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AMR Drug RepurposingSmart Screeningresearch prototype

Lisinopril

FDA-approved product (tablet, oral), marketed as Lisinopril, Prinivil, Qbrelis and 1 more.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Lisinopril
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Cardiovascular disease
  • Congestive heart failure
  • Diabetes mellitus
  • Heart failure
  • Hypertension
  • Myocardial infarction
  • Stroke

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Ace inhibitors, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA39.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli29.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae23.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis65.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Lisinopril in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Lisinopril with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Remission From Stage D Heart Failure

    NCT01774656 · start 2013-01

    Registered record
    Registry ID
    NCT01774656
    Conditions
    Heart Failure NYHA Class III; Heart Failure NYHA Class IV
    Interventions
    Pharmacological Treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-01
    Completion
    2017-12
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure NYHA Class III; Heart Failure NYHA Class IV
    InterventionPharmacological Treatment
    PhasePhase 4
    Registry statusUnknown

  • Non-invasive Haemodynamic Assessment in Hypertension

    NCT01996085 · start 2013-01

    Registered record
    Registry ID
    NCT01996085
    Conditions
    Arterial Hypertension
    Interventions
    lisinopril; Telmisartan; Nebivolol; Indapamide/hydrochlorothiazide; Amlodipine; lisinopril; Telmisartan; Nebivolol; Indapamide/hydrochlorothiazide; Amlodipine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-01
    Completion
    2017-12
    Enrolment
    144

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArterial Hypertension
    Interventionlisinopril; Telmisartan; Nebivolol; Indapamide/hydrochlorothiazide +6 more
    PhaseNot applicable
    Registry statusCompleted

  • Single Pill to Avert Cardiovascular Events

    NCT01313702 · start 2012-10

    Registered record
    Registry ID
    NCT01313702
    Conditions
    Cardiovascular Disease
    Interventions
    polipillV1; polipillV2; usual care
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Withdrawn
    Start
    2012-10
    Completion
    2014-07
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Disease
    InterventionpolipillV1; polipillV2; usual care
    PhasePhase 3
    Registry statusWithdrawn

  • The Renin-Angiotensin-Aldosterone System and Parathyroid Hormone Control: The RAAS-PARC Study

    NCT01691781 · start 2012-10

    Registered record
    Registry ID
    NCT01691781
    Conditions
    Hyperparathyroidism
    Interventions
    Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-10
    Completion
    2016-12
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyperparathyroidism
    InterventionLisinopril
    PhaseNot applicable
    Registry statusCompleted

  • Bioequivalence Study of Lisinopril and Hydrochlorothiazide Tablets (20+25) mg Under Fasting Conditions

    NCT01831700 · start 2012-10

    Registered record
    Registry ID
    NCT01831700
    Conditions
    Fasting
    Interventions
    Lisinopril and Hydrochlorothiazide Tablets (20+25) mg; Zestoretic® 20/25 lisinopril/hydrochlorothiazide Tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-10
    Completion
    2012-10
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFasting
    InterventionLisinopril and Hydrochlorothiazide Tablets (20+25) mg; Zestoretic® 20/25 lisinopril/hydrochlorothiazide Tablets
    PhasePhase 1
    Registry statusCompleted

  • Bioequivalence Study of Lisinopril Tablets 40 mg Under Fasting Condition

    NCT01735318 · start 2012-06

    Registered record
    Registry ID
    NCT01735318
    Conditions
    Fasting
    Interventions
    Lisinopril Tablets 40 mg; Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-06
    Completion
    2012-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFasting
    InterventionLisinopril Tablets 40 mg; Lisinopril
    PhasePhase 1
    Registry statusCompleted

  • Bioequivalence Study of Lisinopril Tablets 40 mg Under Fed Condition

    NCT01735344 · start 2012-06

    Registered record
    Registry ID
    NCT01735344
    Conditions
    Fed
    Interventions
    Lisinopril Tablets 40 mg; Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-06
    Completion
    2012-08
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFed
    InterventionLisinopril Tablets 40 mg; Lisinopril
    PhasePhase 1
    Registry statusCompleted

  • Is There a Benefit to Optimize Heart Failure (HF) Treatment in Aged Over 80 Year's Old Patients?

