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AMR Drug RepurposingSmart Screeningresearch prototype

Estradiol Valerate

FDA-approved product (injectable, injection), marketed as Delestrogen, Estradiol Valerate.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
1 of 4

Chemical structure

Chemical structure of Estradiol Valerate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Atrophic Vaginitis
  • Atrophy
  • Breast cancer
  • Breast carcinoma
  • Breast neoplasm
  • Dyspareunia
  • Hypogonadism
  • Menopause
  • Menorrhagia
  • Osteoporosis
  • Postmenopausal atrophic vaginitis
  • Postmenopausal osteoporosis
  • Premature ovarian insufficiency
  • Primary ovarian insufficiency

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Natural and semisynthetic estrogens, plain
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA. It was surfaced computationally for further investigation; it is not an established treatment for this infection.

AI-predicted activity

AI prediction · nothing measured
  • MRSA50.9% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli31.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae24.4% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis22.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Estradiol Valerate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-7.8 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.9 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.0 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Estradiol Valerate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Effects of Estrogen and Hot Flashes on Mood in Postmenopausal Women

    NCT01126801 · start 2010-05

    Registered record
    Registry ID
    NCT01126801
    Conditions
    Menopausal Depression
    Interventions
    Estradiol; Placebo control
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2010-05
    Completion
    2011-02
    Enrolment
    2

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMenopausal Depression
    InterventionEstradiol; Placebo control
    PhasePhase 2
    Registry statusTerminated

  • Natural Versus HRT Cycles in Frozen Embryo Replacement Treatment

    NCT00843570 · start 2009-11

    Registered record
    Registry ID
    NCT00843570
    Conditions
    Infertility
    Interventions
    Nafarelin acetate, Oestradiol Valerate, Progesterone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-11
    Completion
    2013-05
    Enrolment
    159

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionNafarelin acetate, Oestradiol Valerate, Progesterone
    PhasePhase 4
    Registry statusCompleted

  • Oral Contraceptives and Body Mass Index

    NCT01170390 · start 2009-09

    Registered record
    Registry ID
    NCT01170390
    Conditions
    Body Weight; Contraceptive Usage
    Interventions
    All participants (Aviane); Portia; Aviane
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2009-09
    Completion
    2011-12
    Enrolment
    32

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBody Weight; Contraceptive Usage
    InterventionAll participants (Aviane); Portia; Aviane
    PhasePhase 4
    Registry statusCompleted

  • Progestagen Type in Postmenopausal Hormone Therapy and Blood Gene Expression Profile

    NCT01123538 · start 2008-12

    Registered record
    Registry ID
    NCT01123538
    Conditions
    Pharmacogenomics; Systems Biology
    Interventions
    Progesterone; Chlormadinone acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2008-12
    Completion
    2012-10
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPharmacogenomics; Systems Biology
    InterventionProgesterone; Chlormadinone acetate
    PhasePhase 4
    Registry statusUnknown

  • Drug Interaction - Oral Contraceptive

    NCT00399685 · start 2006-12

    Registered record
    Registry ID
    NCT00399685
    Conditions
    HIV Infections
    Interventions
    Ortho Tri-Cyclen LO; Ortho Cyclen; Ortho Cyclen + Efavirenz; Ortho Cyclen
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2006-12
    Completion
    2007-08
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHIV Infections
    InterventionOrtho Tri-Cyclen LO; Ortho Cyclen; Ortho Cyclen + Efavirenz; Ortho Cyclen
    PhasePhase 1
    Registry statusCompleted

  • Effect of 17ß-estradiol on Inflammatory-immune Responses in Post-menopausal Women According to Administration Route

    NCT00701337 · start 2006-09

    Registered record
    Registry ID
    NCT00701337
    Conditions
    Postmenopausal
    Interventions
    oestradiol; oestradiol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-09
    Completion
    2010-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostmenopausal
    Interventionoestradiol; oestradiol
    PhasePhase 4
    Registry statusCompleted

  • Study of Bleeding With Extended Administration of an Oral Contraceptive

    NCT00338052 · start 2006-06

    Registered record
    Registry ID
    NCT00338052
    Conditions
    Contraception
    Interventions
    Norethindrone 1 mg / ethinyl estradiol 20 mcg
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-06
    Completion
    2007-05
    Enrolment
    207

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraception
    InterventionNorethindrone 1 mg / ethinyl estradiol 20 mcg
    PhasePhase 2
    Registry statusCompleted

