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AMR Drug RepurposingSmart Screeningresearch prototype

Cefdinir

FDA-approved product (capsule, oral), marketed as Cefdinir, Omnicef.

Registered studies
32
Lab records
8
Pathogens at ≥40%
4 of 4

Chemical structure

Chemical structure of Cefdinir
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Bacterial disease
  • Chronic bronchitis
  • Infection
  • Infectious otitis media
  • Otitis media
  • Pharyngitis
  • Pneumonia
  • Recurrent tonsillitis

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Third-generation cephalosporins
FDA pharmacologic class
Cephalosporin Antibacterial FDA label ↗
Anti-infective classification
Classified as an existing antimicrobial.WHO ATC J01DD15; FDA class Cephalosporin Antibacterial

Repurposing investigation

Cefdinir is already an antimicrobial, so it is not counted among the repurposing candidates. Its AI-predicted activity is shown below for reference.

AI-predicted activity

AI prediction · nothing measured
  • MRSA99.0% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • E. coli99.4% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • K. pneumoniae98.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.
  • M. tuberculosis47.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

32registered studies name this medicine, for any condition. See them below.

Experimental

  • MRSA: measured active in 2 of 2 lab records
  • E. coli: measured active in 4 of 4 lab records
  • K. pneumoniae: measured active in 2 of 2 lab records
Open Cefdinir in ChEMBL Registered studies below
Show the 8 laboratory records, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-6.5 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-8.6 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-8.0 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-6.9 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cefdinir with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Optimizing the Diagnostic Approach to Cephalosporin Allergy Testing

    NCT06406114 · start 2025-05-05

    Registered record
    Registry ID
    NCT06406114
    Conditions
    Drug Allergy; Cephalosporin Allergy; Drug Hypersensitivity; Antibiotic Allergy; Beta Lactam Adverse Reaction; Drug-Induced Anaphylaxis; Cephalosporin Reaction
    Interventions
    Beta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing; Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge; Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge; Dissimilar cephalosporin (ceftriaxone or cefazolin) antibiotic double-blind placebo-controlled drug challenge; Amoxicillin double-blind placebo-controlled drug challenge
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Recruiting
    Start
    2025-05-05
    Completion
    2028-12-31
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionDrug Allergy; Cephalosporin Allergy; Drug Hypersensitivity; Antibiotic Allergy +3 more
    InterventionBeta-lactam antibiotic (cefazolin, cefuroxime, cefotaxime, ceftazidime, ceftriaxone, cefepime, pre-pen, penicillin G, ampicillin, and histamine) double-blind skin testing; Culprit cephalosporin (cefazolin, ceftazidime, ceftriaxone, cefepime, cephalexin, cefaclor, cefadroxil, cefuroxime, cefpodoxime, cefdinir, or cefixime) double-blind placebo-controlled drug challenge; Similar cephalosporin (cefepime, ceftriaxone, cefaclor, cephalexin, cefixime, or cefdinir) antibiotic double-blind placebo-controlled drug challenge; Dissimilar cephalosporin (ceftriaxone or cefazolin) antibiotic double-blind placebo-controlled drug challenge +1 more
    PhasePhase 2
    Registry statusRecruiting

  • Single Dose Aminoglycosides for Acute Uncomplicated Cystitis in the Emergency Department Setting

    NCT05702762 · start 2022-10-01

    Registered record
    Registry ID
    NCT05702762
    Conditions
    Urinary Tract Infections
    Interventions
    Gentamicin; Standard of Care
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2022-10-01
    Completion
    2024-06-30
    Enrolment
    160

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infections
    InterventionGentamicin; Standard of Care
    PhasePhase 2
    Registry statusUnknown

  • Pharmacokinetics, Pharmacodynamics, and Safety Profile of Understudied Drugs Administered to Children Per Standard of Care (POPS)

