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AMR Drug RepurposingSmart Screeningresearch prototype

Droperidol

FDA-approved product (injectable, injection), marketed as Droperidol, Inapsine.

Registered studies
42
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Droperidol
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Nausea and vomiting
  • Post operative nausea and vomiting
  • Psychosis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Butyrophenone derivatives
FDA pharmacologic class
Dopamine-2 Receptor Antagonist FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA48.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli43.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae32.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis55.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

42registered studies name this medicine, for any condition. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Droperidol in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-10.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Droperidol with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Drug Interactions Between Paracetamol and Setrons in Pain Management

    NCT01432977 · start 2011-09

    Registered record
    Registry ID
    NCT01432977
    Conditions
    Pain
    Interventions
    paracetamol /droperidol; paracetamol / ondansetron
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2011-09
    Completion
    2012-06
    Enrolment
    72

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    Interventionparacetamol /droperidol; paracetamol / ondansetron
    PhasePhase 3
    Registry statusCompleted

  • Droperidol Versus Metoclopramide + Diphenhydramine for the Treatment of Primary Headaches

    NCT01406860 · start 2011-07

    Registered record
    Registry ID
    NCT01406860
    Conditions
    Primary Headaches (Includes Migraines, Tension, Cluster Headaches)
    Interventions
    Droperidol; Metoclopramide + diphenhydramine
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2011-07
    Completion
    2012-07
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Headaches (Includes Migraines, Tension, Cluster Headaches)
    InterventionDroperidol; Metoclopramide + diphenhydramine
    PhaseNot applicable
    Registry statusTerminated

  • Droperidol and Cardiac Repolarization

    NCT01819857 · start 2011-06

    Registered record
    Registry ID
    NCT01819857
    Conditions
    Cardiac Repolarization
    Interventions
    Xomolix 0.625 mg intravenously; Xomolix 1.25 mg; Zofran 8 mg
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-06
    Completion
    2013-07
    Enrolment
    75

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCardiac Repolarization
    InterventionXomolix 0.625 mg intravenously; Xomolix 1.25 mg; Zofran 8 mg
    PhasePhase 4
    Registry statusCompleted

  • Incidence of Chemotherapy-Induced Nausea and Vomiting Associated With Docetaxel-Cyclophosphamide in Early Breast Cancer.

    NCT01298193 · start 2011-05

    Registered record
    Registry ID
    NCT01298193
    Conditions
    Breast Cancer
    Interventions
    Aprepitant
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-05
    Completion
    2014-04
    Enrolment
    212

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionAprepitant
    PhasePhase 4
    Registry statusCompleted

  • Enhanced Recovery After Laparoscopic Sleeve Gastrectomy - a Randomised Controlled Trial

    NCT01303809 · start 2011-05

    Registered record
    Registry ID
    NCT01303809
    Conditions
    Morbid Obesity
    Interventions
    Enhanced Recovery After Surgey for Sleeve Gastrectomy
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2011-05
    Completion
    2012-05
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMorbid Obesity
    InterventionEnhanced Recovery After Surgey for Sleeve Gastrectomy
    PhaseNot applicable
    Registry statusCompleted

  • Postoperative Vomiting in Children: Comparison Tri - Versus bi -Prophylaxis

    NCT01739985 · start 2010-12

    Registered record
    Registry ID
    NCT01739985
    Conditions
    Postoperative Vomiting
    Interventions
    Dexamethasone + ondansetron + Placebo; Dexamethasone + ondansetron + Droperidol
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2010-12
    Completion
    2014-05
    Enrolment
    322

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Vomiting
    InterventionDexamethasone + ondansetron + Placebo; Dexamethasone + ondansetron + Droperidol
    PhaseNot applicable
    Registry statusCompleted

  • Antagonism Research Between Antiemetics Agents and Acetaminophen in Thyroidectomy's Post-operative Analgesia.

    NCT01679093 · start 2009-06

    Registered record
    Registry ID
    NCT01679093
    Conditions
    Interaction Between Antiemetic Drugs and Paracetamol
    Interventions
    ondansetron; Droperidol; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-06
    Completion
    2011-06
    Enrolment
    66

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInteraction Between Antiemetic Drugs and Paracetamol
    Interventionondansetron; Droperidol; Dexamethasone
    PhasePhase 3
    Registry statusCompleted

  • Comparison of Three Different Prophylactic Treatments of Postoperative Nausea and Vomiting (PONV) in Children

    NCT01434017 · start 2008-11

    Registered record
    Registry ID
    NCT01434017
    Conditions
    Postoperative Nausea and Vomiting
    Interventions
    Dexamethasone; Dexamethasone and droperidol; Dexamethasone and Ondansetron
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-11
    Completion
    2013-06
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostoperative Nausea and Vomiting
    InterventionDexamethasone; Dexamethasone and droperidol; Dexamethasone and Ondansetron
    PhasePhase 4
    Registry statusCompleted

  • Role of Droperidol in Postoperative Vomiting

    NCT00702442 · start 2008-06

    Registered record
    Registry ID
    NCT00702442
    Conditions
    Vomiting
    Interventions
    Droperidol; Saline solution
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-06
    Completion
    2011-07
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionVomiting
    InterventionDroperidol; Saline solution
    PhasePhase 4
    Registry statusCompleted

  • The Effects of the Anti Nausea Drugs Droperidol and Ondansetron on the Way the Heart Recovers Between Beats

    NCT00624208 · start 2008-02

    Registered record
    Registry ID
    NCT00624208
    Conditions
    Myocardial Repolarization
    Interventions
    droperidol and saline; ondansetron and saline; droperidol and ondansetron; saline and saline
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2008-02
    Completion
    2009-08
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMyocardial Repolarization
    Interventiondroperidol and saline; ondansetron and saline; droperidol and ondansetron; saline and saline
    PhaseNot applicable
    Registry statusCompleted

  • Evaluation of 2 Doses of Intravenous Droperidol in the Prevention of Postoperative Nausea

    NCT00445055 · start 2007-04

    Registered record
    Registry ID
    NCT00445055
    Conditions
    Nausea; Vomiting
    Interventions
    Droperidol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2007-04
    Completion
    2009-04
    Enrolment
    71

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionNausea; Vomiting
    InterventionDroperidol
    PhasePhase 4
    Registry statusTerminated

  • Optimal Multimodal Analgesia in Laparoscopic Cholecystectomy

    NCT00209885 · start 2005-10

    Registered record
    Registry ID
    NCT00209885
    Conditions
    Cholecystolithiasis
    Interventions
    Gabapentin; S-ketamine; Lidocaine; Droperidol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2005-10
    Completion
    Not recorded
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCholecystolithiasis
    InterventionGabapentin; S-ketamine; Lidocaine; Droperidol
    PhasePhase 4
    Registry statusUnknown