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AMR Drug RepurposingSmart Screeningresearch prototype

Lincomycin Hydrochloride

FDA-approved product (capsule, oral), marketed as Lincocin, Lincomycin Hydrochloride.

Registered studies
50+
Lab records
9
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Lincomycin Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Infection
  • Multiple sclerosis
  • Pseudomembranous enterocolitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Lincosamides
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01FF02

Repurposing investigation

Lincomycin Hydrochloride is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA60.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli4.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae8.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis4.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 2 of 3 lab records
  • E. coli: measured active in 0 of 1 lab record
  • K. pneumoniae: measured active in 0 of 1 lab record
  • M. tuberculosis: measured active in 0 of 4 lab records
Open Lincomycin Hydrochloride in ChEMBL Registered studies below
Show the 9 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.4 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.5 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lincomycin Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Safety and Pharmacokinetics of Clindamycin in Pediatric Subjects With BMI ≥ 85th Percentile

    NCT01744730 · start 2013-06

    Registered record
    Registry ID
    NCT01744730
    Conditions
    Bacterial Infections; Obesity
    Interventions
    Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-06
    Completion
    2014-08
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections; Obesity
    InterventionClindamycin
    PhasePhase 1
    Registry statusCompleted

  • Efficacy and Safety Study of Antibiotic Treatment to Treat Hip Prosthetic Joint Infection

    NCT01757236 · start 2012-10

    Registered record
    Registry ID
    NCT01757236
    Conditions
    Hip Prosthetic Joint Infection
    Interventions
    VANCOMYCIN; CEFTRIAXONE; CLINDAMYCIN; SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE); FLUOROQUINOLONE; LINEZOLID; RIFAMPIN
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2012-10
    Completion
    2016-04
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Prosthetic Joint Infection
    InterventionVANCOMYCIN; CEFTRIAXONE; CLINDAMYCIN; SULFAMETHOXAZOLE AND TRIMETHOPRIM (CO-TRIMOXAZOLE) +3 more
    PhasePhase 2
    Registry statusUnknown

  • Impact of Artemisinin-based Combination Therapy and Quinine on Treatment Failure and Resistance in Uncomplicated Malaria

    NCT01374581 · start 2012-05

    Registered record
    Registry ID
    NCT01374581
    Conditions
    Malaria
    Interventions
    Artemether/Lumefantrine; Artesunate/Amodiaquine; Quinine + Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-05
    Completion
    2014-06
    Enrolment
    2,117

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionArtemether/Lumefantrine; Artesunate/Amodiaquine; Quinine + Clindamycin
    PhasePhase 3
    Registry statusCompleted

  • Safety and Efficacy Study of Ceftaroline Versus a Comparator in Pediatric Subjects With Complicated Skin Infections

    NCT01400867 · start 2011-12

    Registered record
    Registry ID
    NCT01400867
    Conditions
    Infections, Pediatrics
    Interventions
    Ceftaroline fosamil; Vancomycin +/- Aztreonam or Cefazolin +/- Aztreonam; Cephalexin or Clindamycin or Linezolid
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2011-12
    Completion
    2014-07
    Enrolment
    163

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfections, Pediatrics
    InterventionCeftaroline fosamil; Vancomycin +/- Aztreonam or Cefazolin +/- Aztreonam; Cephalexin or Clindamycin or Linezolid
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Evaluation of Fosmidomycin and Clindamycin in the Treatment of Acute Uncomplicated Plasmodium Falciparum Malaria

    NCT01361269 · start 2011-06

    Registered record
    Registry ID
    NCT01361269
    Conditions
    Malaria
    Interventions
    Fosmidomycin and clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2011-06
    Completion
    2011-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMalaria
    InterventionFosmidomycin and clindamycin
    PhasePhase 2
    Registry statusUnknown

  • Prevention of Arrhythmia Device Infection Trial (PADIT)

    NCT01613092 · start 2011-05

    Registered record
    Registry ID
    NCT01613092
    Conditions
    Arrhythmia
    Interventions
    Incremental; Cefazolin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-05
    Completion
    2013-12
    Enrolment
    241

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrhythmia
    InterventionIncremental; Cefazolin
    PhasePhase 4
    Registry statusCompleted

  • Combination Treatment for Moderate to Severe Acne

    NCT01206348 · start 2010-09

    Registered record
    Registry ID
    NCT01206348
    Conditions
    Acne
    Interventions
    Minocycline, Clindamycin, Tretinoin, Benzoyl Peroxide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-09
    Completion
    2011-07
    Enrolment
    97

