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AMR Drug RepurposingSmart Screeningresearch prototype

Silodosin

FDA-approved product (capsule, oral), marketed as Rapaflo, Silodosin.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Silodosin
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Benign prostatic hyperplasia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Alpha-adrenoreceptor antagonists
FDA pharmacologic class
alpha-Adrenergic Blocker FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA44.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli41.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae29.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis56.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Silodosin in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Silodosin with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Comparison of Silodosin and Tamsulosin for Medical Expulsive Therapy in Patients With Ureteral Stones

    NCT06999135 · start 2023-10-01

    Registered record
    Registry ID
    NCT06999135
    Conditions
    Tamsulosin; Silodosin; Medical Expulsive Therapy
    Interventions
    Silodosin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2023-10-01
    Completion
    2024-08-15
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTamsulosin; Silodosin; Medical Expulsive Therapy
    InterventionSilodosin
    PhaseNot applicable
    Registry statusCompleted

  • The Additive Value of Pyridostigmine to Silodosin in Acute Urinary Retention

    NCT06319469 · start 2023-02-01

    Registered record
    Registry ID
    NCT06319469
    Conditions
    Prostatic Hyperplasia
    Interventions
    silodosin 8 mg capsule and the pyridostigmine bromide 60 mg tablet; silodosin 8 mg capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2023-02-01
    Completion
    2024-01-30
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstatic Hyperplasia
    Interventionsilodosin 8 mg capsule and the pyridostigmine bromide 60 mg tablet; silodosin 8 mg capsule
    PhasePhase 2
    Registry statusCompleted

  • Effect of Preoperative Silodosin on Feasibility of Ureteral Access Sheath Insertion

    NCT05833386 · start 2022-10-01

    Registered record
    Registry ID
    NCT05833386
    Conditions
    Renal Stone
    Interventions
    Ureteral access sheath placement during flexible ureteroscope for renal stones
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2022-10-01
    Completion
    2026-08-01
    Enrolment
    2,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Stone
    InterventionUreteral access sheath placement during flexible ureteroscope for renal stones
    PhaseNot applicable
    Registry statusUnknown

  • The Efficacy and Safety of Silodosin in the Treatment of Benign Prostatic Hyperplasia

    NCT05551221 · start 2022-09-21

    Registered record
    Registry ID
    NCT05551221
    Conditions
    Benign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
    Interventions
    Silodosin Capsules; Tamsulosin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-09-21
    Completion
    2024-09-10
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia With Lower Urinary Tract Symptoms
    InterventionSilodosin Capsules; Tamsulosin
    PhasePhase 4
    Registry statusCompleted

  • The Efficacy and Safety of Qianweitai (Silodosin Capsule) Versus Tamsulosin in the Treatment of BPH

    NCT07134907 · start 2022-07-18

    Registered record
    Registry ID
    NCT07134907
    Conditions
    BPH (Benign Prostatic Hyperplasia)
    Interventions
    Silodosin; Tamsolusin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2022-07-18
    Completion
    2024-07-09
    Enrolment
    110

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBPH (Benign Prostatic Hyperplasia)
    InterventionSilodosin; Tamsolusin
    PhasePhase 4
    Registry statusCompleted

  • Silodosin, Tadalafil Alone vs. Silodosin Plus Tadalafil as MET for Lower Ureteric Stones

    NCT05789732 · start 2022-03-30

    Registered record
    Registry ID
    NCT05789732
    Conditions
    Lower Ureteric Stones; Medical Expulsive Therapy; Tadalafil; Silodosin
    Interventions
    Placebo; Silodosin; Tadalafil; Silodosin and Tadalafil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-03-30
    Completion
    2022-08-30
    Enrolment
    168

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLower Ureteric Stones; Medical Expulsive Therapy; Tadalafil; Silodosin
    InterventionPlacebo; Silodosin; Tadalafil; Silodosin and Tadalafil
    PhaseNot applicable
    Registry statusCompleted

  • Double J Stenting and Sildosin After URSL for Lower Ureteric Stones

    NCT05823662 · start 2022-03-02

    Registered record
    Registry ID
    NCT05823662
    Conditions
    Lower Ureteric Stones; Ureteroscopic Lithotripsy; DJ Stenting
    Interventions
    DJ stent; Silodosin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-03-02
    Completion
    2023-03-02
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLower Ureteric Stones; Ureteroscopic Lithotripsy; DJ Stenting
    InterventionDJ stent; Silodosin
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Safety of Silodosin in the Treatment of Lower Urinary Tract Symptoms in Taiwanese Population.

