Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Methicillin Sodium

FDA-approved product (injectable, injection), marketed as Staphcillin.

Registered studies
50+
Lab records
29
Pathogens at ≥40%
0 of 4

Chemical structure

Chemical structure of Methicillin Sodium
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Beta-lactamase resistant penicillins
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01CF03

Repurposing investigation

Methicillin Sodium is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA10.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli4.3% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae10.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis35.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • MRSA: measured active in 8 of 26 lab records
  • E. coli: measured active in 0 of 2 lab records
  • K. pneumoniae: measured active in 0 of 1 lab record
Open Methicillin Sodium in ChEMBL Registered studies below
Show the 29 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Methicillin Sodium with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Analysis of CA-MRSA Transmission: An ED Population Sampling Strategy

    NCT02363166 · start 2015-08

    Registered record
    Registry ID
    NCT02363166
    Conditions
    Methicillin-Resistant Staphylococcus Aureus
    Interventions
    Acute Abscess Group
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-08
    Completion
    2018-04-04
    Enrolment
    575

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-Resistant Staphylococcus Aureus
    InterventionAcute Abscess Group
    PhaseNot recorded
    Registry statusCompleted

  • MICRO Study: Detecting Bacterial Infections Related to Orthopaedic Surgical Implants

    NCT03132246 · start 2014-04

    Registered record
    Registry ID
    NCT03132246
    Conditions
    Open Reduction and Internal Fixation of Extremity Fractures
    Interventions
    Blood draws
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-04
    Completion
    2018-07-31
    Enrolment
    260

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOpen Reduction and Internal Fixation of Extremity Fractures
    InterventionBlood draws
    PhaseNot recorded
    Registry statusCompleted

  • Vancomycin Versus Daptomycin for the Treatment of Methicillin Resistant Staphylococcus Aureus (MRSA) Bacteremia

    NCT01975662 · start 2014-01

    Registered record
    Registry ID
    NCT01975662
    Conditions
    Bacteremia Due to Staphylococcus Aureus
    Interventions
    Daptomycin; Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2014-01
    Completion
    2015-12
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia Due to Staphylococcus Aureus
    InterventionDaptomycin; Vancomycin
    PhasePhase 2
    Registry statusTerminated

  • Pharmacokinetics/ Pharmacodynamics (PK/PD) Study of Vancomycin

    NCT02443064 · start 2014-01

    Registered record
    Registry ID
    NCT02443064
    Conditions
    Blood Stream Infections; Endocarditis; MRSA
    Interventions
    Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-01
    Completion
    2016-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBlood Stream Infections; Endocarditis; MRSA
    InterventionVancomycin
    PhasePhase 4
    Registry statusUnknown

  • Efficacy of a Short-term Sequential Therapy in Non-complicated Catheter Related Bacteremia by Methicillin- Susceptible S.Aureus.

    NCT01875263 · start 2013-05

    Registered record
    Registry ID
    NCT01875263
    Conditions
    Staphylococcus
    Interventions
    Cloxacilin; Cloxacillin; Levofloxacin
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2013-05
    Completion
    2014-11
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus
    InterventionCloxacilin; Cloxacillin; Levofloxacin
    PhasePhase 3
    Registry statusTerminated

  • Study of the Performance of the KeyPath MRSA/MSSA Blood Culture Test - BTA

    NCT01640886 · start 2012-06

    Registered record
    Registry ID
    NCT01640886
    Conditions
    Bacteremia
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2012-06
    Completion
    2012-12
    Enrolment
    764

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBacteremia
    InterventionNot recorded
    PhaseNot recorded
    Registry statusTerminated

  • Daptomycin Versus Vancomycin in the Treatment of Nosocomial or Healthcare-associated MRSA Bacteremia

    NCT01515020 · start 2012-05

    Registered record
    Registry ID
    NCT01515020
    Conditions
    Nosocomial Infection; Healthcare-associated Infection
    Interventions
    vancomycin monotherapy; daptomycin monotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2012-05
    Completion
    2014-07
    Enrolment
    10

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNosocomial Infection; Healthcare-associated Infection
    Interventionvancomycin monotherapy; daptomycin monotherapy
    PhasePhase 3
    Registry statusTerminated

  • Early Methicillin-resistant Staphylococcus Aureus (MRSA) Therapy in Cystic Fibrosis (CF)

