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AMR Drug RepurposingSmart Screeningresearch prototype

Losartan Potassium

FDA-approved product (tablet, oral), marketed as Arbli, Cozaar, Losartan Potassium.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Losartan Potassium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Chronic kidney disease
  • Hypertension
  • Kidney disease
  • Proteinuria
  • Stroke

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Angiotensin ii receptor blockers (arbs), plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA47.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli33.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae11.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis57.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Losartan Potassium in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.7 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.3 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.6 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Losartan Potassium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Aggressive Medical Treatment Evaluation for Asymptomatic Carotid Artery Stenosis

    NCT00805311 · start 2009-04

    Registered record
    Registry ID
    NCT00805311
    Conditions
    Carotid Artery Stenosis; Atherosclerosis; Stroke
    Interventions
    Carotid Endarterectomy; atorvastatin, aspirin, losartan, amlodipine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2009-04
    Completion
    2014-05
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarotid Artery Stenosis; Atherosclerosis; Stroke
    InterventionCarotid Endarterectomy; atorvastatin, aspirin, losartan, amlodipine
    PhasePhase 4
    Registry statusTerminated

  • Losartan in Treating Patients With Idiopathic Pulmonary Fibrosis

    NCT00879879 · start 2009-03

    Registered record
    Registry ID
    NCT00879879
    Conditions
    Precancerous Condition
    Interventions
    losartan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-03
    Completion
    2012-03
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrecancerous Condition
    Interventionlosartan
    PhaseNot applicable
    Registry statusCompleted

  • Aliskiren's Effect on Arterial Stiffness and Platelet Function in Patients With Diabetes Mellitus (DM)

    NCT00732407 · start 2008-09

    Registered record
    Registry ID
    NCT00732407
    Conditions
    Diabetes Mellitus; Atherosclerosis
    Interventions
    aliskiren; losartan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2008-09
    Completion
    Not recorded
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus; Atherosclerosis
    Interventionaliskiren; losartan
    PhaseNot applicable
    Registry statusUnknown

  • Efficacy and Safety of Nebivolol (Added to Lisinopril or Losartan) in Hypertensive Patients

    NCT00734630 · start 2008-08

    Registered record
    Registry ID
    NCT00734630
    Conditions
    Hypertension
    Interventions
    nebivolol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-08
    Completion
    2010-05
    Enrolment
    491

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionnebivolol; Placebo
    PhasePhase 4
    Registry statusCompleted

  • The Blood Pressure and Metabolic Effects of Nebivolol in Hypertensive Patients With Impaired Glucose Tolerance or Impaired Fasting Glucose

    NCT00673790 · start 2008-05-15

    Registered record
    Registry ID
    NCT00673790
    Conditions
    Hypertension
    Interventions
    Nebivolol with concomitant losartan or lisinopril; HCTZ with concomitant losartan or lisinopril; Placebo with concomitant losartan or lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-05-15
    Completion
    2010-07-09
    Enrolment
    537

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionNebivolol with concomitant losartan or lisinopril; HCTZ with concomitant losartan or lisinopril; Placebo with concomitant losartan or lisinopril
    PhasePhase 4
    Registry statusCompleted

  • Efficacy/Safety of Amlodipine Plus Losartan Versus Losartan in Patients With Essential Hypertension

    NCT00940680 · start 2008-04

    Registered record
    Registry ID
    NCT00940680
    Conditions
    Hypertension
    Interventions
    Amlodipine plus Losartan; Losartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-04
    Completion
    2008-11
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionAmlodipine plus Losartan; Losartan
    PhasePhase 3
    Registry statusCompleted

  • Efficacy and Safety of Valsartan in Combination With Amlodipine Compared to Losartan Plus Hydrochlorothiazide in Patients With Hypertension and Left Ventricular Hypertrophy

    NCT00446563 · start 2007-03

    Registered record
    Registry ID
    NCT00446563
    Conditions
    Hypertension; Hypertrophy, Left Ventricular
    Interventions
    Valsartan; Amlodipine; Hydrochlorothiazide; Losartan
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-03
    Completion
    2010-03
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Hypertrophy, Left Ventricular
    InterventionValsartan; Amlodipine; Hydrochlorothiazide; Losartan
    PhasePhase 3
    Registry statusCompleted

