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AMR Drug RepurposingSmart Screeningresearch prototype

Micafungin Sodium

FDA-approved product (injectable, intravenous), marketed as Micafungin, Micafungin In Sodium Chloride 0.9%, Micafungin Sodium and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Micafungin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Candidiasis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antimycotics for systemic use
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J02AX05

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli, K. pneumoniae and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA66.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli52.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae52.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Micafungin Sodium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Micafungin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Micafungin Prevention Study for Fungal Disease in Child Receiving Allogenic Hematopoietic Stem Cell Transplantation

    NCT01135589 · start 2010-04

    Registered record
    Registry ID
    NCT01135589
    Conditions
    Neutropenia; Hematopoietic Stem Cell Transplantation; Invasive Fungal Disease
    Interventions
    Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2010-04
    Completion
    2012-05
    Enrolment
    145

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeutropenia; Hematopoietic Stem Cell Transplantation; Invasive Fungal Disease
    InterventionMicafungin
    PhasePhase 4
    Registry statusUnknown

  • Liver Transplant European Study Into the Prevention of Fungal Infection

    NCT01058174 · start 2009-12-15

    Registered record
    Registry ID
    NCT01058174
    Conditions
    Liver Transplantation; Mycoses
    Interventions
    micafungin; fluconazole; liposomal amphotericin B; caspofungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-12-15
    Completion
    2012-05-03
    Enrolment
    350

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Transplantation; Mycoses
    Interventionmicafungin; fluconazole; liposomal amphotericin B; caspofungin
    PhasePhase 3
    Registry statusCompleted

  • Drug Concentration Analysis of Micafungin in Overweight, Obese, and Extremely Obese Volunteers

    NCT01090141 · start 2009-11

    Registered record
    Registry ID
    NCT01090141
    Conditions
    Obesity; Nutrition Disorders; Overweight
    Interventions
    Micafungin; Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-11
    Completion
    2010-06
    Enrolment
    36

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Nutrition Disorders; Overweight
    InterventionMicafungin; Micafungin
    PhasePhase 4
    Registry statusCompleted

  • Comparison of Candida Eradication and Serum Cidal Activity of Echinocandins

    NCT00839540 · start 2008-12

    Registered record
    Registry ID
    NCT00839540
    Conditions
    Candidemia
    Interventions
    micafungin; Micafungin; Caspofungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-12
    Completion
    2010-05
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandidemia
    Interventionmicafungin; Micafungin; Caspofungin
    PhasePhase 4
    Registry statusCompleted

  • A Study to Compare Efficacy and Safety of Mycamine® and Itraconazole for Preventing Fungal Infections

    NCT00794703 · start 2008-11

    Registered record
    Registry ID
    NCT00794703
    Conditions
    Fungemia; Fungal Infections
    Interventions
    micafungin (Mycamine); itraconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-11
    Completion
    2009-11
    Enrolment
    288

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFungemia; Fungal Infections
    Interventionmicafungin (Mycamine); itraconazole
    PhasePhase 3
    Registry statusCompleted

  • A Clinical Study of MK0991 (Caspofungin) in Japanese Patients With Deep-seated Candida or Aspergillus Infections (0991-062)(COMPLETED)

    NCT00717860 · start 2008-08

    Registered record
    Registry ID
    NCT00717860
    Conditions
    Fungal Infection
    Interventions
    caspofungin acetate; Comparator: Micafungin sodium
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-08
    Completion
    2010-07
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFungal Infection
    Interventioncaspofungin acetate; Comparator: Micafungin sodium
    PhasePhase 3
    Registry statusCompleted

  • A Study of Safety and Pharmacokinetics of Repeated Dose of Micafungin as Antifungal Prophylaxis in Children and Adolescents Who Undergo Hematopoietic Stem Cell Transplant

    NCT00606268 · start 2007-11

    Registered record
    Registry ID
    NCT00606268
    Conditions
    Fungal Infections
    Interventions
    Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-11
    Completion
    2009-03
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFungal Infections
    InterventionMicafungin
    PhasePhase 1
    Registry statusCompleted

