Losartan Potassium
FDA-approved product (tablet, oral), marketed as Arbli, Cozaar, Losartan Potassium.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 2 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Cardiovascular disease
- Chronic kidney disease
- Hypertension
- Kidney disease
- Proteinuria
- Stroke
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Angiotensin ii receptor blockers (arbs), plain
- Anti-infective classification
- Not classified as an anti-infective.
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis and MRSA. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA47.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli33.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- K. pneumoniae11.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis57.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredAutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Losartan Potassium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Losartan and HCTZ and Amlodipine vs Atenolol and Amlodipine (0954A-309)(COMPLETED)
NCT00140959 · start 2003-02-01
Registered record
- Registry ID
- NCT00140959
- Conditions
- Hypertension
- Interventions
- MK0954, losartan potassium/Duration of Treatment: 18 weeks; Comparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeks
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 2003-02-01
- Completion
- 2004-06-30
- Enrolment
- 120
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHypertensionInterventionMK0954, losartan potassium/Duration of Treatment: 18 weeks; Comparator: losartan, HCTZ, amlodipine, atenolol/Duration of Treatment: 18 weeksPhasePhase 4Registry statusCompletedAntihypertensive Efficacy and Safety of Approved Drugs in Japanese Patients With Essential Hypertension (Banyu Study)(0954A-302)
NCT00092209 · start 2002-04
Registered record
- Registry ID
- NCT00092209
- Conditions
- Hypertension
- Interventions
- MK0954A, hydrochlorothiazide (+) losartan potassium; Comparator: placebo, losartan, hydrochlorothiazide
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2002-04
- Completion
- 2002-11
- Enrolment
- 840
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHypertensionInterventionMK0954A, hydrochlorothiazide (+) losartan potassium; Comparator: placebo, losartan, hydrochlorothiazidePhasePhase 3Registry statusCompletedHealth Assessment Study (0954-946)
NCT00541684 · start 2001-07-11
Registered record
- Registry ID
- NCT00541684
- Conditions
- Hypertension
- Interventions
- MK0954, /Duration of Treatment : 16 Weeks; Comparator : atenolol /Duration of Treatment : 16 Weeks
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2001-07-11
- Completion
- 2003-01-23
- Enrolment
- 143
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHypertensionInterventionMK0954, /Duration of Treatment : 16 Weeks; Comparator : atenolol /Duration of Treatment : 16 WeeksPhasePhase 3Registry statusCompletedA Study on Molecular Genetics of Drug Responsiveness in Essential Hypertension
NCT03276598 · start 1999-11-25
Registered record
- Registry ID
- NCT03276598
- Conditions
- Hypertension; Pharmacogenetics
- Interventions
- Amlodipine; Bisoprolol; Hydrochlorothiazide; Losartan; Placebo
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 1999-11-25
- Completion
- 2004-04-01
- Enrolment
- 233
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHypertension; PharmacogeneticsInterventionAmlodipine; Bisoprolol; Hydrochlorothiazide; Losartan +1 morePhasePhase 4Registry statusCompletedInhibitors of Angiotensin II in Proteinuric Mesangioproliferative Glomerulonephritis
NCT01115426 · start 1997-01
Registered record
- Registry ID
- NCT01115426
- Conditions
- IGA Glomerulonephritis
- Interventions
- Ramipril or losartan
- Study type
- INTERVENTIONAL
- Phase
- Phase 4
- Registry status
- Completed
- Start
- 1997-01
- Completion
- 2008-01
- Enrolment
- 20
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionIGA GlomerulonephritisInterventionRamipril or losartanPhasePhase 4Registry statusCompleted