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AMR Drug RepurposingSmart Screeningresearch prototype

Desogestrel

FDA-approved product (tablet, oral-21).

Registered studies
50+
Lab records
0
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Desogestrel
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

No approved indication recorded

ChEMBL records no approved indication for Desogestrel. Its therapeutic class is shown instead.

WHO therapeutic group
Progestogens
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli32.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae22.0% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis45.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Desogestrel in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.2 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.2 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-8.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Desogestrel with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Traditional Chinese Medicine, Western Medicine and Low-level Light Therapy（LLLT） for Primary Dysmenorrhea（PD）

    NCT03953716 · start 2019-06-22

    Registered record
    Registry ID
    NCT03953716
    Conditions
    Primary Dysmenorrhea; Traditional Chinese Medicine; Light
    Interventions
    low level light therapy; DING KUN DAN; Simulated drug of DING KUN DAN; Marvelon
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-06-22
    Completion
    2020-06-30
    Enrolment
    480

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrimary Dysmenorrhea; Traditional Chinese Medicine; Light
    Interventionlow level light therapy; DING KUN DAN; Simulated drug of DING KUN DAN; Marvelon
    PhasePhase 4
    Registry statusUnknown

  • Abnormal Uterine Bleeding and Progestin-only Contraceptives

    NCT03398811 · start 2018-08-01

    Registered record
    Registry ID
    NCT03398811
    Conditions
    Contraception
    Interventions
    Depot medroxy-progesterone acetate; Etonogestrel; Desogestrel 75 µg
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2018-08-01
    Completion
    2020-11-01
    Enrolment
    390

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraception
    InterventionDepot medroxy-progesterone acetate; Etonogestrel; Desogestrel 75 µg
    PhaseNot recorded
    Registry statusCompleted

  • Optimisation of Follicular Recruitment in IVM Cycles

    NCT03197077 · start 2017-11-01

    Registered record
    Registry ID
    NCT03197077
    Conditions
    Infertility, Female; Polycystic Ovary Syndrome
    Interventions
    blood sampling; transvaginal ultrasound scanning; oocyte retrieval for IVM; Corifollitropin Alfa; Follitropin beta; oral contraceptive pill pretreatment (Marvelon)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-11-01
    Completion
    2022-12-31
    Enrolment
    145

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Female; Polycystic Ovary Syndrome
    Interventionblood sampling; transvaginal ultrasound scanning; oocyte retrieval for IVM; Corifollitropin Alfa +2 more
    PhasePhase 3
    Registry statusCompleted

  • The Female Sexual Functions With Progestogen-only Contraception

    NCT02579590 · start 2017-05-01

    Registered record
    Registry ID
    NCT02579590
    Conditions
    Female Sexual Function
    Interventions
    Depot Medroxyprogesterone Acetate 150 mg; Implanon( 68 mg etonogestrel implant); Cerazette pills (75 micrograms desogestrel)
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2017-05-01
    Completion
    2019-02-01
    Enrolment
    444

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionFemale Sexual Function
    InterventionDepot Medroxyprogesterone Acetate 150 mg; Implanon( 68 mg etonogestrel implant); Cerazette pills (75 micrograms desogestrel)
    PhaseNot recorded
    Registry statusCompleted

  • Evaluation of Hormonal Contraceptive Treatments in Obese Women

    NCT02398903 · start 2015-03-16

    Registered record
    Registry ID
    NCT02398903
    Conditions
    Obesity; Bariatric Surgery Candidate; Oral Contraceptive
    Interventions
    Blood samples for measurement of drug Css; DXA and impedancemetry
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2015-03-16
    Completion
    2018-12
    Enrolment
    174

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Bariatric Surgery Candidate; Oral Contraceptive
    InterventionBlood samples for measurement of drug Css; DXA and impedancemetry
    PhaseNot recorded
    Registry statusUnknown

  • Assessing the Impact of Contraceptives on Bone Health Using 41Ca

    NCT02367846 · start 2015-01

    Registered record
    Registry ID
    NCT02367846
    Conditions
    Other Disorders of Bone Development and Growth
    Interventions
    Combined Oral Contraceptive (COC); Contraceptive Vaginal Ring (CVR)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Active not recruiting
    Start
    2015-01
    Completion
    2028-12
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOther Disorders of Bone Development and Growth
    InterventionCombined Oral Contraceptive (COC); Contraceptive Vaginal Ring (CVR)
    PhasePhase 4
    Registry statusActive not recruiting

