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AMR Drug RepurposingSmart Screeningresearch prototype

Tacrolimus

FDA-approved product (capsule, oral), marketed as Astagraf Xl, Envarsus Xr, Prograf and 2 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Tacrolimus
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Atopic eczema
  • Delayed Graft Function
  • Eczematoid dermatitis
  • Immune system disease
  • Kidney transplant
  • Liver transplant

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Agents for dermatitis, excluding corticosteroids; Calcineurin inhibitors
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA, E. coli and K. pneumoniae. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA62.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli50.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae44.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis53.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Tacrolimus in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Tacrolimus with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Sustained Virological Response (SVR) to Antiviral Treatment of Liver Transplant Recipients With Recurrent Hepatitis C

    NCT00938860 · start 2009-09

    Registered record
    Registry ID
    NCT00938860
    Conditions
    Hepatitis C; Liver Transplantation
    Interventions
    cyclosporin (Neoral); tacrolimus (Prograf)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-09
    Completion
    2013-05
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHepatitis C; Liver Transplantation
    Interventioncyclosporin (Neoral); tacrolimus (Prograf)
    PhasePhase 4
    Registry statusCompleted

  • Low Dose Thymoglobulin to Protect Kidney Function After Liver Transplant

    NCT00970073 · start 2009-08

    Registered record
    Registry ID
    NCT00970073
    Conditions
    Liver Transplantation
    Interventions
    Thymoglobulin 3mg total; Thymoglobulin 4.5mg total; Mycophenolate mofetil; tacrolimus 3-8; tacrolimus 8-12
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-08
    Completion
    2015-12
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Transplantation
    InterventionThymoglobulin 3mg total; Thymoglobulin 4.5mg total; Mycophenolate mofetil; tacrolimus 3-8 +1 more
    PhaseNot applicable
    Registry statusCompleted

  • Mycophenolate Mofetil and Tacrolimus Versus Tacrolimus for the Treatment of Idiopathic Membranous Glomerulonephritis

    NCT00843856 · start 2009-03-03

    Registered record
    Registry ID
    NCT00843856
    Conditions
    Glomerulonephritis, Membranous
    Interventions
    tacrolimus; tacrolimus and mycophenolate mofetil
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-03-03
    Completion
    2018-09-18
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlomerulonephritis, Membranous
    Interventiontacrolimus; tacrolimus and mycophenolate mofetil
    PhasePhase 4
    Registry statusCompleted

  • Polycystic Liver Disease in Kidney Transplant

    NCT00934791 · start 2009-02

    Registered record
    Registry ID
    NCT00934791
    Conditions
    Polycystic Liver Disease
    Interventions
    Tacrolimus; Sirolimus; Mycophenolate Mofetil; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2009-02
    Completion
    2012-12
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPolycystic Liver Disease
    InterventionTacrolimus; Sirolimus; Mycophenolate Mofetil; Prednisone
    PhaseNot applicable
    Registry statusTerminated

  • Steroid Withdrawal Immunosuppression After Renal Transplantation

    NCT01550445 · start 2008-05

    Registered record
    Registry ID
    NCT01550445
    Conditions
    Disorder Related to Renal Transplantation
    Interventions
    Prednisolone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2008-05
    Completion
    2012-07
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDisorder Related to Renal Transplantation
    InterventionPrednisolone
    PhasePhase 4
    Registry statusUnknown

  • A Randomized Study to Assess the Safety and Efficacy of Prograf vs Prograf-XL in de Novo Kidney Transplant Recipients

    NCT00717678 · start 2007-12

    Registered record
    Registry ID
    NCT00717678
    Conditions
    Kidney Transplantation; Transplantation Immunology; Host vs Graft Reaction
    Interventions
    Prograf-XL; Prograf; MMF
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-12
    Completion
    2010-04
    Enrolment
    73

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Transplantation; Transplantation Immunology; Host vs Graft Reaction
    InterventionPrograf-XL; Prograf; MMF
    PhasePhase 3
    Registry statusCompleted

  • A Study of CellCept (Mycophenolate Mofetil) in Combination Therapy in Liver Transplant Patients.

