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AMR Drug RepurposingSmart Screeningresearch prototype

Lovastatin

FDA-approved product (tablet, oral), marketed as Altoprev, Lovastatin, Mevacor.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Lovastatin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Atherosclerosis
  • Cardiovascular disease
  • Coronary artery disease
  • Coronary atherosclerosis
  • Hypercholesterolemia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Hmg coa reductase inhibitors
FDA pharmacologic class
HMG-CoA Reductase Inhibitor FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA56.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli34.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae27.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis38.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lovastatin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.4 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lovastatin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effect of Succinylcholine on Patients Using Statins

    NCT00986583 · start 2009-09

    Registered record
    Registry ID
    NCT00986583
    Conditions
    Pain
    Interventions
    Succinylcholine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2010-07
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionSuccinylcholine
    PhaseNot applicable
    Registry statusCompleted

  • Role of Anti-Inflammatory Agents in Patients With Schizophrenia

    NCT00929955 · start 2009-06

    Registered record
    Registry ID
    NCT00929955
    Conditions
    Schizophrenia; Schizoaffective Disorder; Psychosis Not Otherwise Specified; Schizophreniform Disorder
    Interventions
    Ondansetron; Simvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-06
    Completion
    2010-09
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder; Psychosis Not Otherwise Specified; Schizophreniform Disorder
    InterventionOndansetron; Simvastatin; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Statins for the Early Treatment of Sepsis

    NCT00528580 · start 2008-02

    Registered record
    Registry ID
    NCT00528580
    Conditions
    Sepsis
    Interventions
    Simvastatin; Identical-appearing placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2008-02
    Completion
    2011-09
    Enrolment
    68

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSepsis
    InterventionSimvastatin; Identical-appearing placebo
    PhasePhase 2
    Registry statusTerminated

  • Effects of Metformin Plus Simvastatin on Polycystic Ovarian Syndrome (PCOS): A Prospective, Randomized, Double-Blind, Placebo-Controlled Study

    NCT01021579 · start 2008-01

    Registered record
    Registry ID
    NCT01021579
    Conditions
    Polycystic Ovary Syndrome
    Interventions
    Metformin plus Placebo; Metfomin plus Simvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-01
    Completion
    2009-11
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPolycystic Ovary Syndrome
    InterventionMetformin plus Placebo; Metfomin plus Simvastatin
    PhasePhase 4
    Registry statusCompleted

  • Coadministration of Ezetimibe and Simvastatin in Patients With Primary Hypercholesterolemia (P05457)

    NCT00653523 · start 2007-12-01

    Registered record
    Registry ID
    NCT00653523
    Conditions
    Hypercholesterolemia
    Interventions
    Ezetimibe; Simvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-12-01
    Completion
    2009-06-01
    Enrolment
    151

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionEzetimibe; Simvastatin
    PhasePhase 3
    Registry statusCompleted

  • A Study to Assess the Cholesterol Lowering Effect of Ezetimibe/Simvastatin Combination Tablet Compared to Another Cholesterol Lowering Drug in Elderly Patients With High Cholesterol at High or Moderately High Risk for Coronary Heart Disease (0653A-128)

    NCT00535405 · start 2007-11

    Registered record
    Registry ID
    NCT00535405
    Conditions
    Hypercholesterolemia
    Interventions
    Atorvastatin 10 mg; Ezetimibe 10 mg/simvastatin 20 mg; Atorvastatin 20 mg; Ezetimibe 10 mg/simvastatin 40 mg; Atorvastatin 40 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-11
    Completion
    2009-03
    Enrolment
    1,289

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    InterventionAtorvastatin 10 mg; Ezetimibe 10 mg/simvastatin 20 mg; Atorvastatin 20 mg; Ezetimibe 10 mg/simvastatin 40 mg +1 more
    PhasePhase 3
    Registry statusCompleted

  • A Multicenter, Randomized, Open Label Study to Evaluate the Lipid Lowering Efficacy and Safety of Vytorin® 10/20 vs. Atorvastatin 10mg in Hypercholesterolemia Patients With Metabolic Syndrome in Korea (0653A-129)(COMPLETED)

    NCT00496730 · start 2007-07

    Registered record
    Registry ID
    NCT00496730
    Conditions
    Hypercholesterolemia
    Interventions
    simvastatin (+) ezetimibe; Comparator: atorvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-07
    Completion
    2008-08
    Enrolment
    256

