Lurasidone Hydrochloride
FDA-approved product (tablet, oral), marketed as Latuda, Lurasidone Hydrochloride.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Bipolar disorder
- Bipolar I disorder
- Schizophrenia
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Indole derivatives
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA56.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli42.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae37.1% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis49.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Lurasidone Hydrochloride with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- FurazolidoneExisting use: Other antiinfectives and antiseptics91.4% AI-predicted activityagainst M. tuberculosisLab records exist49 registered studies
- TriflupromazineExisting use: Psychosis90.6% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- ValdecoxibExisting use: Dysmenorrhea, Osteoarthritis, Rheumatic disease and 1 more88.6% AI-predicted activityagainst M. tuberculosisLab records exist31 registered studies
- CelecoxibExisting use: Ankylosing spondylitis, Cancer, Colorectal neoplasm and 15 more87.6% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Dorzolamide HydrochlorideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma86.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- MethazolamideExisting use: Glaucoma, Open-angle glaucoma85.6% AI-predicted activityagainst M. tuberculosisLab records exist11 registered studies
- AcetazolamideExisting use: Altitude sickness, Angle-closure glaucoma, Congestive heart failure and 5 more85.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- Trifluoperazine HydrochlorideExisting use: Anxiety disorder, Mental or behavioural disorder, Psychosis and 1 more84.6% AI-predicted activityagainst M. tuberculosis1 registered study
- TriclosanExisting use: Phenol and derivatives, Medicated dressings with antiinfectives84.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- NitrofurazoneExisting use: Eye infection, Leishmaniasis, Trypanosomiasis84.0% AI-predicted activityagainst M. tuberculosis8 registered studies
- BrinzolamideExisting use: Glaucoma, Ocular hypertension, Open-angle glaucoma83.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- ZonisamideExisting use: Epilepsy, Focal-onset seizure, Partial epilepsy and 1 more82.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
A Randomized, Placebo-Controlled, Two-Period, Crossover Study to Evaluate the Effect of Lurasidone HCl on Oral Contraceptive Pharmacokinetics in Healthy Female Subjects
NCT00549666 · start 2007-08
Registered record
- Registry ID
- NCT00549666
- Conditions
- Pharmacokinetics
- Interventions
- Lurasidone 40 mg; Placebo 40 mg; Ortho Tri-Cyclen
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2007-08
- Completion
- 2007-12
- Enrolment
- 23
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokineticsInterventionLurasidone 40 mg; Placebo 40 mg; Ortho Tri-CyclenPhasePhase 1Registry statusCompletedA Study to Test the Safety and Tolerability of a New Medication in the Treatment of Schizophrenia
NCT00088621 · start 2004-07
Registered record
- Registry ID
- NCT00088621
- Conditions
- Schizophrenia
- Interventions
- Lurasidone 80mg tablet
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2004-07
- Completion
- 2005-10
- Enrolment
- 61
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionLurasidone 80mg tabletPhasePhase 2Registry statusCompletedA Study to Test the Effectiveness and Safety of a New Medication in the Treatment of Schizophrenia
NCT00088634 · start 2004-05
Registered record
- Registry ID
- NCT00088634
- Conditions
- Schizophrenia
- Interventions
- Lurasidone; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2004-05
- Completion
- 2004-12
- Enrolment
- 180
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionLurasidone; PlaceboPhasePhase 2Registry statusCompletedSafety and Tolerability Study of Drug to Treat Schizophrenia
NCT00044005 · start 2002-09
Registered record
- Registry ID
- NCT00044005
- Conditions
- Schizophrenia
- Interventions
- Lurasidone 20 mg; Lurasidone 40 mg; Lurasidone 80mg
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2002-09
- Completion
- 2003-11
- Enrolment
- 98
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionLurasidone 20 mg; Lurasidone 40 mg; Lurasidone 80mgPhasePhase 2Registry statusCompletedA Comparison of Study Drug With Placebo and Haloperidol in Patients With Schizophrenia
NCT00044044 · start 2002-07
Registered record
- Registry ID
- NCT00044044
- Conditions
- Schizophrenia
- Interventions
- Lurasidone 20 mg; Lurasidone 40mg; Lurasidone 80 mg; Haloperidol 10mg; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 2
- Registry status
- Completed
- Start
- 2002-07
- Completion
- 2003-05
- Enrolment
- 356
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionSchizophreniaInterventionLurasidone 20 mg; Lurasidone 40mg; Lurasidone 80 mg; Haloperidol 10mg +1 morePhasePhase 2Registry statusCompleted