    NCT04278404 · start 2020-03-05

    Registered record
    Registry ID
    NCT04278404
    Conditions
    Coronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension; Pain; Hyperphosphatemia; Primary Hyperaldosteronism; Edema; Hypokalemia; Heart Failure; Hemophilia; Menorrhagia; Insomnia; Pneumonia; Skin Infection; Arrythmia; Asthma in Children; Bronchopulmonary Dysplasia; Adrenal Insufficiency; Fibrinolysis; Hemorrhage; Attention Deficit Hyperactivity Disorder; Multisystem Inflammatory Syndrome in Children (MIS-C); Kawasaki Disease; Coagulation Disorder; Down Syndrome
    Interventions
    The POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Recruiting
    Start
    2020-03-05
    Completion
    2026-12
    Enrolment
    5,000

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionCoronavirus Infection (COVID-19); Pulmonary Arterial Hypertension; Urinary Tract Infections in Children; Hypertension +22 more
    InterventionThe POP02 study is collecting bodily fluid samples (i.e., whole blood, effluent samples) of children prescribed the following drugs of interest per standard of care:
    PhaseNot recorded
    Registry statusRecruiting

  • The Effect of Chinese Herbal Medicine for Reducing the Application of Antibiotics in the Treatment of Acute Mastitis

    NCT03756324 · start 2018-12-20

    Registered record
    Registry ID
    NCT03756324
    Conditions
    Mastitis Acute Female
    Interventions
    CHPM (Chinese Herbal Patent Medicine ); Antibiotics Cefdinir Capsules; Education; Antibiotics Cefdinir Capsules
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Unknown
    Start
    2018-12-20
    Completion
    2021-03-31
    Enrolment
    306

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMastitis Acute Female
    InterventionCHPM (Chinese Herbal Patent Medicine ); Antibiotics Cefdinir Capsules; Education; Antibiotics Cefdinir Capsules
    PhasePhase 2 / Phase 3
    Registry statusUnknown

  • Comparison of Cefdinir and Cefdinir/Clavulanic Acid Combination in Adults

    NCT03400735 · start 2017-11-01

    Registered record
    Registry ID
    NCT03400735
    Conditions
    Acute Exacerbation of Chronic Bronchitis; Community-Acquired Pneumoniae
    Interventions
    Cefdinir/clavulanic acide 300/125 mg film-coated tablets; Cefdinir 300Mg Capsule
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2017-11-01
    Completion
    2018-08-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Exacerbation of Chronic Bronchitis; Community-Acquired Pneumoniae
    InterventionCefdinir/clavulanic acide 300/125 mg film-coated tablets; Cefdinir 300Mg Capsule
    PhasePhase 4
    Registry statusUnknown

  • Prophylactic Oral Antibiotics on Sinonasal Outcomes Following Endoscopic Transsphenoidal Surgery for Pituitary Lesions

    NCT03014687 · start 2017-07-01

    Registered record
    Registry ID
    NCT03014687
    Conditions
    Antibiotics; Pituitary Adenoma
    Interventions
    Placebo; Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2017-07-01
    Completion
    2019-07
    Enrolment
    116

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAntibiotics; Pituitary Adenoma
    InterventionPlacebo; Oral Antibiotics cefdinir or trimethoprim/sulfamethoxazole
    PhasePhase 4
    Registry statusRecruiting

  • Trial to Evaluate Beta-Lactam Antimicrobial Therapy of Community Acquired Pneumonia in Children

    NCT02891915 · start 2016-12-02

    Registered record
    Registry ID
    NCT02891915
    Conditions
    Pneumonia
    Interventions
    Amoxicillin; Amoxicillin-clavulanate; Cefdinir; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2016-12-02
    Completion
    2019-12-16
    Enrolment
    385

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPneumonia
    InterventionAmoxicillin; Amoxicillin-clavulanate; Cefdinir; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Safety and Efficacy of Cefecin Tab. in Patients With Acute Sinusitis

    NCT04664803 · start 2015-08-31

    Registered record
    Registry ID
    NCT04664803
    Conditions
    Acute Sinusitis
    Interventions
    Cefecin Tab.; Omnicef Cap.
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2015-08-31
    Completion
    2019-08-31
    Enrolment
    284

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Sinusitis
    InterventionCefecin Tab.; Omnicef Cap.
    PhasePhase 4
    Registry statusTerminated

