Furazolidone
FDA-approved product (tablet, oral), marketed as Furoxone.
- Registered studies
- 49
- Lab records
- 2
- Pathogens at ≥40%
- 1 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLNo approved indication recorded
ChEMBL records no approved indication for Furazolidone. Its therapeutic class is shown instead.
- WHO therapeutic group
- Other antiinfectives and antiseptics
- Anti-infective classification
- Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC G01AX06
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.
AI-predicted activity
AI prediction · nothing measured- MRSA23.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- E. coli32.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae16.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis91.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
49registered studies name this medicine, for any condition. See them below.
Experimental
- M. tuberculosis: measured active in 2 of 2 lab records
Show the 2 laboratory records, with sources
Loading records…
“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Furazolidone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
- DichlorphenamideExisting use: Glaucoma73.9% AI-predicted activityagainst M. tuberculosisLab records exist2 registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Quadruple Therapy Versus Dual Therapy as Rescue Regimens for Helicobacter Pylori Infection
NCT01805934 · start 2012-05
Registered record
- Registry ID
- NCT01805934
- Conditions
- Rescue Therapy for Helicobacter Pylori
- Interventions
- RBLF; RA
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2012-05
- Completion
- 2013-02
- Enrolment
- 114
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionRescue Therapy for Helicobacter PyloriInterventionRBLF; RAPhasePhase 2Registry statusCompletedHelicobacter Pylori Treatment in Immune Thrombocytopenic Purpura (ITP) Patients
NCT01730352 · start 2008-10
Registered record
- Registry ID
- NCT01730352
- Conditions
- Immune Thrombocytopenic Purpura; Helicobacter Pylori Infection
- Interventions
- H. pylori triple therapy
- Study type
- INTERVENTIONAL
- Phase
- Phase 2 / Phase 3
- Registry status
- Completed
- Start
- 2008-10
- Completion
- 2012-03
- Enrolment
- 100
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionImmune Thrombocytopenic Purpura; Helicobacter Pylori InfectionInterventionH. pylori triple therapyPhasePhase 2 / Phase 3Registry statusCompletedQuadruple Therapy for Triple Therapy Resistant Helicobacter Pylori Infection
NCT00520949 · start 2006-10
Registered record
- Registry ID
- NCT00520949
- Conditions
- Treatment of Helicobacter Pylori
- Interventions
- Augmentin (Amoxicillin-clavulanic); Furoxone (furazolidone); Cebes (colloidal bismuth subcitrate); Esso (esomeprazole)
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2006-10
- Completion
- 2008-06
- Enrolment
- 176
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionTreatment of Helicobacter PyloriInterventionAugmentin (Amoxicillin-clavulanic); Furoxone (furazolidone); Cebes (colloidal bismuth subcitrate); Esso (esomeprazole)PhaseNot applicableRegistry statusCompletedHome Based Child Care to Reduce Mortality and Malnutrition in Tribal Children of Melghat, India: CRCT
NCT02473796 · start 2004-01
Registered record
- Registry ID
- NCT02473796
- Conditions
- Acute Respiratory Tract Infections; Diarrhea; Malaria; Neonatal Sepsis; Birth Asphyxia
- Interventions
- Home based child care
- Study type
- INTERVENTIONAL
- Phase
- Not applicable
- Registry status
- Completed
- Start
- 2004-01
- Completion
- 2010-04
- Enrolment
- 7,594
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAcute Respiratory Tract Infections; Diarrhea; Malaria; Neonatal Sepsis +1 moreInterventionHome based child carePhaseNot applicableRegistry statusCompleted