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AMR Drug RepurposingSmart Screeningresearch prototype

Mirtazapine

FDA-approved product (tablet, oral), marketed as Mirtazapine, Remeron, Remeron Soltab.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Mirtazapine
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Depressive disorder
  • Insomnia
  • Major depressive disorder

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antidepressants
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA38.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • E. coli38.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae25.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis58.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Mirtazapine in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-9.0 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.0 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-6.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.2 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Mirtazapine with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Pilot Study of Mirtazapine for the Dual Tx of Depression and CINV in High-Grade Glioma Pts on TMZ

    NCT03935685 · start 2019-02-26

    Registered record
    Registry ID
    NCT03935685
    Conditions
    Glioma of Brain
    Interventions
    Mirtazapine (Remeron)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2019-02-26
    Completion
    2030-12-31
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGlioma of Brain
    InterventionMirtazapine (Remeron)
    PhasePhase 2
    Registry statusActive not recruiting

  • Effect of Mirtazapine Versus Placebo in Patients With Non-small Cell Lung Cancer and Anorexia

    NCT04748523 · start 2018-08-29

    Registered record
    Registry ID
    NCT04748523
    Conditions
    Anorexia; Non-small Cell Lung Cancer
    Interventions
    Mirtazapine; Placebo Oral Tablet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2018-08-29
    Completion
    2022-10-29
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAnorexia; Non-small Cell Lung Cancer
    InterventionMirtazapine; Placebo Oral Tablet
    PhaseNot applicable
    Registry statusCompleted

  • Prophylactic Mirtazapine or Clonidine for Post-spinal Anesthesia Shivering

    NCT03679052 · start 2018-03-01

    Registered record
    Registry ID
    NCT03679052
    Conditions
    Shivering
    Interventions
    Mirtazapine; Clonidine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2018-03-01
    Completion
    2018-08-31
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionShivering
    InterventionMirtazapine; Clonidine; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Multi-Dimensional Diagnosis,Individualized Therapy,and Management Technique for Major Depressive Disorder:Based on Clinical and Pathological Characteristics

    NCT03219008 · start 2017-08-01

    Registered record
    Registry ID
    NCT03219008
    Conditions
    Depressive Disorder
    Interventions
    Fluoxetine; fluoxetine + cognitive-behavioral treatment（CBT）; fluoxetine + Amfebutamone; physical treatment+fluoxetine+amfebutamone; Fluvoxamine; Lithium+fluvoxamine; fluvoxamine + lithium + physical therapy; Cognitive behavior treatment +fluvoxamine; Mirtazapine/SNRIs; mirtazapine+ Cognitive behavior treatment; mirtazapine + SNRIs; mirtazapine + SNRIs + physical therapy; TAU(treat as usual)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-08-01
    Completion
    2020-12
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepressive Disorder
    InterventionFluoxetine; fluoxetine + cognitive-behavioral treatment（CBT）; fluoxetine + Amfebutamone; physical treatment+fluoxetine+amfebutamone +9 more
    PhasePhase 4
    Registry statusUnknown

  • Efficacy and Safety Analyses of Mirtazapine in NSCLC Patients With Depression

    NCT02650544 · start 2015-12

    Registered record
    Registry ID
    NCT02650544
    Conditions
    Carcinoma, Non-Small-Cell Lung; Depression
    Interventions
    Mirtazapine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2015-12
    Completion
    2019-06
    Enrolment
    236

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCarcinoma, Non-Small-Cell Lung; Depression
    InterventionMirtazapine; Placebo
    PhasePhase 2
    Registry statusUnknown

  • eIMPACT Trial: Modernized Collaborative Care to Reduce the Excess CVD Risk of Older Depressed Patients

    NCT02458690 · start 2015-07

    Registered record
    Registry ID
    NCT02458690
    Conditions
    Depression; Major Depressive Disorder; Dysthymic Disorder; Depressive Symptoms; Cardiovascular Diseases; Heart Diseases; Coronary Artery Disease; Stroke
    Interventions
    Beating the Blues (BtB); Problem Solving Treatment in Primary Care (PST-PC); Antidepressant Medications; Usual Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-07
    Completion
    2021-03
    Enrolment
    216

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression; Major Depressive Disorder; Dysthymic Disorder; Depressive Symptoms +4 more
    InterventionBeating the Blues (BtB); Problem Solving Treatment in Primary Care (PST-PC); Antidepressant Medications; Usual Care
    PhasePhase 2
    Registry statusCompleted