    NCT01437371 · start 2011-08

    Registered record
    Registry ID
    NCT01437371
    Conditions
    Heart Failure
    Interventions
    - Angiotensin conversing enzyme inhibitors: enalapril, captopril, lisinopril, ramipril, trandolapril.
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-08
    Completion
    2014-06
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Failure
    Intervention- Angiotensin conversing enzyme inhibitors: enalapril, captopril, lisinopril, ramipril, trandolapril.
    PhasePhase 3
    Registry statusCompleted

  • A Study of the Effect of LY2189265 on Two Blood Pressure Drugs

    NCT01324388 · start 2011-03

    Registered record
    Registry ID
    NCT01324388
    Conditions
    Diabetes Mellitus, Type 2
    Interventions
    LY2189265; Metoprolol; Lisinopril; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-03
    Completion
    2011-08
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDiabetes Mellitus, Type 2
    InterventionLY2189265; Metoprolol; Lisinopril; Placebo
    PhasePhase 1
    Registry statusCompleted

  • Benazepril Hydrochloride, Lisinopril, Ramipril, or Losartan Potassium in Treating Hypertension in Patients With Solid Tumors

    NCT01234922 · start 2011-02

    Registered record
    Registry ID
    NCT01234922
    Conditions
    Hypertension; Unspecified Adult Solid Tumor, Protocol Specific
    Interventions
    lisinopril; losartan potassium; laboratory biomarker analysis; benazepril hydrochloride; ramipril
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2011-02
    Completion
    2014-04
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension; Unspecified Adult Solid Tumor, Protocol Specific
    Interventionlisinopril; losartan potassium; laboratory biomarker analysis; benazepril hydrochloride +1 more
    PhasePhase 2
    Registry statusTerminated

  • Lisinopril or Coreg CR® in Reducing Side Effects in Women With Breast Cancer Receiving Trastuzumab

    NCT01009918 · start 2010-03

    Registered record
    Registry ID
    NCT01009918
    Conditions
    Breast Cancer; Cardiac Toxicity
    Interventions
    Coreg CR®; lisinopril; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-03
    Completion
    2018-11
    Enrolment
    468

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer; Cardiac Toxicity
    InterventionCoreg CR®; lisinopril; placebo
    PhasePhase 2
    Registry statusCompleted

  • Blood Pressure Effects of Nebivolol Versus Lisinopril in New Onset or Worsening Hypertension Induced by Bevacizumab

    NCT01076140 · start 2010-02

    Registered record
    Registry ID
    NCT01076140
    Conditions
    Hypertension
    Interventions
    Nebivolol; Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Withdrawn
    Start
    2010-02
    Completion
    2011-08
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    InterventionNebivolol; Lisinopril
    PhaseNot applicable
    Registry statusWithdrawn

  • Clinical Trial of Coenzyme Q10 and Lisinopril in Muscular Dystrophies

    NCT01126697 · start 2010-02

    Registered record
    Registry ID
    NCT01126697
    Conditions
    Duchenne Muscular Dystrophy; Becker Muscular Dystrophy; Limb Girdle Muscular Dystrophy
    Interventions
    Coenzyme Q10 and Lisinopril
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2010-02
    Completion
    2017-12
    Enrolment
    63

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDuchenne Muscular Dystrophy; Becker Muscular Dystrophy; Limb Girdle Muscular Dystrophy
    InterventionCoenzyme Q10 and Lisinopril
    PhasePhase 2 / Phase 3
    Registry statusCompleted

  • Polypill For Prevention of Cardiovascular Disease

    NCT00567307 · start 2009-01

    Registered record
    Registry ID
    NCT00567307
    Conditions
    Cardiovascular Disease
    Interventions
    Red Heart Pill 2b (Polypill); Standard Practice
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-01
    Completion
    2010-01
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiovascular Disease
    InterventionRed Heart Pill 2b (Polypill); Standard Practice
    PhasePhase 2
    Registry statusCompleted

  • Physical and Chemical Study of Atherosclerosis Mechanisms

    NCT01700075 · start 2009-01

    Registered record
    Registry ID
    NCT01700075
    Conditions
    Myocardial Infarction; Coronary Artery Diseases; Diabetes Mellitus, Type 2; Atherosclerosis of Femoral Artery
    Interventions
    Conventional treatment; Weight loss treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-01
    Completion
    2011-12
    Enrolment
    97

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Infarction; Coronary Artery Diseases; Diabetes Mellitus, Type 2; Atherosclerosis of Femoral Artery
    InterventionConventional treatment; Weight loss treatment
    PhasePhase 4
    Registry statusCompleted