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AMR Drug RepurposingSmart Screeningresearch prototype

Cholecalciferol

FDA-approved product (solution, intravenous).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Cholecalciferol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Anemia (phenotype)
  • Iron deficiency anemia
  • Osteoporosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Vitamin d and analogues
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA51.5% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli23.5% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.7% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis35.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cholecalciferol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.3 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-6.8 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-9.1 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cholecalciferol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Relationship Between Neuropathic Pain and Geriatric Assessment Parameters in Patients Aged 80 Years and Older

    NCT07487610 · start 2026-03-17

    Registered record
    Registry ID
    NCT07487610
    Conditions
    Neuropathic Pain; Old Age; Debility; Pain
    Interventions
    Detailed geriatric assessment
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2026-03-17
    Completion
    2026-06-30
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNeuropathic Pain; Old Age; Debility; Pain
    InterventionDetailed geriatric assessment
    PhaseNot recorded
    Registry statusCompleted

  • A Household-Based Dietary Intervention Study of Vitamin D Fortified Bread in Irish Families

    NCT07481240 · start 2025-11-17

    Registered record
    Registry ID
    NCT07481240
    Conditions
    Vitamin D Deficiency
    Interventions
    Fortified Bread; Unfortified bread
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-11-17
    Completion
    2026-04-04
    Enrolment
    128

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVitamin D Deficiency
    InterventionFortified Bread; Unfortified bread
    PhaseNot applicable
    Registry statusCompleted

  • Bone Turnover Markers and Treatment Efficacy in Postmenopausal Osteoporosis

    NCT07242612 · start 2025-10-01

    Registered record
    Registry ID
    NCT07242612
    Conditions
    Osteoporosis; Osteoporosis, Postmenopausal
    Interventions
    Alendronate, Ibandronate; Risedronate; Teriparatide
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2025-10-01
    Completion
    2026-04-15
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoporosis; Osteoporosis, Postmenopausal
    InterventionAlendronate, Ibandronate; Risedronate; Teriparatide
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of 8-week Dietary Intake of Novel Food Supplement on Minimal Erythema Dose

    NCT06343610 · start 2024-04-15

    Registered record
    Registry ID
    NCT06343610
    Conditions
    Minimal Erythema Dose
    Interventions
    Active product; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2024-04-15
    Completion
    2024-09-10
    Enrolment
    54

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMinimal Erythema Dose
    InterventionActive product; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Injectable Vitamin D Supplementation in Females With Polycystic Ovary Syndrome

    NCT06045351 · start 2024-01-01

    Registered record
    Registry ID
    NCT06045351
    Conditions
    Anovulatory Infertility
    Interventions
    Vitamin D; Active Comparator
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Recruiting
    Start
    2024-01-01
    Completion
    2026-12-31
    Enrolment
    142

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnovulatory Infertility
    InterventionVitamin D; Active Comparator
    PhasePhase 1
    Registry statusRecruiting

  • Multi-domain Intervention Program for Post-stroke Bone Health in Older Adults (BOUNCE)

    NCT05939531 · start 2023-03-01

    Registered record
    Registry ID
    NCT05939531
    Conditions
    Bone Loss; Stroke; Geriatrics
    Interventions
    BOUNCE Program; Standard Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2023-03-01
    Completion
    2025-08-31
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBone Loss; Stroke; Geriatrics
    InterventionBOUNCE Program; Standard Care
    PhaseNot applicable
    Registry statusUnknown

  • Study of Rituximab Monotherapy on Children With New-onset Nephrotic Syndrome: A Randomized Controlled Trial

    NCT05734794 · start 2023-02-09

    Registered record
    Registry ID
    NCT05734794
    Conditions
    Nephrotic Syndrome in Children; Rituximab
    Interventions
    Rituximab; Steroid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2023-02-09
    Completion
    2026-07-30
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNephrotic Syndrome in Children; Rituximab
    InterventionRituximab; Steroid
    PhasePhase 3
    Registry statusUnknown

  • Vitamin D and Polycystic Ovarian Syndrome (PCOS)

    NCT03989778 · start 2023-02-01

    Registered record
    Registry ID
    NCT03989778
    Conditions
    Infertility, Female; Infertility; Vitamin D Deficiency
    Interventions
    Vitamin D
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2023-02-01
    Completion
    2025-07-13
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Female; Infertility; Vitamin D Deficiency
    InterventionVitamin D
    PhasePhase 2
    Registry statusRecruiting

  • Impact of Ultraviolet Radiation on Bone Density and Muscle Strength in Postmenopausal Women

