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AMR Drug RepurposingSmart Screeningresearch prototype

Cholecalciferol

FDA-approved product (solution, intravenous).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Cholecalciferol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Iron deficiency anemia
  • Osteoporosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vitamin d and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli23.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis35.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cholecalciferol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cholecalciferol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Anti-proliferative Effects of Vitamin D and Melatonin in Breast Cancer

    NCT01965522 · start 2013-10

    Registered record
    Registry ID
    NCT01965522
    Conditions
    Early Stage Breast Cancer
    Interventions
    Melatonin; Vitamin D; Placebo (melatonin); Placebo (vitamin D)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-10
    Completion
    2017-05
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEarly Stage Breast Cancer
    InterventionMelatonin; Vitamin D; Placebo (melatonin); Placebo (vitamin D)
    PhasePhase 2
    Registry statusCompleted

  • A Trial on Different Dosages of Vitamin D in Preterm Infants With Late-onset Sepsis

    NCT02273843 · start 2013-09

    Registered record
    Registry ID
    NCT02273843
    Conditions
    Prematurity; Late-onset Sepsis
    Interventions
    High-dose vitamin D 3; Conventional-Dose Vitamin D 3
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2013-09
    Completion
    2015-08
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrematurity; Late-onset Sepsis
    InterventionHigh-dose vitamin D 3; Conventional-Dose Vitamin D 3
    PhasePhase 1
    Registry statusCompleted

  • The Effect of Calcitriol on Progress and Activity of Lupus Nephritis

    NCT01863641 · start 2013-04

    Registered record
    Registry ID
    NCT01863641
    Conditions
    Systemic Lupus Erythematosus
    Interventions
    calcitriol; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2013-04
    Completion
    2014-04
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSystemic Lupus Erythematosus
    Interventioncalcitriol; placebo
    PhasePhase 2
    Registry statusUnknown

  • Olive Oil Polyphenols, Vitamin D, Docosahexaenoic Acid (DHA) and Locomotor Function (PolivD3)

    NCT01828944 · start 2012-12

    Registered record
    Registry ID
    NCT01828944
    Conditions
    Osteopenia; Sarcopenia
    Interventions
    olive oil
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-12
    Completion
    2015-04
    Enrolment
    149

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteopenia; Sarcopenia
    Interventionolive oil
    PhaseNot applicable
    Registry statusCompleted

  • The Impact of Severe Vitamin D Deficiency and Its Correction on Bone Mineral Density (BMD) in Postmenopausal Women

    NCT01694355 · start 2012-10

    Registered record
    Registry ID
    NCT01694355
    Conditions
    Vitamin D Deficiency
    Interventions
    Vitamin D
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-10
    Completion
    2018-12
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionVitamin D
    PhaseNot applicable
    Registry statusCompleted

  • Effect of Vitamin D Replacement on Immune Function and Cognition in MS Patients

    NCT01952483 · start 2012-08

    Registered record
    Registry ID
    NCT01952483
    Conditions
    Multiple Sclerosis (MS)
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2012-08
    Completion
    2017-06-30
    Enrolment
    108

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMultiple Sclerosis (MS)
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • The Effect of Vitamin D Supplementation on Arterial Stiffness in Diabetic Patients

    NCT01500005 · start 2010-08

    Registered record
    Registry ID
    NCT01500005
    Conditions
    Diabetes
    Interventions
    Baby D3 drops
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-08
    Completion
    2011-04
    Enrolment
    74

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes
    InterventionBaby D3 drops
    PhaseNot applicable
    Registry statusCompleted

  • Age-related Macular Degeneration (AMD) in the Vitamin D and Omega-3 Trial (VITAL)

    NCT01782352 · start 2010-07

    Registered record
    Registry ID
    NCT01782352
    Conditions
    Age-related Macular Degeneration
    Interventions
    Omega-3 fatty acids (fish oil); Vitamin D3; Vitamin D3 placebo; Fish oil placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2010-07
    Completion
    2024-09
    Enrolment
    25,871

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAge-related Macular Degeneration
    InterventionOmega-3 fatty acids (fish oil); Vitamin D3; Vitamin D3 placebo; Fish oil placebo
    PhaseNot applicable
    Registry statusUnknown

  • Sunlight Exposure and Vitamin D in Children

    NCT01477827 · start 2010-06

    Registered record
    Registry ID
    NCT01477827
    Conditions
    Healthy Schoolchildren
    Interventions
    None - observational study
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-06
    Completion
    2012-07
    Enrolment
    125

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Schoolchildren
    InterventionNone - observational study
    PhaseNot recorded
    Registry statusCompleted

  • Vitamin D Supplementation and Metabolism in Vitamin D Deficient Elderly

    NCT01145703 · start 2010-05

    Registered record
    Registry ID
    NCT01145703
    Conditions
    Vitamin D Deficiency; Metabolic Syndrome
    Interventions
    RDA Vitamin D3 only; Vitamin D2/3 Repletion only; Vitamin D2/3 Repletion + AEX; Vitamin D2/3 Repletion + RT
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-05
    Completion
    2013-02
    Enrolment
    39

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency; Metabolic Syndrome
    InterventionRDA Vitamin D3 only; Vitamin D2/3 Repletion only; Vitamin D2/3 Repletion + AEX; Vitamin D2/3 Repletion + RT
    PhaseNot applicable
    Registry statusTerminated

  • Effect of Lanthanum Carbonate in Patients Previously Treated With Calcium-based Phosphate Binder Therapy

    NCT01130831 · start 2010-04-26

    Registered record
    Registry ID
    NCT01130831
    Conditions
    End Stage Renal Disease
    Interventions
    Lanthanum carbonate
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-04-26
    Completion
    2012-06-12
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEnd Stage Renal Disease
    InterventionLanthanum carbonate
    PhaseNot recorded
    Registry statusCompleted

  • Vitamin D and the Influenza Epidemic

    NCT01182870 · start 2010-04

    Registered record
    Registry ID
    NCT01182870
    Conditions
    Influenza
    Interventions
    choleclaciferol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-04
    Completion
    2010-10
    Enrolment
    569

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfluenza
    Interventioncholeclaciferol
    PhasePhase 3
    Registry statusCompleted

  • Maternal and Infant Vitamin Status During the First Nine Months of Infant Life

    NCT02548520 · start 2008-10

    Registered record
    Registry ID
    NCT02548520
    Conditions
    Rickets; Osteomalacia; Osteoporosis
    Interventions
    Blood and breastmilk samples
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-10
    Completion
    2012-03
    Enrolment
    107

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRickets; Osteomalacia; Osteoporosis
    InterventionBlood and breastmilk samples
    PhaseNot recorded
    Registry statusCompleted

  • Vitamin D Supplementation Prevents Elderly Pneumonia

    NCT00877422 · start 2008-08

    Registered record
    Registry ID
    NCT00877422
    Conditions
    Bacterial Pneumonia
    Interventions
    Vitamin D3
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-08
    Completion
    Not recorded
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Pneumonia
    InterventionVitamin D3
    PhaseNot applicable
    Registry statusCompleted

  • A Randomised, Controlled Comparison of Vitamin D Strategies is Acute Hip Fracture Patients

    NCT00424619 · start 2007-10

    Registered record
    Registry ID
    NCT00424619
    Conditions
    Hip Fracture
    Interventions
    Vitamin D2; Vitamin D2; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2007-10
    Completion
    2009-07
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Fracture
    InterventionVitamin D2; Vitamin D2; Placebo
    PhasePhase 4
    Registry statusCompleted