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AMR Drug RepurposingSmart Screeningresearch prototype

Tiagabine Hydrochloride

FDA-approved product (tablet, oral), marketed as Gabitril, Tiagabine Hydrochloride.

Registered studies
21
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Tiagabine Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Epilepsy
  • Seizure

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Fatty acid derivatives
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA37.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli30.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae24.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis63.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

21registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tiagabine Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.3 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tiagabine Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Population Pharmacokinetics of Antiepileptic in Pediatrics

    NCT03196466 · start 2017-06-19

    Registered record
    Registry ID
    NCT03196466
    Conditions
    Epilepsy
    Interventions
    Valproic acid; carbamazepine; phenobarbital; phenytoin; levetiracetam; lamotrigine; topiramate; oxcarbazepine; stiripentol; clobazam; brivaracétam; felbamate; lacosamide; rufinamide; gabapentine; pregabaline; sultiame; tiagabine; vigabatrine; mesuximide; primidone; perampanel; ethosuximide; zonisamide; cannabidiol; genetic polymorphisms
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-06-19
    Completion
    2023-06-15
    Enrolment
    753

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionValproic acid; carbamazepine; phenobarbital; phenytoin +22 more
    PhaseNot recorded
    Registry statusCompleted

  • Perampanel for Treatment of Adults With Refractory Focal Epilepsy : a Pilot Study.

    NCT02727101 · start 2015-11

    Registered record
    Registry ID
    NCT02727101
    Conditions
    Epilepsy
    Interventions
    perampanel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2015-11
    Completion
    2017-07
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    Interventionperampanel
    PhasePhase 4
    Registry statusTerminated

  • Tiagabine to Enhance Slow Wave Sleep in Patients With Sleep Apnea

    NCT02387710 · start 2015-03

    Registered record
    Registry ID
    NCT02387710
    Conditions
    Sleep Apnea, Obstructive
    Interventions
    Tiagabine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-03
    Completion
    2016-07
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSleep Apnea, Obstructive
    InterventionTiagabine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Characterization of [11C]Flumazenil to Image GABA Transmission in Healthy Adult Subjects and Subjects With Alcohol Dependence

    NCT01904487 · start 2011-04-19

    Registered record
    Registry ID
    NCT01904487
    Conditions
    Alcoholism
    Interventions
    [11C]flumazenil; Tiagabine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-04-19
    Completion
    2013-10-01
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAlcoholism
    Intervention[11C]flumazenil; Tiagabine
    PhasePhase 1
    Registry statusCompleted

  • Clinical and Economic Burden of Uncontrolled Epilepsy: Analyses From a Medicaid Database and a Private Health Plan Database

    NCT01390909 · start 2010-05

    Registered record
    Registry ID
    NCT01390909
    Conditions
    Epilepsy
    Interventions
    Anti-epileptic drug (AED)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-05
    Completion
    2011-01
    Enrolment
    12,386

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy
    InterventionAnti-epileptic drug (AED)
    PhaseNot recorded
    Registry statusCompleted

  • Ketogenic Diet vs.Antiepileptic Drug Treatment in Drug Resistant Epilepsy

    NCT00552526 · start 2007-11

    Registered record
    Registry ID
    NCT00552526
    Conditions
    Epilepsy; Mental Retardation
    Interventions
    Ketogenic diet; Antiepileptic drug (AED)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2007-11
    Completion
    2013-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEpilepsy; Mental Retardation
    InterventionKetogenic diet; Antiepileptic drug (AED)
    PhasePhase 4
    Registry statusUnknown

  • A Prospective, Observational Study On The Effectiveness Of New Antiepileptic Drugs As First Bitherapy In The Daily Clinical Practice

    NCT00855738 · start 2007-05

    Registered record
    Registry ID
    NCT00855738
    Conditions
    Focal Epilepsy
    Interventions
    Gabapentin, Lamotrigine, Levetiracetam, Pregabalin, Oxcarbacepine, Tiagabine, Topiramate, Zonisamide
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-05
    Completion
    2009-06
    Enrolment
    111

