Isavuconazonium Sulfate
FDA-approved product (capsule, oral), marketed as Cresemba.
- Registered studies
- 50+
- Lab records
- 0
- Pathogens at ≥40%
- 3 of 4
Chemical structure
Existing / approved use
Documented · FDA, WHO, ChEMBLApproved for
- Aspergillosis
- Mucormycosis
Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗
- WHO therapeutic group
- Triazole and tetrazole derivatives
- Anti-infective classification
- Classified as another kind of anti-infective (for example an antifungal, antiviral or antiparasitic medicine).WHO ATC J02AC05
Repurposing investigation
This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.
AI-predicted activity
AI prediction · nothing measured- MRSA64.3% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- E. coli45.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
- K. pneumoniae31.2% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
- M. tuberculosis52.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.
Evidence
Clinical and experimental
Documented evidenceClinical
50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.
Experimental
No evidence found
No laboratory measurement against the four pathogens in the ChEMBL records loaded here.
Docking
Computational · nothing measuredDihydrofolate reductase ↗ (E. coli)
Not yet docked: queued in the docking rundetails
KPC-2 carbapenemase ↗ (K. pneumoniae)
Not yet docked: queued in the docking rundetails
Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)
Not yet docked: queued in the docking rundetails
Dihydrofolate reductase ↗ (MRSA)
Not yet docked: queued in the docking rundetails
AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.
Other medicines to investigate
AI prediction · nothing measuredOther repurposing candidates: approved medicines besides Isavuconazonium Sulfate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.
Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.
- Ozanimod HydrochlorideExisting use: Multiple sclerosis, Relapsing-remitting multiple sclerosis, Ulcerative colitis66.8% AI-predicted activityagainst MRSA7 registered studies
- Micafungin SodiumExisting use: Candidiasis66.8% AI-predicted activityagainst MRSA50+ registered studies
- AbemaciclibExisting use: Breast cancer, Breast carcinoma, Breast neoplasm and 3 more66.4% AI-predicted activityagainst MRSA50+ registered studies
- RisperidoneExisting use: Aggressive behavior, Autism, Bipolar disorder and 4 more66.4% AI-predicted activityagainst MRSA50+ registered studies
- Lazertinib MesylateExisting use: Non-small cell lung carcinoma66.1% AI-predicted activityagainst MRSANo documented evidence found
- Desmopressin AcetateExisting use: Central diabetes insipidus, Diabetes insipidus, Enuresis and 5 more65.8% AI-predicted activityagainst MRSA50+ registered studies
- Terazosin HydrochlorideExisting use: Benign prostatic hyperplasia65.8% AI-predicted activityagainst MRSA41 registered studies
- VemurafenibExisting use: Cancer, Cutaneous melanoma, Melanoma and 2 more65.8% AI-predicted activityagainst MRSA50+ registered studies
- Caspofungin AcetateExisting use: Aspergillosis, Candidemia, Candidiasis and 1 more65.5% AI-predicted activityagainst MRSA50+ registered studies
- VenetoclaxExisting use: Cancer, Chronic lymphocytic leukemia, Neoplasm65.5% AI-predicted activityagainst MRSA50+ registered studies
- Larotrectinib SulfateExisting use: Abdominal Neoplasms, Cancer, Metastasis and 1 more65.4% AI-predicted activityagainst MRSA5 registered studies
- SirolimusExisting use: Adenoma sebaceum, Angiofibroma, Cancer and 5 more65.2% AI-predicted activityagainst MRSA50+ registered studies
Registered studies
A registration describes a study; it does not establish a positive result.
