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AMR Drug RepurposingSmart Screeningresearch prototype

Trazodone Hydrochloride

FDA-approved product (tablet, oral), marketed as Desyrel, Oleptro, Raldesy and 2 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Trazodone Hydrochloride
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Depressive disorder
  • Major depressive disorder

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antidepressants
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA42.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli43.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis54.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Trazodone Hydrochloride in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.6 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-7.3 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Trazodone Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of Chinese Medicine Treating Depression

    NCT02873234 · start 2016-06

    Registered record
    Registry ID
    NCT02873234
    Conditions
    Depression
    Interventions
    Traditional Chinese Medicine; Antidepressants
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2016-06
    Completion
    2020-05
    Enrolment
    4,600

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    InterventionTraditional Chinese Medicine; Antidepressants
    PhaseNot recorded
    Registry statusUnknown

  • Role of Enhancing Serotonin Receptors Activity for Sleep Apnea Treatment in Patients With SCI

    NCT02458469 · start 2015-05-14

    Registered record
    Registry ID
    NCT02458469
    Conditions
    Spinal Cord Injury; Sleep Disordered Breathing
    Interventions
    Buspirone; Trazodone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-05-14
    Completion
    2019-04-12
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSpinal Cord Injury; Sleep Disordered Breathing
    InterventionBuspirone; Trazodone; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Pharmacovigilance in Gerontopsychiatric Patients

    NCT02374567 · start 2015-01

    Registered record
    Registry ID
    NCT02374567
    Conditions
    Dementia; Depression; Schizophrenia; Psychosomatic Disorders; Anxiety Disorders
    Interventions
    Phenobarbital; Phenytoin; Carbamazepine; Oxcarbazepine; Valproic Acid; Lamotrigine; Topiramate; Gabapentin; Levetiracetam; Pregabalin; Lacosamide; Clonazepam; Biperiden; Levomepromazine; Fluphenazine; Perphenazine; Perazine; Thioridazine; Haloperidol; Melperone; Pipamperone; Bromperidol; Benperidol; Sertindole; Ziprasidone; Flupentixol; Chlorprothixene; Zuclopenthixol; Fluspirilene; Pimozide; Clozapine; Olanzapine; Quetiapine; Sulpiride; Tiapride; Amisulpride; Prothipendyl; Risperidone; Aripiprazole; Paliperidone; Diazepam; Oxazepam; Lorazepam; Bromazepam; Clobazam; Alprazolam; Hydroxyzine; Buspirone; Chloral Hydrate; Flurazepam; Nitrazepam; Triazolam; Lormetazepam; Temazepam; Midazolam; Brotizolam; Zopiclone; Zolpidem; Zaleplon; Melatonin; Clomethiazole; Diphenhydramine; Promethazine; Imipramine; Clomipramine; Opipramol; Trimipramine; Amitriptyline; Nortriptyline; Doxepin; Maprotiline; Amitriptyline oxide; Fluoxetine; Citalopram; Paroxetine; Sertraline; Fluvoxamine; Escitalopram; Tran
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2015-01
    Completion
    2017-06-28
    Enrolment
    407

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDementia; Depression; Schizophrenia; Psychosomatic Disorders +1 more
    InterventionPhenobarbital; Phenytoin; Carbamazepine; Oxcarbazepine +75 more
    PhasePhase 3
    Registry statusTerminated

  • Interpersonal Psychotherapy for Treatment Resistant Depression

    NCT01896349 · start 2013-04

    Registered record
    Registry ID
    NCT01896349
    Conditions
    Treatment Resistant Depression
    Interventions
    IPT+ antidepressant drugs; fluoxetine; sertraline; paroxetine; Citalopram; escitalopram; fluvoxamine; Venlafaxine; Duloxetine; Bupropion; Lithium; Risperidone; tranylcypromine; Imipramine; amitriptyline; Clomipramine; nortriptyline; trazodone; Mirtazapine; sulpiride
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2013-04
    Completion
    2014-11
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTreatment Resistant Depression
    InterventionIPT+ antidepressant drugs; fluoxetine; sertraline; paroxetine +16 more
    PhaseNot applicable
    Registry statusUnknown

  • The Effects of Trazodone on Sleep Apnea Severity

    NCT01817907 · start 2013-03

    Registered record
    Registry ID
    NCT01817907
    Conditions
    Sleep Apnea, Obstructive
    Interventions
    Placebo pill; Trazodone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-03
    Completion
    2014-12
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSleep Apnea, Obstructive
    InterventionPlacebo pill; Trazodone
    PhaseNot applicable
    Registry statusCompleted

  • Trazodone Once a Day in Major Depression Disorder

    NCT02086929 · start 2012-12

    Registered record
    Registry ID
    NCT02086929
    Conditions
    Major Depressive Disorder
    Interventions
    Trazodone; Venlafaxine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-12
    Completion
    2014-04
    Enrolment
    364