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFocal Epilepsy
    InterventionGabapentin, Lamotrigine, Levetiracetam, Pregabalin, Oxcarbacepine, Tiagabine, Topiramate, Zonisamide
    PhasePhase 4
    Registry statusCompleted

  • Tetra-O-Methyl Nordihydroguaiaretic Acid in Treating Patients With Recurrent High-Grade Glioma

    NCT00404248 · start 2007-01

    Registered record
    Registry ID
    NCT00404248
    Conditions
    Brain and Central Nervous System Tumors
    Interventions
    terameprocol; pharmacological study
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2007-01
    Completion
    2012-02
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBrain and Central Nervous System Tumors
    Interventionterameprocol; pharmacological study
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Study to Evaluate the Safety and Efficacy of GABITRIL Treatment in Adults With Generalized Anxiety Disorder.

    NCT00214994 · start 2005-01

    Registered record
    Registry ID
    NCT00214994
    Conditions
    Anxiety Disorders
    Interventions
    Gabitril
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-01
    Completion
    2006-12
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety Disorders
    InterventionGabitril
    PhasePhase 3
    Registry statusCompleted

  • Effectiveness of Tiagabine for Cocaine Dependence in Methadone-Maintained Individuals - 1

    NCT00129298 · start 2004-12

    Registered record
    Registry ID
    NCT00129298
    Conditions
    Cocaine-Related Disorders; Opiate Dependence
    Interventions
    Tiagabine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-12
    Completion
    2007-04
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCocaine-Related Disorders; Opiate Dependence
    InterventionTiagabine
    PhasePhase 2
    Registry statusCompleted

  • A 10-Week Efficacy and Safety Study of Gabitril in the Treatment of Adults With Generalized Anxiety Disorder

    NCT00236015 · start 2004-11

    Registered record
    Registry ID
    NCT00236015
    Conditions
    Anxiety Disorder
    Interventions
    Gabitril
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-11
    Completion
    2006-03
    Enrolment
    880

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety Disorder
    InterventionGabitril
    PhasePhase 3
    Registry statusCompleted

  • A 10-Week Efficacy and Safety Study for of Gabitril in the Treatment of Adults With Generalized Anxiety Disorder

    NCT00236054 · start 2004-10

    Registered record
    Registry ID
    NCT00236054
    Conditions
    Generalized Anxiety Disorder
    Interventions
    Gabitril
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-10
    Completion
    2005-12
    Enrolment
    440

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneralized Anxiety Disorder
    InterventionGabitril
    PhasePhase 3
    Registry statusCompleted

  • A 10-Week Study for Efficacy and Safety Study of Gabitril in the Treatment of Adults With Generalized Anxiety Disorder

    NCT00236067 · start 2004-10

    Registered record
    Registry ID
    NCT00236067
    Conditions
    Generalized Anxiety Disorder
    Interventions
    Gabitril
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-10
    Completion
    2006-03
    Enrolment
    440

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGeneralized Anxiety Disorder
    InterventionGabitril
    PhasePhase 3
    Registry statusCompleted

  • Switching From an SSRI to Tiagabine(GABITRIL) in Order to Alleviate SSRI Induced Sexual Dysfunction

    NCT00174850 · start 2004-07

    Registered record
    Registry ID
    NCT00174850
    Conditions
    Anxiety; Sexual Dysfunction
    Interventions
    Gaitril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-07
    Completion
    2005-05
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnxiety; Sexual Dysfunction
    InterventionGaitril
    PhasePhase 4
    Registry statusCompleted

  • Treating Schizophrenia by Correcting Abnormal Brain Development

    NCT00179465 · start 2003-11

    Registered record
    Registry ID
    NCT00179465
    Conditions
    Schizophrenia
    Interventions
    Tiagabine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Active not recruiting
    Start
    2003-11
    Completion
    2026-09
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionTiagabine; Placebo
    PhasePhase 3
    Registry statusActive not recruiting