    NCT01349192 · start 2011-04

    Registered record
    Registry ID
    NCT01349192
    Conditions
    Cystic Fibrosis; Methicillin-resistant Staphylococcus Aureus
    Interventions
    Rifampin; Trimethoprim/Sulfamethoxazole; Minocycline; Mupirocin; chlorhexidine gluconate oral rinse; 2% Chlorhexidine solution wipes; Environmental Decontamination
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-04
    Completion
    2015-05
    Enrolment
    47

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCystic Fibrosis; Methicillin-resistant Staphylococcus Aureus
    InterventionRifampin; Trimethoprim/Sulfamethoxazole; Minocycline; Mupirocin +3 more
    PhasePhase 2
    Registry statusTerminated

  • Community-acquired Methicillin-Resistant Staphylococcus Aureus Carriage Among Athletes

    NCT01148485 · start 2011-01

    Registered record
    Registry ID
    NCT01148485
    Conditions
    Staphylococcus Aureus
    Interventions
    Nasal, throat, inguinal and skin lesions swab samples will be performed
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-01
    Completion
    2011-12
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus
    InterventionNasal, throat, inguinal and skin lesions swab samples will be performed
    PhaseNot recorded
    Registry statusCompleted

  • Risk Factors for Early Infant Colonization With Methicillin-Resistant Staphylococcus Aureus

    NCT01141101 · start 2010-06

    Registered record
    Registry ID
    NCT01141101
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2010-06
    Completion
    2012-06
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Methicillin-resistant Staphylococcus Aureus (MRSA) Skin and Soft Tissue Infection (SSTI) Prevention in Military Trainees

    NCT01105767 · start 2010-05

    Registered record
    Registry ID
    NCT01105767
    Conditions
    Staphylococcus Aureus; MRSA Skin Infections; Staphylococcal Skin Infections
    Interventions
    Chlorhexidine gluconate; Supplemental training, education and hygiene
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-05
    Completion
    2012-01
    Enrolment
    30,209

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStaphylococcus Aureus; MRSA Skin Infections; Staphylococcal Skin Infections
    InterventionChlorhexidine gluconate; Supplemental training, education and hygiene
    PhaseNot applicable
    Registry statusCompleted

  • Randomized Controlled Trial of Antibiotics in the Management of Children With Community-Acquired Abscess

    NCT01498744 · start 2010-02

    Registered record
    Registry ID
    NCT01498744
    Conditions
    Abscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    Interventions
    Oral Clindamycin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2010-02
    Completion
    2013-02
    Enrolment
    53

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbscess Soft Tissue; Methicillin-resistant Staphylococcus Aureus (MRSA) Infection; Skin Abscess
    InterventionOral Clindamycin
    PhaseNot applicable
    Registry statusTerminated

  • Epidemiology and Prevention of Methicillin Resistant Staphylococcus Aureus (MRSA) Transmission in the Community

    NCT00966446 · start 2009-09

    Registered record
    Registry ID
    NCT00966446
    Conditions
    MRSA - Methicillin Resistant Staphylococcus Aureus Infection
    Interventions
    Unsupervised Decolonization; Supervised Decolonization
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2014-12
    Enrolment
    223

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMRSA - Methicillin Resistant Staphylococcus Aureus Infection
    InterventionUnsupervised Decolonization; Supervised Decolonization
    PhaseNot applicable
    Registry statusCompleted

  • Cluster Randomized Trial of Hospitals to Assess Impact of Targeted Versus Universal Strategies to Reduce Methicillin-resistant Staphylococcus Aureus (MRSA) in Intensive Care Units (ICUs)

    NCT00980980 · start 2009-09

    Registered record
    Registry ID
    NCT00980980
    Conditions
    Methicillin-resistant Staphylococcus Aureus
    Interventions
    Chlorhexidine bath and nasal mupirocin
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-09
    Completion
    2011-09
    Enrolment
    74,256

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMethicillin-resistant Staphylococcus Aureus
    InterventionChlorhexidine bath and nasal mupirocin
    PhaseNot applicable
    Registry statusCompleted

  • Fosfomycin Plus Imipenem for Treatment of Infective Endocarditis

    NCT00871104 · start 2009-07

    Registered record
    Registry ID
    NCT00871104
    Conditions
    Infective Endocarditis
    Interventions
    Fosfomycin and imipenem; Vancomycin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-07
    Completion
    2015-04-15
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfective Endocarditis
    InterventionFosfomycin and imipenem; Vancomycin
    PhasePhase 4
    Registry statusCompleted