  • Attenuation of Cardiac Effects of Arteriovenous Fistula Creation With Losartan

    NCT00602004 · start 2006-10

    Registered record
    Registry ID
    NCT00602004
    Conditions
    Renal Failure; Left Ventricular Hypertrophy
    Interventions
    losartan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2006-10
    Completion
    2014-12
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRenal Failure; Left Ventricular Hypertrophy
    Interventionlosartan
    PhaseNot applicable
    Registry statusCompleted

  • A 52 Week Study to Evaluate the Effects of Losartan With or Without HCTZ on Plasma Glucose, Metabolic Parameters, Blood Pressure in Hypertensive Patients With Metabolic Syndrome (0954A-331)

    NCT00546052 · start 2005-09-01

    Registered record
    Registry ID
    NCT00546052
    Conditions
    Hypertension; Metabolic Disorder
    Interventions
    losartan potassium (+) hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-09-01
    Completion
    2008-01-01
    Enrolment
    1,738

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Metabolic Disorder
    Interventionlosartan potassium (+) hydrochlorothiazide
    PhasePhase 3
    Registry statusCompleted

  • Evaluation of the Antihypertensive Effect of Hyzaar(R) and Cognitive Function of Hypertensive Patients (0954A-322)

    NCT00398541 · start 2005-03-01

    Registered record
    Registry ID
    NCT00398541
    Conditions
    Hypertension
    Interventions
    losartan potassium (+) hydrochlorothiazide
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2005-03-01
    Completion
    2007-06-01
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionlosartan potassium (+) hydrochlorothiazide
    PhasePhase 3
    Registry statusCompleted

  • Effectiveness Study on Fosinopril and/or Losartan in Patients With Chronic Kidney Disease Stage 3

    NCT00565396 · start 2004-09

    Registered record
    Registry ID
    NCT00565396
    Conditions
    Chronic Kidney Insufficiency; Angiotensin-Converting Enzyme Inhibitors; Angiotensin II Type 1 Receptor Blockers; Proteinuria
    Interventions
    Fosinopril and Losartan
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2004-09
    Completion
    2008-07
    Enrolment
    400

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Insufficiency; Angiotensin-Converting Enzyme Inhibitors; Angiotensin II Type 1 Receptor Blockers; Proteinuria
    InterventionFosinopril and Losartan
    PhaseNot applicable
    Registry statusUnknown

  • Bioequivalency Study of Losartan Potassium 100 mg Tablet Under Fasted Conditions

    NCT01216852 · start 2004-08

    Registered record
    Registry ID
    NCT01216852
    Conditions
    Hypertension
    Interventions
    Losartan Potassium
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-08
    Completion
    2004-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionLosartan Potassium
    PhaseNot applicable
    Registry statusCompleted

  • Bioequivalence of Losartan and Hydrochlorothiazide (HCTZ) Combination Tablet and Coadministration of Its Components (0954A-306)

    NCT00953680 · start 2004-04

    Registered record
    Registry ID
    NCT00953680
    Conditions
    Hypertension
    Interventions
    losartan potassium (+) hydrochlorothiazide (HCTZ); losartan potassium; hydrochlorothiazide (HCTZ)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2004-04
    Completion
    2004-07
    Enrolment
    77

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionlosartan potassium (+) hydrochlorothiazide (HCTZ); losartan potassium; hydrochlorothiazide (HCTZ)
    PhasePhase 1
    Registry statusCompleted

  • Determinants of Warfarin Metabolism

    NCT00162474 · start 2003-09

    Registered record
    Registry ID
    NCT00162474
    Conditions
    Healthy
    Interventions
    Warfarin; Phenytoin; Losartan & Hydrochlorothiazide; Flurbiprofen; Siponimod; Dicloxacillin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2003-09
    Completion
    2030-12
    Enrolment
    1,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionWarfarin; Phenytoin; Losartan & Hydrochlorothiazide; Flurbiprofen +2 more
    PhaseNot applicable
    Registry statusRecruiting

  • Olmesartan Medoxomil in Hypertension and Renal Impairment

    NCT00151827 · start 2003-08

    Registered record
    Registry ID
    NCT00151827
    Conditions
    Essential Hypertension; Renal Impairment
    Interventions
    Olmesartan medoxomil; Losartan; Furosemide oral tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-08
    Completion
    2005-07
    Enrolment
    393

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Hypertension; Renal Impairment
    InterventionOlmesartan medoxomil; Losartan; Furosemide oral tablets
    PhasePhase 3
    Registry statusCompleted