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AMR Drug RepurposingSmart Screeningresearch prototype

Cetrorelix Acetate

FDA-approved product (powder, subcutaneous), marketed as Cetrorelix Acetate, Cetrotide.

Registered studies
50+
Lab records
0
Pathogens at ≥40%
3 of 4

Chemical structure

Chemical structure of Cetrorelix Acetate
A drawing shows what the molecule is, not what it does.

Existing / approved use

Documented · FDA, WHO, ChEMBL

Approved for

  • Ovulation Inhibition
  • Positive regulation of ovulation

Indications ChEMBL records as approved, from FDA and DailyMed labels.

WHO therapeutic group
Anti-gonadotropin-releasing hormones
Anti-infective classification
Not classified as an anti-infective.

Repurposing investigation

This medicine is being investigated here for AI-predicted antimicrobial activity against MRSA, E. coli and M. tuberculosis. It was surfaced computationally for further investigation; it is not an established treatment for these infections.

AI-predicted activity

AI prediction · nothing measured
  • MRSA63.2% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • E. coli55.7% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.
  • K. pneumoniae28.6% AI-predicted activityBelow the ≥40% mark this site uses to surface candidates.
  • M. tuberculosis62.8% AI-predicted activityAt or above the ≥40% mark this site uses to surface candidates.

A model’s estimate of laboratory activity against each pathogen species. It is not clinical effectiveness.

Evidence

Clinical and experimental

Documented evidence

Clinical

50+registered studies name this medicine, for any condition. The registry search keeps the first 50, so there may be more. See them below.

Experimental

No evidence found

No laboratory measurement against the four pathogens in the ChEMBL records loaded here.

Open Cetrorelix Acetate in ChEMBL Registered studies below

Docking

Computational · nothing measured

Dihydrofolate reductase ↗ (E. coli)

Not yet docked: queued in the docking rundetails

KPC-2 carbapenemase ↗ (K. pneumoniae)

Not yet docked: queued in the docking rundetails

Enoyl-ACP reductase (InhA) ↗ (M. tuberculosis)

Not yet docked: queued in the docking rundetails

Dihydrofolate reductase ↗ (MRSA)

Not yet docked: queued in the docking rundetails

AutoDock Vina, one experimentally solved protein per pathogen. This project’s screening target is -7.0 kcal/mol, its own mark rather than a universal cutoff. A docking score is a structural hypothesis, not proof of binding, and requires experimental validation.

Other medicines to investigate

AI prediction · nothing measured

Other repurposing candidates: approved medicines besides Cetrorelix Acetate with AI-predicted activity ≥40% against the chosen pathogen, leaving out existing antimicrobials. They are computational candidates for further investigation, not alternatives and not recommendations.

Sorted by AI-predicted activity, high to low. The order is not a ranking of which medicine is better.

Registered studies

A registration describes a study; it does not establish a positive result.

  • Traditional Chinese Medicine Herbs in the Freeze-all IVF Cycle

    NCT04935073 · start 2021-06-15

    Registered record
    Registry ID
    NCT04935073
    Conditions
    Infertility, Female
    Interventions
    Prescription of traditional Chinese Medicine named Er Zhi Wan combined with Si Wu Tang; Recombinant Human Follitropin Alfa for Injection、Fructose Injection、Tetyacycline Hydrochloride Capsules、Cetrorelix Acetate Powder for Injection
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Unknown
    Start
    2021-06-15
    Completion
    2022-12-30
    Enrolment
    90

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Female
    InterventionPrescription of traditional Chinese Medicine named Er Zhi Wan combined with Si Wu Tang; Recombinant Human Follitropin Alfa for Injection、Fructose Injection、Tetyacycline Hydrochloride Capsules、Cetrorelix Acetate Powder for Injection
    PhasePhase 3
    Registry statusUnknown

  • GnRH Antagonist Pre-treatment in the Early Follicular Phase for Resolution of a Baseline Functional Ovarian Cyst

    NCT04993924 · start 2021-05-01

    Registered record
    Registry ID
    NCT04993924
    Conditions
    IVF; Ovarian Cysts
    Interventions
    Cetrorelix Acetate, Ganerelix Acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2021-05-01
    Completion
    2023-03-01
    Enrolment
    15

