Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Lisinopril

FDA-approved product (tablet, oral), marketed as Lisinopril, Prinivil, Qbrelis and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Lisinopril
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Congestive heart failure
  • Diabetes mellitus
  • Heart failure
  • Hypertension
  • Myocardial infarction
  • Stroke

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Ace inhibitors, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA39.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli29.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis65.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lisinopril in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lisinopril with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Prognostic Value of the Circadian Pattern of Ambulatory Blood Pressure for Multiple Risk Assessment

    NCT00741585 · start 2008-09-01

    Registered record
    Registry ID
    NCT00741585
    Conditions
    Essential Hypertension; Cardiovascular Disease; Stroke; Chronic Kidney Disease
    Interventions
    Any antihypertensive medication alone or in combination; Any antihypertensive medication alone or in combination; Ambulatory blood pressure monitoring
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-09-01
    Completion
    2018-06-30
    Enrolment
    21,983

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEssential Hypertension; Cardiovascular Disease; Stroke; Chronic Kidney Disease
    InterventionAny antihypertensive medication alone or in combination; Any antihypertensive medication alone or in combination; Ambulatory blood pressure monitoring
    PhasePhase 4
    Registry statusCompleted

  • Aliskiren and Renin Inhibition in Diastolic Heart Failure

    NCT00773084 · start 2008-09

    Registered record
    Registry ID
    NCT00773084
    Conditions
    Diastolic Heart Failure
    Interventions
    Aliskiren plus spironolactone vs. Lisinopril plus spironolactone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2008-09
    Completion
    2009-08
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiastolic Heart Failure
    InterventionAliskiren plus spironolactone vs. Lisinopril plus spironolactone
    PhaseNot applicable
    Registry statusWithdrawn

  • VA NEPHRON-D: Diabetes iN Nephropathy Study

    NCT00555217 · start 2008-07

    Registered record
    Registry ID
    NCT00555217
    Conditions
    Kidney Disease; Nephropathy; Type 2 Diabetes
    Interventions
    losartan; lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2008-07
    Completion
    2014-10
    Enrolment
    1,448

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKidney Disease; Nephropathy; Type 2 Diabetes
    Interventionlosartan; lisinopril
    PhasePhase 3
    Registry statusTerminated

  • Modulating Effects of Lisinopril on Sildenafil Activity in Pulmonary Arterial Hypertension(PAH)( MELISSA)

    NCT01181284 · start 2008-05

    Registered record
    Registry ID
    NCT01181284
    Conditions
    Pulmonary Arterial Hypertension
    Interventions
    Not recorded
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2008-05
    Completion
    2011-07
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPulmonary Arterial Hypertension
    InterventionNot recorded
    PhaseNot recorded
    Registry statusCompleted

  • Research Study To Test Carvedilol CR + Lisinopril Versus Lisinopril + Placebo In Patients With High Blood Pressure

    NCT00624065 · start 2008-03

    Registered record
    Registry ID
    NCT00624065
    Conditions
    Hypertension
    Interventions
    carvedilol controlled release/lisinopril; lisinopril + placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-03
    Completion
    2008-08
    Enrolment
    348

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventioncarvedilol controlled release/lisinopril; lisinopril + placebo
    PhasePhase 3
    Registry statusCompleted

  • Renal Protective Effect of ACEI and ARB in Primary Hyperoxaluria

    NCT00280215 · start 2007-12

    Registered record
    Registry ID
    NCT00280215
    Conditions
    Hyperoxaluria
    Interventions
    ACEI / Angiotensin converting enzyme inhibitor; ARB /Angiotensin Receptor Blocker; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2007-12
    Completion
    2011-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyperoxaluria
    InterventionACEI / Angiotensin converting enzyme inhibitor; ARB /Angiotensin Receptor Blocker; Placebo
    PhasePhase 3
    Registry statusWithdrawn

  • A Study to Compare COREG CR to COREG CR Fixed-dose Combination in Patients With High Blood Pressure

    NCT00537043 · start 2007-10

    Registered record
    Registry ID
    NCT00537043
    Conditions
    Hypertension
    Interventions
    SK&F-105517 (COREG CR FDC)
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-10
    Completion
    2008-01
    Enrolment
    24

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionSK&F-105517 (COREG CR FDC)
    PhasePhase 1
    Registry statusCompleted

  • A Study Investigating the Bioequivalence of the Fixed Dose Combination of COREG CR to COREG CR and ZESTRIL.