A Study to Evaluate the Pharmacokinetics of BAL8728 After a Single Dose of Pyridinylmethyl-14C-Labeled Isavuconazonium Sulfate in Healthy Male Subjects
NCT02059590 · start 2013-04
Registered record
- Registry ID
- NCT02059590
- Conditions
- Pharmacokinetics of 14C-labeled Isavuconazonium Sulfate; Healthy Subjects
- Interventions
- Pyridinylmethyl-14C-labeled isavuconazonium sulfate
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2013-04
- Completion
- 2013-04
- Enrolment
- 6
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of 14C-labeled Isavuconazonium Sulfate; Healthy SubjectsInterventionPyridinylmethyl-14C-labeled isavuconazonium sulfatePhasePhase 1Registry statusCompletedA Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Metformin
NCT01884558 · start 2013-02
Registered record
- Registry ID
- NCT01884558
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Metformin; Healthy Subjects
- Interventions
- isavuconazole; metformin
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2013-02
- Completion
- 2013-02
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Metformin; Healthy SubjectsInterventionisavuconazole; metforminPhasePhase 1Registry statusCompletedStudy to Evaluate the Pharmacokinetics of 14C-labeled Isavuconazole Following a Single Oral Dose of 14C-labeled Prodrug Isavuconazonium Sulfate (BAL8557) in Healthy Male Subjects
NCT01813461 · start 2012-10
Registered record
- Registry ID
- NCT01813461
- Conditions
- Pharmacokinetics of 14C-labeled Isavuconazole; Healthy Subjects
- Interventions
- 14C-labeled prodrug isavuconazonium sulfate
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-10
- Completion
- 2012-11
- Enrolment
- 8
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of 14C-labeled Isavuconazole; Healthy SubjectsIntervention14C-labeled prodrug isavuconazonium sulfatePhasePhase 1Registry statusCompletedDrug Interaction Study of Multiple Doses of Isavuconazole and a Single Dose of Bupropion
NCT01635972 · start 2012-06
Registered record
- Registry ID
- NCT01635972
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Bupropion; Healthy Volunteers
- Interventions
- Isavuconazole; bupropion hydrochloride
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-06
- Completion
- 2012-07
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Bupropion; Healthy VolunteersInterventionIsavuconazole; bupropion hydrochloridePhasePhase 1Registry statusCompletedDrug-drug Interaction Study Between Lopinavir/Ritonavir and Isavuconazole
NCT01660477 · start 2012-06
Registered record
- Registry ID
- NCT01660477
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Lopinavir/Ritonavir; Healthy Volunteers
- Interventions
- Isavuconazole; Lopinavir/ritonavir
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-06
- Completion
- 2012-10
- Enrolment
- 68
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Lopinavir/Ritonavir; Healthy VolunteersInterventionIsavuconazole; Lopinavir/ritonavirPhasePhase 1Registry statusCompletedDrug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Dextromethorphan in Healthy Adult Subjects
NCT01651325 · start 2012-05
Registered record
- Registry ID
- NCT01651325
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Dextromethorphan; Healthy Adult Volunteers
- Interventions
- Isavuconazole; dextromethorphan
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-05
- Completion
- 2012-05
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Dextromethorphan; Healthy Adult VolunteersInterventionIsavuconazole; dextromethorphanPhasePhase 1Registry statusCompletedDrug Interaction Study of the Effect of Ketoconazole at Steady State on the Pharmacokinetics of a Single Dose of Isavuconazole in Healthy Adult Subjects
NCT01657838 · start 2012-05
Registered record
- Registry ID
- NCT01657838
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Ketoconazole; Healthy Adult Volunteers
- Interventions
- Isavuconazole; Ketoconazole
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-05
- Completion
- 2012-05
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Ketoconazole; Healthy Adult VolunteersInterventionIsavuconazole; KetoconazolePhasePhase 1Registry statusCompletedDrug Interaction Study of Isavuconazole and Methadone
NCT01582425 · start 2012-04
Registered record
- Registry ID
- NCT01582425
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Methadone; Healthy Volunteers
- Interventions
- Isavuconazole; Methadone
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-04
- Completion
- 2012-06
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Methadone; Healthy VolunteersInterventionIsavuconazole; MethadonePhasePhase 1Registry statusCompletedDrug Interaction Study of Isavuconazole and Oral Contraceptive Containing Ethinyl Estradiol and Norethindrone
NCT01597986 · start 2012-04
Registered record
- Registry ID
- NCT01597986
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Ethinyl Estradiol and Norethindrone; Healthy Volunteers
- Interventions
- isavuconazole; Oral Contraceptive (ethinyl estradiol / norethindrone)
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-04
- Completion
- 2012-06
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Ethinyl Estradiol and Norethindrone; Healthy VolunteersInterventionisavuconazole; Oral Contraceptive (ethinyl estradiol / norethindrone)PhasePhase 1Registry statusCompletedStudy of the Effect of Renal Impairment on the Pharmacokinetics of Isavuconazole.
