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AMR Drug RepurposingSmart Screeningresearch prototype

Micafungin Sodium

FDA-approved product (injectable, intravenous), marketed as Micafungin, Micafungin In Sodium Chloride 0.9%, Micafungin Sodium and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Micafungin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Candidiasis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antimycotics for systemic use
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J02AX05

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA66.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli52.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae52.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Micafungin Sodium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Micafungin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Use of Micafungin (Mycamine®) as Antifungal Prophylaxis in Haematology and Onco-haematology

    NCT02127788 · start 2014-07-03

    Registered record
    Registry ID
    NCT02127788
    Conditions
    Antifungal Prophylaxis; Haemopathy
    Interventions
    Micafungin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-07-03
    Completion
    2016-01-27
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntifungal Prophylaxis; Haemopathy
    InterventionMicafungin
    PhaseNot recorded
    Registry statusCompleted

  • Pharmacokinetics of Micafungin in Patients of Intensive Care Units

    NCT02164890 · start 2014-06

    Registered record
    Registry ID
    NCT02164890
    Conditions
    Invasive Candidiasis
    Interventions
    micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2014-06
    Completion
    2016-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Candidiasis
    Interventionmicafungin
    PhasePhase 4
    Registry statusCompleted

  • A Pharmacokinetic Study of Pediatric Micafungin Prophylaxis

    NCT02057289 · start 2014-01

    Registered record
    Registry ID
    NCT02057289
    Conditions
    Immunocompromised; Bone Marrow Transplant; Cancer
    Interventions
    Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2014-01
    Completion
    2014-11
    Enrolment
    9

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionImmunocompromised; Bone Marrow Transplant; Cancer
    InterventionMicafungin
    PhasePhase 1
    Registry statusTerminated

  • A Study to Evaluate the Efficacy and Safety of Micafungin Against Invasive Candidiasis or Candidemia

    NCT01982071 · start 2013-09-26

    Registered record
    Registry ID
    NCT01982071
    Conditions
    Candidemia; Candidiasis
    Interventions
    Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2013-09-26
    Completion
    2015-08-28
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandidemia; Candidiasis
    InterventionMicafungin
    PhasePhase 4
    Registry statusTerminated

  • Antifungal Prophylaxis With Micafungin After Cord Blood Allogeneic Stem Cell Transplantation (MycaCOORD)

    NCT01888458 · start 2013-09

    Registered record
    Registry ID
    NCT01888458
    Conditions
    Invasive Fungal Infection
    Interventions
    Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-09
    Completion
    2016-04
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Fungal Infection
    InterventionMicafungin
    PhasePhase 2
    Registry statusCompleted

  • A Phase II Study on Allogeneic Stem Cell Transplantation in Patients With Active Acute Leukemia

    NCT01814488 · start 2013-07

    Registered record
    Registry ID
    NCT01814488
    Conditions
    Acute Leukemia
    Interventions
    allogeneic transplant
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-07
    Completion
    2017-06-30
    Enrolment
    101

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Leukemia
    Interventionallogeneic transplant
    PhasePhase 2
    Registry statusCompleted

  • Pharmacokinetics of Micafungin in Children on Extracorporeal Membrane Oxygenation

    NCT01666769 · start 2013-01

    Registered record
    Registry ID
    NCT01666769
    Conditions
    Invasive Candidiasis
    Interventions
    Micafungin; Micafungin; Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-01
    Completion
    2016-02-09
    Enrolment
    18

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Candidiasis
    InterventionMicafungin; Micafungin; Micafungin
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetics of Micafungin in Patients Intensive Care Unit

    NCT01783379 · start 2013-01

    Registered record
    Registry ID
    NCT01783379
    Conditions
    Invasive Fungal Infection
    Interventions
    micafungin
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2013-01
    Completion
    2014-03
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Fungal Infection
    Interventionmicafungin
    PhaseNot recorded
    Registry statusCompleted

  • Short and Long-term Safety of Micafungin and Other Parenteral Antifungal Agents

    NCT01686607 · start 2012-10-01

    Registered record
    Registry ID
    NCT01686607
    Conditions
    Systemic Fungal Infections
    Interventions
    Parenteral micafungin application; Other parenteral antifungal drugs
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-10-01
    Completion
    2018-04-30
    Enrolment
    40,110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSystemic Fungal Infections
    InterventionParenteral micafungin application; Other parenteral antifungal drugs
    PhaseNot recorded
    Registry statusCompleted

  • Pharmacokinetics of Micafungin in Critically Ill Patients

    NCT01716988 · start 2012-10

    Registered record
    Registry ID
    NCT01716988
    Conditions
    Critical Illness; Invasive Candidiasis
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-10
    Completion
    2017-01
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCritical Illness; Invasive Candidiasis
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Micafungin Versus Fluconazole for Prevention of Invasive Fungal Disease in Living Donor Liver Transplant Recipients

    NCT01974375 · start 2012-08

    Registered record
    Registry ID
    NCT01974375
    Conditions
    Liver Transplant Recipient
    Interventions
    micafungin; Fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2012-08
    Completion
    2014-12
    Enrolment
    172

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Transplant Recipient
    Interventionmicafungin; Fluconazole
    PhasePhase 3
    Registry statusUnknown

  • Pharmacokinetics of Micafungin During Continuous Venovenous Hemofiltration

    NCT02651038 · start 2012-05

    Registered record
    Registry ID
    NCT02651038
    Conditions
    Candida Sepsis
    Interventions
    Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-05
    Completion
    2016-01
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandida Sepsis
    InterventionMicafungin
    PhasePhase 4
    Registry statusCompleted

  • Micafungin Prevention Study for Invasive Fungal Disease in Pediatric & Adolescent Patients Undergoing Autologous Hematopoietic Stem Cell Transplantation

    NCT01417169 · start 2011-08

    Registered record
    Registry ID
    NCT01417169
    Conditions
    Neutropenia; Fungal Disease
    Interventions
    micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2011-08
    Completion
    2014-12
    Enrolment
    112

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeutropenia; Fungal Disease
    Interventionmicafungin
    PhasePhase 2
    Registry statusUnknown

  • Micafungin Versus Intravenous Itraconazole as Empirical Antifungal Therapy for Febrile Neutropenic Patients With Hematological Diseases

    NCT01344681 · start 2011-06

    Registered record
    Registry ID
    NCT01344681
    Conditions
    Febrile Neutropenia; Hematological Diseases
    Interventions
    Micafungin sodium; Itraconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2011-06
    Completion
    2014-03
    Enrolment
    153

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFebrile Neutropenia; Hematological Diseases
    InterventionMicafungin sodium; Itraconazole
    PhasePhase 2
    Registry statusCompleted

  • A Study to Evaluate Pre-emptive Treatment for Invasive Candidiasis in High Risk Surgical Subjects

    NCT01122368 · start 2010-07-13

    Registered record
    Registry ID
    NCT01122368
    Conditions
    Mycoses
    Interventions
    micafungin; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-07-13
    Completion
    2011-12-15
    Enrolment
    252

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMycoses
    Interventionmicafungin; placebo
    PhasePhase 2
    Registry statusCompleted