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AMR Drug RepurposingSmart Screeningresearch prototype

Methicillin Sodium

FDA-approved product (injectable, injection), marketed as Staphcillin.

Registered studies
50+
Lab records
29
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Methicillin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Beta-lactamase resistant penicillins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CF03

Repurposing investigation

Methicillin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA10.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli4.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae10.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis35.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 8 of 26 lab records
  • E. coli: measured active in 0 of 2 lab records
  • K. pneumoniae: measured active in 0 of 1 lab record
Open Methicillin Sodium in ChEMBL Registered studies below
Show the 29 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Methicillin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy Study of Altabax to Clear Methicillin-resistant Staphylococcus Aureus (MRSA) Nasal Colonization

    NCT00856089 · start 2009-05

    Registered record
    Registry ID
    NCT00856089
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    Retapamulin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2009-05
    Completion
    2009-10
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    InterventionRetapamulin
    PhasePhase 4
    Registry statusWithdrawn

  • Retapamulin Versus Linezolid in the Treatment of SITL and Impetigo Due to MRSA

    NCT00852540 · start 2009-04

    Registered record
    Registry ID
    NCT00852540
    Conditions
    Skin Infections, Bacterial
    Interventions
    Retpamulin Ointment, 1%; Linezolid
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-04
    Completion
    2010-09
    Enrolment
    410

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Infections, Bacterial
    InterventionRetpamulin Ointment, 1%; Linezolid
    PhasePhase 3
    Registry statusCompleted

  • Immunologic Predisposition of HIV Patients to Develop Methicillin-Resistant Staphylococcus Aureus (MRSA) Colonization and Infection

    NCT00859677 · start 2009-03

    Registered record
    Registry ID
    NCT00859677
    Conditions
    HIV Infections; Staphylococcal Infections
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2009-03
    Completion
    2016-08-26
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Staphylococcal Infections
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Clinical Trial on the Reduction of Methicillin Resistant Staphylococcus Aureus (MRSA)

    NCT00790608 · start 2009-01

    Registered record
    Registry ID
    NCT00790608
    Conditions
    Skin Ulcers; Methicillin-resistant Staphylococcus Aureus Infection
    Interventions
    Nitric Oxide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2009-01
    Completion
    2011-08
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Ulcers; Methicillin-resistant Staphylococcus Aureus Infection
    InterventionNitric Oxide
    PhasePhase 2
    Registry statusTerminated

  • Emergency Bedside Ultrasound for Pediatric Soft Tissue Infections

    NCT00595881 · start 2008-07

    Registered record
    Registry ID
    NCT00595881
    Conditions
    Abscess
    Interventions
    Bedside emergency ultrasound
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-07
    Completion
    2010-05
    Enrolment
    420

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscess
    InterventionBedside emergency ultrasound
    PhaseNot recorded
    Registry statusCompleted

  • Staphylococcus Aureus Decolonization Study

    NCT00731783 · start 2008-07

    Registered record
    Registry ID
    NCT00731783
    Conditions
    Staphylococcal Skin Infections; Abscesses; Furunculosis; Staphylococcus Aureus; MRSA Infection
    Interventions
    2% Mupirocin Ointment; 4% Chlorhexidine liquid soap; Hygiene protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-07
    Completion
    2010-12
    Enrolment
    183

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcal Skin Infections; Abscesses; Furunculosis; Staphylococcus Aureus +1 more
    Intervention2% Mupirocin Ointment; 4% Chlorhexidine liquid soap; Hygiene protocol
    PhaseNot applicable
    Registry statusCompleted

  • Two Strategies for Methicillin-resistant Staphylococcus Aureus (MRSA) Infection Prevention in Surgical Patients

    NCT00685867 · start 2008-05

    Registered record
    Registry ID
    NCT00685867
    Conditions
    MRSA Infection
    Interventions
    Rapid molecular MRSA test; Hand hygiene promotion
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-05
    Completion
    2010-12
    Enrolment
    126,750

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA Infection
    InterventionRapid molecular MRSA test; Hand hygiene promotion
    PhaseNot applicable
    Registry statusCompleted

  • A Prospective Cohort Pilot Study of the Clinical and Molecular Epidemiology of Staphylococcus Aureus in Pregnant Women at the Time of Group B Streptococcal Screening in a Large Urban Medical Center in Chicago, IL USA