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne
    InterventionMinocycline, Clindamycin, Tretinoin, Benzoyl Peroxide
    PhasePhase 4
    Registry statusCompleted

  • Multifactorial Approach to Emergent Cerclage

    NCT01114516 · start 2010-03

    Registered record
    Registry ID
    NCT01114516
    Conditions
    Cervical Insufficiency
    Interventions
    Indomethacin and antibiotics (cefazolin or clindamycin)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-03
    Completion
    2014-03
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCervical Insufficiency
    InterventionIndomethacin and antibiotics (cefazolin or clindamycin)
    PhaseNot applicable
    Registry statusCompleted

  • Trial Comparing Efficacy of Treatments for Hidradenitis Suppurativa

    NCT01063270 · start 2010-02

    Registered record
    Registry ID
    NCT01063270
    Conditions
    Hidradenitis Suppurativa
    Interventions
    Clindamycin & Rifampin; Clindamycin + Rifampin along with NdYag Laser treatment
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-02
    Completion
    2013-12
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHidradenitis Suppurativa
    InterventionClindamycin & Rifampin; Clindamycin + Rifampin along with NdYag Laser treatment
    PhaseNot applicable
    Registry statusCompleted

  • Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Abscess

    NCT01498744 · start 2010-02

    Registered record
    Registry ID
    NCT01498744
    Conditions
    Abscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    Interventions
    Oral Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-02
    Completion
    2013-02
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    InterventionOral Clindamycin
    PhaseNot applicable
    Registry statusTerminated

  • A Study to Evaluate Tolerability of Two Topical Drug Products in the Treatment of Facial Acne

    NCT00964223 · start 2009-07

    Registered record
    Registry ID
    NCT00964223
    Conditions
    Acne Vulgaris
    Interventions
    Clindamycin and benzoyl peroxide gel (Duac® Topical Gel); benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2009-11
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionClindamycin and benzoyl peroxide gel (Duac® Topical Gel); benzoyl peroxide and adapalene gel (EPIDUO™ Gel)
    PhasePhase 4
    Registry statusCompleted

  • Relative Bioavailability Study Of Two Lincomycin Hydrochloride Hard Gelatinous Capsule

    NCT01058824 · start 2009-04

    Registered record
    Registry ID
    NCT01058824
    Conditions
    Bacterial Infections
    Interventions
    Lincomycin; Lincomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-04
    Completion
    2009-04
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections
    InterventionLincomycin; Lincomycin
    PhasePhase 1
    Registry statusCompleted

  • Systemic and Topical Treatments for Rash Secondary to Erlotinib in Lung Cancer

    NCT00473083 · start 2009-01

    Registered record
    Registry ID
    NCT00473083
    Conditions
    Rash
    Interventions
    Minocycline; Clindamycin 2% in hydrocortisone 1% lotion; Erlotinib; Topical clindamycin 2%, triamcinolone acetonide 0.1% soln
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-01
    Completion
    2013-08
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRash
    InterventionMinocycline; Clindamycin 2% in hydrocortisone 1% lotion; Erlotinib; Topical clindamycin 2%, triamcinolone acetonide 0.1% soln
    PhasePhase 2
    Registry statusCompleted

  • W0265-103: A Single-Center, Evaluator-Blinded, Randomized, Placebo Controlled, Phase 1 Clinical Trial Evaluating The Phototoxic Potential Of Topically Applied Clindamycin 1.0% - Tretinoin 0.025% Gel (Ct Gel) In Healthy Volunteers

    NCT01929278 · start 2008-12-08

    Registered record
    Registry ID
    NCT01929278
    Conditions
    Acne Vulgaris
    Interventions
    CT Gel (clindamycin 1% and tretinoin 0.025%); Vehicle gel patch; Blank patch
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-12-08
    Completion
    2008-12-19
    Enrolment
    37

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionCT Gel (clindamycin 1% and tretinoin 0.025%); Vehicle gel patch; Blank patch
    PhasePhase 1
    Registry statusCompleted

  • Trial of Clindamycin / Benzoyl Peroxide Gel in Subjects With Acne

    NCT00776919 · start 2008-10

    Registered record
    Registry ID
    NCT00776919
    Conditions
    Acne Vulgaris
    Interventions
    clindamycin / benzoyl peroxide gel; clindamycin gel; BPO gel; vehicle gel
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-10
    Completion
    2009-09
    Enrolment
    1,315

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    Interventionclindamycin / benzoyl peroxide gel; clindamycin gel; BPO gel; vehicle gel
    PhasePhase 3
    Registry statusCompleted