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AMR Drug RepurposingSmart Screeningresearch prototype

Codeine Sulfate

FDA-approved product (tablet, oral), marketed as Codeine Sulfate.

Registered studies
23
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Codeine Sulfate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cough
  • Drug dependence
  • Migraine disorder
  • Muscle spasm
  • Pain

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Natural opium alkaloids; Opium alkaloids and derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA40.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli37.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae48.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis43.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

23registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Codeine Sulfate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.4 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Codeine Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Evaluation of NaproxenSodium and CodeinePhosphate Combination in Osteoarthritis

    NCT02501564 · start 2013-05

    Registered record
    Registry ID
    NCT02501564
    Conditions
    Osteoarthritis
    Interventions
    Naproxen Sodium Codeine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-05
    Completion
    2015-11
    Enrolment
    135

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionNaproxen Sodium Codeine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Naproxen Codeine in Arthroscopic Surgery

    NCT01952652 · start 2013-01

    Registered record
    Registry ID
    NCT01952652
    Conditions
    Arthroscopic Meniscus Surgery
    Interventions
    Group N:Naproxen sodium; Group NC :naproxen sodium codeine phosphate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2013-01
    Completion
    2013-07
    Enrolment
    61

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthroscopic Meniscus Surgery
    InterventionGroup N:Naproxen sodium; Group NC :naproxen sodium codeine phosphate
    PhasePhase 4
    Registry statusCompleted

  • Comparison of the Efficacy of Oral Oxycodone and Oral Codeine in the Treatment of Postcraniotomy Pain

    NCT01672112 · start 2012-07

    Registered record
    Registry ID
    NCT01672112
    Conditions
    Postcraniotomy Pain
    Interventions
    Oxycodone; Codeine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-07
    Completion
    2015-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostcraniotomy Pain
    InterventionOxycodone; Codeine
    PhasePhase 4
    Registry statusCompleted

  • A Comparison of Postoperative Tramadol Versus Acetaminophen With Codeine in Children Undergoing Tonsillectomy

    NCT01267136 · start 2011-01

    Registered record
    Registry ID
    NCT01267136
    Conditions
    Tonsillitis; Pain
    Interventions
    Codeine with acetaminophen; Tramadol suspension
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-01
    Completion
    2012-05
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTonsillitis; Pain
    InterventionCodeine with acetaminophen; Tramadol suspension
    PhasePhase 4
    Registry statusCompleted

  • SB-705498 Dental Pain Study After Tooth Extraction

    NCT00281684 · start 2005-12-07

    Registered record
    Registry ID
    NCT00281684
    Conditions
    Toothache
    Interventions
    SB705498 400 mg; SB705498 1000 mg; Placebo; Co-Codamol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-12-07
    Completion
    2007-10-03
    Enrolment
    145

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionToothache
    InterventionSB705498 400 mg; SB705498 1000 mg; Placebo; Co-Codamol
    PhasePhase 2
    Registry statusCompleted

  • Toxicity Substudy of Evaluation of Subcutaneous Proleukin in a Randomised International Trial (ESPRIT): TOXIL-2 Substudy

    NCT00147355 · start 2005-11

    Registered record
    Registry ID
    NCT00147355
    Conditions
    HIV Infections
    Interventions
    ondansetron, ibuprofen, paracetamol; Ondansetron, ibuprofen, paracetamol; metoclopramide, ibuprofen, paracetamol; Metoclopramide, codeine phosphate, ibuprofen, paracetamol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2005-11
    Completion
    2008-12
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    Interventionondansetron, ibuprofen, paracetamol; Ondansetron, ibuprofen, paracetamol; metoclopramide, ibuprofen, paracetamol; Metoclopramide, codeine phosphate, ibuprofen, paracetamol
    PhasePhase 3
    Registry statusTerminated

  • Oxycodone or Standard Pain Therapy in Treating Patients With Cancer Pain

    NCT00378937 · start 2004-01

    Registered record
    Registry ID
    NCT00378937
    Conditions
    Pain; Unspecified Adult Solid Tumor, Protocol Specific
    Interventions
    acetaminophen; codeine phosphate; dextropropoxyphene hydrochloride; morphine sulfate; oxycodone hydrochloride; management of therapy complications; quality-of-life assessment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-01
    Completion
    2006-02
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain; Unspecified Adult Solid Tumor, Protocol Specific
    Interventionacetaminophen; codeine phosphate; dextropropoxyphene hydrochloride; morphine sulfate +3 more
    PhasePhase 4
    Registry statusCompleted

  • Double Blind Randomized Study Into the Efficacy of Codeine Phosphate Analgesia After Cleft Palate Repair in Infants

    NCT00386269 · start 2004-01

    Registered record
    Registry ID
    NCT00386269
    Conditions
    Cleft Palate Repair
    Interventions
    Codeine Phosphate Analgesia
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-01
    Completion
    2007-09
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCleft Palate Repair
    InterventionCodeine Phosphate Analgesia
    PhasePhase 4
    Registry statusCompleted