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionTrazodone; Venlafaxine
    PhasePhase 3
    Registry statusCompleted

  • Sequenced Therapies for Comorbid and Primary Insomnias

    NCT01651442 · start 2012-08-01

    Registered record
    Registry ID
    NCT01651442
    Conditions
    Insomnia Comorbid to Psychiatric Disorder; Primary Insomnia
    Interventions
    Behavioral Insomnia Therapy; Zolpidem; Trazodone; Cognitive Therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-08-01
    Completion
    2017-03-01
    Enrolment
    211

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia Comorbid to Psychiatric Disorder; Primary Insomnia
    InterventionBehavioral Insomnia Therapy; Zolpidem; Trazodone; Cognitive Therapy
    PhaseNot applicable
    Registry statusCompleted

  • Comparison of Quetiapine and Trazodone Treatment for Insomnia in Dually Diagnosed Veterans

    NCT01662297 · start 2012-07

    Registered record
    Registry ID
    NCT01662297
    Conditions
    Insomnia; Mental Health Disorder; Substance Use Disorder
    Interventions
    Quetiapine; Trazodone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-07
    Completion
    2015-10
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia; Mental Health Disorder; Substance Use Disorder
    InterventionQuetiapine; Trazodone
    PhasePhase 4
    Registry statusTerminated

  • Orthostatic Hypotension Treatment on Rehab Unit

    NCT01030874 · start 2011-10

    Registered record
    Registry ID
    NCT01030874
    Conditions
    Orthostatic Hypotension; Falls
    Interventions
    Medication review; Nutrition/Salt intake; Education; Exercise; Drug Recommendations
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-10
    Completion
    2016-05
    Enrolment
    356

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOrthostatic Hypotension; Falls
    InterventionMedication review; Nutrition/Salt intake; Education; Exercise +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Study of Trazodone & Cognitive Behavioral Therapy to Treat Insomnia

    NCT01348542 · start 2011-04

    Registered record
    Registry ID
    NCT01348542
    Conditions
    Insomnia
    Interventions
    Trazodone; Cognitive Behavioral Therapy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-04
    Completion
    2018-06-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInsomnia
    InterventionTrazodone; Cognitive Behavioral Therapy
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Safety of Risperidone and Trazodone Monotherapy and Combination Therapy in Critically Ill Patients With Delirium

    NCT02118688 · start 2011-03

    Registered record
    Registry ID
    NCT02118688
    Conditions
    Delirium; Agitation
    Interventions
    Risperidone; Trazodone; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2011-03
    Completion
    2016-03
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDelirium; Agitation
    InterventionRisperidone; Trazodone; Placebo
    PhasePhase 4
    Registry statusWithdrawn

  • Piloting Acute Care to Primary Care Linkage of Safety Net Patients

    NCT01347541 · start 2011-01

    Registered record
    Registry ID
    NCT01347541
    Conditions
    Posttraumatic Stress Disorder
    Interventions
    Cognitive Behavioral Therapy; Motivational Interviewing; FDA-Approved Anti-Anxiety Medications; Standard Care Control
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2011-01
    Completion
    2011-11
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPosttraumatic Stress Disorder
    InterventionCognitive Behavioral Therapy; Motivational Interviewing; FDA-Approved Anti-Anxiety Medications; Standard Care Control
    PhasePhase 1
    Registry statusTerminated

  • Trazodone and Its Augmentation With Pregabalin in the Treatment of Fibromyalgia

    NCT00791739 · start 2008-04

    Registered record
    Registry ID
    NCT00791739
    Conditions
    Fibromyalgia
    Interventions
    trazodone, pregabalin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-04
    Completion
    2009-10
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFibromyalgia
    Interventiontrazodone, pregabalin
    PhasePhase 4
    Registry statusCompleted

  • Effects of Discontinuation of Benzodiazepine-derivative Hypnotics on Cognitive and Motor Functions in Elderly Persons

    NCT00707915 · start 2008-01

    Registered record
    Registry ID
    NCT00707915
    Conditions
    Adverse Effects
    Interventions
    Drug: Benzodiazepine (listed out below)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-01
    Completion
    2010-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdverse Effects
    InterventionDrug: Benzodiazepine (listed out below)
    PhasePhase 4
    Registry statusCompleted

  • A Study to Compare the Bioavailability of 300 mg Trazodone Hydrochloride Extended-release Caplets and 100 mg Trazodone Hydrochloride Immediate-release Tablets at Steady State

    NCT01121926 · start 2008-01

    Registered record
    Registry ID
    NCT01121926
    Conditions
    Healthy Subjects; Bioavailability; Pharmacokinetics
    Interventions
    Trazodone HCl; Trazodone HCl
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2008-01
    Completion
    2008-03
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Subjects; Bioavailability; Pharmacokinetics
    InterventionTrazodone HCl; Trazodone HCl
    PhasePhase 1
    Registry statusCompleted