  • Pilot Trial of Antibiotics Versus Surgery for Treating Acute Appendicitis

    NCT02447224 · start 2015-03

    Registered record
    Registry ID
    NCT02447224
    Conditions
    Acute Uncomplicated Appendicitis
    Interventions
    1 gm IV ertapenem at enrollment; 1 gm IV ertapenem at Day 2 and oral metronidazole and cefdinir to complete 10 days; Appendectomy
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Completed
    Start
    2015-03
    Completion
    2017-12-31
    Enrolment
    30

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Uncomplicated Appendicitis
    Intervention1 gm IV ertapenem at enrollment; 1 gm IV ertapenem at Day 2 and oral metronidazole and cefdinir to complete 10 days; Appendectomy
    PhaseEarly phase 1
    Registry statusCompleted

  • Patients Response to Early Switch To Oral:Osteomyelitis Study

    NCT02099240 · start 2014-03-06

    Registered record
    Registry ID
    NCT02099240
    Conditions
    Osteomyelitis
    Interventions
    oral antibiotics; intravenous antibiotics
    Study type
    INTERVENTIONAL
    Phase
    Early phase 1
    Registry status
    Terminated
    Start
    2014-03-06
    Completion
    2018-11-07
    Enrolment
    11

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteomyelitis
    Interventionoral antibiotics; intravenous antibiotics
    PhaseEarly phase 1
    Registry statusTerminated

  • Comparative Effectiveness of Antibiotics for Respiratory Infections

    NCT02297815 · start 2014-01

    Registered record
    Registry ID
    NCT02297815
    Conditions
    Acute Otitis Media; Acute Sinusitis; Group A Streptococcal Pharyngitis
    Interventions
    Broad-spectrum antibiotics; Narrow-spectrum antibiotics
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Completed
    Start
    2014-01
    Completion
    2016-04
    Enrolment
    2,472

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Otitis Media; Acute Sinusitis; Group A Streptococcal Pharyngitis
    InterventionBroad-spectrum antibiotics; Narrow-spectrum antibiotics
    PhaseNot recorded
    Registry statusCompleted

  • Influence of Medication Taste on Pediatric Prescribers' Prescribing Habits

    NCT01734759 · start 2012-11

    Registered record
    Registry ID
    NCT01734759
    Conditions
    Healthy
    Interventions
    Taste Test
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2012-11
    Completion
    2013-01
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionTaste Test
    PhasePhase 1
    Registry statusCompleted

  • The SCOUT Study: "Short Course Therapy for Urinary Tract Infections in Children"

    NCT01595529 · start 2012-05-18

    Registered record
    Registry ID
    NCT01595529
    Conditions
    Urinary Tract Infection
    Interventions
    Cefixime; Cephalexin; Placebo; Trimethoprim/Sulfamethoxazole
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2012-05-18
    Completion
    2019-08-12
    Enrolment
    717

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionUrinary Tract Infection
    InterventionCefixime; Cephalexin; Placebo; Trimethoprim/Sulfamethoxazole
    PhasePhase 2
    Registry statusCompleted

  • Comparing Healthcare Utilization Between Adenotonsillectomy Patients With and Without Postoperative Antibiotic Use

    NCT01561703 · start 2012-03

    Registered record
    Registry ID
    NCT01561703
    Conditions
    Snoring; Strep Throat
    Interventions
    Antibiotic
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2012-03
    Completion
    2015-06
    Enrolment
    58

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionSnoring; Strep Throat
    InterventionAntibiotic
    PhaseNot applicable
    Registry statusCompleted

  • Effectiveness of Oral Antibiotics in the Treatment of Severe Acute Malnutrition

    NCT01000298 · start 2009-12

    Registered record
    Registry ID
    NCT01000298
    Conditions
    Kwashiorkor; Marasmus
    Interventions
    Placebo; Amoxicillin; Cefdinir
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2009-12
    Completion
    2011-05
    Enrolment
    2,767

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKwashiorkor; Marasmus
    InterventionPlacebo; Amoxicillin; Cefdinir
    PhaseNot applicable
    Registry statusCompleted