Isavuconazonium Sulfate
FDA-approved product (capsule, oral), marketed as Cresemba.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Aspergillosis
- Mucormycosis
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Triazole and tetrazole derivatives
- Anti-infective classification
- Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J02AC05
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against M. tuberculosis, MRSA and E. coli. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA64.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli45.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae31.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis52.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Isavuconazonium Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Mefloquine HydrochlorideExisting use: Malaria, Plasmodium falciparum malaria, Plasmodium vivax malaria81.8% AI-predicted activityagainst M. tuberculosisLab records exist8 registered studies
- KetoconazoleExisting use: Adrenal gland disease, Blastomycosis, Cushing syndrome and 3 more81.2% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- LevoketoconazoleExisting use: Adrenal gland disease, Adrenal gland hyperfunction, Cushing syndrome81.2% AI-predicted activityagainst M. tuberculosis6 registered studies
- Fluphenazine DecanoateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosis4 registered studies
- Fluphenazine EnanthateExisting use: Mental or behavioural disorder, Psychosis80.7% AI-predicted activityagainst M. tuberculosisNo documented evidence found
- NifurtimoxExisting use: American trypanosomiasis, Chagas disease, Leishmaniasis and 1 more78.4% AI-predicted activityagainst M. tuberculosis19 registered studies
- Fluphenazine HydrochlorideExisting use: Mental or behavioural disorder, Psychosis77.8% AI-predicted activityagainst M. tuberculosis5 registered studies
- NitazoxanideExisting use: Amebiasis, Diarrhea77.8% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TopiramateExisting use: Epilepsy, Lennox-Gastaut syndrome, Migraine disorder and 1 more77.4% AI-predicted activityagainst M. tuberculosisLab records exist50+ registered studies
- TrabectedinExisting use: Cancer, Dedifferentiated liposarcoma, Leiomyosarcoma and 7 more76.8% AI-predicted activityagainst M. tuberculosis50+ registered studies
- Chlorpromazine HydrochlorideExisting use: Conduct disorder, Mental or behavioural disorder, Nausea and vomiting and 3 more75.0% AI-predicted activityagainst M. tuberculosis33 registered studies
- ProchlorperazineExisting use: Anxiety disorder, Nausea and vomiting, Psychosis and 1 more74.1% AI-predicted activityagainst M. tuberculosis50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
Drug Interaction Study of Isavuconazole and Cyclosporine
NCT01494597 · start 2011-11
Registered record
- Registry ID
- NCT01494597
- Conditions
- Healthy
- Interventions
- isavuconazole; cyclosporine
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2011-11
- Completion
- 2011-12
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthyInterventionisavuconazole; cyclosporinePhasePhase 1Registry statusCompletedDrug Interaction Study of Isavuconazole and Midazolam
NCT01406171 · start 2011-05
Registered record
- Registry ID
- NCT01406171
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Midazolam; Healthy Volunteers
- Interventions
- Isavuconazole; Midazolam
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2011-05
- Completion
- 2011-06
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Midazolam; Healthy VolunteersInterventionIsavuconazole; MidazolamPhasePhase 1Registry statusCompletedIsavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi
NCT00634049 · start 2008-04-22
Registered record
- Registry ID
- NCT00634049
- Conditions
- Aspergillosis; Invasive Fungal Infections
- Interventions
- isavuconazole
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2008-04-22
- Completion
- 2016-05-05
- Enrolment
- 149
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAspergillosis; Invasive Fungal InfectionsInterventionisavuconazolePhasePhase 3Registry statusCompletedIsavuconazole (BAL8557) in the Treatment of Candidemia and Other Invasive Candida Infections
NCT00413218 · start 2007-03-08
Registered record
- Registry ID
- NCT00413218
- Conditions
- Candidiasis, Invasive; Candidemia; Mycoses
- Interventions
- Isavuconazole; Caspofungin; Voriconazole
- Study type
- INTERVENTIONAL
- Phase
- Phase 3
- Registry status
- Completed
- Start
- 2007-03-08
- Completion
- 2015-03-03
- Enrolment
- 450
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionCandidiasis, Invasive; Candidemia; MycosesInterventionIsavuconazole; Caspofungin; VoriconazolePhasePhase 3Registry statusCompletedSafety, Efficacy and Pharmacokinetics of an Antifungal in Patients Undergoing Chemotherapy
NCT00413439 · start 2006-05
Registered record
- Registry ID
- NCT00413439
- Conditions
- Acute Myeloid Leukemia
- Interventions
- Isavuconazole
- Study type
- INTERVENTIONAL
- Phase
- Phase 2 / Phase 3
- Registry status
- Completed
- Start
- 2006-05
- Completion
- 2007-06
- Enrolment
- 18
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionAcute Myeloid LeukemiaInterventionIsavuconazolePhasePhase 2 / Phase 3Registry statusCompleted