    NCT00545402 · start 2007-11

    Registered record
    Registry ID
    NCT00545402
    Conditions
    Liver Transplantation
    Interventions
    Mycophenolate mofetil, adjusted dose; Tacrolimus; Corticosteroids, IV; Mycophenolate mofetil, Standard dose; Corticosteroids, PO
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-11
    Completion
    2011-07
    Enrolment
    180

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLiver Transplantation
    InterventionMycophenolate mofetil, adjusted dose; Tacrolimus; Corticosteroids, IV; Mycophenolate mofetil, Standard dose +1 more
    PhasePhase 4
    Registry statusCompleted

  • Oral Paricalcitol in Kidney Transplant Recipients

    NCT00587158 · start 2007-01

    Registered record
    Registry ID
    NCT00587158
    Conditions
    Transplant; Failure, Kidney; Renal Disease, End Stage; Hyperparathyroidism, Secondary
    Interventions
    Paricalcitol; Corticosteroid Avoidance Immune Suppression Protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-01
    Completion
    2011-11
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTransplant; Failure, Kidney; Renal Disease, End Stage; Hyperparathyroidism, Secondary
    InterventionParicalcitol; Corticosteroid Avoidance Immune Suppression Protocol
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy and Safety of AEB071 Plus Tacrolimus (Converted to Mycophenolic Acid After 3 Months), in Renal Transplant Patients

    NCT00403416 · start 2006-10

    Registered record
    Registry ID
    NCT00403416
    Conditions
    Kidney Transplantation
    Interventions
    AEB071; Mycophenolic Acid
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2006-10
    Completion
    2008-05
    Enrolment
    215

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Transplantation
    InterventionAEB071; Mycophenolic Acid
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Tacrolimus and Mycophenolate Mofetil (MMF) in GVHD Prophylactic Regimen Compared to Tacrolimus and Methotrexate (MTX

    NCT00360685 · start 2005-09

    Registered record
    Registry ID
    NCT00360685
    Conditions
    Mucositis; Graft-versus-host Disease
    Interventions
    Tac+MTX; TAC + MMF
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-09
    Completion
    2011-01
    Enrolment
    89

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMucositis; Graft-versus-host Disease
    InterventionTac+MTX; TAC + MMF
    PhaseNot applicable
    Registry statusCompleted

  • Study of Unrelated Cord Blood Transplantation Using Tacrolimus and Sirolimus

    NCT00133367 · start 2005-08

    Registered record
    Registry ID
    NCT00133367
    Conditions
    Multiple Myeloma; Non-Hodgkin's Lymphoma; Hodgkin's Disease; Myelogenous Leukemia; Lymphoblastic Leukemia
    Interventions
    Tacrolimus; Sirolimus; G-CSF; Antithymocyte globulin; Thymoglobulin; Fludarabine; Melphalan
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-08
    Completion
    2011-11
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Myeloma; Non-Hodgkin's Lymphoma; Hodgkin's Disease; Myelogenous Leukemia +1 more
    InterventionTacrolimus; Sirolimus; G-CSF; Antithymocyte globulin +3 more
    PhasePhase 2
    Registry statusCompleted

  • Rapamycin for Immunosuppression and B Cell Modulation Post Stem Cell Transplant for Acute Lymphoblastic Leukemia (ALL)

    NCT00795886 · start 2005-08

    Registered record
    Registry ID
    NCT00795886
    Conditions
    Acute Lymphoblastic Leukemia
    Interventions
    RAPAMYCIN
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2005-08
    Completion
    2010-03
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Lymphoblastic Leukemia
    InterventionRAPAMYCIN
    PhasePhase 2
    Registry statusCompleted

  • Effect of Rapid Steroid Withdrawal on Subclinical Markers of Rejection

    NCT00133172 · start 2005-07

    Registered record
    Registry ID
    NCT00133172
    Conditions
    Kidney Transplantation
    Interventions
    Tacrolimus; mycophenolate mofetil; Prednisone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2005-07
    Completion
    2007-03
    Enrolment
    85

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Transplantation
    InterventionTacrolimus; mycophenolate mofetil; Prednisone
    PhasePhase 4
    Registry statusTerminated

  • Tacrolimus Ointment in Oral Lichen Planus

    NCT01544842 · start 2004-08

    Registered record
    Registry ID
    NCT01544842
    Conditions
    Oral Lichen Planus
    Interventions
    0.1 % tacrolimus ointment; 0.1 % triamcinolone paste; Orabase paste
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2004-08
    Completion
    2015-07
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Lichen Planus
    Intervention0.1 % tacrolimus ointment; 0.1 % triamcinolone paste; Orabase paste
    PhaseNot applicable
    Registry statusTerminated

  • Islet Allotransplantation With Steroid Free Immunosuppression

    NCT00446264 · start 2003-05

    Registered record
    Registry ID
    NCT00446264
    Conditions
    Type 1 Diabetes; Hypoglycemia; Metabolic Diseases
    Interventions
    islet transplantation; daclizumab - sirolimus - tacrolimus
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2003-05
    Completion
    2009-02
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionType 1 Diabetes; Hypoglycemia; Metabolic Diseases
    Interventionislet transplantation; daclizumab - sirolimus - tacrolimus
    PhasePhase 2
    Registry statusCompleted