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    Interventionsimvastatin (+) ezetimibe; Comparator: atorvastatin
    PhasePhase 3
    Registry statusCompleted

  • A Study To Evaluate The Safety And Tolerability Of SB-656933-AAA Following Repeated Doses In Healthy Adult Subjects

    NCT00504439 · start 2007-06-04

    Registered record
    Registry ID
    NCT00504439
    Conditions
    Pulmonary Disease, Chronic Obstructive
    Interventions
    SB-656933-AAA; Matching placebo; Simvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-06-04
    Completion
    2007-09-06
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Disease, Chronic Obstructive
    InterventionSB-656933-AAA; Matching placebo; Simvastatin
    PhasePhase 1
    Registry statusCompleted

  • Effects of Statin and Ezetimibe Association on Kinetics of Artificial Chilomicrons

    NCT00481351 · start 2007-06

    Registered record
    Registry ID
    NCT00481351
    Conditions
    Coronary Heart Disease
    Interventions
    Simvastatin 20mg plus ezetimibe 10mg; ezetimibe; simvastatin 20mg; Simvastatin 80mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-06
    Completion
    2010-01
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronary Heart Disease
    InterventionSimvastatin 20mg plus ezetimibe 10mg; ezetimibe; simvastatin 20mg; Simvastatin 80mg
    PhasePhase 4
    Registry statusCompleted

  • Simvastatin in Aneurysmal Subarachnoid Haemorrhage (STASH) a Multicentre Randomised Controlled Clinical Trial

    NCT00731627 · start 2007-01

    Registered record
    Registry ID
    NCT00731627
    Conditions
    Subarachnoid Haemorrhage
    Interventions
    placebo; simvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-01
    Completion
    2014-02
    Enrolment
    803

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubarachnoid Haemorrhage
    Interventionplacebo; simvastatin
    PhasePhase 3
    Registry statusCompleted

  • An Evaluation of Simvastatin Plus Omacor Compared to Simvastatin Plus Placebo in Subjects With Mixed Dyslipidemia

    NCT00487591 · start 2006-11

    Registered record
    Registry ID
    NCT00487591
    Conditions
    Mixed Dyslipidemia
    Interventions
    Omacor (omega-3-acid ethyl esters)plus simvastatin; simvastatin plus placebo
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2006-11
    Completion
    2007-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMixed Dyslipidemia
    InterventionOmacor (omega-3-acid ethyl esters)plus simvastatin; simvastatin plus placebo
    PhaseNot recorded
    Registry statusCompleted

  • A Study for Pre-diabetic Patients With Cholesterol Lowering Drugs

    NCT00831129 · start 2006-09

    Registered record
    Registry ID
    NCT00831129
    Conditions
    Pre-diabetes
    Interventions
    Rosiglitazone; Placebo Rosiglitazone; Simvastatin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2006-09
    Completion
    2011-04
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPre-diabetes
    InterventionRosiglitazone; Placebo Rosiglitazone; Simvastatin
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Paroxysmal Atrial Fibrillation: Role of Inflammation, Oxidative Stress Injury and Effect of Statins

    NCT00321802 · start 2006-04

    Registered record
    Registry ID
    NCT00321802
    Conditions
    Atrial Fibrillation
    Interventions
    Simvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-04
    Completion
    2012-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAtrial Fibrillation
    InterventionSimvastatin; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Effects of Vytorin Versus Placebo in Subjects With Primary Hypercholesterolemia (Study P04420)

    NCT00413972 · start 2006-04

    Registered record
    Registry ID
    NCT00413972
    Conditions
    Hypercholesterolemia
    Interventions
    ezetimibe with simvastatin; Ezetimibe with Simvastatin; Ezetimibe with Simvastatin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2006-04
    Completion
    2006-11
    Enrolment
    392

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypercholesterolemia
    Interventionezetimibe with simvastatin; Ezetimibe with Simvastatin; Ezetimibe with Simvastatin; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Effects of Statins on Pro- and Antioxidant Status : Link With Statin-Associated Myopathy.

    NCT00285181 · start 2005-11

    Registered record
    Registry ID
    NCT00285181
    Conditions
    Healthy
    Interventions
    Simvastatin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-11
    Completion
    2007-04
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionSimvastatin
    PhaseNot applicable
    Registry statusCompleted