NCT01555866 · start 2012-03
Registered record
- Registry ID
- NCT01555866
- Conditions
- Pharmacokinetics of Isavuconazole; Healthy Volunteers; Renal Impaired
- Interventions
- isavuconazole
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-03
- Completion
- 2013-04
- Enrolment
- 49
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Healthy Volunteers; Renal ImpairedInterventionisavuconazolePhasePhase 1Registry statusCompletedStudy of the Effect of Repeat Doses of Isavuconazole on Cardiac Repolarization
NCT01565720 · start 2012-03
Registered record
- Registry ID
- NCT01565720
- Conditions
- Pharmacokinetics of Isavuconazole; Healthy Volunteers
- Interventions
- Isavuconazole; Placebo; Moxifloxacin
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-03
- Completion
- 2012-06
- Enrolment
- 161
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Healthy VolunteersInterventionIsavuconazole; Placebo; MoxifloxacinPhasePhase 1Registry statusCompletedDrug Interaction Study of Isavuconazole and Digoxin
NCT01582412 · start 2012-03
Registered record
- Registry ID
- NCT01582412
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Digoxin; Healthy Volunteers
- Interventions
- Isavuconazole; digoxin
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-03
- Completion
- 2012-05
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Digoxin; Healthy VolunteersInterventionIsavuconazole; digoxinPhasePhase 1Registry statusCompletedA Study to Assess the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Mycophenolate Mofetil in Healthy Adult Subjects
NCT01711489 · start 2012-03
Registered record
- Registry ID
- NCT01711489
- Conditions
- Healthy Subjects; Pharmacokinetics of Isavuconazole; Pharmacokinetics of Plasma Mycophenolic Acid (MPA); Pharmacokinetics of Plasma Phenolic Glucuronide of MPA (MPAG)
- Interventions
- isavuconazole; Mycophenolate mofetil
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-03
- Completion
- 2012-04
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthy Subjects; Pharmacokinetics of Isavuconazole; Pharmacokinetics of Plasma Mycophenolic Acid (MPA); Pharmacokinetics of Plasma Phenolic Glucuronide of MPA (MPAG)Interventionisavuconazole; Mycophenolate mofetilPhasePhase 1Registry statusCompletedA Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of a Single Dose of Prednisone in Healthy Adult Subjects
NCT01711827 · start 2012-02
Registered record
- Registry ID
- NCT01711827
- Conditions
- Healthy Subjects; Pharmacokinetics of Isavuconazole; Pharmacokinetics of Prednisolone
- Interventions
- Isavuconazole; Prednisone
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2012-02
- Completion
- 2012-03
- Enrolment
- 21
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionHealthy Subjects; Pharmacokinetics of Isavuconazole; Pharmacokinetics of PrednisoloneInterventionIsavuconazole; PrednisonePhasePhase 1Registry statusCompletedDrug Interaction Study of Isavuconazole and Tacrolimus
NCT01535547 · start 2011-12
Registered record
- Registry ID
- NCT01535547
- Conditions
- Pharmacokinetics of Isavuconazole; Pharmacokinetics of Tacrolimus; Healthy Volunteers
- Interventions
- isavuconazole; tacrolimus
- Study type
- INTERVENTIONAL
- Phase
- Phase 1
- Registry status
- Completed
- Start
- 2011-12
- Completion
- 2012-01
- Enrolment
- 24
As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.
ConditionPharmacokinetics of Isavuconazole; Pharmacokinetics of Tacrolimus; Healthy VolunteersInterventionisavuconazole; tacrolimusPhasePhase 1Registry statusCompleted