Skip to content
AMR Drug RepurposingSmart Screeningresearch prototype

Droperidol

FDA-approved product (injectable, injection), marketed as Droperidol, Inapsine.

Registered studies
42
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Droperidol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Nausea and vomiting
  • Post operative nausea and vomiting
  • Psychosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Butyrophenone derivatives
FDA pharmacologic class
Dopamine-2 Receptor Antagonist FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against E. coli, MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae32.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

42registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Droperidol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-10.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Droperidol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Awake Nasal Intubation in Laryngopharyngeal Tumors

    NCT03546088 · start 2018-02-20

    Registered record
    Registry ID
    NCT03546088
    Conditions
    Airway Management
    Interventions
    fiberoptic naso-tracheal intubation; Topical anaesthesia; Light sedation
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-02-20
    Completion
    2018-12-25
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAirway Management
    Interventionfiberoptic naso-tracheal intubation; Topical anaesthesia; Light sedation
    PhaseNot applicable
    Registry statusCompleted

  • Serratus Anterior Plane Block: Post-operative Analgesia in Video-assisted Thoracic Surgery

    NCT03277391 · start 2017-04-14

    Registered record
    Registry ID
    NCT03277391
    Conditions
    Regional Anesthesia; Thoracic Surgery; Post-operative Pain; Post-operative Chronic Pain; Pharmacokinetic Analysis; Serratus Anterior Plane Block
    Interventions
    Serratus anterior plane block; patient-controlled analgesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2017-04-14
    Completion
    2018-05
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRegional Anesthesia; Thoracic Surgery; Post-operative Pain; Post-operative Chronic Pain +2 more
    InterventionSerratus anterior plane block; patient-controlled analgesia
    PhaseNot applicable
    Registry statusUnknown

  • Sublingual Sufentanil Tablet System (SSTS) Versus Intravenous Patient Controlled Analgesia After Back Surgery.

    NCT03036514 · start 2017-04-05

    Registered record
    Registry ID
    NCT03036514
    Conditions
    Pain, Postoperative
    Interventions
    Sublingual sufentanil tablet system; Patient-controlled intravenous analgesia
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2017-04-05
    Completion
    2019-09-01
    Enrolment
    27

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative
    InterventionSublingual sufentanil tablet system; Patient-controlled intravenous analgesia
    PhaseNot applicable
    Registry statusCompleted

  • E7 TCR T Cells for Human Papillomavirus-Associated Cancers

    NCT02858310 · start 2017-01-27

    Registered record
    Registry ID
    NCT02858310
    Conditions
    Papillomavirus Infections; Cervical Intraepithelial Neoplasia; Carcinoma In Situ; Vulvar Neoplasms; Vulvar Diseases
    Interventions
    E7 TCR cells; Aldesleukin; Fludarabine; Cyclophosphamide; EKG; Biopsy; Chest CT and MRI or PET; PFT; Granisetron; Ondansetron; Droperidol; Prochlorperazine; Diphenoxylate HCL; Atropine sulfate; Codeine sulfate; Loperamide; Indomethacin; Acetaminophen; Diphenhydramine HCL; Hydroxyzine HCL; Meperidine
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2017-01-27
    Completion
    2025-07-02
    Enrolment
    224

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPapillomavirus Infections; Cervical Intraepithelial Neoplasia; Carcinoma In Situ; Vulvar Neoplasms +1 more
    InterventionE7 TCR cells; Aldesleukin; Fludarabine; Cyclophosphamide +17 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Real-time Decision Support for Postoperative Nausea and Vomiting (PONV) Prophylaxis

    NCT02625181 · start 2016-07

    Registered record
    Registry ID
    NCT02625181
    Conditions
    Postoperative Nausea and Vomiting
    Interventions
    Automated recommendation at the start of the case; Automated notification at the start of surgery; Preoperative recommendations: by email; Automated notification at the end of surgery; Anesthesia Information Management System (AIMS); Perioperative Data Warehouse (PDW); General anesthesia; Elective surgery; Propofol; Sevoflurane; Isoflurane; Desflurane; Scopolamine; Droperidol; Haloperidol; Dexamethasone; Promethazine; Meclizine; Aprepitant; Metoclopramide; Fentanyl; Sufentanil; Alfentanil; Remifentanil; Morphine; Meperidine; Hydromorphone; Methadone; Oxycodone; Oxymorphone; Hydrocodone; Ketamine; Ondansetron; Granisetron; Dolasetron mesylate; Palonosetron; Tropisetron; Ramosetron
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-07
    Completion
    2017-11-30
    Enrolment
    27,034

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Nausea and Vomiting
    InterventionAutomated recommendation at the start of the case; Automated notification at the start of surgery; Preoperative recommendations: by email; Automated notification at the end of surgery +34 more
    PhaseNot applicable
    Registry statusCompleted

  • A Fast-track Versus Conventional Recovery Protocol in Laparoscopic Hysterctomy

    NCT03828981 · start 2016-05-31

    Registered record
    Registry ID
    NCT03828981
    Conditions
    Gynecologic Surgery
    Interventions
    fast-track recovery program
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2016-05-31
    Completion
    2018-05-30
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGynecologic Surgery
    Interventionfast-track recovery program
    PhaseNot applicable
    Registry statusCompleted

  • Prophylaxis of Postoperative Nausea and Vomiting After Cardiac Surgery

    NCT02744495 · start 2016-02

    Registered record
    Registry ID
    NCT02744495
    Conditions
    Postoperative Vomiting; Postoperative Nausea; Postoperative Emesis
    Interventions
    Betamethasone; Droperidol
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2016-02
    Completion
    2016-12
    Enrolment
    502

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Vomiting; Postoperative Nausea; Postoperative Emesis
    InterventionBetamethasone; Droperidol
    PhasePhase 3
    Registry statusCompleted

