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AMR Drug RepurposingSmart Screeningresearch prototype

Celecoxib

FDA-approved product (capsule, oral), marketed as Celebrex, Celecoxib, Elyxyb and 1 more.

Registered studies
50+
Lab records
1
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Celecoxib
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Ankylosing spondylitis
  • Cancer
  • Colorectal neoplasm
  • Dysmenorrhea
  • Familial adenomatous polyposis
  • Familial adenomatous polyposis 1
  • Hemorrhage
  • Juvenile idiopathic arthritis
  • Migraine disorder
  • Neoplasm
  • Osteoarthritis
  • Pain
  • Peptic ulcer
  • Peptic ulcer disease
  • Rheumatic disease
  • Rheumatoid arthritis
  • and 2 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antineoplastic agents; Coxibs
FDA pharmacologic class
Nonsteroidal Anti-inflammatory Drug FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA45.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli25.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae14.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis87.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 1 of 1 lab record
Open Celecoxib in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Celecoxib with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Study To Evaluate Efficacy And Safety Of An Additional Dose Of Celecoxib (YM177) In Patients With Post-Tooth Extraction Pain

    NCT01062113 · start 2010-04

    Registered record
    Registry ID
    NCT01062113
    Conditions
    Pain
    Interventions
    Celecoxib; Celecoxib; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2010-04
    Completion
    2010-08
    Enrolment
    255

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionCelecoxib; Celecoxib; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Study of Epicutaneously Applied Ketoprofen Transfersome® Gel With or Without Combination With Oral Celecoxib for the Treatment of Muscle Pain Induced by Eccentric Exercise

    NCT01020279 · start 2009-10

    Registered record
    Registry ID
    NCT01020279
    Conditions
    Musculoskeletal Pain
    Interventions
    Celecoxib, Ketoprofen; Ketoprofen
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-10
    Completion
    2010-01
    Enrolment
    82

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMusculoskeletal Pain
    InterventionCelecoxib, Ketoprofen; Ketoprofen
    PhasePhase 1
    Registry statusCompleted

  • Protocol for the Treatment of Metastatic Ewing Sarcoma

    NCT02727387 · start 2009-06-01

    Registered record
    Registry ID
    NCT02727387
    Conditions
    Ewing's Sarcoma (ES)
    Interventions
    TEMIRI; ADM; IFO; CYC; ETO; BUMEL; VIN
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2009-06-01
    Completion
    2022-04-29
    Enrolment
    155

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionEwing's Sarcoma (ES)
    InterventionTEMIRI; ADM; IFO; CYC +3 more
    PhasePhase 2
    Registry statusCompleted

  • Efficacy and Safety of Shinbaro Capsule

    NCT01535417 · start 2009-05

    Registered record
    Registry ID
    NCT01535417
    Conditions
    Osteoarthritis
    Interventions
    Shinbaro Capsule; Celebrex
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2009-05
    Completion
    2009-12
    Enrolment
    198

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis
    InterventionShinbaro Capsule; Celebrex
    PhasePhase 3
    Registry statusCompleted

  • Naturalistic Safety Registry Of Celecoxib (CELEBREX(R)) And NSAIDs In Juvenile Idiopathic Arthritis

    NCT00688545 · start 2009-04

    Registered record
    Registry ID
    NCT00688545
    Conditions
    Arthritis, Juvenile Rheumatoid
    Interventions
    Celecoxib; nsNSAIDs
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Terminated
    Start
    2009-04
    Completion
    2012-01
    Enrolment
    275

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthritis, Juvenile Rheumatoid
    InterventionCelecoxib; nsNSAIDs
    PhaseNot recorded
    Registry statusTerminated

  • A Pilot Open-Label Crossover Bioavailability Study of Celecoxib in Healthy Volunteers

    NCT00813241 · start 2009-01

    Registered record
    Registry ID
    NCT00813241
    Conditions
    Healthy Volunteers
    Interventions
    celecoxib reference formulation; celecoxib test formulation A1; celecoxib test formulation B2; celecoxib test formulation C1
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2009-01
    Completion
    2009-03
    Enrolment
    16

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy Volunteers
    Interventioncelecoxib reference formulation; celecoxib test formulation A1; celecoxib test formulation B2; celecoxib test formulation C1
    PhasePhase 1
    Registry statusCompleted

