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AMR Drug RepurposingSmart Screeningresearch prototype

Celecoxib

FDA-approved product (capsule, oral), marketed as Celebrex, Celecoxib, Elyxyb and 1 more.

Registered studies
50+
Lab records
1
Pathogens at ≥40%
2 of 4

Chemical structure

Chemical structure of Celecoxib
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Ankylosing spondylitis
  • Cancer
  • Colorectal neoplasm
  • Dysmenorrhea
  • Familial adenomatous polyposis
  • Familial adenomatous polyposis 1
  • Hemorrhage
  • Juvenile idiopathic arthritis
  • Migraine disorder
  • Neoplasm
  • Osteoarthritis
  • Pain
  • Peptic ulcer
  • Peptic ulcer disease
  • Rheumatic disease
  • Rheumatoid arthritis
  • and 2 more

Indications ChEMBL records as approved, from FDA and DailyMed labels. Label ↗

WHO therapeutic group
Other antineoplastic agents; Coxibs
FDA pharmacologic class
Nonsteroidal Anti-inflammatory Drug FDA label ↗
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA45.1% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli25.8% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae14.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis87.6% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates. This medicine was in the model's training data, so this is recall, not a new prediction.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

  • M. tuberculosis: measured active in 1 of 1 lab record
Open Celecoxib in ChEMBL Registered studies below
Show the 1 laboratory record, with sources

Loading records…

“Active” means the measured value reached this project’s laboratory cutoff (10 µM or stronger). A laboratory result does not show an effect in patients.

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

-8.1 kcal/mol

0better fit →-12

KPC-2 carbapenemase ↗ (K. pneumoniae)

-7.1 kcal/mol

0better fit →-12

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

-7.7 kcal/mol

0better fit →-12

Dihydrofolate reductase ↗ (MRSA)

-9.8 kcal/mol

0better fit →-12

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Celecoxib with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Efficacy of Opioid-limiting Pain Management Protocol in Men Undergoing Urethroplasty

    NCT03859024 · start 2019-03-22

    Registered record
    Registry ID
    NCT03859024
    Conditions
    Pain, Postoperative; Urethral Stricture
    Interventions
    Oxycodone; Acetaminophen; Gabapentin; celebrex; Bupivacaine; Ibuprofen 800 mg; Dexamethasone
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-03-22
    Completion
    2023-06-30
    Enrolment
    48

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain, Postoperative; Urethral Stricture
    InterventionOxycodone; Acetaminophen; Gabapentin; celebrex +3 more
    PhasePhase 4
    Registry statusCompleted

  • NSAIDs vs. Coxibs in the Presence of Aspirin

    NCT03699293 · start 2018-09-22

    Registered record
    Registry ID
    NCT03699293
    Conditions
    Rheumatoid Arthritis; Cardiovascular Diseases
    Interventions
    celecoxib 200mg capsule; naproxen sodium 550mg tablet; Aspirin 81mg tablet
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Terminated
    Start
    2018-09-22
    Completion
    2023-01-01
    Enrolment
    8

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionRheumatoid Arthritis; Cardiovascular Diseases
    Interventioncelecoxib 200mg capsule; naproxen sodium 550mg tablet; Aspirin 81mg tablet
    PhasePhase 4
    Registry statusTerminated

  • Can DFN-15 Terminate Migraine With Allodynia?

    NCT03472378 · start 2018-05-09

    Registered record
    Registry ID
    NCT03472378
    Conditions
    Migraine With Aura; Migraine Without Aura; Allodynia
    Interventions
    DFN-15; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2018-05-09
    Completion
    2019-04-12
    Enrolment
    51

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMigraine With Aura; Migraine Without Aura; Allodynia
    InterventionDFN-15; Placebo
    PhasePhase 2
    Registry statusCompleted

  • Safety and Activity of F14 for Management of Pain Following Total Knee Replacement

    NCT03541655 · start 2018-05-04

    Registered record
    Registry ID
    NCT03541655
    Conditions
    Total Knee Replacement; Postoperative Pain
    Interventions
    Bupivacaine HCl; F14 (celecoxib)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Completed
    Start
    2018-05-04
    Completion
    2020-03-30
    Enrolment
    20

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionTotal Knee Replacement; Postoperative Pain
    InterventionBupivacaine HCl; F14 (celecoxib)
    PhasePhase 2
    Registry statusCompleted

  • Co-crystal E-58425 vs Tramadol and Celecoxib for Moderate to Severe Acute Pain After Bunionectomy. Phase III Clinical Trial.