    NCT05650437 · start 2022-12-30

    Registered record
    Registry ID
    NCT05650437
    Conditions
    Postmenopausal Osteoporosis
    Interventions
    Ultraviolet Radiation; Aerobic exercise; Vitamin D supplementation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-12-30
    Completion
    2023-12-15
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostmenopausal Osteoporosis
    InterventionUltraviolet Radiation; Aerobic exercise; Vitamin D supplementation
    PhaseNot applicable
    Registry statusCompleted

  • The Roles of Vitamin D and Microbiome in Children With Post-acute COVID-19 Syndromes (PACS) and Long COVID

    NCT05633472 · start 2022-10-18

    Registered record
    Registry ID
    NCT05633472
    Conditions
    Post-acute COVID-19 Syndromes
    Interventions
    Vitamin D; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-10-18
    Completion
    2024-08-23
    Enrolment
    33

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-acute COVID-19 Syndromes
    InterventionVitamin D; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • The Thoracic Peri-Operative Integrative Surgical Care Evaluation Trial - Stage III

    NCT04871412 · start 2022-04-04

    Registered record
    Registry ID
    NCT04871412
    Conditions
    Lung Cancer; Gastric Cancer; Esophageal Cancer
    Interventions
    Vitamin D3 Drops; Coriolus Versicolor; Trident SAP 66:33 Lemon; Probiotic Pro12; Provitalix Pure Whey Protein; Theracurmin 2X; Green Tea Extract; Nutrition Recommendations; Physical Activity Recommendations; Psychological Recommendations
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Recruiting
    Start
    2022-04-04
    Completion
    2029-12-01
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLung Cancer; Gastric Cancer; Esophageal Cancer
    InterventionVitamin D3 Drops; Coriolus Versicolor; Trident SAP 66:33 Lemon; Probiotic Pro12 +6 more
    PhasePhase 3
    Registry statusRecruiting

  • Magnesium and Vitamin D Combination for Post-COVID Syndrome

    NCT05630339 · start 2022-01-30

    Registered record
    Registry ID
    NCT05630339
    Conditions
    Post-COVID-19 Syndrome; Long COVID; Vitamin D Deficiency; Magnesium Deficiency
    Interventions
    Magnesium chloride; Vitamin D; Inert placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2022-01-30
    Completion
    2023-09-01
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-COVID-19 Syndrome; Long COVID; Vitamin D Deficiency; Magnesium Deficiency
    InterventionMagnesium chloride; Vitamin D; Inert placebo
    PhaseNot applicable
    Registry statusCompleted

  • C Reactive Protein in Home Quarantined Coronavirus Disease 2019 (COVID -19) Patients.

    NCT04935515 · start 2021-04-15

    Registered record
    Registry ID
    NCT04935515
    Conditions
    COVID -19
    Interventions
    Oral Antibiotic, Antihistamine, Anti-inflammatory, Multivitamins; Oral low dose steroid; Intravenous Antibiotics with Low dose steroid.; Oral anti-coagulant
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2021-04-15
    Completion
    2021-06-06
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCOVID -19
    InterventionOral Antibiotic, Antihistamine, Anti-inflammatory, Multivitamins; Oral low dose steroid; Intravenous Antibiotics with Low dose steroid.; Oral anti-coagulant
    PhaseNot applicable
    Registry statusCompleted

  • Clinical Efficacy and Safety Comparative Study Between CMAB807 Injection and Prolia® .

    NCT04591275 · start 2021-03-31

    Registered record
    Registry ID
    NCT04591275
    Conditions
    Postmenopausal Osteoporosis
    Interventions
    CMAB807 Injection; Prolia®
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2021-03-31
    Completion
    2024-11-01
    Enrolment
    278

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostmenopausal Osteoporosis
    InterventionCMAB807 Injection; Prolia®
    PhasePhase 3
    Registry statusCompleted

  • Effects of a Paleolithic Lifestyle Intervention in Breast Cancer Patients Undergoing Radiotherapy

    NCT04574323 · start 2020-03-19

    Registered record
    Registry ID
    NCT04574323
    Conditions
    Breast Cancer; Body Weight Changes
    Interventions
    Curative radiotherapy; Paleolithic lifestyle intervention
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2020-03-19
    Completion
    2020-07-16
    Enrolment
    13

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer; Body Weight Changes
    InterventionCurative radiotherapy; Paleolithic lifestyle intervention
    PhaseNot applicable
    Registry statusCompleted