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AMR Drug RepurposingSmart Screeningresearch prototype

Risperidone

FDA-approved product (tablet, oral), marketed as Perseris Kit, Risperdal, Risperdal Consta and 4 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Risperidone
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Aggressive behavior
  • Autism
  • Bipolar disorder
  • Bipolar I disorder
  • Psychosis
  • Schizoaffective disorder
  • Schizophrenia

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antipsychotics
FDA pharmacologic class
Atypical Antipsychotic FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against K. pneumoniae, MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA66.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli54.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae43.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis56.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Risperidone in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.9 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.5 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-10.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Risperidone with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Unraveling the Relation of Patient's Profile and Therapeutical Effects of Atypicals, Including Quetiapine Effect

    NCT00534222 · start 2005-09

    Registered record
    Registry ID
    NCT00534222
    Conditions
    Mania; Schizophrenia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2005-09
    Completion
    2007-12
    Enrolment
    387

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMania; Schizophrenia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • An Efficacy and Safety Study of Long-Term Risperidone Microspheres in Participants With Schizophrenia

    NCT00269919 · start 2005-08

    Registered record
    Registry ID
    NCT00269919
    Conditions
    Schizophrenia; Schizoaffective Disorder
    Interventions
    Risperidone Long-Acting Injectable (RLAI)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-08
    Completion
    2008-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder
    InterventionRisperidone Long-Acting Injectable (RLAI)
    PhasePhase 4
    Registry statusCompleted

  • SPECT Investigation Of The NMDA Receptor System In Healthy Volunteers And Patients With Schizophrenia

    NCT00364429 · start 2005-07

    Registered record
    Registry ID
    NCT00364429
    Conditions
    Schizophrenia
    Interventions
    [123]I-CNS 1261; Lorazepam; Risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Terminated
    Start
    2005-07
    Completion
    2005-07
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    Intervention[123]I-CNS 1261; Lorazepam; Risperidone
    PhasePhase 1
    Registry statusTerminated

  • A Switch Study of BMS-337039 in Schizophrenic Out-patients

    NCT00232687 · start 2005-06-01

    Registered record
    Registry ID
    NCT00232687
    Conditions
    Schizophrenia
    Interventions
    Aripiprazole; Aripiprazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-06-01
    Completion
    2007-04-01
    Enrolment
    450

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionAripiprazole; Aripiprazole
    PhasePhase 4
    Registry statusCompleted

  • Use of Risperidone in ECT for Treatment Resistant Depression

    NCT00203723 · start 2005-03

    Registered record
    Registry ID
    NCT00203723
    Conditions
    Major Depression
    Interventions
    Risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2005-03
    Completion
    2006-05
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depression
    InterventionRisperidone
    PhasePhase 4
    Registry statusTerminated

  • Investigate Risperidone for the Treatment of Schizophrenia in Adolescents

    NCT00088075 · start 2004-08

    Registered record
    Registry ID
    NCT00088075
    Conditions
    Schizophrenia
    Interventions
    Risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-08
    Completion
    2005-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionRisperidone
    PhasePhase 3
    Registry statusCompleted

  • A Study to Compare the Efficacy and Safety of Ziprasidone and Risperidone for the Treatment of Schizophrenia in Chinese Patients

    NCT00645372 · start 2004-07

    Registered record
    Registry ID
    NCT00645372
    Conditions
    Schizophrenia
    Interventions
    Risperidone; Ziprasidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-07
    Completion
    2005-05
    Enrolment
    242

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionRisperidone; Ziprasidone
    PhasePhase 3
    Registry statusCompleted

  • Determining the Effects of Risperdal Consta in Patients With Psychotic Disorders and Incomplete Adherence

    NCT00215579 · start 2004-04

    Registered record
    Registry ID
    NCT00215579
    Conditions
    Schizophrenia; Schizoaffective Disorder
    Interventions
    Depot Risperidone Microsphere (Consta)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-04
    Completion
    2006-04
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder
    InterventionDepot Risperidone Microsphere (Consta)
    PhasePhase 4
    Registry statusCompleted

  • Risperdal Consta for Bipolar Disorder

    NCT00177164 · start 2003-11

    Registered record
    Registry ID
    NCT00177164
    Conditions
    Bipolar I Disorder
    Interventions
    Injectable Risperidone (Consta) or oral antipsychotic
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-11
    Completion
    2009-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar I Disorder
    InterventionInjectable Risperidone (Consta) or oral antipsychotic
    PhasePhase 3
    Registry statusCompleted

  • Seroquel Therapy for Substance Use Disorders Comorbid With Schizophrenia

    NCT00208143 · start 2003-11

    Registered record
    Registry ID
    NCT00208143
    Conditions
    Schizophrenia; Schizoaffective Disorder; Substance Abuse; Substance Dependence
    Interventions
    Quetiapine; Risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-11
    Completion
    2005-12
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia; Schizoaffective Disorder; Substance Abuse; Substance Dependence
    InterventionQuetiapine; Risperidone
    PhasePhase 4
    Registry statusCompleted

  • A Comparison of Two Standard Therapies in the Management of Dementia With Agitation

    NCT00208819 · start 2003-09

    Registered record
    Registry ID
    NCT00208819
    Conditions
    Senile Dementia, Alzheimer Type; Dementia, Alzheimer Type; Alzheimer Disease; Dementia
    Interventions
    risperidone; quetiapine; olanzapine; divalproex
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-09
    Completion
    2007-07
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSenile Dementia, Alzheimer Type; Dementia, Alzheimer Type; Alzheimer Disease; Dementia
    Interventionrisperidone; quetiapine; olanzapine; divalproex
    PhasePhase 4
    Registry statusCompleted

  • A Prospective Study of Risperdal (Risperidone) for the Treatment of Behavioral Disorder Following Psychological Therapy for Challenging Behavior in Learning Disabled Children

    NCT00254930 · start 2003-09

    Registered record
    Registry ID
    NCT00254930
    Conditions
    Learning Disorders; Child Behavior Disorders
    Interventions
    risperidone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-09
    Completion
    2006-06
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLearning Disorders; Child Behavior Disorders
    Interventionrisperidone
    PhasePhase 3
    Registry statusCompleted

  • Risperidone Augmentation in Patients With Schizophrenia

    NCT00289861 · start 2003-02

    Registered record
    Registry ID
    NCT00289861
    Conditions
    Schizophrenia
    Interventions
    Risperidone; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-02
    Completion
    2007-03
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionRisperidone; placebo
    PhasePhase 4
    Registry statusCompleted

  • Atypical Antipsychotics for Continuation and Maintenance Treatment After an Acute Manic Episode

    NCT01977300 · start 2003-01

    Registered record
    Registry ID
    NCT01977300
    Conditions
    Bipolar I Disorder
    Interventions
    Valproate; Lithium; Risperidone; Olanzapine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2003-01
    Completion
    2011-08
    Enrolment
    159

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar I Disorder
    InterventionValproate; Lithium; Risperidone; Olanzapine +1 more
    PhasePhase 3
    Registry statusCompleted

  • Risperidone Versus Olanzapine for Mania in Preschool Children 4 to 6 Years of Age With Bipolar Disorder

    NCT00181935 · start 2001-03

    Registered record
    Registry ID
    NCT00181935
    Conditions
    Bipolar Disorder; Mania
    Interventions
    risperidone (Risperdal); olanzapine (Zyprexa)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2001-03
    Completion
    2004-07
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Disorder; Mania
    Interventionrisperidone (Risperdal); olanzapine (Zyprexa)
    PhasePhase 4
    Registry statusCompleted