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AMR Drug RepurposingSmart Screeningresearch prototype

Cangrelor

FDA-approved product (powder, intravenous), marketed as Cangrelor, Kengreal.

Registered studies
45
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cangrelor
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Myocardial infarction
  • Percutaneous Coronary Intervention
  • Recurrent thrombophlebitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Platelet aggregation inhibitors excl. heparin
FDA pharmacologic class
P2Y12 Platelet Inhibitor FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA44.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli45.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae36.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis44.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

45registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cangrelor in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cangrelor with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Impact of Timing of PD Assessments on Measures of Platelet Reactivity in Patients Undergoing PCI Treated With Cangrelor

    NCT04668495 · start 2021-01-28

    Registered record
    Registry ID
    NCT04668495
    Conditions
    Coronary Artery Disease
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-01-28
    Completion
    2021-07-20
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • ARCANGELO (itAlian pRospective Study on CANGrELOr)

    NCT04471870 · start 2020-10-23

    Registered record
    Registry ID
    NCT04471870
    Conditions
    Acute Coronary Syndrome
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-10-23
    Completion
    2022-01-17
    Enrolment
    1,005

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Evolution of COVID-19 in Anticoagulated or Antiaggregated Patients (CORONA Study)

    NCT04518735 · start 2020-04-01

    Registered record
    Registry ID
    NCT04518735
    Conditions
    Covid19
    Interventions
    Antithrombotic Therapy (anticoagulant and/or antiplatelet) before admission for Covid19
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2020-04-01
    Completion
    2020-06-30
    Enrolment
    1,707

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCovid19
    InterventionAntithrombotic Therapy (anticoagulant and/or antiplatelet) before admission for Covid19
    PhaseNot recorded
    Registry statusCompleted

  • Dutch Cangrelor Registry

    NCT04138641 · start 2019-12-17

    Registered record
    Registry ID
    NCT04138641
    Conditions
    STEMI - ST Elevation Myocardial Infarction; NSTEMI - Non-ST Segment Elevation MI; Coronary Artery Disease
    Interventions
    Cangrelor
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2019-12-17
    Completion
    2020-07-24
    Enrolment
    250

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSTEMI - ST Elevation Myocardial Infarction; NSTEMI - Non-ST Segment Elevation MI; Coronary Artery Disease
    InterventionCangrelor
    PhaseNot recorded
    Registry statusCompleted

  • Cangrelor in Acute Myocardial Infarction: Effectiveness and Outcomes Registry

    NCT04076813 · start 2019-10-16

    Registered record
    Registry ID
    NCT04076813
    Conditions
    Myocardial Infarction
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Active not recruiting
    Start
    2019-10-16
    Completion
    2025-06-30
    Enrolment
    5,050

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Infarction
    InterventionNot recorded
    PhaseNot recorded
    Registry statusActive not recruiting

  • Cangrelor in Comatose Survivors of OHCA Undergoing Primary PCI

    NCT04005729 · start 2019-07-01

    Registered record
    Registry ID
    NCT04005729
    Conditions
    Out-Of-Hospital Cardiac Arrest; Acute Coronary Syndrome
    Interventions
    Cangrelor 50 MG
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-07-01
    Completion
    2021-11-27
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOut-Of-Hospital Cardiac Arrest; Acute Coronary Syndrome
    InterventionCangrelor 50 MG
    PhasePhase 4
    Registry statusCompleted

  • Maintenance Of aNtiplatElet Therapy in Patients With Coronary Stenting Undergoing Surgery (MONET BRIDGE)

    NCT03862651 · start 2019-06-01

    Registered record
    Registry ID
    NCT03862651
    Conditions
    Platelet Aggregation Inhibitors
    Interventions
    Cangrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2019-06-01
    Completion
    2021-01-01
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPlatelet Aggregation Inhibitors
    InterventionCangrelor
    PhasePhase 2
    Registry statusUnknown

  • Cangrelor vs. Ticagrelor for Early Platelet Inhibition in STEMI

    NCT03182855 · start 2018-09-01

    Registered record
    Registry ID
    NCT03182855
    Conditions
    Acute Coronary Syndrome; Myocardial Infarction; STEMI - ST Elevation Myocardial Infarction
    Interventions
    Ticagrelor; Cangrelor Tetrasodium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-09-01
    Completion
    2019-08-01
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Coronary Syndrome; Myocardial Infarction; STEMI - ST Elevation Myocardial Infarction
    InterventionTicagrelor; Cangrelor Tetrasodium
    PhasePhase 4
    Registry statusUnknown