  • Family Intervention in Recent Onset Schizophrenia Treatment (FIRST)

    NCT02600741 · start 2015-07-24

    Registered record
    Registry ID
    NCT02600741
    Conditions
    Schizophrenia
    Interventions
    Caregiver psycho-education and skills training; Caregiver support available at the study site; Paliperidone palmitate; Chlorpromazine; Droperidol; Fluphenazine; Haloperidol; Loxapine; Perphenazine; Pimozide; Prochlorperazine; Thiothixene; Thioridazine; Trifluoperazine; Aripiprazole; Asenapine; Clozapine; Iloperidone; Olanzapine; Paliperidone; Quetiapine; Risperidone; Ziprasidone
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2015-07-24
    Completion
    2018-07-05
    Enrolment
    296

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSchizophrenia
    InterventionCaregiver psycho-education and skills training; Caregiver support available at the study site; Paliperidone palmitate; Chlorpromazine +19 more
    PhaseNot recorded
    Registry statusCompleted

  • Ultrasound Guided Single Shot Block of Posterior Tibial Nerve for Postoperative Pain Relief After Hallux Valgus Surgery

    NCT02282956 · start 2014-10

    Registered record
    Registry ID
    NCT02282956
    Conditions
    Hallux Valgus
    Interventions
    Ropivacaine 0,75%; posterior tibial nerve block; morphine and droperidol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2014-10
    Completion
    2017-03
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHallux Valgus
    InterventionRopivacaine 0,75%; posterior tibial nerve block; morphine and droperidol
    PhasePhase 4
    Registry statusUnknown

  • Optimization of Procedural Sedation Protocol Used for Dental Care Delivery in People With Mental Disability

    NCT02078336 · start 2013-12

    Registered record
    Registry ID
    NCT02078336
    Conditions
    Dental Care for Disabled
    Interventions
    Midazolam Mylan; Lorazepam Mylan; Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2013-12
    Completion
    2025-07
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDental Care for Disabled
    InterventionMidazolam Mylan; Lorazepam Mylan; Valium + Akineton + Dehydrobenzperidol + Atropine sulfate
    PhasePhase 4
    Registry statusUnknown

  • Akathisia in Post Operative Outpatients Surgery

    NCT01942343 · start 2013-10

    Registered record
    Registry ID
    NCT01942343
    Conditions
    Akathisia
    Interventions
    Droperidol 1,25 mg administration, Droperidol 0,625 mg administration, Odansetron 4 mg administration
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2013-10
    Completion
    2015-10
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAkathisia
    InterventionDroperidol 1,25 mg administration, Droperidol 0,625 mg administration, Odansetron 4 mg administration
    PhasePhase 3
    Registry statusCompleted

  • Clinical Trial to Evaluate the Efficacy of Treatment vs Discontinuation in a First Episode of Non-affective Psychosis

    NCT01765829 · start 2012-11

    Registered record
    Registry ID
    NCT01765829
    Conditions
    Psychosis Nos/Other
    Interventions
    Discontinuation antipsychotic treatment; Antipsychotic treatment
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2012-11
    Completion
    2015-11
    Enrolment
    104

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPsychosis Nos/Other
    InterventionDiscontinuation antipsychotic treatment; Antipsychotic treatment
    PhasePhase 3
    Registry statusUnknown

  • Efficacy and Safety of Fosaprepitant Dimeglumine in Preventing Chemotherapy-Induced Nausea and Vomiting (MK-0517-031)

    NCT01594749 · start 2012-09-24

    Registered record
    Registry ID
    NCT01594749
    Conditions
    Chemotherapy-Induced Nausea and Vomiting (CINV)
    Interventions
    Fosaprepitant dimeglumine; Fosaprepitant Placebo; Dexamethasone; Ondansetron; Dexamethasone Placebo; Ondansetron Placebo; Rescue Therapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2012-09-24
    Completion
    2014-11-03
    Enrolment
    1,015

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionChemotherapy-Induced Nausea and Vomiting (CINV)
    InterventionFosaprepitant dimeglumine; Fosaprepitant Placebo; Dexamethasone; Ondansetron +3 more
    PhasePhase 3
    Registry statusCompleted

  • Study of Anesthesia Techniques to Reduce Nausea and Vomiting After Jaw Corrective Surgery

    NCT01592708 · start 2012-06

    Registered record
    Registry ID
    NCT01592708
    Conditions
    Post-operative Nausea; Post-operative Vomiting; Nausea Persistent
    Interventions
    Antiemetic anesthesia protocol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-06
    Completion
    2014-04
    Enrolment
    233

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPost-operative Nausea; Post-operative Vomiting; Nausea Persistent
    InterventionAntiemetic anesthesia protocol
    PhaseNot applicable
    Registry statusCompleted

  • Postoperative Analgesia in Abdominal Surgery: a Medico-economic Study

    NCT01470846 · start 2011-11

    Registered record
    Registry ID
    NCT01470846
    Conditions
    Extended Ileal Resection Under Laparotomy; Total Proctocolectomy Under Laparotomy; Colectomy Left/Right/Total Under Laparotomy; Rectosigmoidal Resection Under Laparotomy; Anterior Resection of Rectum Under Laparotomy; Abdomino-perineal Amputation Under Laparotomy
    Interventions
    epidural analgesia; PCA
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2011-11
    Completion
    2013-04
    Enrolment
    35

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionExtended Ileal Resection Under Laparotomy; Total Proctocolectomy Under Laparotomy; Colectomy Left/Right/Total Under Laparotomy; Rectosigmoidal Resection Under Laparotomy +2 more
    Interventionepidural analgesia; PCA
    PhasePhase 4
    Registry statusTerminated