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIVF; Ovarian Cysts
    InterventionCetrorelix Acetate, Ganerelix Acetate
    PhasePhase 4
    Registry statusUnknown

  • PErsonalized Addition of Recombinant LH in Ovarian Stimulation

    NCT04719000 · start 2021-02-04

    Registered record
    Registry ID
    NCT04719000
    Conditions
    Infertility
    Interventions
    rhFSH+rhLH; rhFSH
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Recruiting
    Start
    2021-02-04
    Completion
    2027-11
    Enrolment
    120

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionrhFSH+rhLH; rhFSH
    PhasePhase 4
    Registry statusRecruiting

  • Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology During IVF/ICSI

    NCT04724486 · start 2020-08-22

    Registered record
    Registry ID
    NCT04724486
    Conditions
    In Vitro Fertilization; Intracytoplasmic Sperm Injection; Infertility
    Interventions
    Triptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-08-22
    Completion
    2022-07-15
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIn Vitro Fertilization; Intracytoplasmic Sperm Injection; Infertility
    InterventionTriptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
    PhasePhase 4
    Registry statusCompleted

  • Effect of GnRH Agonist vs GnRH Antagonist on Oocyte Morphology in Polycystic Ovary Syndrome Patients During IVF/ICSI

    NCT04727684 · start 2020-08-22

    Registered record
    Registry ID
    NCT04727684
    Conditions
    In Vitro Fertilization; Infertility; Intracytoplasmic Sperm Injection; Polycystic Ovary Syndrome
    Interventions
    Triptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2020-08-22
    Completion
    2022-05-12
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIn Vitro Fertilization; Infertility; Intracytoplasmic Sperm Injection; Polycystic Ovary Syndrome
    InterventionTriptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
    PhasePhase 4
    Registry statusCompleted

  • Effect of GnRH Agonist vs GnRH Antagonist on IVF/ICSI Outcomes.

    NCT04724343 · start 2019-12-22

    Registered record
    Registry ID
    NCT04724343
    Conditions
    In Vitro Fertilization; Intracytoplasmic Sperm Injection; Infertility
    Interventions
    Triptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-12-22
    Completion
    2022-07-05
    Enrolment
    50

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionIn Vitro Fertilization; Intracytoplasmic Sperm Injection; Infertility
    InterventionTriptorelin acetate; Cetrorelix; recombinant-FSH or recombinant-FSH + human Menopausal Gonadotropin; Human Chorionic Gonadotropin (hCG)
    PhasePhase 4
    Registry statusCompleted

  • Comparison Between Two Different Protocols in Polycystic Ovary Symdrome Women Undergoing Intra-cytoplasmic Injection

    NCT04094467 · start 2019-12-07

    Registered record
    Registry ID
    NCT04094467
    Conditions
    Polycystic Ovary Syndrome
    Interventions
    Cetrorelix; Leuprolide Acetate
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2019-12-07
    Completion
    2021-01
    Enrolment
    150

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionPolycystic Ovary Syndrome
    InterventionCetrorelix; Leuprolide Acetate
    PhasePhase 4
    Registry statusUnknown

  • Coasting Versus Antagonist Protocol in Patients at High Risk of OHSS

    NCT03996434 · start 2019-07-01

    Registered record
    Registry ID
    NCT03996434
    Conditions
    Ovarian Hyperstimulation Syndrome
    Interventions
    Gonadotropin; Antagonist
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2019-07-01
    Completion
    2019-11-20
    Enrolment
    300

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionOvarian Hyperstimulation Syndrome
    InterventionGonadotropin; Antagonist
    PhasePhase 4
    Registry statusCompleted

  • Follitropin Delta in Long GnRH Agonist and GnRH Antagonist Protocols (BEYOND)

    NCT03809429 · start 2019-04-29

    Registered record
    Registry ID
    NCT03809429
    Conditions
    Infertility, Female
    Interventions
    FE 999049 + GnRH agonist (GONAPEPTYL); FE 999049 + GnRH antagonist (CETROTIDE)
    Study type
    INTERVENTIONAL
    Phase
    Phase 3
    Registry status
    Completed
    Start
    2019-04-29
    Completion
    2022-02-16
    Enrolment
    437