    NCT06332235 · start 2022-02-18

    Registered record
    Registry ID
    NCT06332235
    Conditions
    Human Trichinellosis
    Interventions
    Silodosin 8 mg
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2022-02-18
    Completion
    2024-12-31
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHuman Trichinellosis
    InterventionSilodosin 8 mg
    PhaseNot recorded
    Registry statusUnknown

  • Intermittent Catheterization Versus Trial Without Catheter

    NCT05094947 · start 2021-08-03

    Registered record
    Registry ID
    NCT05094947
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    intermittent catheterization; trial without catheter; alpha-blockers
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2021-08-03
    Completion
    2022-05
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    Interventionintermittent catheterization; trial without catheter; alpha-blockers
    PhaseNot applicable
    Registry statusUnknown

  • Effect of Preoperative Alpha-blockers on Successful Insertion Ureteral Access Sheath and Reduce Ureteral Injury in Non-prestented Patients During RIRS. Assessment of Factors for Successful Ureteral Access Sheath Insertion.

    NCT07202923 · start 2021-07-09

    Registered record
    Registry ID
    NCT07202923
    Conditions
    Urolithiasis; Ureteral Injury; Ureteral Access Sheath; Retrograde Intrarenal Surgery
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2021-07-09
    Completion
    2024-06-02
    Enrolment
    140

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrolithiasis; Ureteral Injury; Ureteral Access Sheath; Retrograde Intrarenal Surgery
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of Silodosin and Pelvic Floor Muscle Training in Men With Benign Prostatic Hyperplasia and Overactive Bladder

    NCT04681625 · start 2021-01-11

    Registered record
    Registry ID
    NCT04681625
    Conditions
    Benign Prostatic Hyperplasia (BPH); Overactive Bladder
    Interventions
    Pelvic floor muscle training (PFMT) with suppressive urgency technique
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-01-11
    Completion
    2022-09-30
    Enrolment
    172

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia (BPH); Overactive Bladder
    InterventionPelvic floor muscle training (PFMT) with suppressive urgency technique
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Silodosin in the Treatment of Symptomatic Benign Prostatic Hyperplasia (BPH)

    NCT04107896 · start 2017-08-31

    Registered record
    Registry ID
    NCT04107896
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    Silodosin; Tamsulosin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-08-31
    Completion
    2018-08-31
    Enrolment
    141

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionSilodosin; Tamsulosin
    PhasePhase 4
    Registry statusCompleted

  • Comparative Study of Use of Alpha-Blockers to Treat Symptoms in Prostate Cancer Patients Undergoing Radiation Therapy

    NCT02220829 · start 2016-06

    Registered record
    Registry ID
    NCT02220829
    Conditions
    Urinary Problems; Prostate Cancer
    Interventions
    Preventive administration of Rapaflo; Standard Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-06
    Completion
    2023-08
    Enrolment
    148

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Problems; Prostate Cancer
    InterventionPreventive administration of Rapaflo; Standard Care
    PhasePhase 3
    Registry statusCompleted

  • A Study of Tadalafil (LY450190) in Participants With Lower Urinary Tract Symptoms (LUTS) Suggestive of Benign Prostatic Hyperplasia LUTS (BPH-LUTS).

    NCT02431754 · start 2015-04

    Registered record
    Registry ID
    NCT02431754
    Conditions
    Benign Prostatic Hyperplasia
    Interventions
    Tadalafil; Placebo; Alpha1 Blocker
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-04
    Completion
    2016-02
    Enrolment
    171

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBenign Prostatic Hyperplasia
    InterventionTadalafil; Placebo; Alpha1 Blocker
    PhasePhase 4
    Registry statusCompleted

  • Effectiveness of Silodosin in Medical Expulsive Therapy for Ureteral Pelvic Stone From 4 to 10 mm.

    NCT02090439 · start 2014-07

    Registered record
    Registry ID
    NCT02090439
    Conditions
    Kidney Stone; Expulsive Medical Therapy
    Interventions
    Silodosin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2014-07
    Completion
    2015-12
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Stone; Expulsive Medical Therapy
    InterventionSilodosin
    PhasePhase 3
    Registry statusTerminated