyl penicillin; Gentamicin Sulfate; Ceftriaxone; Amoxicillin Clavulanate; Intravenous fluid; Nasogastric feeds; Ampicillin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2019-08-19
    Completion
    2024-04-05
    Enrolment
    4,392

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionBenzyl penicillin; Gentamicin Sulfate; Ceftriaxone; Amoxicillin Clavulanate +3 more
    PhasePhase 3
    Registry statusCompleted

  • Antibiotic Irrigations for Intra-Abdominal Drains

    NCT03476941 · start 2019-04-01

    Registered record
    Registry ID
    NCT03476941
    Conditions
    Abdominal Abscess
    Interventions
    Gentamicin Sulfate Inj 20mg/2ml vial for injection; Clindamycin phosphate 6 mg/1ml for injection; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2019-04-01
    Completion
    2020-10-21
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbdominal Abscess
    InterventionGentamicin Sulfate Inj 20mg/2ml vial for injection; Clindamycin phosphate 6 mg/1ml for injection; Placebo
    PhasePhase 2
    Registry statusTerminated

  • Gentamicin Bladder Instillation in Individuals With Spinal Cord Injury Having Chronic Urinary Tract Infections

    NCT03931408 · start 2019-02-19

    Registered record
    Registry ID
    NCT03931408
    Conditions
    Neurogenic Bladder; Spinal Cord Injuries
    Interventions
    Gentamicin Sulfate; Placebo instillation (saline alone); No instillation
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2019-02-19
    Completion
    2020-12-30
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeurogenic Bladder; Spinal Cord Injuries
    InterventionGentamicin Sulfate; Placebo instillation (saline alone); No instillation
    PhasePhase 2
    Registry statusCompleted

  • Gentamicin Bladder Instillations to Prevent Urinary Tract Infections in Patients With Spinal Cord Injury

    NCT03503513 · start 2018-08-24

    Registered record
    Registry ID
    NCT03503513
    Conditions
    Urinary Tract Infections; Spinal Cord Injuries; Spinal Cord Diseases; Neurogenic Bladder
    Interventions
    Gentamicin Sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2018-08-24
    Completion
    2023-09-30
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections; Spinal Cord Injuries; Spinal Cord Diseases; Neurogenic Bladder
    InterventionGentamicin Sulfate
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Noninferiority Comparison of Prophylactic Open Fracture Antimicrobial Regimens

    NCT03560232 · start 2018-07-09

    Registered record
    Registry ID
    NCT03560232
    Conditions
    Open Fracture; Post-Op Wound Infection
    Interventions
    Ceftriaxone; Ampicillin/sulbactam; Piperacillin/tazobactam; Cefazolin + Gentamicin; Clindamycin + Gentamicin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2018-07-09
    Completion
    2020-02-19
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen Fracture; Post-Op Wound Infection
    InterventionCeftriaxone; Ampicillin/sulbactam; Piperacillin/tazobactam; Cefazolin + Gentamicin +1 more
    PhasePhase 4
    Registry statusTerminated