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility, Female
    InterventionFE 999049 + GnRH agonist (GONAPEPTYL); FE 999049 + GnRH antagonist (CETROTIDE)
    PhasePhase 3
    Registry statusCompleted

  • Sex Differences in Myocardial Steatosis Induced Left Ventricular Dysfunction

    NCT04671966 · start 2018-09-13

    Registered record
    Registry ID
    NCT04671966
    Conditions
    Heart Diseases; Left Ventricular Dysfunction
    Interventions
    Estradiol patch; Cetrotide; Fasting; Lower Body Negative Pressure
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Unknown
    Start
    2018-09-13
    Completion
    2024-12
    Enrolment
    100

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionHeart Diseases; Left Ventricular Dysfunction
    InterventionEstradiol patch; Cetrotide; Fasting; Lower Body Negative Pressure
    PhasePhase 4
    Registry statusUnknown

  • Extended Letrozole Regimen Co-treatment With Gonadotropin Releasing Hormone Antagonist Protocol Versus Gonadotropin Releasing Hormone Antagonist Protocol in Poor Responders Undergoing IVF-ET

    NCT04268927 · start 2018-04-01

    Registered record
    Registry ID
    NCT04268927
    Conditions
    Infertility
    Interventions
    GnRH ant/letrozole; GnRH ant
    Study type
    INTERVENTIONAL
    Phase
    Phase 2
    Registry status
    Unknown
    Start
    2018-04-01
    Completion
    2020-04-20
    Enrolment
    106

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionGnRH ant/letrozole; GnRH ant
    PhasePhase 2
    Registry statusUnknown

  • NATural Ovarian Stimulation

    NCT02892942 · start 2017-01-13

    Registered record
    Registry ID
    NCT02892942
    Conditions
    Infertility
    Interventions
    Gonal-F®; Cetrotide®; Cetrotide®
    Study type
    INTERVENTIONAL
    Phase
    Phase 4
    Registry status
    Completed
    Start
    2017-01-13
    Completion
    2019-02-08
    Enrolment
    129

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInfertility
    InterventionGonal-F®; Cetrotide®; Cetrotide®
    PhasePhase 4
    Registry statusCompleted

  • Early Follicular Phase vs Lutheal Phase Ovarian Stimulation in Bologna Criteria IVF/ICSI Cycles (LUTEAL Trial)

    NCT02625532 · start 2015-12

    Registered record
    Registry ID
    NCT02625532
    Conditions
    Reproductive Techniques, Assisted
    Interventions
    Follicular phase; Luteal phase
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2015-12
    Completion
    2019-01
    Enrolment
    60

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionReproductive Techniques, Assisted
    InterventionFollicular phase; Luteal phase
    PhaseNot applicable
    Registry statusUnknown

  • Dysregulation of FSH in Obesity: Functional and Statistical Analysis

    NCT02478775 · start 2015-07

    Registered record
    Registry ID
    NCT02478775
    Conditions
    Obesity; Fertility
    Interventions
    Degarelix (GnRH antagonist); recombinant FSH; Cetrorelix
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Completed
    Start
    2015-07
    Completion
    2021-06-30
    Enrolment
    99

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionObesity; Fertility
    InterventionDegarelix (GnRH antagonist); recombinant FSH; Cetrorelix
    PhaseNot applicable
    Registry statusCompleted

  • The Impact of Body Weight on Reproductive Outcomes in Poor Ovarian Responders in ICSI Cycles

    NCT03457233 · start 2015-01-03

    Registered record
    Registry ID
    NCT03457233
    Conditions
    Invitro Fertilization
    Interventions
    Gonadotropins; GNRH antagonist; Human chorionic gonadotropin Chorimon; Natural progesterone
    Study type
    INTERVENTIONAL
    Phase
    Not applicable
    Registry status
    Unknown
    Start
    2015-01-03
    Completion
    2018-03
    Enrolment
    185

    As stored from ClinicalTrials.gov. Registration describes a study; it does not mean the study worked.

    ConditionInvitro Fertilization
    InterventionGonadotropins; GNRH antagonist; Human chorionic gonadotropin Chorimon; Natural progesterone
    PhaseNot applicable
    Registry statusUnknown