  • Dual Antiplatelet Therapy For Shock Patients With Acute Myocardial Infarction

    NCT03551964 · start 2018-08-01

    Registered record
    Registry ID
    NCT03551964
    Conditions
    Acute Myocardial Infarction; Cardiogenic Shock
    Interventions
    Cangrelor; Ticagrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-08-01
    Completion
    2025-04-01
    Enrolment
    605

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Myocardial Infarction; Cardiogenic Shock
    InterventionCangrelor; Ticagrelor
    PhasePhase 4
    Registry statusCompleted

  • Platelet Inhibition With Cangrelor and Crushed Ticagrelor in STEMI

    NCT03247738 · start 2017-11-20

    Registered record
    Registry ID
    NCT03247738
    Conditions
    ST Segment Elevation Myocardial Infarction; Percutaneous Coronary Intervention
    Interventions
    Cangrelor; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-11-20
    Completion
    2018-12-13
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionST Segment Elevation Myocardial Infarction; Percutaneous Coronary Intervention
    InterventionCangrelor; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Platelet Inhibition to Target Reperfusion Injury

    NCT03102723 · start 2017-10-01

    Registered record
    Registry ID
    NCT03102723
    Conditions
    STEMI
    Interventions
    Cangrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2017-10-01
    Completion
    2022-12
    Enrolment
    228

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSTEMI
    InterventionCangrelor
    PhasePhase 2
    Registry statusUnknown

  • Add-on Cangrelor in STEMI-triggered Cardiac Arrest

    NCT03273075 · start 2017-09

    Registered record
    Registry ID
    NCT03273075
    Conditions
    Cardiopulmonary Arrest With Successful Resuscitation; ACS - Acute Coronary Syndrome; Hypothermia, Induced
    Interventions
    Cangrelor; Placebo; Prasugrel; Ticagrelor
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-09
    Completion
    2021-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiopulmonary Arrest With Successful Resuscitation; ACS - Acute Coronary Syndrome; Hypothermia, Induced
    InterventionCangrelor; Placebo; Prasugrel; Ticagrelor
    PhasePhase 4
    Registry statusUnknown

  • Antiplatelet Effects of Tirofiban vs. Cangrelor N-STEMI Patients Undergoing Percutaneous Coronary Intervention

    NCT03048019 · start 2017-08-23

    Registered record
    Registry ID
    NCT03048019
    Conditions
    Non-ST Elevation Myocardial Infarction (NSTEMI)
    Interventions
    Tirofiban; Cangrelor
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2017-08-23
    Completion
    2019-06-27
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNon-ST Elevation Myocardial Infarction (NSTEMI)
    InterventionTirofiban; Cangrelor
    PhaseNot recorded
    Registry statusTerminated

  • Cangrelor Following Ticagrelor Loading vs Ticagrelor Loading Alone in STEMI

    NCT02943369 · start 2017-07-28

    Registered record
    Registry ID
    NCT02943369
    Conditions
    STEMI
    Interventions
    Ticagrelor 180 mg loading dose; Cangrelor 30 mcg/kg bolus + 4 mcg/kg/min
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-07-28
    Completion
    2017-12-26
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSTEMI
    InterventionTicagrelor 180 mg loading dose; Cangrelor 30 mcg/kg bolus + 4 mcg/kg/min
    PhasePhase 4
    Registry statusCompleted

  • Randomized Comparison of Cangrelor, Tirofiban and Prasugrel in Patients With STEMI Referred for Primary PCI.

    NCT02978040 · start 2017-07-04

    Registered record
    Registry ID
    NCT02978040
    Conditions
    Coronary Artery Disease; STEMI - ST Elevation Myocardial Infarction
    Interventions
    Cangrelor; Tirofiban; Prasugrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-07-04
    Completion
    2019-12-27
    Enrolment
    122

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Artery Disease; STEMI - ST Elevation Myocardial Infarction
    InterventionCangrelor; Tirofiban; Prasugrel
    PhasePhase 4
    Registry statusCompleted