    NCT03108482 · start 2017-03-14

    Registered record
    Registry ID
    NCT03108482
    Conditions
    Acute Post-surgical Pain
    Interventions
    Co-crystal E-58425 (Tramadol/Celecoxib); Tramadol (Ultram®); Celecoxib (Celebrex®); Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2017-03-14
    Completion
    2017-11-28
    Enrolment
    637

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionAcute Post-surgical Pain
    InterventionCo-crystal E-58425 (Tramadol/Celecoxib); Tramadol (Ultram®); Celecoxib (Celebrex®); Placebo
    PhasePhase 3
    Registry statusCompleted

  • Perioperative Use of a Selective COX2 Inhibitor in Patients Undergoing Elective Colorectal Surgery: the Effect on Post-operative Bowel Motility and Post-operative Pain

    NCT02790203 · start 2016-06

    Registered record
    Registry ID
    NCT02790203
    Conditions
    Prevention of Post Operative Ileus
    Interventions
    Celecoxib; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2016-06
    Completion
    Not recorded
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPrevention of Post Operative Ileus
    InterventionCelecoxib; Placebo
    PhaseNot applicable
    Registry statusUnknown

  • Early Diuresis Following Colorectal Surgery

    NCT02351934 · start 2015-02

    Registered record
    Registry ID
    NCT02351934
    Conditions
    Colorectal Disorders
    Interventions
    Furosemide; Celecoxib; Gabapentin
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2015-02
    Completion
    2016-04
    Enrolment
    123

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionColorectal Disorders
    InterventionFurosemide; Celecoxib; Gabapentin
    PhasePhase 4
    Registry statusCompleted

  • Bleeding in Laser Haemorrhoidoplasty

    NCT04667169 · start 2015-01

    Registered record
    Registry ID
    NCT04667169
    Conditions
    Hemorrhoids
    Interventions
    Haemorrhoidal Artery Ligation; Laser Haemorrhoidoplasty
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-01
    Completion
    2018-10
    Enrolment
    76

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHemorrhoids
    InterventionHaemorrhoidal Artery Ligation; Laser Haemorrhoidoplasty
    PhaseNot applicable
    Registry statusCompleted

  • Adjuvant Tumor Lysate Vaccine and Iscomatrix With or Without Metronomic Oral Cyclophosphamide and Celecoxib in Patients With Malignancies Involving Lungs, Esophagus, Pleura, or Mediastinum

    NCT02054104 · start 2014-09-03

    Registered record
    Registry ID
    NCT02054104
    Conditions
    Thoracic Sarcomas; Thorasic Cancers; Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura; Sarcoma; Melanoma
    Interventions
    H1299 cell lysates; Cyclophosphamide; Celecoxib; Iscomatrix adjuvant
    Study type
    INTERVENTIONAL
    Phase
    Phase 1 / Phase 2
    Registry status
    Terminated
    Start
    2014-09-03
    Completion
    2015-06-15
    Enrolment
    21

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionThoracic Sarcomas; Thorasic Cancers; Cancers of Non-thoracic Origin With Metastases to the Lungs or Pleura; Sarcoma +1 more
    InterventionH1299 cell lysates; Cyclophosphamide; Celecoxib; Iscomatrix adjuvant
    PhasePhase 1 / Phase 2
    Registry statusTerminated

