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AMR Drug RepurposingSmart Screeningresearch prototype

Nelfinavir Mesylate

FDA-approved product (powder, oral), marketed as Viracept.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Nelfinavir Mesylate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • HIV infection
  • HIV-1 infection

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Protease inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AE04

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA46.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli42.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae34.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis59.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Nelfinavir Mesylate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Nelfinavir Mesylate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of Several Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Used Indinavir

    NCT00000892

    Registered record
    Registry ID
    NCT00000892
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir; Delavirdine mesylate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1999-08
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Addition of Efavirenz or Nelfinavir to a Lamivudine/Zidovudine/Indinavir HIV Treatment Regimen

    NCT00000903

    Registered record
    Registry ID
    NCT00000903
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Lamivudine/Zidovudine; Nelfinavir mesylate; Efavirenz
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2001-07
    Enrolment
    444

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Lamivudine/Zidovudine; Nelfinavir mesylate; Efavirenz
    PhasePhase 3
    Registry statusCompleted

  • A Study of the Effectiveness of Different Anti-HIV Treatments in HIV-Positive Individuals Who Have Been on a Protease Inhibitor-Containing Drug Regimen for at Least 16 Weeks

    NCT00000914

    Registered record
    Registry ID
    NCT00000914
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Ritonavir; Nelfinavir mesylate; Efavirenz
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2000-06
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Ritonavir; Nelfinavir mesylate; Efavirenz
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Compare The Ability of Different Anti-HIV Drugs to Decrease Viral Load After Nelfinavir (an Anti-HIV Drug)Treatment Failure

    NCT00000918

    Registered record
    Registry ID
    NCT00000918
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Lamivudine/Zidovudine; Ritonavir; Amprenavir; Efavirenz; Saquinavir; Lamivudine; Stavudine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2002-02
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Lamivudine/Zidovudine; Ritonavir; Amprenavir +6 more
    PhasePhase 2
    Registry statusCompleted

  • A Study to Compare Two Different Anti-HIV Drug Regimens

    NCT00000924

    Registered record
    Registry ID
    NCT00000924
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate; Nevirapine; Stavudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2001-06
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate; Nevirapine; Stavudine +1 more
    PhasePhase 2
    Registry statusCompleted

  • A Comparison of Nelfinavir Plus Saquinavir Plus Delavirdine or 3TC/ZDV Versus Nelfinavir Plus 3TC/ZDV in HIV-Infected Patients

    NCT00001094

    Registered record
    Registry ID
    NCT00001094
    Conditions
    HIV Infections
    Interventions
    Lamivudine/Zidovudine; Nelfinavir mesylate; Saquinavir; Delavirdine mesylate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionLamivudine/Zidovudine; Nelfinavir mesylate; Saquinavir; Delavirdine mesylate
    PhasePhase 2
    Registry statusWithdrawn

  • A Study of an Adherence Plan to Help HIV-Positive Patients Take Their First Anti-HIV Medications Correctly

    NCT00001122

    Registered record
    Registry ID
    NCT00001122
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate; Efavirenz; Stavudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate; Efavirenz; Stavudine; Didanosine
    PhasePhase 2
    Registry statusCompleted

  • Phase I Study of Safety, Tolerability, and Pharmacokinetics of Viracept in HIV-1 Infected Children and Exposed Infants

    NCT00002164

    Registered record
    Registry ID
    NCT00002164
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate
    PhasePhase 1
    Registry statusCompleted

  • Viracept Expanded Access Program

    NCT00002165

    Registered record
    Registry ID
    NCT00002165
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate
    PhaseNot applicable
    Registry statusCompleted

  • A Phase II, Stratified, Randomized, Double-Blind, Multi-Center Study of the Safety and Efficacy of Adefovir Dipivoxil (ADF) at Two Dose Levels in Triple Combination Therapies With Protease Inhibitors (PI) and Nucleoside Reverse Transcriptase Inhibitors (RTI) for the Treatment of HIV-Infected Patient

    NCT00002184

    Registered record
    Registry ID
    NCT00002184
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir; Lamivudine; Stavudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir +3 more
    PhasePhase 2
    Registry statusCompleted

  • A Study of Ritonavir (ABT-538) When Used With Nelfinavir in HIV-Infected Patients

    NCT00002201

    Registered record
    Registry ID
    NCT00002201
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate
    PhaseNot applicable
    Registry statusCompleted

  • Safety and Effectiveness of Giving Combinations of Three or Four Anti-HIV Drugs to HIV-Infected Patients

    NCT00002211

    Registered record
    Registry ID
    NCT00002211
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate; Delavirdine mesylate; Stavudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate; Delavirdine mesylate; Stavudine; Didanosine
    PhaseNot applicable
    Registry statusCompleted

  • Indinavir Plus Efavirenz Plus Adefovir Dipivoxil in HIV-Infected Patients Who Have Not Had Success With Nelfinavir

    NCT00002220

    Registered record
    Registry ID
    NCT00002220
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Efavirenz; Levocarnitine; Adefovir dipivoxil
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Efavirenz; Levocarnitine; Adefovir dipivoxil
    PhasePhase 3
    Registry statusCompleted

  • A Study of 141W94 in Combination With Other Anti-HIV Drugs

    NCT00002372

    Registered record
    Registry ID
    NCT00002372
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Amprenavir; Nelfinavir mesylate; Saquinavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Amprenavir; Nelfinavir mesylate; Saquinavir
    PhasePhase 1
    Registry statusCompleted

  • A Study of Saquinavir Soft Gelatin Capsules Combined With Other Anti-HIV Drugs in HIV-1 Infected Patients

    NCT00002374

    Registered record
    Registry ID
    NCT00002374
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate; Saquinavir; Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate; Saquinavir; Stavudine
    PhasePhase 3
    Registry statusCompleted