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AMR Drug RepurposingSmart Screeningresearch prototype

Desogestrel

FDA-approved product (tablet, oral-21).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Desogestrel
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Desogestrel. Its therapeutic class is shown instead.

WHO therapeutic group
Progestogens
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli32.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis45.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Desogestrel in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Desogestrel with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effects of Sex Steroid Hormones on Human Brain Function, Structure and Connectivity

    NCT01292785 · start 2011-01

    Registered record
    Registry ID
    NCT01292785
    Conditions
    Gender Identity Disorder
    Interventions
    Hormones
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2011-01
    Completion
    2015-04
    Enrolment
    80

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionGender Identity Disorder
    InterventionHormones
    PhaseNot recorded
    Registry statusCompleted

  • A Multicenter Study to Evaluate the Effects of a 91-Day Extended Cycle Oral Contraceptive on Hemostatic Parameters in Healthy Women

    NCT01252186 · start 2010-11

    Registered record
    Registry ID
    NCT01252186
    Conditions
    Hemostasis; Oral Contraceptive
    Interventions
    91-day Levonorgestrel Oral Contraceptive; 28-day Levonorgestrel Oral Contraceptive; 28-day Desogestrel Oral Contraceptive
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-11
    Completion
    2011-12
    Enrolment
    265

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemostasis; Oral Contraceptive
    Intervention91-day Levonorgestrel Oral Contraceptive; 28-day Levonorgestrel Oral Contraceptive; 28-day Desogestrel Oral Contraceptive
    PhasePhase 2
    Registry statusCompleted

  • Evaluation of an Oral Contraceptive Containing 30 mg Ethinyloestradiol and 150 mg Desogestrel on Women's Health

    NCT01256619 · start 2010-09

    Registered record
    Registry ID
    NCT01256619
    Conditions
    Women With PMS
    Interventions
    Marvelon
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2010-09
    Completion
    Not recorded
    Enrolment
    61

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionWomen With PMS
    InterventionMarvelon
    PhasePhase 2
    Registry statusUnknown

  • A Study to Evaluate the Efficacy and Safety of DR-102 for the Prevention of Pregnancy

    NCT01178125 · start 2010-08

    Registered record
    Registry ID
    NCT01178125
    Conditions
    Contraception; Female Contraception
    Interventions
    DR-102
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-08
    Completion
    2013-01
    Enrolment
    2,858

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraception; Female Contraception
    InterventionDR-102
    PhasePhase 3
    Registry statusCompleted

  • Comparative Trial in Hormone Withdrawal Associated Symptoms

    NCT01076582 · start 2010-04

    Registered record
    Registry ID
    NCT01076582
    Conditions
    Oral Contraceptive
    Interventions
    EE20/DRSP (YAZ, BAY86-5300); Ethinylestradiol (EE) and desogestrel (DSG) (Mercilon)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2010-04
    Completion
    2011-10
    Enrolment
    592

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Contraceptive
    InterventionEE20/DRSP (YAZ, BAY86-5300); Ethinylestradiol (EE) and desogestrel (DSG) (Mercilon)
    PhasePhase 3
    Registry statusCompleted

  • Fat Mediated Modulation of Reproductive and Endocrine Function in Young Athletes

    NCT00946192 · start 2009-05

    Registered record
    Registry ID
    NCT00946192
    Conditions
    Exercise-related Amenorrhea
    Interventions
    Transdermal 17Beta-estradiol, progesterone; Ethinyl Estradiol + Desogestrel; Sham Comparator
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-05
    Completion
    2021-04
    Enrolment
    121

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionExercise-related Amenorrhea
    InterventionTransdermal 17Beta-estradiol, progesterone; Ethinyl Estradiol + Desogestrel; Sham Comparator
    PhasePhase 3
    Registry statusCompleted

  • Oral Microdose Lupron Versus Luteal Estradiol Trial in Poor Responder In Vitro Fertilization (IVF) Patients

    NCT00826839 · start 2009-01

    Registered record
    Registry ID
    NCT00826839
    Conditions
    Infertility
    Interventions
    Oral contraceptive pill and microdose lupron; E2 patch/antagonist
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Withdrawn
    Start
    2009-01
    Completion
    2012-01
    Enrolment
    0

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionOral contraceptive pill and microdose lupron; E2 patch/antagonist
    PhasePhase 4
    Registry statusWithdrawn

  • An Efficacy and Safety Study Comparing Oral Contraceptive Containing Norgestimate or Desogestrel for Acne Treatment