    NCT00552708 · start 2007-09

    Registered record
    Registry ID
    NCT00552708
    Conditions
    Hypertension
    Interventions
    COREG CR; Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2007-09
    Completion
    2007-12
    Enrolment
    55

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionCOREG CR; Lisinopril
    PhasePhase 1
    Registry statusCompleted

  • The Vascular Effects of Carvedilol Controlled Release (CR) in Abdominally Obese Hypertensive Patients

    NCT00459056 · start 2007-04

    Registered record
    Registry ID
    NCT00459056
    Conditions
    Abdominal Obesity; Hypertension
    Interventions
    Carvedilol CR + Lisinopril; Lisinopril + HCTZ
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2007-04
    Completion
    2010-05
    Enrolment
    25

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAbdominal Obesity; Hypertension
    InterventionCarvedilol CR + Lisinopril; Lisinopril + HCTZ
    PhasePhase 3
    Registry statusCompleted

  • Reducing Total Cardiovascular Risk in an Urban Community

    NCT00241904 · start 2006-05

    Registered record
    Registry ID
    NCT00241904
    Conditions
    Cardiovascular Diseases; Heart Diseases; Coronary Disease; Diabetes Mellitus; Atherosclerosis; Cerebral Arteriosclerosis; Hypertension
    Interventions
    Lifestyle Changes; Antiplatelet Agents; Beta Blocker; ACE Inhibitors
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-05
    Completion
    2010-05
    Enrolment
    525

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Diseases; Heart Diseases; Coronary Disease; Diabetes Mellitus +3 more
    InterventionLifestyle Changes; Antiplatelet Agents; Beta Blocker; ACE Inhibitors
    PhasePhase 4
    Registry statusCompleted

  • The Effects on Blood Pressure Control, Pulse Wave Velocity, as Well as Safety and Tolerability of Felodipine Sustained Release in Chinese Patients.

    NCT02336607 · start 2005-12

    Registered record
    Registry ID
    NCT02336607
    Conditions
    Hypertension
    Interventions
    Felodipine tablet (Plendil) alone; Felodipine tablet (Plendil)+Hydrochlorothiazide; Felodipine tablet (Plendil)+Metoprolol tablet (Betaloc ZOK); Felodipine tablets (Plendil)+Lisinopril (Zestril)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-12
    Completion
    2006-08
    Enrolment
    529

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionFelodipine tablet (Plendil) alone; Felodipine tablet (Plendil)+Hydrochlorothiazide; Felodipine tablet (Plendil)+Metoprolol tablet (Betaloc ZOK); Felodipine tablets (Plendil)+Lisinopril (Zestril)
    PhaseNot applicable
    Registry statusCompleted

  • Hypertension in Hemodialysis Patients (Aim 3)

    NCT00582114 · start 2005-08

    Registered record
    Registry ID
    NCT00582114
    Conditions
    Hemodialysis; Hypertension; Left Ventricular Hypertrophy
    Interventions
    Lisinopril; Atenolol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2005-08
    Completion
    2013-09
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemodialysis; Hypertension; Left Ventricular Hypertrophy
    InterventionLisinopril; Atenolol
    PhasePhase 3
    Registry statusTerminated

  • The Canadian Prevention of Renal and Cardiovascular Endpoints Trial

    NCT00231803 · start 2005-04

    Registered record
    Registry ID
    NCT00231803
    Conditions
    Chronic Kidney Disease
    Interventions
    Combined CKD and CVD Prevention; Cardiovascular Disease prevention; Treatment of Chronic Kidney Disease complications; Usual care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2005-04
    Completion
    2008-06
    Enrolment
    474

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChronic Kidney Disease
    InterventionCombined CKD and CVD Prevention; Cardiovascular Disease prevention; Treatment of Chronic Kidney Disease complications; Usual care
    PhaseNot applicable
    Registry statusCompleted

  • Interaction Between Antihypertensives and Non-Steroidal Anti-Inflammatory Drugs (NSAIDs)

    NCT00631514 · start 2005-01

    Registered record
    Registry ID
    NCT00631514
    Conditions
    Hypertension
    Interventions
    acetaminophen; ibuprofen; piroxicam
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2005-01
    Completion
    2006-09
    Enrolment
    88

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventionacetaminophen; ibuprofen; piroxicam
    PhasePhase 4
    Registry statusCompleted

  • Antiproteinuric Effect of Valsartan and Lisinopril

    NCT00171574 · start 2004-11

    Registered record
    Registry ID
    NCT00171574
    Conditions
    Hypertension; Diabetic Nephropathy
    Interventions
    Valsartan; Valsartan plus HCTZ; Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-11
    Completion
    2006-07
    Enrolment
    124

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Diabetic Nephropathy
    InterventionValsartan; Valsartan plus HCTZ; Lisinopril
    PhasePhase 4
    Registry statusCompleted