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AMR Drug RepurposingSmart Screeningresearch prototype

Ezetimibe

FDA-approved product (tablet, oral), marketed as Ezetimibe, Zetia.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Ezetimibe
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Familial hypercholesterolemia
  • Homozygous familial hypercholesterolemia
  • Hypercholesterolemia
  • Hyperlipidemia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other lipid modifying agents
FDA pharmacologic class
Dietary Cholesterol Absorption Inhibitor FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli43.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis49.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Ezetimibe in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.9 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.5 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Ezetimibe with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Ezetimibe In Addition To Atorvastatin Therapy On The Plaque Composition In Patients With Acute Myocardial Infarction.

    NCT01385631 · start 2011-06

    Registered record
    Registry ID
    NCT01385631
    Conditions
    ST-Segment Elevation Myocardial Infarction
    Interventions
    Ezetimibe; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-06
    Completion
    2014-09
    Enrolment
    87

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionST-Segment Elevation Myocardial Infarction
    InterventionEzetimibe; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Tolerability and Lipid Lowering Effect of Weekly/Biweekly Crestor in Statin Intolerant Patients Treated With Zetia

    NCT00972829 · start 2009-09

    Registered record
    Registry ID
    NCT00972829
    Conditions
    Hypercholesterolemia
    Interventions
    Rosuvastatin; Ezetimibe
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2009-09
    Completion
    2011-03
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionRosuvastatin; Ezetimibe
    PhasePhase 4
    Registry statusUnknown

  • The Influence of Ezetimibe on Gallbladder Function

    NCT00634140 · start 2009-08

    Registered record
    Registry ID
    NCT00634140
    Conditions
    Chronic Acalculous Cholecystitis
    Interventions
    ezetimibe; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2009-08
    Completion
    2009-08
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Acalculous Cholecystitis
    Interventionezetimibe; Placebo
    PhaseNot applicable
    Registry statusWithdrawn

  • Phytosterols, Ezetimibe, and Cholesterol Metabolism

    NCT00863265 · start 2009-06

    Registered record
    Registry ID
    NCT00863265
    Conditions
    Hypercholesterolemia; Coronary Heart Disease
    Interventions
    Ezetimibe; Phytosterols + ezetimibe; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2009-06
    Completion
    2010-02
    Enrolment
    22

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia; Coronary Heart Disease
    InterventionEzetimibe; Phytosterols + ezetimibe; Placebo
    PhaseEarly phase 1
    Registry statusCompleted

  • Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457)

    NCT00653523 · start 2007-12-01

    Registered record
    Registry ID
    NCT00653523
    Conditions
    Hypercholesterolemia
    Interventions
    Ezetimibe; Simvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-12-01
    Completion
    2009-06-01
    Enrolment
    151

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionEzetimibe; Simvastatin
    PhasePhase 3
    Registry statusCompleted

  • A Study to Assess the Cholesterol Lowering Effect of Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Elderly Patients With High Cholesterol at High or Moderately High Risk for Coronary Heart Disease (0653A-128)

    NCT00535405 · start 2007-11

    Registered record
    Registry ID
    NCT00535405
    Conditions
    Hypercholesterolemia
    Interventions
    Atorvastatin 10 mg; Ezetimibe 10 mg/simvastatin 20 mg; Atorvastatin 20 mg; Ezetimibe 10 mg/simvastatin 40 mg; Atorvastatin 40 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-11
    Completion
    2009-03
    Enrolment
    1,289

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionAtorvastatin 10 mg; Ezetimibe 10 mg/simvastatin 20 mg; Atorvastatin 20 mg; Ezetimibe 10 mg/simvastatin 40 mg +1 more
    PhasePhase 3
    Registry statusCompleted

  • A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin® 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea (0653A-129)(COMPLETED)

    NCT00496730 · start 2007-07

    Registered record
    Registry ID
    NCT00496730
    Conditions
    Hypercholesterolemia
    Interventions
    simvastatin (+) ezetimibe; Comparator: atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-07
    Completion
    2008-08
    Enrolment
    256

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    Interventionsimvastatin (+) ezetimibe; Comparator: atorvastatin
    PhasePhase 3
    Registry statusCompleted

  • Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons

    NCT00481351 · start 2007-06

    Registered record
    Registry ID
    NCT00481351
    Conditions
    Coronary Heart Disease
    Interventions
    Simvastatin 20mg plus ezetimibe 10mg; ezetimibe; simvastatin 20mg; Simvastatin 80mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-06
    Completion
    2010-01
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Heart Disease
    InterventionSimvastatin 20mg plus ezetimibe 10mg; ezetimibe; simvastatin 20mg; Simvastatin 80mg
    PhasePhase 4
    Registry statusCompleted

  • Evaluation of Chylomicrons Metabolism in Sub-Clinical Atherosclerosis in Patients Whit Heterozigous Familial Hypercholesterolemia (FH) Treated With Statin Plus Ezetimibe

    NCT00475826 · start 2007-04

    Registered record
    Registry ID
    NCT00475826
    Conditions
    Heterozigous Familial Hypercholesterolemia
    Interventions
    Statins and Ezetimibe
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2007-04
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeterozigous Familial Hypercholesterolemia
    InterventionStatins and Ezetimibe
    PhaseNot applicable
    Registry statusUnknown

  • Ezetimibe and Atorvastatin vs. Atorvastatin in Patients Age 65 and Older at High Risk for Coronary Heart Disease (CHD)(0653-112)

    NCT00418834 · start 2007-01

    Registered record
    Registry ID
    NCT00418834
    Conditions
    Hypercholesterolemia
    Interventions
    ezetimibe and atorvastatin; atorvastatin; Placebo (unspecified)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-01
    Completion
    2008-10
    Enrolment
    1,053

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    Interventionezetimibe and atorvastatin; atorvastatin; Placebo (unspecified)
    PhasePhase 3
    Registry statusCompleted

  • Comparative Study of the Effect of Ezetimibe Versus Extended-Release Niacin on Atherosclerosis

    NCT00397657 · start 2006-11

    Registered record
    Registry ID
    NCT00397657
    Conditions
    Atherosclerosis
    Interventions
    extended release niacin; ezetimibe
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2006-11
    Completion
    2009-10
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtherosclerosis
    Interventionextended release niacin; ezetimibe
    PhasePhase 4
    Registry statusTerminated

  • Plant Sterols Effect on Previous Statin Therapy

    NCT02089867 · start 2006-10

    Registered record
    Registry ID
    NCT02089867
    Conditions
    Coronary Artery Disease
    Interventions
    Ezetimibe + plant sterols; Ezetimibe; Plant sterols
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2006-10
    Completion
    2008-01
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease
    InterventionEzetimibe + plant sterols; Ezetimibe; Plant sterols
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Ezetrol Post-Marketing Study

    NCT00753883 · start 2006-07

    Registered record
    Registry ID
    NCT00753883
    Conditions
    Hyperlipidemia
    Interventions
    simvastatin; Ezetimibe
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-07
    Completion
    Not recorded
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyperlipidemia
    Interventionsimvastatin; Ezetimibe
    PhasePhase 4
    Registry statusCompleted

  • Effects of Vytorin Versus Placebo in Subjects With Primary Hypercholesterolemia (Study P04420)

    NCT00413972 · start 2006-04

    Registered record
    Registry ID
    NCT00413972
    Conditions
    Hypercholesterolemia
    Interventions
    ezetimibe with simvastatin; Ezetimibe with Simvastatin; Ezetimibe with Simvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-04
    Completion
    2006-11
    Enrolment
    392

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    Interventionezetimibe with simvastatin; Ezetimibe with Simvastatin; Ezetimibe with Simvastatin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Evaluation of the Safety, Tolerability and Efficacy of Ezetimibe on a Select Population of Filipinos With Hypercholesterolemia (Study P04748)(COMPLETED)

    NCT00704535 · start 2006-03

    Registered record
    Registry ID
    NCT00704535
    Conditions
    Primary Hypercholesterolemia; Homozygous Familial Hypercholesterolemia
    Interventions
    Ezetimibe
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-03
    Completion
    2008-04
    Enrolment
    4,105

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Hypercholesterolemia; Homozygous Familial Hypercholesterolemia
    InterventionEzetimibe
    PhaseNot recorded
    Registry statusCompleted