    NCT01466673 · start 2008-12

    Registered record
    Registry ID
    NCT01466673
    Conditions
    Acne Vulgaris
    Interventions
    Ethinyl estradiol/Norgestimate (EE/NGM); Ethinyl estradiol/Desogestrel (EE/DSG)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-12
    Completion
    2010-03
    Enrolment
    201

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcne Vulgaris
    InterventionEthinyl estradiol/Norgestimate (EE/NGM); Ethinyl estradiol/Desogestrel (EE/DSG)
    PhasePhase 4
    Registry statusCompleted

  • Antagonist/Letrozole in Poor Responders

    NCT00823004 · start 2008-06

    Registered record
    Registry ID
    NCT00823004
    Conditions
    Ovarian Stimulation
    Interventions
    letrozole; oral contraceptive (Marvelone); GnRH agonist (buserelin); recombinant FSH or hMG; ganirelix acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2008-06
    Completion
    2009-10
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Stimulation
    Interventionletrozole; oral contraceptive (Marvelone); GnRH agonist (buserelin); recombinant FSH or hMG +1 more
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Efficacy Study of Atorvastatin in Pelvic Pain Relief in Women With Endometriosis

    NCT00675779 · start 2008-04

    Registered record
    Registry ID
    NCT00675779
    Conditions
    Endometriosis; Pain
    Interventions
    oral contraceptive (Mercilon); atorvastatin + oral contraceptive
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2008-04
    Completion
    2011-03
    Enrolment
    44

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis; Pain
    Interventionoral contraceptive (Mercilon); atorvastatin + oral contraceptive
    PhaseNot applicable
    Registry statusUnknown

  • Feasibility Study Into the Contraceptive Effect of Estetrol

    NCT00563472 · start 2007-11

    Registered record
    Registry ID
    NCT00563472
    Conditions
    Healthy
    Interventions
    estetrol; estetrol; estetrol and desogestrel; estetrol and progesterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2007-11
    Completion
    2008-08
    Enrolment
    52

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    Interventionestetrol; estetrol; estetrol and desogestrel; estetrol and progesterone
    PhasePhase 2
    Registry statusCompleted

  • Mid-luteal Phase Synchronization of Ovarian Folliculogenesis in Women

    NCT00565240 · start 2007-11

    Registered record
    Registry ID
    NCT00565240
    Conditions
    Ovarian Follicle
    Interventions
    Marvelon; Nuvaring; Letrozole
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-11
    Completion
    2009-09
    Enrolment
    41

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Follicle
    InterventionMarvelon; Nuvaring; Letrozole
    PhaseNot applicable
    Registry statusCompleted

  • The Effect of Hormonal Contraceptives on Androgens and Glucose Metabolism

    NCT01087879 · start 2007-10

    Registered record
    Registry ID
    NCT01087879
    Conditions
    Contraception
    Interventions
    Desogestrel-Ethinyl Estradiol contraceptive pill; Etonogestrel-Ethinyl Estradiol vaginal ring; Norelgestromin-Ethinyl Estradiol contraceptive patch
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-10
    Completion
    2011-01
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraception
    InterventionDesogestrel-Ethinyl Estradiol contraceptive pill; Etonogestrel-Ethinyl Estradiol vaginal ring; Norelgestromin-Ethinyl Estradiol contraceptive patch
    PhaseNot applicable
    Registry statusCompleted

  • Hormonal Contraception and Vaginal Health

    NCT00612508 · start 2007-05

    Registered record
    Registry ID
    NCT00612508
    Conditions
    Contraceptive Usage; Vaginal Epithelial Disruption
    Interventions
    Desogen (ethinyl estradiol and desogestrel); NuvaRing (ethinyl estradiol and etonogestrel)
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2007-05
    Completion
    2008-05
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraceptive Usage; Vaginal Epithelial Disruption
    InterventionDesogen (ethinyl estradiol and desogestrel); NuvaRing (ethinyl estradiol and etonogestrel)
    PhaseNot applicable
    Registry statusCompleted

  • Continuous Versus Cyclic Use of Oral Contraceptive Pills in Adolescents

    NCT00326404 · start 2006-05

    Registered record
    Registry ID
    NCT00326404
    Conditions
    Contraception
    Interventions
    Desogestrel-Ethinyl Estradiol 21 tablets; Desogestrel-Ethinyl Estradiol 28 tablets
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2006-05
    Completion
    2009-05
    Enrolment
    130

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraception
    InterventionDesogestrel-Ethinyl Estradiol 21 tablets; Desogestrel-Ethinyl Estradiol 28 tablets
    PhasePhase 3
    Registry statusUnknown