  • Study of Mycamine® in Children With Fungal Infections to Evaluate Safety and Blood Levels of the Drug

    NCT00608335 · start 2007-10-14

    Registered record
    Registry ID
    NCT00608335
    Conditions
    Oropharyngeal Candidiasis; Candidemia; Invasive Candidiasis; Esophageal Candidiasis
    Interventions
    Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-10-14
    Completion
    2011-09-08
    Enrolment
    84

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOropharyngeal Candidiasis; Candidemia; Invasive Candidiasis; Esophageal Candidiasis
    InterventionMicafungin
    PhasePhase 1
    Registry statusCompleted

  • An Open-Label Study of the Safety and Pharmacokinetics of Repeated-Dose Micafungin in Neonates

    NCT00818584 · start 2007-08

    Registered record
    Registry ID
    NCT00818584
    Conditions
    Candida
    Interventions
    Micafungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-08
    Completion
    2007-10
    Enrolment
    13

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandida
    InterventionMicafungin
    PhasePhase 1
    Registry statusCompleted

  • Micafungin Salvage Mono-therapy in Invasive Aspergillosis

    NCT00376337 · start 2006-06

    Registered record
    Registry ID
    NCT00376337
    Conditions
    Invasive Aspergillosis
    Interventions
    Micafungin; Systemic antifungal therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2006-06
    Completion
    2008-09
    Enrolment
    17

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Aspergillosis
    InterventionMicafungin; Systemic antifungal therapy
    PhasePhase 2
    Registry statusTerminated

  • Study of Micafungin in Patients With Invasive Candidiasis or Candidemia

    NCT00105144 · start 2004-09

    Registered record
    Registry ID
    NCT00105144
    Conditions
    Candidiasis; Candidemia
    Interventions
    Micafungin; Caspofungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-09
    Completion
    2006-04
    Enrolment
    611

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandidiasis; Candidemia
    InterventionMicafungin; Caspofungin
    PhasePhase 3
    Registry statusCompleted

  • Micafungin Versus Fluconazole in the Treatment of Invasive Candidiasis and Candidemia

    NCT00189709 · start 2004-08

    Registered record
    Registry ID
    NCT00189709
    Conditions
    Invasive Candidiasis; Candidemia
    Interventions
    Micafungin; fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-08
    Completion
    2006-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Candidiasis; Candidemia
    InterventionMicafungin; fluconazole
    PhasePhase 3
    Registry statusCompleted

  • Trial of Two Dosing Regimens of Micafungin Versus Caspofungin for the Treatment of Esophageal Candidiasis

    NCT00665639 · start 2004-06

    Registered record
    Registry ID
    NCT00665639
    Conditions
    Candidiasis, Oral
    Interventions
    micafungin; caspofungin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-06
    Completion
    2004-12
    Enrolment
    454

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandidiasis, Oral
    Interventionmicafungin; caspofungin
    PhasePhase 3
    Registry statusCompleted

  • Comparative Trial of Micafungin Versus Fluconazole for Treating Esophageal Candidiasis

    NCT00666185 · start 2003-08

    Registered record
    Registry ID
    NCT00666185
    Conditions
    Candidiasis, Oral
    Interventions
    Micafungin; Fluconazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-08
    Completion
    2004-02
    Enrolment
    523

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCandidiasis, Oral
    InterventionMicafungin; Fluconazole
    PhasePhase 3
    Registry statusCompleted

  • Comparative Study of Micafungin (FK463) Versus Placebo as Prophylactic Antifungal Therapy in the ICU

    NCT00048750 · start 2003-01

    Registered record
    Registry ID
    NCT00048750
    Conditions
    Invasive Fungal Infections
    Interventions
    Micafungin; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2003-01
    Completion
    2003-06
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvasive Fungal Infections
    InterventionMicafungin; Placebo
    PhasePhase 3
    Registry statusTerminated