  • Treatment of Young Adults With Comorbid AUD/MDD: A Pilot Medication Trial

    NCT02646449 · start 2015-06

    Registered record
    Registry ID
    NCT02646449
    Conditions
    Major Depressive Disorder; Alcohol Use Disorder
    Interventions
    Mirtazapine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2015-06
    Completion
    2016-12
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Alcohol Use Disorder
    InterventionMirtazapine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Adding Mirtazapine to Dexamethasone and Aprepitant for Delayed Emesis

    NCT02336750 · start 2014-12

    Registered record
    Registry ID
    NCT02336750
    Conditions
    Breast Cancer
    Interventions
    Aprepitant; Mirtazapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2014-12
    Completion
    2021-12
    Enrolment
    212

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionAprepitant; Mirtazapine
    PhasePhase 3
    Registry statusCompleted

  • Double-blind Pilot Trial of Mirtazapine for the Treatment of Co-occurring AD/MDD.

    NCT02185131 · start 2013-09

    Registered record
    Registry ID
    NCT02185131
    Conditions
    Major Depressive Disorder; Alcohol Use Disorder
    Interventions
    Mirtazapine; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2013-09
    Completion
    2016-07
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Alcohol Use Disorder
    InterventionMirtazapine; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Mirtazapine Plus Gemcitabine Versus Gemcitabine in Metastasis Pancreatic Cancer

    NCT01598584 · start 2012-06

    Registered record
    Registry ID
    NCT01598584
    Conditions
    Pancreatic Cancer
    Interventions
    Mirtazapine plus gemcitabine; Gemcitabine, placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Withdrawn
    Start
    2012-06
    Completion
    2015-12
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPancreatic Cancer
    InterventionMirtazapine plus gemcitabine; Gemcitabine, placebo
    PhasePhase 2 / Phase 3
    Registry statusWithdrawn

  • LEPR Polymorphism Weight Gain by Mirtazapine in Late Life Depression

    NCT01601002 · start 2012-06

    Registered record
    Registry ID
    NCT01601002
    Conditions
    Major Depressive Disorder
    Interventions
    Mirtazapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2012-06
    Completion
    2015-12
    Enrolment
    19

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder
    InterventionMirtazapine
    PhasePhase 4
    Registry statusCompleted

  • Depression in the Elderly and Cerebral Amyloid Plaques: Characterization by [18F] AV-45 Affectives Symptoms and Amyloïd Plaques (ASAP)

    NCT01962753 · start 2012-05-10

    Registered record
    Registry ID
    NCT01962753
    Conditions
    Elderly; Major Depression
    Interventions
    18FAV45
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-05-10
    Completion
    2020-01-22
    Enrolment
    92

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionElderly; Major Depression
    Intervention18FAV45
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy Study of Mirtazapine to Treat Interferon-related Depression During Antiviral Therapy for Hepatitis C

    NCT01465919 · start 2011-08

    Registered record
    Registry ID
    NCT01465919
    Conditions
    Depression
    Interventions
    Mirtazapine; Supportive psychotherapy
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2011-08
    Completion
    2018-03
    Enrolment
    5

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDepression
    InterventionMirtazapine; Supportive psychotherapy
    PhasePhase 4
    Registry statusTerminated

  • Pilot Study to Evaluate Individualized Choice of Antidepressants in Patients With Cancer

    NCT01725048 · start 2011-01

    Registered record
    Registry ID
    NCT01725048
    Conditions
    Major Depressive Disorder; Neoplasms
    Interventions
    Mirtazapine; Citalopram
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2011-01
    Completion
    2013-10
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMajor Depressive Disorder; Neoplasms
    InterventionMirtazapine; Citalopram
    PhaseEarly phase 1
    Registry statusCompleted

  • Strategic Use of New Generation Antidepressants for Depression

    NCT01109693 · start 2010-12

    Registered record
    Registry ID
    NCT01109693
    Conditions
    Unipolar Major Depressive Episode
    Interventions
    Sertraline; Mirtazapine
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2010-12
    Completion
    2015-12
    Enrolment
    2,011

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUnipolar Major Depressive Episode
    InterventionSertraline; Mirtazapine
    PhasePhase 4
    Registry statusCompleted