    NCT00532324 · start 2008-02

    Registered record
    Registry ID
    NCT00532324
    Conditions
    Staphylococcus Aureus
    Interventions
    CA-MRSA Decolonization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-02
    Completion
    2013-10
    Enrolment
    107

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionCA-MRSA Decolonization
    PhaseNot applicable
    Registry statusCompleted

  • Incidence and Relationship of Positive Preoperative Methicillin Resistant Staphylococcus Aureus (MRSA) Screens and Post-operative Infections

    NCT01028105 · start 2008-02

    Registered record
    Registry ID
    NCT01028105
    Conditions
    Methicillin-resistant Staphylococcus Aureus Infection
    Interventions
    Preoperative MRSA screening
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2008-02
    Completion
    2013-10
    Enrolment
    975

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus Infection
    InterventionPreoperative MRSA screening
    PhaseNot applicable
    Registry statusTerminated

  • Prospective Randomized Trial of Bactrim on 7 Day Outcome in Patients With Uncomplicated Abscesses

    NCT00973765 · start 2007-11

    Registered record
    Registry ID
    NCT00973765
    Conditions
    Abscesses
    Interventions
    bactrim; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-11
    Completion
    2009-08
    Enrolment
    212

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscesses
    Interventionbactrim; placebo
    PhasePhase 3
    Registry statusCompleted

  • Prospective Study of Methicillin-Resistant Staphylococcus Aureus (MRSA) Among HIV-Infected Persons

    NCT00631566 · start 2007-05

    Registered record
    Registry ID
    NCT00631566
    Conditions
    HIV Infections; Staphylococcal Infections
    Interventions
    Mupirocin (Bactroban) 2%; hexachlorophene (pHisoHex) 3%; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-05
    Completion
    2017-10
    Enrolment
    550

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections; Staphylococcal Infections
    InterventionMupirocin (Bactroban) 2%; hexachlorophene (pHisoHex) 3%; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Comparative Study of Ceftaroline vs. Vancomycin Plus Aztreonam in Adult Subjects With Complicated Skin Infections

    NCT00423657 · start 2007-03

    Registered record
    Registry ID
    NCT00423657
    Conditions
    Bacterial Infections
    Interventions
    ceftaroline; vancomycin plus aztreonam; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-03
    Completion
    2007-12
    Enrolment
    680

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections
    Interventionceftaroline; vancomycin plus aztreonam; Placebo
    PhasePhase 3
    Registry statusCompleted

  • Study Evaluating the Safety and Efficacy of a Once-daily Dose of Tigecycline vs Ertapenem in Diabetic Foot Infections (DFI) With a Substudy in Patients With Diabetic Foot Infections Complicated by Osteomyelitis.

    NCT00366249 · start 2007-01

    Registered record
    Registry ID
    NCT00366249
    Conditions
    Bacterial Infections; Diabetic Foot; Osteomyelitis
    Interventions
    Tigecycline; Ertapenem
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-01
    Completion
    2009-03
    Enrolment
    1,061

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacterial Infections; Diabetic Foot; Osteomyelitis
    InterventionTigecycline; Ertapenem
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Cephalexin Versus Clindamycin for Suspected CA-MRSA Skin Infections

    NCT00352612 · start 2006-09

    Registered record
    Registry ID
    NCT00352612
    Conditions
    Staphylococcal Infection; Abscess; Staphylococcal Skin Infection; Folliculitis
    Interventions
    clindamycin; cephalexin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2009-08
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcal Infection; Abscess; Staphylococcal Skin Infection; Folliculitis
    Interventionclindamycin; cephalexin
    PhasePhase 4
    Registry statusCompleted

  • Study Comparing the Safety and Efficacy of Tigecycline With Ampicillin-Sulbactam or Amoxicillin-Clavulanate to Treat Skin Infections

    NCT00368537 · start 2006-09

    Registered record
    Registry ID
    NCT00368537
    Conditions
    Skin Diseases, Bacterial
    Interventions
    Tigecycline; ampicillin-sulbactam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2008-09
    Enrolment
    550

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSkin Diseases, Bacterial
    InterventionTigecycline; ampicillin-sulbactam
    PhasePhase 4
    Registry statusCompleted