  • Hormonal Stimulation in IUI Treatment: Is Clomifen Combined With Ethinyl Estradiol Better, Worse or Equal to Menopur

    NCT01569945 · start 2004-09

    Registered record
    Registry ID
    NCT01569945
    Conditions
    Subfertility
    Interventions
    Clomifen, Ethinyl Estradiol; Menotropins
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-09
    Completion
    2011-12
    Enrolment
    371

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSubfertility
    InterventionClomifen, Ethinyl Estradiol; Menotropins
    PhaseNot applicable
    Registry statusCompleted

  • Docetaxel, Estramustine, and Thalidomide in Treating Patients With Androgen-Independent Metastatic Adenocarcinoma of the Prostate

    NCT00083005 · start 2004-03

    Registered record
    Registry ID
    NCT00083005
    Conditions
    Prostate Cancer
    Interventions
    docetaxel; estramustine phosphate sodium; thalidomide
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2004-03
    Completion
    2007-12
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    Interventiondocetaxel; estramustine phosphate sodium; thalidomide
    PhasePhase 2
    Registry statusCompleted

  • 3-year Study of Menostar Versus Evista to Prevent Osteoporosis in Post-menopausal Women

    NCT00310531 · start 2004-02

    Registered record
    Registry ID
    NCT00310531
    Conditions
    Osteopenia
    Interventions
    Menostar (Estradiol, BAY86-5435); Raloxifene
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2004-02
    Completion
    2007-06
    Enrolment
    500

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteopenia
    InterventionMenostar (Estradiol, BAY86-5435); Raloxifene
    PhasePhase 3
    Registry statusCompleted

  • Evaluation of Women's Experience With EVRA (Norelgestromin + Ethinyl Estradiol) Transdermal Contraceptive Patch Compared With Previous Methods of Contraception.

    NCT00261482 · start 2003-07

    Registered record
    Registry ID
    NCT00261482
    Conditions
    Contraception; Female Contraception
    Interventions
    norelgestromin + ethinyl estradiol
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2003-07
    Completion
    2004-12
    Enrolment
    778

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionContraception; Female Contraception
    Interventionnorelgestromin + ethinyl estradiol
    PhasePhase 4
    Registry statusCompleted

  • A Study of Epirubicin With Estramustine Phosphate and Celecoxib for the Treatment of Prostate Cancer

    NCT00218205 · start 2002-07

    Registered record
    Registry ID
    NCT00218205
    Conditions
    Prostate Cancer
    Interventions
    Epirubicin; Estramustine Phosphate; Celecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2002-07
    Completion
    2006-06
    Enrolment
    28

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer
    InterventionEpirubicin; Estramustine Phosphate; Celecoxib
    PhasePhase 2
    Registry statusUnknown

  • Postmenopausal Women Estrogen and Progesterone Infusion

    NCT00455741 · start 2000-11

    Registered record
    Registry ID
    NCT00455741
    Conditions
    Postmenopause; Aging
    Interventions
    Estradiol infusion; Progesterone infusion
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2000-11
    Completion
    2015-08-22
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPostmenopause; Aging
    InterventionEstradiol infusion; Progesterone infusion
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Combination Chemotherapy Plus Warfarin in Treating Patients With Prostate Cancer

    NCT00014352 · start 2000-09

    Registered record
    Registry ID
    NCT00014352
    Conditions
    Prostate Cancer; Thromboembolism
    Interventions
    docetaxel; doxorubicin hydrochloride; estramustine phosphate sodium; ketoconazole; warfarin
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2000-09
    Completion
    Not recorded
    Enrolment
    Not recorded

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionProstate Cancer; Thromboembolism
    Interventiondocetaxel; doxorubicin hydrochloride; estramustine phosphate sodium; ketoconazole +1 more
    PhasePhase 2
    Registry statusCompleted

  • Assessment of the Sensitivity of the Hypothalamic GnRH Pulse Generator to Estradiol and Progesterone Inhibition

    NCT01425541 · start 2000-04

    Registered record
    Registry ID
    NCT01425541
    Conditions
    Hyperandrogenemia; Polycystic Ovary Syndrome (PCOS)
    Interventions
    estrace; Progesterone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2000-04
    Completion
    2025-08
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHyperandrogenemia; Polycystic Ovary Syndrome (PCOS)
    Interventionestrace; Progesterone
    PhaseNot applicable
    Registry statusUnknown