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AMR Drug RepurposingSmart Screeningresearch prototype

Losartan Potassium

FDA-approved product (tablet, oral), marketed as Arbli, Cozaar, Losartan Potassium.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Losartan Potassium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Chronic kidney disease
  • Hypertension
  • Kidney disease
  • Proteinuria
  • Stroke

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Angiotensin ii receptor blockers (arbs), plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA47.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli33.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Losartan Potassium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Losartan Potassium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Evaluation of Losartan and Perindopril in Blacks Type 2 Diabetics Patients

    NCT04222686 · start 2017-12-20

    Registered record
    Registry ID
    NCT04222686
    Conditions
    Type 2 Diabetes Mellitus
    Interventions
    Perindopril Arginine; Losartan Potassium
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-12-20
    Completion
    2018-04-30
    Enrolment
    23

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 2 Diabetes Mellitus
    InterventionPerindopril Arginine; Losartan Potassium
    PhasePhase 4
    Registry statusCompleted

  • Vascular Dysfunction in Hypertensive Postmenopausal Women

    NCT03371823 · start 2017-09-01

    Registered record
    Registry ID
    NCT03371823
    Conditions
    Cardiovascular Diseases; Hypertension
    Interventions
    Normotensive; Hypertensives
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2017-09-01
    Completion
    2019-12-31
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Diseases; Hypertension
    InterventionNormotensive; Hypertensives
    PhasePhase 4
    Registry statusTerminated

  • Effect of Losartan on Airway Mucociliary Dysfunction in Patients With COPD and Chronic Bronchitis

    NCT02416102 · start 2016-03-31

    Registered record
    Registry ID
    NCT02416102
    Conditions
    COPD; Chronic Bronchitis
    Interventions
    Losartan 50 mg; Losartan 100 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2016-03-31
    Completion
    2017-04-03
    Enrolment
    31

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOPD; Chronic Bronchitis
    InterventionLosartan 50 mg; Losartan 100 mg
    PhasePhase 4
    Registry statusTerminated

  • Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With Nephropathy

    NCT03006952 · start 2015-04

    Registered record
    Registry ID
    NCT03006952
    Conditions
    Diabetic Nephropathies
    Interventions
    Pentoxifylline; Losartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-04
    Completion
    2015-09
    Enrolment
    59

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetic Nephropathies
    InterventionPentoxifylline; Losartan
    PhasePhase 4
    Registry statusCompleted

  • The Study to Evaluate Efficacy and Safety of Candesartan vs Losartan in Hypertension With Heart Failure (HONOR)

    NCT01766505 · start 2012-06

    Registered record
    Registry ID
    NCT01766505
    Conditions
    Hypertension
    Interventions
    Candemore tablet; Cozzar tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-06
    Completion
    2014-03
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionCandemore tablet; Cozzar tablet
    PhasePhase 4
    Registry statusTerminated

  • The Effect of Losartan in Bicuspid Aortic Valve Patients

    NCT01390181 · start 2011-09

    Registered record
    Registry ID
    NCT01390181
    Conditions
    Bicuspid Aortic Valve; Thoracic Aortic Aneurysm
    Interventions
    Cozaar
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2011-09
    Completion
    2014-01
    Enrolment
    4

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBicuspid Aortic Valve; Thoracic Aortic Aneurysm
    InterventionCozaar
    PhaseNot applicable
    Registry statusTerminated

  • A Long-term Study of the Safety of MK-0954A in Patients With Essential Hypertension (MK-0954A-351)

    NCT01307033 · start 2011-03-29

    Registered record
    Registry ID
    NCT01307033
    Conditions
    Hypertension
    Interventions
    MK-0954A; MK-954H; Placebo to MK-0954A; Placebo to MK-954H
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-03-29
    Completion
    2012-12-04
    Enrolment
    278

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionMK-0954A; MK-954H; Placebo to MK-0954A; Placebo to MK-954H
    PhasePhase 3
    Registry statusCompleted

  • MK-0954A in Japanese Patients With Essential Hypertension Not Adequately Controlled With Losartan (MK-0954A-352)

    NCT01307046 · start 2011-03-29

    Registered record
    Registry ID
    NCT01307046
    Conditions
    Hypertension
    Interventions
    MK-0954A; Losartan; Placebo to MK-0954A; Placebo to losartan 100 mg; Placebo to losartan 50 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-03-29
    Completion
    2012-02-07
    Enrolment
    336