  • Changes in Breast Cancer Biomarkers Using Synergistic Prostaglandin Inhibitors

    NCT01425476 · start 2008-07

    Registered record
    Registry ID
    NCT01425476
    Conditions
    Breast Cancer
    Interventions
    Celecoxib; Placebo; Cholecalciferol
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Completed
    Start
    2008-07
    Completion
    2016-11
    Enrolment
    45

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    InterventionCelecoxib; Placebo; Cholecalciferol
    PhasePhase 1 / Phase 2
    Registry statusCompleted

  • Celebrex In Acute Gouty Arthritis Study

    NCT00549549 · start 2008-02

    Registered record
    Registry ID
    NCT00549549
    Conditions
    Arthritis, Gouty
    Interventions
    Indomethacin; Celecoxib; Celecoxib; Celecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2008-02
    Completion
    2009-12
    Enrolment
    402

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthritis, Gouty
    InterventionIndomethacin; Celecoxib; Celecoxib; Celecoxib
    PhasePhase 3
    Registry statusCompleted

  • The Role of COX-2 Inhibition in Salt Sensitivity of Blood Pressure

    NCT00624559 · start 2008-02

    Registered record
    Registry ID
    NCT00624559
    Conditions
    Hypertension
    Interventions
    celecoxib (Celebrex); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2008-02
    Completion
    2009-01
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHypertension
    Interventioncelecoxib (Celebrex); Placebo
    PhasePhase 4
    Registry statusCompleted

  • A Study of High-Risk Oral Cavity Cancer

    NCT00934739 · start 2007-06

    Registered record
    Registry ID
    NCT00934739
    Conditions
    Oral Cavity Cancer
    Interventions
    Thalidomide, Celebrex; Cyclophosphamide, Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 2 / Phase 3
    Registry status
    Terminated
    Start
    2007-06
    Completion
    2012-12
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOral Cavity Cancer
    InterventionThalidomide, Celebrex; Cyclophosphamide, Dexamethasone
    PhasePhase 2 / Phase 3
    Registry statusTerminated

  • Prospective Randomized Evaluation Of Celecoxib Integrated Safety Vs Ibuprofen Or Naproxen

    NCT00346216 · start 2006-10-04

    Registered record
    Registry ID
    NCT00346216
    Conditions
    Arthritis, Rheumatoid
    Interventions
    celecoxib; Ibuprofen; Naproxen
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2006-10-04
    Completion
    2016-04-12
    Enrolment
    24,081

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionArthritis, Rheumatoid
    Interventioncelecoxib; Ibuprofen; Naproxen
    PhasePhase 4
    Registry statusCompleted

  • Combination Therapy Selection Trial in Amyotrophic Lateral Sclerosis

    NCT00355576 · start 2006-07

    Registered record
    Registry ID
    NCT00355576
    Conditions
    Amyotrophic Lateral Sclerosis
    Interventions
    Celecoxib; Creatine; Minocycline
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2006-07
    Completion
    2007-05
    Enrolment
    86

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAmyotrophic Lateral Sclerosis
    InterventionCelecoxib; Creatine; Minocycline
    PhasePhase 2
    Registry statusCompleted

  • S0300, Celecoxib in Preventing Breast Cancer in Premenopausal Women

    NCT00088972 · start 2004-11

    Registered record
    Registry ID
    NCT00088972
    Conditions
    Breast Cancer
    Interventions
    celecoxib; placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Terminated
    Start
    2004-11
    Completion
    2009-07
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBreast Cancer
    Interventioncelecoxib; placebo
    PhasePhase 2
    Registry statusTerminated

  • Predicting Patients' Response to Spinal Manipulation

    NCT00285649 · start 2004-07

    Registered record
    Registry ID
    NCT00285649
    Conditions
    Low Back Pain
    Interventions
    HVLA-SM; LVVA-SM; Usual Medical Care
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2004-07
    Completion
    2007-03
    Enrolment
    192

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionLow Back Pain
    InterventionHVLA-SM; LVVA-SM; Usual Medical Care
    PhaseNot applicable
    Registry statusCompleted

  • Efficacy of Celecoxib vs Placebo to Prevent Pain in a Paced Walk

    NCT00194090 · start 2004-06

    Registered record
    Registry ID
    NCT00194090
    Conditions
    Knee Osteoarthritis
    Interventions
    celecoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2004-06
    Completion
    2005-09-01
    Enrolment
    40

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionKnee Osteoarthritis
    Interventioncelecoxib
    PhasePhase 4
    Registry statusCompleted