  • MT2013-31: Allo HCT for Metabolic Disorders and Severe Osteopetrosis

    NCT02171104 · start 2014-07-10

    Registered record
    Registry ID
    NCT02171104
    Conditions
    Mucopolysaccharidosis Disorders; Hurler Syndrome; Hunter Syndrome; Maroteaux Lamy Syndrome; Sly Syndrome; Alpha-Mannosidosis; Fucosidosis; Aspartylglucosaminuria; Glycoprotein Metabolic Disorders; Sphingolipidoses; Recessive Leukodystrophies; Globoid Cell Leukodystrophy; Metachromatic Leukodystrophy; Niemann-Pick B; Niemann-Pick C Subtype 2; Sphingomyelin Deficiency; Peroxisomal Disorders; Adrenoleukodystrophy With Cerebral Involvement; Zellweger Syndrome; Neonatal Adrenoleukodystrophy; Infantile Refsum Disease; Acyl-CoA Oxidase Deficiency; D-Bifunctional Enzyme Deficiency; Multifunctional Enzyme Deficiency; Alpha-methylacyl-CoA Racmase Deficiency; Mitochondrial Neurogastrointestingal Encephalopathy; Severe Osteopetrosis; Hereditary Leukoencephalopathy With Axonal Spheroids (HDLS; CSF1R Mutation); Inherited Metabolic Disorders
    Interventions
    Stem Cell Transplantation; IMD Preparative Regimen; Osteopetrosis Only Preparative Regimen; Osteopetrosis Haploidentical Only Preparative Regimen; cALD SR-A (Standard-Risk, Regimen A); cALD SR-B (Standard-Risk, Regimen B); cALD HR-D (High-Risk, Regimen C); cALD HR-D (High-Risk, Regimen D)
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Active not recruiting
    Start
    2014-07-10
    Completion
    2029-07-14
    Enrolment
    149

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionMucopolysaccharidosis Disorders; Hurler Syndrome; Hunter Syndrome; Maroteaux Lamy Syndrome +26 more
    InterventionStem Cell Transplantation; IMD Preparative Regimen; Osteopetrosis Only Preparative Regimen; Osteopetrosis Haploidentical Only Preparative Regimen +4 more
    PhasePhase 2
    Registry statusActive not recruiting

  • Tourniquet and Quadricepsforce

    NCT01808859 · start 2013-02

    Registered record
    Registry ID
    NCT01808859
    Conditions
    Osteoarthritis; Total Knee Arthroplasty
    Interventions
    Tourniquet
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2013-02
    Completion
    2014-07
    Enrolment
    64

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOsteoarthritis; Total Knee Arthroplasty
    InterventionTourniquet
    PhaseNot applicable
    Registry statusCompleted

  • Clinical Research of the Prognostic Influence of NSAIDS's Anti-inflammatory Effect on Senior Patients With Hip Fracture

    NCT01583660 · start 2012-01

    Registered record
    Registry ID
    NCT01583660
    Conditions
    Hip Fracture
    Interventions
    celecoxib; Acetaminophen oxycodone
    Study type
    OBSERVATIONAL
    Phase
    Not recorded
    Registry status
    Unknown
    Start
    2012-01
    Completion
    2015-12
    Enrolment
    800

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHip Fracture
    Interventioncelecoxib; Acetaminophen oxycodone
    PhaseNot recorded
    Registry statusUnknown

  • Cyclooxygenase-2-Inhibitor Combination Treatment for Bipolar Depression

    NCT01479829 · start 2011-03-23

    Registered record
    Registry ID
    NCT01479829
    Conditions
    Bipolar Depression
    Interventions
    Escitalopram; Celecoxib; Placebo
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2011-03-23
    Completion
    2018-01-24
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionBipolar Depression
    InterventionEscitalopram; Celecoxib; Placebo
    PhasePhase 4
    Registry statusCompleted

  • Effect of Celecoxib and Etoricoxib on the Pharmacokinetics and Pharmacodynamics of Oral Tramadol

    NCT01304069 · start 2011-01

    Registered record
    Registry ID
    NCT01304069
    Conditions
    Healthy
    Interventions
    Placebo; Selecoxib; Etoricoxib
    Study type
    INTERVENTIONAL
    Phase
    Phase 1
    Registry status
    Completed
    Start
    2011-01
    Completion
    2011-07
    Enrolment
    12

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHealthy
    InterventionPlacebo; Selecoxib; Etoricoxib
    PhasePhase 1
    Registry statusCompleted

  • Effectiveness of Celecoxib After Surgical Sperm Retrieval

    NCT01323595 · start 2011-01

    Registered record
    Registry ID
    NCT01323595
    Conditions
    Pain
    Interventions
    Celecoxib; Sugar Pill
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Terminated
    Start
    2011-01
    Completion
    2013-03
    Enrolment
    78

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPain
    InterventionCelecoxib; Sugar Pill
    PhaseNot applicable
    Registry statusTerminated