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AMR Drug RepurposingSmart Screeningresearch prototype

Droperidol

FDA-approved product (injectable, injection), marketed as Droperidol, Inapsine.

Registered studies
42
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Droperidol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Nausea and vomiting
  • Post operative nausea and vomiting
  • Psychosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Butyrophenone derivatives
FDA pharmacologic class
Dopamine-2 Receptor Antagonist FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae32.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

42registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Droperidol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-10.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Droperidol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • TEAS Combined With Triple Antiemetic Drugs to Prevent PONV in High-Risk Patients

    NCT07480785 · start 2026-01-16

    Registered record
    Registry ID
    NCT07480785
    Conditions
    Uterine Fibroids (Leiomyoma); Ovarian Tumors; Gallstones
    Interventions
    transcutaneous electrical acupoint stimulation; Sham transcutaneous electrical acupoint stimulation; triple antiemetic drugs
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2026-01-16
    Completion
    2027-10-31
    Enrolment
    780

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterine Fibroids (Leiomyoma); Ovarian Tumors; Gallstones
    Interventiontranscutaneous electrical acupoint stimulation; Sham transcutaneous electrical acupoint stimulation; triple antiemetic drugs
    PhaseNot applicable
    Registry statusRecruiting

  • Assessment of Drug Liking In Peri-procedural Clinical Settings

    NCT07015528 · start 2025-09-30

    Registered record
    Registry ID
    NCT07015528
    Conditions
    Drug Liking
    Interventions
    Droperidol; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Enrolling by invitation
    Start
    2025-09-30
    Completion
    2027-08-31
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Liking
    InterventionDroperidol; Placebo
    PhaseEarly phase 1
    Registry statusEnrolling by invitation

  • Supra Inguinal Fascia Iliaca Block as Rescue Analgesia Following Total Hip Arthroplasty

    NCT06982625 · start 2025-09-22

    Registered record
    Registry ID
    NCT06982625
    Conditions
    Hip Arthroplasty, Total; Post Operative Pain, Acute; Nerve Block
    Interventions
    Ultrasound guided supra inguinal fascia iliaca block; Placebo Injection; Surgical and anesthetic protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Recruiting
    Start
    2025-09-22
    Completion
    2027-12-31
    Enrolment
    310

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Arthroplasty, Total; Post Operative Pain, Acute; Nerve Block
    InterventionUltrasound guided supra inguinal fascia iliaca block; Placebo Injection; Surgical and anesthetic protocol
    PhaseNot applicable
    Registry statusRecruiting

  • Droperidol and QTc Interval Changes in ED Patients

    NCT06726811 · start 2024-10-17

    Registered record
    Registry ID
    NCT06726811
    Conditions
    Emergency Department Patient; QTc Intervals Changes
    Interventions
    Droperidol injection
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2024-10-17
    Completion
    2026-09-30
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEmergency Department Patient; QTc Intervals Changes
    InterventionDroperidol injection
    PhaseNot recorded
    Registry statusRecruiting

  • Low-dose Droperidol for Prevention of Postoperative Delirium in Elderly Patients After Non-cardiac Surgery

    NCT05401058 · start 2022-11-21

    Registered record
    Registry ID
    NCT05401058
    Conditions
    Digestive System Disease; Urologic Diseases; Gynecological Disease; Orthopedic Surgery
    Interventions
    Droperidol Injection; Saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2022-11-21
    Completion
    2025-07-30
    Enrolment
    797

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDigestive System Disease; Urologic Diseases; Gynecological Disease; Orthopedic Surgery
    InterventionDroperidol Injection; Saline
    PhaseNot applicable
    Registry statusTerminated

  • Droperidol on Prevention of Cannabis Hyperemesis Syndrome

    NCT05244460 · start 2021-12-02

    Registered record
    Registry ID
    NCT05244460
    Conditions
    Cannabis Hyperemesis Syndrome
    Interventions
    Droperidol Injectable Product; Diphenhydramine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2021-12-02
    Completion
    2023-01-31
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCannabis Hyperemesis Syndrome
    InterventionDroperidol Injectable Product; Diphenhydramine
    PhasePhase 3
    Registry statusUnknown

  • Low-dose Neuroleptanalgesia for Postoperative Delirium in Elderly Patients

    NCT05068180 · start 2021-10-05

    Registered record
    Registry ID
    NCT05068180
    Conditions
    Stomach Neoplasms; Colonic Neoplasms; Rectal Neoplasms; Sigmoid Neoplasms; Liver Neoplasms; Kidney Neoplasms; Urinary Bladder Neoplasms; Prostatic Neoplasms; Osteoarthropathy; Fractures, Bone; Gynecologic Cancer
    Interventions
    low-dose neuroleptanalgesia; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2021-10-05
    Completion
    2022-04-10
    Enrolment
    200

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionStomach Neoplasms; Colonic Neoplasms; Rectal Neoplasms; Sigmoid Neoplasms +7 more
    Interventionlow-dose neuroleptanalgesia; Placebo
    PhasePhase 4
    Registry statusUnknown

  • Opioid Free Anaesthesia-Analgesia Strategy on Surgical Stress and Immunomodulation in Elective VATS-Lobectomy for NSCLC

