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AMR Drug RepurposingSmart Screeningresearch prototype

Saquinavir

FDA-approved product (capsule, oral), marketed as Fortovase, Invirase.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Saquinavir
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • HIV infection
  • HIV-1 infection
  • Viral disease

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Protease inhibitors
Anti-infective classification
Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J05AE01

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli49.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae33.9% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis71.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Saquinavir in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Saquinavir with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • A Study of Several Anti-HIV Drug Combinations in HIV-Infected Patients Who Have Used Indinavir

    NCT00000892

    Registered record
    Registry ID
    NCT00000892
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir; Delavirdine mesylate
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    1999-08
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil +2 more
    PhaseNot applicable
    Registry statusCompleted

  • Interactions of HIV Protease Inhibitors and Methadone in HIV-Infected Patients

    NCT00000906

    Registered record
    Registry ID
    NCT00000906
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Saquinavir; Methadone hydrochloride
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2000-09
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Saquinavir; Methadone hydrochloride
    PhasePhase 1
    Registry statusCompleted

  • A Study on Amprenavir in Combination With Other Anti-HIV Drugs in HIV-Positive Patients

    NCT00000912

    Registered record
    Registry ID
    NCT00000912
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Abacavir sulfate; Amprenavir; Nelfinavir mesylate; Efavirenz; Levocarnitine; Adefovir dipivoxil; Saquinavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2000-05
    Enrolment
    475

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Abacavir sulfate; Amprenavir; Nelfinavir mesylate +4 more
    PhasePhase 2
    Registry statusCompleted

  • A Study of the Effectiveness of Different Anti-HIV Treatments in HIV-Positive Individuals Who Have Been on a Protease Inhibitor-Containing Drug Regimen for at Least 16 Weeks

    NCT00000914

    Registered record
    Registry ID
    NCT00000914
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Ritonavir; Nelfinavir mesylate; Efavirenz
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2000-06
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Ritonavir; Nelfinavir mesylate; Efavirenz
    PhaseNot applicable
    Registry statusCompleted

  • A Study to Compare The Ability of Different Anti-HIV Drugs to Decrease Viral Load After Nelfinavir (an Anti-HIV Drug)Treatment Failure

    NCT00000918

    Registered record
    Registry ID
    NCT00000918
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Lamivudine/Zidovudine; Ritonavir; Amprenavir; Efavirenz; Saquinavir; Lamivudine; Stavudine; Zidovudine; Didanosine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2002-02
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Lamivudine/Zidovudine; Ritonavir; Amprenavir +6 more
    PhasePhase 2
    Registry statusCompleted

  • Fortovase (Saquinavir) Given With Low-Dose Ritonavir, Zidovudine, and Lamivudine to HIV-Positive Pregnant Women During and After Pregnancy and to Their Newborns

    NCT00000920

    Registered record
    Registry ID
    NCT00000920
    Conditions
    HIV Infections; Pregnancy
    Interventions
    Ritonavir; Saquinavir; Lamivudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2003-04
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Pregnancy
    InterventionRitonavir; Saquinavir; Lamivudine; Zidovudine
    PhasePhase 1
    Registry statusCompleted

  • A Comparison of Nelfinavir Plus Saquinavir Plus Delavirdine or 3TC/ZDV Versus Nelfinavir Plus 3TC/ZDV in HIV-Infected Patients

    NCT00001094

    Registered record
    Registry ID
    NCT00001094
    Conditions
    HIV Infections
    Interventions
    Lamivudine/Zidovudine; Nelfinavir mesylate; Saquinavir; Delavirdine mesylate
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Withdrawn
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionLamivudine/Zidovudine; Nelfinavir mesylate; Saquinavir; Delavirdine mesylate
    PhasePhase 2
    Registry statusWithdrawn

  • Safety and Tolerance of Indinavir Plus Ritonavir in HIV-Positive Patients Failing Therapy With Amprenavir, Nelfinavir, or Saquinavir

    NCT00001133

    Registered record
    Registry ID
    NCT00001133
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Ritonavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    2006-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Ritonavir
    PhasePhase 1
    Registry statusCompleted

  • A Phase II, Stratified, Randomized, Double-Blind, Multi-Center Study of the Safety and Efficacy of Adefovir Dipivoxil (ADF) at Two Dose Levels in Triple Combination Therapies With Protease Inhibitors (PI) and Nucleoside Reverse Transcriptase Inhibitors (RTI) for the Treatment of HIV-Infected Patient

    NCT00002184

    Registered record
    Registry ID
    NCT00002184
    Conditions
    HIV Infections
    Interventions
    Nelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir; Lamivudine; Stavudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionNelfinavir mesylate; Levocarnitine; Adefovir dipivoxil; Saquinavir +3 more
    PhasePhase 2
    Registry statusCompleted

  • Safety and Effectiveness of Adding Saquinavir (FORTOVASE) in Soft Gel Capsule Form to an Anti-HIV Drug Combination in HIV-Infected Patients

    NCT00002229

    Registered record
    Registry ID
    NCT00002229
    Conditions
    HIV Infections
    Interventions
    Saquinavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionSaquinavir
    PhasePhase 4
    Registry statusCompleted

  • A Study of Zidovudine (AZT) Used Alone or in Combination With Other Anti-HIV Drugs in HIV-Infected Patients With Little or No Previous Treatment

    NCT00002334

    Registered record
    Registry ID
    NCT00002334
    Conditions
    HIV Infections
    Interventions
    Saquinavir; Zidovudine; Zalcitabine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    3,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionSaquinavir; Zidovudine; Zalcitabine
    PhasePhase 3
    Registry statusCompleted

  • A Study of Saquinavir Soft Gelatin Capsules Plus Zidovudine Plus Lamivudine in the Treatment of HIV-1 Infected Patients Who Have Never Taken Anti-HIV Drugs

    NCT00002367

    Registered record
    Registry ID
    NCT00002367
    Conditions
    HIV Infections
    Interventions
    Saquinavir; Lamivudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionSaquinavir; Lamivudine; Zidovudine
    PhasePhase 3
    Registry statusCompleted

  • A Study of 141W94 in Combination With Other Anti-HIV Drugs

    NCT00002372

    Registered record
    Registry ID
    NCT00002372
    Conditions
    HIV Infections
    Interventions
    Indinavir sulfate; Amprenavir; Nelfinavir mesylate; Saquinavir
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionIndinavir sulfate; Amprenavir; Nelfinavir mesylate; Saquinavir
    PhasePhase 1
    Registry statusCompleted

  • A Study of Saquinavir Soft Gelatin Capsules Combined With Other Anti-HIV Drugs in HIV-1 Infected Patients

    NCT00002374

    Registered record
    Registry ID
    NCT00002374
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate; Saquinavir; Stavudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate; Saquinavir; Stavudine
    PhasePhase 3
    Registry statusCompleted

  • A Comparison of Three Anti-HIV Drug Combinations Containing Saquinavir Soft Gelatin Capsules Used in HIV-1 Infected Patients

    NCT00002378

    Registered record
    Registry ID
    NCT00002378
    Conditions
    HIV Infections
    Interventions
    Ritonavir; Nelfinavir mesylate; Saquinavir; Delavirdine mesylate; Lamivudine; Stavudine; Zidovudine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    Not recorded
    Completion
    Not recorded
    Enrolment
    825

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionRitonavir; Nelfinavir mesylate; Saquinavir; Delavirdine mesylate +3 more
    PhasePhase 3
    Registry statusCompleted