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionMK-0954A; Losartan; Placebo to MK-0954A; Placebo to losartan 100 mg +1 more
    PhasePhase 3
    Registry statusCompleted

  • Hearing Outcomes Using Fractionated Proton Radiation Therapy for Vestibular Schwannoma

    NCT01199978 · start 2011-03-08

    Registered record
    Registry ID
    NCT01199978
    Conditions
    Vestibular Schwannoma; Acoustic Neuroma
    Interventions
    Fractionated proton radiation; Losartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2011-03-08
    Completion
    2026-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVestibular Schwannoma; Acoustic Neuroma
    InterventionFractionated proton radiation; Losartan
    PhasePhase 2
    Registry statusActive not recruiting

  • Influence of Losartan and Diphenhydramine on Emotional and Cognitive Functions in Healthy Human Subjects

    NCT01321021 · start 2011-03

    Registered record
    Registry ID
    NCT01321021
    Conditions
    Memory, Long-Term; Memory, Short-Term
    Interventions
    Losartan, Diphenhydramine, Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-03
    Completion
    2011-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMemory, Long-Term; Memory, Short-Term
    InterventionLosartan, Diphenhydramine, Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Benazepril Hydrochloride, Lisinopril, Ramipril, or Losartan Potassium in Treating Hypertension in Patients With Solid Tumors

    NCT01234922 · start 2011-02

    Registered record
    Registry ID
    NCT01234922
    Conditions
    Hypertension; Unspecified Adult Solid Tumor, Protocol Specific
    Interventions
    lisinopril; losartan potassium; laboratory biomarker analysis; benazepril hydrochloride; ramipril
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-02
    Completion
    2014-04
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Unspecified Adult Solid Tumor, Protocol Specific
    Interventionlisinopril; losartan potassium; laboratory biomarker analysis; benazepril hydrochloride +1 more
    PhasePhase 2
    Registry statusTerminated

  • Development of Minidose Inje Cocktail Method for Simultaneous Evaluating Five Cytochrome P450 Isoforms in Human

    NCT01570569 · start 2011-01

    Registered record
    Registry ID
    NCT01570569
    Conditions
    Healthy
    Interventions
    Omeprazole; Losartan; Dextromethorphan; Cocktail; Midazolam; Caffeine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-01
    Completion
    2011-03
    Enrolment
    26

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionOmeprazole; Losartan; Dextromethorphan; Cocktail +2 more
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetic Study to Investigate Low-dose Combinations of a Cocktail of Seven Drugs for Simultaneous Phenotyping of Cytochromes

    NCT01187862 · start 2010-07

    Registered record
    Registry ID
    NCT01187862
    Conditions
    Cytochrome; Pharmacokinetics
    Interventions
    caffeine, efavirenz, losartan, omeprazole, metoprolol, chlorzoxazone and midazolam
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-07
    Completion
    Not recorded
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCytochrome; Pharmacokinetics
    Interventioncaffeine, efavirenz, losartan, omeprazole, metoprolol, chlorzoxazone and midazolam
    PhasePhase 1
    Registry statusCompleted

  • Pharmacokinetic Study in Patients With Chronic Kidney Disease and Healthy Volunteers

    NCT01087749 · start 2010-03

    Registered record
    Registry ID
    NCT01087749
    Conditions
    Kidney Disease
    Interventions
    Propranolol; Losartan; Eprosartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-03
    Completion
    2012-12
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Disease
    InterventionPropranolol; Losartan; Eprosartan
    PhasePhase 1
    Registry statusCompleted

  • The Effect of Hypertension Medications on Renal Blood Flow Measurements in Healthy Males (MK-0000-127)

    NCT00856960 · start 2010-01

    Registered record
    Registry ID
    NCT00856960
    Conditions
    Hypertension
    Interventions
    Aliskiren; Aliskiren; Comparator: Losartan; Comparator: Placebo to Aliskiren; Comparator: Placebo to Losartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2010-01
    Completion
    2010-04
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionAliskiren; Aliskiren; Comparator: Losartan; Comparator: Placebo to Aliskiren +1 more
    PhasePhase 1
    Registry statusCompleted