    NCT05172739 · start 2021-10-01

    Registered record
    Registry ID
    NCT05172739
    Conditions
    Systemic Inflammatory Response Syndrome; Postoperative Pain, Acute; Postoperative Pain, Chronic; Infections Postoperative; Opioid Use; Anesthesia; Non-small Cell Lung Cancer
    Interventions
    Opioid-Based Anesthesia-Analgesia Strategy; Opioid-free Anesthesia-Analgesia Strategy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2021-10-01
    Completion
    2026-11-01
    Enrolment
    70

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSystemic Inflammatory Response Syndrome; Postoperative Pain, Acute; Postoperative Pain, Chronic; Infections Postoperative +3 more
    InterventionOpioid-Based Anesthesia-Analgesia Strategy; Opioid-free Anesthesia-Analgesia Strategy
    PhasePhase 4
    Registry statusRecruiting

  • Haloperidol, Droperidol, Ondansetron in Cannabis Hyperemesis

    NCT05065567 · start 2021-08-30

    Registered record
    Registry ID
    NCT05065567
    Conditions
    Cyclic Vomiting Syndrome
    Interventions
    Droperidol; Haloperidol; Ondansetron 8mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Terminated
    Start
    2021-08-30
    Completion
    2023-11-20
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCyclic Vomiting Syndrome
    InterventionDroperidol; Haloperidol; Ondansetron 8mg
    PhasePhase 3
    Registry statusTerminated

  • Opioid Free Anesthesia-Analgesia Strategy and Surgical Stress in Elective Open Abdominal Aortic Aneurysm Repair

    NCT04894864 · start 2020-10-08

    Registered record
    Registry ID
    NCT04894864
    Conditions
    Elective Surgical Procedures; Postoperative Pain; Anesthesia; Opioid Use; Abdominal Aortic Aneurysm Without Rupture; Vascular Surgical Procedure; Interleukin 6; Immunomodulators
    Interventions
    Opioid-Based Anesthesia-Analgesia Strategy; Opioid-free Anesthesia-Analgesia Strategy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2020-10-08
    Completion
    2027-09-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionElective Surgical Procedures; Postoperative Pain; Anesthesia; Opioid Use +4 more
    InterventionOpioid-Based Anesthesia-Analgesia Strategy; Opioid-free Anesthesia-Analgesia Strategy
    PhasePhase 4
    Registry statusRecruiting

  • Efficacy of an Anterior Quadratus Lumborum Block vs. a TAP-block for Inguinal Hernia Repair

    NCT03023462 · start 2019-09-05

    Registered record
    Registry ID
    NCT03023462
    Conditions
    Inguinal Hernia; Pain, Postoperative
    Interventions
    Oksykodonhydroklorid; Ondansetron and Droperidol; Ropivacaine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-09-05
    Completion
    2020-06-30
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInguinal Hernia; Pain, Postoperative
    InterventionOksykodonhydroklorid; Ondansetron and Droperidol; Ropivacaine
    PhaseNot applicable
    Registry statusCompleted

  • Lumbar Erector Spinae Plane Block for Back Surgery

    NCT03825198 · start 2019-08-01

    Registered record
    Registry ID
    NCT03825198
    Conditions
    Pain, Postoperative; Anaesthesia; Surgery; Nerve Block; Anesthesia, Local; Back Pain; Spinal Fusion
    Interventions
    Erector spinae plane block; Levobupivacaine 0,25%; spine fusion; NaCL 0,9%; Sufentanil; propofol; Rocuronium Bromide; sevoflurane; paracetamol; Ketorolac; morphine pca; Dexamethasone; Morphine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2019-08-01
    Completion
    2023-12-15
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative; Anaesthesia; Surgery; Nerve Block +3 more
    InterventionErector spinae plane block; Levobupivacaine 0,25%; spine fusion; NaCL 0,9% +9 more
    PhasePhase 3
    Registry statusUnknown

  • Gender Influence on Torsadogenic Actions of Droperidol.

    NCT03944681 · start 2019-04-23

    Registered record
    Registry ID
    NCT03944681
    Conditions
    Arrhythmia, Droperidol
    Interventions
    Droperidol Injectable Solution
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-04-23
    Completion
    2020-12-31
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArrhythmia, Droperidol
    InterventionDroperidol Injectable Solution
    PhaseNot applicable
    Registry statusCompleted

  • Simplified Algorithm for the Prevention of Postoperative Nausea and Vomiting in an Oncological Hospital

    NCT04411069 · start 2019-02-20

    Registered record
    Registry ID
    NCT04411069
    Conditions
    Postoperative Nausea; Postoperative Vomiting
    Interventions
    Droperidol
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2019-02-20
    Completion
    2021-03-20
    Enrolment
    270

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Nausea; Postoperative Vomiting
    InterventionDroperidol
    PhasePhase 2
    Registry statusCompleted

  • Evaluation of the Efficacy of VR on Pain and Anxiety When Performing an Ultrasound-controlled Ankle Block.

    NCT03677323 · start 2019-01-02

    Registered record
    Registry ID
    NCT03677323
    Conditions
    Hallux Valgus; Surgery
    Interventions
    Virtual reality; Droleptan; Propofol; Sufentanyl
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2019-01-02
    Completion
    2019-02-21
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHallux Valgus; Surgery
    InterventionVirtual reality; Droleptan; Propofol; Sufentanyl
    PhaseNot applicable
    Registry statusCompleted