  • Contraception in Women With Sickle Cell Disease

    NCT02594462 · start 2015-01

    Registered record
    Registry ID
    NCT02594462
    Conditions
    Sickle Cell Disease
    Interventions
    etonogestrel-releasing implant contraceptive
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-01
    Completion
    2019-06
    Enrolment
    29

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSickle Cell Disease
    Interventionetonogestrel-releasing implant contraceptive
    PhasePhase 4
    Registry statusCompleted

  • Efficacy of Cyclic DSG Compared With Cyclic MPA for the Treatment of Anovulatory DUB

    NCT02103764 · start 2013-08

    Registered record
    Registry ID
    NCT02103764
    Conditions
    Dysfunctional Uterine Bleeding
    Interventions
    Desogestrel; Medroxyprogesterone acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2013-08
    Completion
    2018-12
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDysfunctional Uterine Bleeding
    InterventionDesogestrel; Medroxyprogesterone acetate
    PhasePhase 3
    Registry statusUnknown

  • NuvaRing Versus Marvelon in the Coordination of In Vitro Fertilization Cycles

    NCT01638767 · start 2012-07

    Registered record
    Registry ID
    NCT01638767
    Conditions
    Infertility
    Interventions
    Contraceptives, Oral; Contraceptive, Vaginal ring
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-07
    Completion
    2014-07
    Enrolment
    7

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionContraceptives, Oral; Contraceptive, Vaginal ring
    PhasePhase 4
    Registry statusTerminated

  • Contraceptive Pill and Hormonal Vaginal Ring in Women With Polycystic Ovary Syndrome

    NCT01588873 · start 2012-04

    Registered record
    Registry ID
    NCT01588873
    Conditions
    Adverse Effect of Oral Contraceptives, Sequela
    Interventions
    oc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2012-04
    Completion
    2019-12
    Enrolment
    42

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAdverse Effect of Oral Contraceptives, Sequela
    Interventionoc:E-E-desogestrel/vaginal ring:E-E -ethonogestrel
    PhasePhase 4
    Registry statusUnknown

  • Therapeutic Effect of Desogestrel on Ventilatory Control in Patients With Congenital Central Hypoventilation Syndrome

    NCT01500473 · start 2012-02

    Registered record
    Registry ID
    NCT01500473
    Conditions
    Congenital Central Hypoventilation Syndrome
    Interventions
    Desogestrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2012-02
    Completion
    2016-05-11
    Enrolment
    1

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCongenital Central Hypoventilation Syndrome
    InterventionDesogestrel
    PhasePhase 2
    Registry statusTerminated

  • Postoperative Desogestrel for Endometriosis Related Pain

    NCT01559480 · start 2012-01

    Registered record
    Registry ID
    NCT01559480
    Conditions
    Endometriosis
    Interventions
    Desogestrel; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-01
    Completion
    2014-10
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEndometriosis
    InterventionDesogestrel; Placebo
    PhaseNot applicable
    Registry statusCompleted

  • Study of the Efficacy of Dienogest in the Treatment of Uterine Leiomyomas When Compared to Desogestrel and Goserelin

    NCT01738724 · start 2012-01

    Registered record
    Registry ID
    NCT01738724
    Conditions
    Uterine Leiomyoma
    Interventions
    Dienogest; Goserelin; Desogestrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2012-01
    Completion
    2017-12
    Enrolment
    14

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUterine Leiomyoma
    InterventionDienogest; Goserelin; Desogestrel
    PhasePhase 4
    Registry statusTerminated

  • Is Cerazette Use Before Nexplanon Insertion Predictive for Bleeding Pattern?

    NCT01438736 · start 2011-09

    Registered record
    Registry ID
    NCT01438736
    Conditions
    Bleeding
    Interventions
    Desogestrel 75 micrograms POP (Cerazette), Etonogestrel 68 mg implant (Nexplanon); Etonogestrel 68 mg subdermal implant
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2011-09
    Completion
    Not recorded
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBleeding
    InterventionDesogestrel 75 micrograms POP (Cerazette), Etonogestrel 68 mg implant (Nexplanon); Etonogestrel 68 mg subdermal implant
    PhasePhase 4
    Registry statusUnknown

  • Assessment of Desogestrel in Ondine Syndrome

    NCT01243697 · start 2011-04

    Registered record
    Registry ID
    NCT01243697
    Conditions
    Ondine Syndrome
    Interventions
    desogestrel
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Completed
    Start
    2011-04
    Completion
    2013-09
    Enrolment
    6

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOndine Syndrome
    Interventiondesogestrel
    PhasePhase 2 / Phase 3
    Registry statusCompleted